EugeneHwangMD

Pediatric Hematology & Oncology • Washington, DC

Pediatric Neuro-Oncology

Associate Chief, Oncology

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Office
111 Michigan Ave, NW
Washington, DC 20010
Phone+1 202-476-5046
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Education & Training

Duke University HospitalFellowship, Pediatric Hematology/Oncology, 2008
Brown UniversityResidency, Pediatrics, 2002 - 2005
Duke University School of MedicineClass of 2002

Certifications & Licensure

VA State Medical License 2024 - 2026
DC State Medical License 2010 - 2024
NC State Medical License 2005 - 2010
American Board of Pediatrics Pediatric Hematology-Oncology

Clinical Trials

Vaccine Immunotherapy for Recurrent Medulloblastoma and Primitive Neuroectodermal Tumor Start of enrollment: 2010 Sep 07
Active, not recruiting
Phase 2
Vinorelbine for Children With Progressive or Recurrent Low-grade Gliomas Start of enrollment: 2011 Jul 01
Completed
Phase 2
Palbociclib Isethionate in Treating Younger Patients With Recurrent, Progressive, or Refractory Central Nervous System Tumors Start of enrollment: 2014 Dec 08
Terminated
Phase 1
Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma Start of enrollment: 2015 May 22
Recruiting
Phase 1
HeadStart4: Newly Diagnosed Children (<10 y/o) With Medulloblastoma and Other CNS Embryonal Tumors Start of enrollment: 2015 Sep 01
Active, not recruiting
Phase 4
Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG Start of enrollment: 2017 Apr 04
Recruiting
Not Applicable
Phase I Study of APX005M in Pediatric CNS Tumors Start of enrollment: 2018 Mar 01
Active, not recruiting
Phase 1
SGT-53 in Children With Recurrent or Progressive CNS Malignancies Start of enrollment: 2022 Jun 01
Not yet recruiting
Early Phase 1
A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma Start of enrollment: 2018 Aug 01
Active, not recruiting
Phase 1
Roles: Contact, Principal Investigator
A Pilot Study of Larotrectinib for Newly-Diagnosed High-Grade Glioma With NTRK Fusion Start of enrollment: 2021 Apr 08
Recruiting
Early Phase 1
Multi-antigen T Cell Infusion Against Neuro-oncologic Disease Start of enrollment: 2018 Dec 12
Recruiting
Phase 1
Roles: Contact, Principal Investigator
MEKTOVI® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma Start of enrollment: 2023 Apr 10
Recruiting
Phase 2
Roles: Contact
PEP-CMV Vaccine Targeting CMV Antigen to Treat Newly Diagnosed Pediatric HGG and DIPG and Recurrent Medulloblastoma Start of enrollment: 2024 Apr 15
Not yet recruiting
Phase 2
Roles: Principal Investigator, Contact
ACTEMRA® for the Treatment of Pediatric Adamantinomatous Craniopharyngioma Start of enrollment: 2022 Dec 16
Recruiting
Phase 2
Roles: Contact
A Pilot Study of SurVaxM in Children Progressive or Relapsed Medulloblastoma, High Grade Glioma, Ependymoma and Newly Diagnosed Diffuse Intrinsic Pontine Glioma Start of enrollment: 2022 Jul 01
Recruiting
Phase 1
Roles: Contact
Targeted Pediatric High-Grade Glioma Therapy Start of enrollment: 2024 May 30
Not yet recruiting
Roles: Contact
Study of Ribociclib and Everolimus in HGG and DIPG Start of enrollment: 2024 May 30
Not yet recruiting
Phase 2
Roles: Contact
Study of Olutasidenib and Temozolomide in HGG Start of enrollment: 2024 Jun 01
Not yet recruiting
Phase 2
Roles: Contact
Lorlatinib for Newly-Diagnosed High-Grade Glioma With ROS or ALK Fusion Start of enrollment: 2024 Sep 01
Not yet recruiting
Early Phase 1
Roles: Contact
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Publications & Presentations

