FelipeFregniMD

Assistant Professor and Director of the Labortory of Neuromodulation Spaulding Rehabiliation Hospital. Director, Principles and Practice of Clinical Research (PPCR), Harvard T.H. Chan School of Public Health. Associate Professor of Physical Medicine & Rehabilitation, Harvard Medical School.

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Office
330 Brookline Ave
Boston, MA 02215
Phone+1 617-667-5272

Fax+1 617-975-5322
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Summary

Dr. Felipe Fregni, MD is a neurologist in Boston, Massachusetts. He is an Assistant Professor and Director of the Labortory of Neuromodulation Spaulding Rehabiliation Hospital. Director at Harvard T.H. Chan School of Public Health. Associate Professor of Physical Medicine & Rehabilitation.

Clinical Trials

TMS for the Treatment of Pancreatic Cancer Pain Start of enrollment: 2006 May 01
Completed
Not Applicable
Migraine--Investigational Treatment of Migraine With Noninvasive Brain Stimulation. (tDCS- Migraine) Start of enrollment: 2007 Jul 01
Completed
Not Applicable
tDCS and Physical Therapy in Stroke Start of enrollment: 2007 Sep 01
Completed
Not Applicable
Cortical Plasticity Assessment in Athletes With a History of Concussion Start of enrollment: 2010 Apr 01
Terminated
Not Applicable
Application of Transcranial Direct Current Stimulation (tDCS) in Patients With Chronic Pain After Spinal Cord Injury Start of enrollment: 2010 Apr 01
Terminated
Not Applicable
Use of Noninvasive Brain Stimulation in Parkinson's Disease Start of enrollment: 2009 Dec 01
Completed
Not Applicable
Transcranial Direct Stimulation in Chronic Pelvic Pain Start of enrollment: 2010 Apr 01
Completed
Phase 2
Use of Transcranial Direct Current Stimulation (tDCS) Coupled With Constraint Induced Movement Therapy in Stroke Patient Start of enrollment: 2010 Apr 01
Completed
Not Applicable
Exploration of Parameters of Transcranial Direct Current Stimulation (tDCS) in Chronic Pain Start of enrollment: 2011 Apr 01
Completed
Not Applicable
Effects of Transcranial Direct Current Stimulation (tDCS) on Neuropathic Symptoms Due to Burn Injury Start of enrollment: 2011 Jun 01
Completed
Not Applicable
Investigating Motor Cortex Processing for Pain Modulation Start of enrollment: 2010 Sep 01
Terminated
Phase 1
Effects of Transcranial Direct Current Stimulation (tDCS) and Transcranial Ultrasound on Osteoarthritis Pain of the Knee Start of enrollment: 2011 Jan 01
Completed
Not Applicable
Effects of Transcranial Direct Current Stimulation (tDCS) and Visual Illusion on Chronic Pain Due to Spinal Cord Injury Start of enrollment: 2010 Dec 01
Terminated
Not Applicable
