EugenioCersosimoMD

Endocrinology • San Antonio, TX

Diabetes, Lipid Metabolism

Associate Professor, Medicine, University of Texas Medical School, San Antonio

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Office
701 S Zarzamora
San Antonio, TX 78207
Phone+1 210-358-7500

Fax+1 210-358-7515
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Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Endocrinology, Diabetes, and Metabolism, 1991 - 1994
Mayo Clinic College of Medicine and Science (Rochester)Residency, Internal Medicine, 1988 - 1991
Fluminense Federal University Faculty of MedicineClass of 1974

Certifications & Licensure

TX State Medical License 2002 - 2024
MN State Medical License 1990 - 2003
NY State Medical License 1994 - 2001

Clinical Trials

Mechanisms of Glucose Lowering Effects of Sitagliptin and Metformin Alone and in Combination in Patients With T2DM Start of enrollment: 2009 Oct 01
Completed
Phase 4
Acute Effect of Exenatide on Brain Glucose Metabolism Start of enrollment: 2010 Jul 01
Completed
Phase 4
ESR-15-11293 - Saxa/Dapa, Safety and Efficacy Study Start of enrollment: 2016 Jan 01
Completed
Not Applicable
Effect of Chronic Exenatide Therapy on Beta Cell Function and Insulin Sensitivity in T2DM Start of enrollment: 2017 Dec 15
Completed
Phase 4
Effect of Dapagliflozin on Hepatic and Renal Glucose Metabolism Subjects Start of enrollment: 2019 May 23
Completed
Phase 4
Paradoxical Stimulation of Hepatic Glucose Production With Dapagliflozin Start of enrollment: 2017 Sep 06
Completed
Phase 3
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Publications & Presentations