PubMed

2 citations
Why haven't we solved intracranial pediatric ependymoma? Current questions and barriers to treatment advances.
Eugene I Hwang, Derek Hanson, Mariella G Filbin, Stephen C Mack> ;Neoplasia. 2023 May 1
2 citations
Two clinically distinct cases of infant hemispheric glioma carrying ZCCHC8:ROS1 fusion and responding to entrectinib.
Ludmila Papusha, Margarita Zaytseva, Agnesa Panferova, Alexander Druy, Andge Valiakhmetova, Anton Artemov, Ekaterina Salnikova, Alexey Kislyakov, Evgeny Imyanitov, Ale...> ;Neuro-Oncology. 2022 Jun 1
16 citations
The current landscape of immunotherapy for pediatric brain tumors.
Eugene I Hwang, Elias J Sayour, Catherine T Flores, Gerald Grant, Robert Wechsler-Reya, Lan B Hoang-Minh, Mark W Kieran, Joanne Salcido, Robert M Prins, John W Figg, M...> ;Nature Cancer. 2022 Jan 1
1 citations
Safety of Tumor Treating Fields (TTFields) therapy in pediatric patients with malignant brain tumors: Post-marketing surveillance data.
Stewart Goldman, Ashley Margol, Eugene I Hwang, Kazuhiro Tanaka, Bogdana Suchorska, John R Crawford, Santosh Kesari> ;Frontiers in Oncology. 2022 Jan 1
10 citations
Clinical phenotypes and prognostic features of embryonal tumours with multi-layered rosettes: a Rare Brain Tumor Registry study
Sara Khan, Palma Solano-Paez, Tannu Suwal, Mei Lu, Salma Al-Karmi, Ben Ho, Iqra Mumal, Mary Shago, Lindsey Hoffman, Andrew Dodgshun, Sumihito Nobusawa, Uri Tabori, Ute...> ;The Lancet. Child & Adolescent Health. 2021 Sep 29
18 citations
Therapeutic implications of improved molecular diagnostics for rare CNS embryonal tumor entities: results of an international, retrospective study.
Katja von Hoff, Christine Haberler, Felix Schmitt-Hoffner, Elizabeth Schepke, Teresa de Rojas, Sandra Jacobs, Michal Zapotocky, David Sumerauer, Marta Perek-Polnik, Ch...> ;Neuro-Oncology. 2021 Sep 1
50 citations
Efficacy of Carboplatin and Isotretinoin in Children With High-risk Medulloblastoma: A Randomized Clinical Trial From the Children's Oncology Group.
Sarah Leary, Roger J. Packer, Yimei Li, Catherine A. Billups, Kyle S. Smith, Alok Jaju, Linda Heier, Peter C. Burger, Karin S. Walsh, Yuanyuan Han, Leanne Embry, Jenni...> ;JAMA Oncology. 2021 Jul 22
35 citations
Clinical and molecular heterogeneity of pineal parenchymal tumors: a consensus study
Anthony P. Y. Liu, Bryan K. Li, Elke Pfaff, Brian Gudenas, Alexandre Vasiljevic, Brent A. Orr, Christelle Dufour, Matija Snuderl, Matthias A. Karajannis, Marc K. Rosen...> ;Acta Neuropathologica. 2021 Feb 22
9 citations
A Phase I and Surgical Study of Ribociclib and Everolimus in Children with Recurrent or Refractory Malignant Brain Tumors: A Pediatric Brain Tumor Consortium Study.
Mariko DeWire, Christine Fuller, Olivia Campagne, Tong Lin, Haitao Pan, Tina Young Poussaint, Patricia Baxter, Eugene Hwang, Andrew Bukowinski, Kathleen Dorris, Lindse...> ;Clinical Cancer Research. 2021 Feb 5
8 citations
Phase 1 study of pomalidomide in children with recurrent, refractory, and progressive central nervous system tumors: A Pediatric Brain Tumor Consortium trial.
Jason Fangusaro, Duane Mitchell, Mehmet Kocak, Giles W. Robinson, Patricia Baxter, Eugene I Hwang, Jianping Huang, Arzu Onar-Thomas, Ira J. Dunkel, Maryam Fouladi, Kat...> ;Pediatric Blood & Cancer. 2021 Feb 1
5 citations
Considerations when treating high-grade pediatric glioma patients with immunotherapy.
Erin E. Crotty, Kira Downey, Lauren Ferrerosa, Catherine Flores, Bindu Hegde, Scott Raskin, Eugene Hwang, Nicholas A Vitanza, Hideho Okada> ;Expert Review of Neurotherapeutics. 2021 Feb 1
22 citations
A phase I trial of the CDK 4/6 inhibitor palbociclib in pediatric patients with progressive brain tumors: A Pediatric Brain Tumor Consortium study (PBTC-042).
David Van Mater, Sridharan Gururangan, Oren J. Becher, Olivia Campagne, Sarah Leary, Joanna J. Phillips, Jie Huang, Tong Lin, Tina Young Poussaint, Stewart Goldman, Pa...> ;Pediatric Blood & Cancer. 2021 Jan 6
8 citations
The experience of successful treatment of ETV6-NTRK3-positive infant glioblastoma with entrectinib
Ludmila Papusha, Margarita Zaytseva, Alexander Druy, Andge Valiakhmetova, Ludmila Yasko, Ekaterina Salnikova, Anastasia Shekhtman, Alexander Karachunsky, Alexey Mascha...> ;Neuro-Oncology Advances. 2021 Jan 1
6 citations
Pediatric diffuse leptomeningeal glioneuronal tumor: Two clinical cases of successful targeted therapy