Closed-loop System Using Transcranial Direct Current Stimulation (tDCS) for Epilepsy Start of enrollment: 2011 Jul 01
Completed
Not Applicable
Effects of rTMS and tDCS on Motor Function in Stroke Start of enrollment: 2011 May 01
Completed
Not Applicable
Effects of Transcranial Direct Current Stimulation (tDCS) in Chronic Corneal Pain Start of enrollment: 2012 Jan 01
Completed
Not Applicable
Spaulding-Harvard Model System: Effects of Transcranial Direct Current Stimulation (tDCS) on Chronic Pain in Spinal Cord Injury Start of enrollment: 2011 Dec 01
Completed
Not Applicable
Effects of Transcranial Direct Current Stimulation (tDCS) on Neuropathic Symptoms Following Burn Injury Start of enrollment: 2013 Jan 01
Completed
Not Applicable
Single-arm, Open-label, Phase II Trial of HD-tDCS in Fibromyalgia Patients Start of enrollment: 2013 Mar 01
Completed
Not Applicable
Effects of Transcranial Direct Current Stimulation (tDCS) and Motor Learning in Children With Cerebral Palsy (CP) Start of enrollment: 2013 May 01
Completed
Not Applicable
Niche Trial: Navigated Inhibitory rTMS to Contralesional Hemisphere Trial Start of enrollment: 2014 Apr 01
Completed
Not Applicable
Effects rTMS Combined With Fluoxetine on Motor Recovery in Stroke Patients Start of enrollment: 2014 Sep 01
Completed
Phase 2
Optimizing Rehabilitation for Phantom Limb Pain Using Mirror Therapy and Transcranial Direct Current Stimulation (tDCS) Start of enrollment: 2015 Jul 01
Active, not recruiting
Not Applicable
Neurophysiological Effects on tPCS and tDCS on Healthy Subjects and on Patients With Chronic Visceral Pain Start of enrollment: 2015 Jul 01
Completed
Not Applicable
The Effects of Sensory Training On Pain Modulation, Cognition and Time to Fatigue in Healthy Adults Start of enrollment: 2017 Jun 01
Withdrawn
Not Applicable
Effects of tDCS and tUS on Pain Perception in OA of the Knee Start of enrollment: 2016 Sep 01
Active, not recruiting
Effects of tDCS and TUS on the Perception of Pain and Functional Limitations Due to Non-Specific Chronic Low Back Pain Start of enrollment: 2016 Nov 01
Active, not recruiting
Electric Field Navigated 1hz Rtms for Post-stroke Motor Recovery Trial Start of enrollment: 2017 Mar 01
Completed
Not Applicable
Optimized tDCS for Fibromyalgia: Targeting the Endogenous Pain Control System Start of enrollment: 2019 May 01
Recruiting
Not Applicable
Parkinson's Disease: Enhancing Physical Therapy With Brain Stimulation for Treating Postural Instability. Start of enrollment: 2020 Jan 23
Recruiting
Not Applicable
Noninvasive Brain Stimulation for Treating Carpal Tunnel Syndrome Start of enrollment: 2021 Apr 16
Recruiting
Not Applicable
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Publications & Presentations