PubMed

Effect of Dapagliflozin on Renal and Hepatic Glucose Kinetics in T2DM and NGT Subjects.
Xi Chen, Robert Chilton, Andrea Hansis-Diarte, Devjit Tripathy, Marzieh Salehi, Carolina Solis-Herrera, Eugenio Cersosimo, Ralph A DeFronzo> ;Diabetes. 2024 Mar 21
1 citations
Emergence of a New Glucoregulatory Mechanism for Glycemic Control With Dapagliflozin/Exenatide Therapy in Type 2 Diabetes.
Eugenio Cersosimo, Mariam Alatrach, Carolina Solis-Herrera, John Adams, Andrea Hansis-Diarte, Amalia Gastaldelli, Alberto Chavez, Curtis Triplitt, Ralph A DeFronzo, Ba...> ;The Journal of Clinical Endocrinology and Metabolism. 2023 Dec 21
6 citations
Pioglitazone reduces epicardial fat and improves diastolic function in patients with type 2 diabetes.
Alexander J Moody, Marjorie Molina-Wilkins, Geoffrey D Clarke, Aurora Merovci, Carolina Solis-Herrera, Eugenio Cersosimo, Robert J Chilton, Patricia Iozzo, Amalia Gast...> ;Diabetes, Obesity & Metabolism. 2023 Feb 1
3 citations
Bromocriptine-QR Therapy Reduces Sympathetic Tone and Ameliorates a Pro-Oxidative/Pro-Inflammatory Phenotype in Peripheral Blood Mononuclear Cells and Plasma of Type 2...
Anthony H Cincotta, Eugenio Cersosimo, Mariam Alatrach, Michael Ezrokhi, Christina Agyin, John Adams, Robert Chilton, Curtis Triplitt, Bindu Chamarthi, Nicholas Comino...> ;International Journal of Molecular Sciences. 2022 Aug 9
4 citations
FGF21 contributes to metabolic improvements elicited by combination therapy with exenatide and pioglitazone in patients with type 2 diabetes.
Ricardo J Samms, Christine C Cheng, Marcel Fourcaudot, Sami Heikkinen, Ahmed Khattab, John Adams, Eugenio Cersosimo, Curtis Triplitt, Curtis Puckett, Kostas Tsintzas, ...> ;American Journal of Physiology. Endocrinology and Metabolism. 2022 Aug 1
11 citations
Combination therapy with pioglitazone/exenatide/metformin reduces the prevalence of hepatic fibrosis and steatosis: The efficacy and durability of initial combination ...
Olga Lavynenko, Muhammad Abdul-Ghani, Mariam Alatrach, Curtiss Puckett, John Adams, Siham Abdelgani, Naim Alkhouri, Curtis Triplitt, Geoffrey D Clarke, Juan A Vasquez,...> ;Diabetes, Obesity & Metabolism. 2022 May 1
1 citations
Antihyperglycemic Algorithms for Type 2 Diabetes: Focus on Nonglycemic Outcomes.
Carolina Solis-Herrera, Eugenio Cersosimo, Curtis L Triplitt> ;Diabetes Spectrum. 2021 Aug 1
21 citations
Durability of Triple Combination Therapy Versus Stepwise Addition Therapy in Patients With New-Onset T2DM: 3-Year Follow-up of EDICT
Muhammad A. Abdul-Ghani, Curtiss Puckett, John Adams, Ahmad Khattab, Gozde Baskoy, Eugenio Cersosimo, Curtis L Triplitt, Ralph A. DeFronzo> ;Diabetes Care. 2021 Feb 1
Clinical Parameters, Fuel Oxidation, and Glucose Kinetics in Patients With Type 2 Diabetes Treated With Dapagliflozin Plus Saxagliptin
Yuejuan Qin, John Adams, Carolina Solis-Herrera, Curtis L Triplitt, Ralph A. DeFronzo, Eugenio Cersosimo> ;Diabetes Care. 2020 Jul 21
10 citations
Improved Beta Cell Glucose Sensitivity Plays Predominant Role in the Decrease in HbA1c with Cana and Lira in T2DM
Ali M. Ali, Andrea Mari, Hussein Al-Jobori, John Adams, Curtis L Triplitt, Ralph A. DeFronzo, Eugenio Cersosimo, Muhammad A. Abdul-Ghani> ;The Journal of Clinical Endocrinology and Metabolism. 2020 Oct 1
5 citations
Anti-inflammatory and anti-proliferative action of adiponectin mediated by insulin signaling cascade in human vascular smooth muscle cells.
Eugenio Cersosimo, Xiaojing Xu, Tomoko Terasawa, Lily Q. Dong> ;Molecular Biology Reports. 2020 Aug 12
12 citations
Increase in Endogenous Glucose Production With SGLT2 Inhibition Is Unchanged by Renal Denervation and Correlates Strongly With the Increase in Urinary Glucose Excretion
Carolina Solis-Herrera, Giuseppe Daniele, Mariam Alatrach, Christina Agyin, Curtis L Triplitt, John Adams, Rupal Patel, Amalia Gastaldelli, Henri Honka, Xi Chen, Muham...> ;Diabetes Care. 2020 May 1
16 citations
Evidence Against an Important Role of Plasma Insulin and Glucagon Concentrations in the Increase in EGP Caused by SGLT2 Inhibitors.