Andge Valiakhmetova, Ludmila Papusha, Alexander Druy, Ludmila Yasko, Anastasia Ektova, Alexander Karachunsky, Alexei Maschan, Eugene I Hwang, Galina Novichkova, Roger ...> ;Pediatric Blood & Cancer. 2020 Aug 25
37 citations
Implications of new understandings of gliomas in children and adults with NF1: Report of a consensus conference
Roger J. Packer, Antonio Iavarone, David T.W. Jones, Jaishri O. Blakeley, Eric Bouffet, Michael Fisher, Eugene Hwang, Cynthia Hawkins, Lindsay Kilburn, Tobey J. MacDon...> ;Neuro-Oncology. 2020 Jun 9
19 citations
ΔNp73/ETS2 complex drives glioblastoma pathogenesis- targeting downstream mediators by rebastinib prolongs survival in preclinical models of glioblastoma.
Maren Cam, Manish Charan, Alessandra M. Welker, Piyush Dravid, Adam W. Studebaker, Jeffrey R. Leonard, Christopher R. Pierson, Ichiro Nakano, Christine E. Beattie, Eug...> ;Neuro-Oncology. 2020 Mar 5
54 citations
Pineoblastoma segregates into molecular sub-groups with distinct clinico-pathologic features: a Rare Brain Tumor Consortium registry study
Bryan K. Li, Alexandre Vasiljevic, Christelle Dufour, Fupan Yao, Ben L. B. Ho, Mei Lu, Eugene Hwang, Sridharan Gururangan, Jordan R. Hansford, Maryam Fouladi, Sumihito...> ;Acta Neuropathologica. 2020 Feb 1
8 citations
Molecularly Targeted Agents in the Therapy of Pediatric Brain Tumors
Miriam Bornhorst, Eugene Hwang> ;Paediatric Drugs. 2020 Feb 1
1 citations
Immunotherapy Approaches for Pediatric CNS Tumors and Associated Neurotoxicity
Elizabeth A. Finch, Elizabeth S. Duke, Eugene Hwang, Roger J. Packer> ;Pediatric Neurology. 2020 Jan 27
9 citations
MRI Features of Histologically Diagnosed Supratentorial Primitive Neuroectodermal Tumors and Pineoblastomas in Correlation with Molecular Diagnoses and Outcomes: A Rep...
Alok Jaju, Eugene Hwang, Marcel Kool, David Capper, Lukas Chavez, Sebastian Brabetz, Catherine A. Billups, Yuxin Li, Maryam Fouladi, Roger J. Packer, Stefan M. Pfister...> ;AJNR. American Journal of Neuroradiology. 2019 Oct 10
19 citations
Medulloblastoma rendered susceptible to NK-cell attack by TGFβ neutralization.
Allison B. Powell, Sridevi Yadavilli, Devin Saunders, Stacey Van Pelt, Elizabeth Chorvinsky, Rachel A. Burga, Shuroug Albihani, Patrick J. Hanley, Zhenhua Xu, Yanxin P...> ;Journal of Translational Medicine. 2019 Sep 23
58 citations
A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor
Patrick Sin-Chan, Iqra Mumal, Tannu Suwal, Ben Ho, Xiaolian Fan, Irtisha Singh, Yuchen Du, Mei Lu, Neilket Patel, Jonathon Torchia, Dean Popovski, Maryam Fouladi, Paul...> ;Cancer Cell. 2019 Jul 8
5 citations
Differential Expression of Wilms’ Tumor Protein in Diffuse Intrinsic Pontine Glioma
Sulgi Lee, Madhuri Kambhampati, Sridevi Yadavilli, Heather Gordish-Dressman, Mariarita Santi, Conrad Russell Y. Cruz, Roger J. Packer, M Isabel Almira-Suarez, Eugene H...> ;Journal of Neuropathology and Experimental Neurology. 2019 May 1
99 citations
Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy
Eshini Panditharatna, Lindsay Kilburn, Mariam Aboian, Madhuri Kambhampati, Heather Gordish-Dressman, Suresh N. Magge, Nalin Gupta, John S. Myseros, Eugene Hwang, Cassi...> ;Clinical Cancer Research. 2018 Dec 1
54 citations
Extensive Molecular and Clinical Heterogeneity in Patients With Histologically Diagnosed CNS-PNET Treated as a Single Entity: A Report From the Children’s Oncology Gro...
Eugene Hwang, Marcel Kool, Peter C. Burger, David Capper, Lukas Chavez, Sebastian Brabetz, Chris Williams-Hughes, Catherine A. Billups, Linda Heier, Alok Jaju, Jeff M....> ;Journal of Clinical Oncology. 2018 Oct 17
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Journal Articles

Clinically Relevant and Minimally Invasive Tumor Surveillance of Pediatric Diffuse Midline Gliomas Using Patient-Derived Liquid Biopsy
Eugene I Hwang, Cassie Kline, Soonmee Cha, Michael Prados, Lindsay B Kilburn, Nalin Gupta, Roger J Packer, Suresh N Magge, Clinical Cancer Research
Heterogeneity Within the PF-EPN-B Ependymoma Subgroup
Andrew Grossbach, Vijay Ramaswamy, Benjamin Lu, Mariarita Santi, Caterina Giannini, Linda M Liau, Terri S Armstrong, Sarah Leary, Matthias A Karajannis, Kenneth Aldape..., Acta Neuropathologica

Hospital Affiliations

Children's National HospitalWashington, District of Columbia
Children's National HospitalWashington, District of Columbia

EugeneHwangMD

Dr. Hwang is on Doximity

Education & Training

Certifications & Licensure

Clinical Trials

Publications & Presentations

Hospital Affiliations

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