PubMed

The role of clinical and demographic predictors for understanding the cognitive impairment in Spinal Cord Injury (SCI) patients.
Ana Clara Portela Hara, Nicole C Aching, Lucas M Marques, Sara P Barbosa, Daniel R Souza, Linamara R Battistella, Marcel Simis, Felipe Fregni> ;Spinal Cord. 2024 Apr 12
Treating neuropathic pain and comorbid affective disorders: Preclinical and clinical evidence.
David Richer Araujo Coelho, Maia Gersten, Alma Sanchez Jimenez, Willians Fernando Vieira, Felipe Fregni, Paolo Cassano> ;Pain Practice. 2024 Apr 4
Non-invasive sound wave brain stimulation with Transcranial Pulse Stimulation (TPS) improves neuropsychiatric symptoms in Alzheimer's disease.
Gilson Tanaka Shinzato, Tatiane Assone, Paulo C Sandler, Kevin Pacheco-Barrios, Marcia Radanovic, Orestes Vicente Forlenza, Linamara Rizzo Battistella, Felipe Fregni> ;Brain Stimulation. 2024 Mar 20
Resting-state EEG as Biomarker of Maladaptive Motor Function and Depressive Profile in Stroke Patients.
Marques, L., Barbosa, S., Gianlorenço, A., Pacheco-Barrios, K., Souza, D., Matheus, D., Battistella, L., Simis, M., Fregni, F.> ;Clinical EEG and Neuroscience. 2024 Mar 9
Transauricular Vagus Nerve Stimulation (taVNS) enhances Conditioned Pain Modulation (CPM) in healthy subjects: A randomized controlled trial.
Kevin Pacheco-Barrios, Anna Carolyna Gianlorenco, Lucas Camargo, Maria Fernanda Andrade, Hyuk Choi, Jae-Jun Song, Felipe Fregni> ;Brain Stimulation. 2024 Mar 5
Using Home-based, Remotely Supervised, Transcranial Direct Current Stimulation for Phantom Limb Pain.
Kevin Pacheco-Barrios, Daniela Martinez-Magallanes, Cristina Xicota Naqui, Marianna Daibes, Elly Pichardo, Alejandra Cardenas-Rojas, Abhishek Datta, Wolnei Caumo, Davi...> ;Journal of Visualized Experiments. 2024 Mar 1
Effect of transcranial direct current stimulation combined with pelvic muscle training in women: Randomized, controlled, double-blind, and clinical trial.
Fernanda Ishida Corrêa, Ângela Cristina Ledur, Laura Uehara, Michele Lacerda de Andrade, João Carlos Ferrari Corrêa, Felipe Fregni> ;Neurourology and Urodynamics. 2024 Mar 1
Distinct patterns of metabolic motor cortex activity for phantom and residual limb pain in people with amputations: A functional near-infrared spectroscopy study.
Marcel Simis, Lucas Murrins Marques, Sara Pinto Barbosa, André Tadeu Sugawara, João Ricardo Sato, Kevin Pacheco-Barrios, Linamara Rizzo Battistella, Felipe Fregni> ;Neurophysiologie Clinique = Clinical Neurophysiology. 2024 Feb 1
Brain-heart interactions in fibromyalgia syndrome.
Costa, V., Gianlorenço, A., Pacheco-Barrios, K., Fregni, F.> ;Principles and Practice of Clinical Research. 2024 Feb 16
Impact of multiple-session home-based transcranial direct current stimulation (M-HB-tDCS) on eating behavior in fibromyalgia: A factorial randomized clinical trial.
Jornada, M., Antunes, L., Alves, C., Torres, I., S Sanches, P., P Silva, D., Caumo, W., Fregni, F.> ;Brain Stimulation. 2024 Feb 8
Understanding the Effects of Non-Invasive Transauricular Vagus Nerve Stimulation On EEG and HRV.
Gianlorenco, A., Pacheco-Barrios, K., Camargo, L., Pichardo, E., Choi, H., Song, J., Fregni, F.> ;Journal of Visualized Experiments. 2024 Jan 19
Accelerating the development of noninvasive brain stimulation devices: using design thinking to facilitate its clinical use and acceptance.
Dodurgali, M. R., Kevin Pacheco-Barrios, Anna Carolyna Gianlorenco, Lucas Camargo, Mustafa Reha Dodurgali, Anamon Tangjade, Felipe Fregni> ;Expert Review of Neurotherapeutics. 2024 Jan 8
Physical Conditioning, Obesity and Fibromyalgia: Causal Relationship or Confounding?
Costa, V., Gianlorenço, A., Daibes, M., Queiroz, F., Lacerda, G., Martinez-Magallanes, D., Camargo, L., Alves, L., Andrade, M., Dodurgali, M., Pacheco-Barrios, K., Fre...> ;Principles and Practice of Clinical Research. 2023 Nov 28
OPRM1 and BDNF polymorphisms associated with a compensatory neurophysiologic signature in knee osteoarthritis patients.