Mariam Alatrach, Nitchakarn Laichuthai, Christina Agyin, Ali M. Ali, Hussein Al-Jobori, Olga Lavynenko, John Adams, Curtis L Triplitt, Ralph A. DeFronzo, Eugenio Cerso...> ;Diabetes. 2020 Apr 1
25 citations
Combination Therapy With Canagliflozin Plus Liraglutide Exerts Additive Effect on Weight Loss, but Not on HbA1c, in Patients With Type 2 Diabetes.
Ali M. Ali, Hussein Al-Jobori, John Adams, Curtis L Triplitt, Ralph A. DeFronzo, Eugenio Cersosimo, Muhammad A. Abdul-Ghani> ;Diabetes Care. 2020 Mar 20
5 citations
Challenges of Diabetes Care in Older People With Type 2 Diabetes and the Role of Basal Insulin
Eugenio Cersosimo, Pearl G. Lee, Naushira Pandya> ;Clinical Diabetes. 2019 Oct 1
4 citations
Hormonal, Metabolic and Hemodynamic Adaptations to Glycosuria in Type 2 Diabetes Patients Treated with Sodium-Glucose Co-Transporter Inhibitors.
Eugenio Cersosimo, John M. Miles> ;Current Diabetes Reviews. 2019 Jul 31
7 citations
Glucose lowering and vascular protective effects of cycloset added to GLP-1 receptor agonists in patients with type 2 diabetes.
Mariam Alatrach, Christina Agyin, John Adams, Robert J. Chilton, Curtis L Triplitt, Ralph A. DeFronzo, Eugenio Cersosimo> ;Endocrinology, Diabetes & Metabolism. 2018 Aug 15
6 citations
Impaired left ventricular diastolic function in T2DM patients is closely related to glycemic control.
Geoffrey D. Clarke, Marjorie Molina-Wilkins, Carolina Solis-Herrera, Verna Mendez, Adriana Monroy, Eugenio Cersosimo, Robert J. Chilton, Muhammad A. Abdul-Ghani, Ralph...> ;Endocrinology, Diabetes & Metabolism. 2018 Apr 6
38 citations
Endogenous Glucose Production and Hormonal Changes in Response to Canagliflozin and Liraglutide Combination Therapy.
Hussein Al-Jobori, Ali M. Ali, John Adams, Muhammad A. Abdul-Ghani, Curtis L Triplitt, Ralph A. DeFronzo, Eugenio Cersosimo> ;Diabetes. 2018 Mar 30
53 citations
Empagliflozin Treatment Is Associated With Improved β-Cell Function in Type 2 Diabetes Mellitus.
Hussein Al Jobori, Giuseppe Daniele, John Adams, Eugenio Cersosimo, Carolina Solis-Herrera, Curtis L Triplitt, Ralph A. DeFronzo, Muhammad A. Abdul-Ghani> ;The Journal of Clinical Endocrinology and Metabolism. 2018 Apr 1
26 citations
Initiating therapy in patients newly diagnosed with type 2 diabetes: Combination therapy vs a stepwise approach.
Eugenio Cersosimo, Eric L. Johnson, Christina Chovanes, Neil Skolnik> ;Diabetes, Obesity & Metabolism. 2018 Mar 1
39 citations
Pioglitazone Improves Left Ventricular Diastolic Function in Subjects With Diabetes
Geoffrey D. Clarke, Carolina Solis-Herrera, Marjorie Molina-Wilkins, Sandra Serrano Martínez, Aurora Merovci, Eugenio Cersosimo, Robert J. Chilton, Patricia Iozzo, Ama...> ;Diabetes Care. 2017 Nov 1
1 citations
Use of Canagliflozin in Combination With and Compared to Incretin-Based Therapies in Type 2 Diabetes.
Richard E. Pratley, Eugenio Cersosimo> ;Clinical Diabetes. 2017 Jul 1
20 citations
Inhibition of Renal Sodium-Glucose Cotransport With Empagliflozin Lowers Fasting Plasma Glucose and Improves β-Cell Function in Subjects With Impaired Fasting Glucose
Muhammad A. Abdul-Ghani, Hussein Al Jobori, Giuseppe Daniele, John Adams, Eugenio Cersosimo, Curtis L Triplitt, Ralph A. DeFronzo> ;Diabetes. 2017 Sep 1
47 citations
Empagliflozin and Kinetics of Renal Glucose Transport in Healthy Individuals and Individuals With Type 2 Diabetes.
Hussein Al-Jobori, Giuseppe Daniele, Eugenio Cersosimo, Curtis L Triplitt, Rucha J. Mehta, Luke Norton, Ralph A. DeFronzo, Muhammad A. Abdul-Ghani> ;Diabetes. 2017 Jul 1
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Lectures

Effects of Metformin on Metabolic and Inflammatory Insulin Signaling Pathways in Vascular Smooth Muscle Cell
San Antonio, TX - 6/16/2014

Grant Support

CD Mutations And Type 2 DiabetesNational Center For Research Resources2000–2001
Kidney And Glucose MetabolismNational Institute Of Diabetes And Digestive And Kidney Diseases1994–1998

Hospital Affiliations

University Health / UT Health Science Center at San AntonioSan Antonio, Texas
University Health / UT Health Science Center at San AntonioSan Antonio, Texas