Fernanda de Toledo Gonçalves, Lucas Murrins Marques, Anne Victório Pessotto, Sara Pinto Barbosa, Marta Imamura, Marcel Simis, Felipe Fregni, Linamara Battistella> ;Neurophysiologie Clinique = Clinical Neurophysiology. 2023 Dec 1
Neural, Anti-Inflammatory, and Clinical Effects of Transauricular Vagus Nerve Stimulation in Major Depressive Disorder: A Systematic Review.
Joao Parente, Ingrid Rebello-Sanchez, Minkyung Kim, Hyuk Choi, Jae-Jun Song, Felipe Fregni, Anna Carolyna Gianlorenco, Jose Mario Prati, Chi Kyung Kim> ;The International Journal of Neuropsychopharmacology. 2024 Mar 1
2 citations
Efficacy of Home-Based Transcranial Direct Current Stimulation Over the Primary Motor Cortex and Dorsolateral Prefrontal Cortex in the Disability Due to Pain in Fibrom...
Wolnei Caumo, Rael Lopes Ramos, Paul Vicuña Serrano, Camila Fernanda da Silveira Alves, Liciane Medeiros, Leticia Ramalho, Rafalea Tomeddi, Samara Bruck, Lucas Boher, ...> ;The Journal of Pain. 2024 Feb 1
Editorial - Seeking Brain Homeostatic Compensatory Mechanisms for Pain Control.
Kevin Pacheco-Barrios, Lucas M Marques, Daniela Martinez-Magallanes, Sara P Barbosa, Marianna De Andrade, Jorge Ortega Márquez, Paulo S de Melo, Marcel Simis, Wolnei C...> ;Principles and Practice of Clinical Research. 2023 Sep 3
The effect of transcranial direct current stimulation associated with video game training on the postural balance of older women in the community: A blind, randomized,...
Fernanda Ishida Corrêa, Andre Issao Kunitake, Wellington Segheto, Max Duarte de Oliveira, Felipe Fregni, João Carlos Ferrari Corrêa> ;Physiotherapy Research International. 2024 Jan 1
1 citations
Electric Field Navigated 1-Hz rTMS for Poststroke Motor Recovery: The E-FIT Randomized Controlled Trial.
Dylan J Edwards, Charles Y Liu, Kari Dunning, Felipe Fregni, Jarmo Laine, Benjamin E Leiby, Lynn M Rogers, Richard L Harvey> ;Stroke. 2023 Sep 1
Functional and Neural Correlates Associated with Conditioned Pain Modulation in Patients with Chronic Knee Osteoarthritis Pain: A Cross-Sectional Study.
Marcel Simis, Kevin Pacheco-Barrios, Karen Vasquez-Avila, Ingrid Rebello-Sanchez, Joao Parente, Luis Castelo-Branco, Anna Marduy, Paulo S de Melo, Marta Imamura, Linam...> ;Life. 2023 Aug 7
4 citations
Non-invasive brain stimulation on clinical symptoms in multiple sclerosis patients: A systematic review and meta-analysis.
Elif Uygur-Kucukseymen, Kevin Pacheco-Barrios, Burcu Yuksel, Paola Gonzalez-Mego, Aysun Soysal, Felipe Fregni> ;Multiple Sclerosis and Related Disorders. 2023 Oct 1
Preemptive transcranial direct current stimulation induces analgesia, prevents chronic inflammation and fibrosis, and promotes tissue repair in a rat model of postoper...
Mayra Zancanaro, Dirson J Stein, Bettega C Lopes, Andressa de Souza, Roberta Ströher Toledo, Alessandra H de Souza, Sara M Oliveira, Fernanda Visioli, Paulo R S Sanche...> ;Neuroscience Letters. 2023 Sep 14
Factors associated with pain pressure threshold in both local and remote sites in knee osteoarthritis.
Marta Imamura, Ingrid Rebello-Sanchez, Joao Parente, Anna Marduy, Karen Vasquez-Avila, Kevin Pacheco-Barrios, Luis Castelo-Branco, Marcel Simis, Linamara Battistella, ...> ;PM & R. 2024 Feb 1
Editorial - The Use of Large Language Models in Science: Opportunities and Challenges.
Bassel Almarie, Paulo E P Teixeira, Kevin Pacheco-Barrios, Carlos Augusto Rossetti, Felipe Fregni> ;Principles and Practice of Clinical Research. 2023 Jul 10
Editorial - The Secret Life of Retractions in Scientific Publications.
Bianca Barros Parron Fernandes, Carlos Augusto Rossetti, Kevin Pacheco-Barrios, Felipe Fregni, Dodurgali, M. R., Mustafa Reha Dodurgali> ;Principles and Practice of Clinical Research. 2023 Jul 10
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Press Mentions

Novel Motor Test Added to Trial of Highland’s Brain Stimulation DeviceNovember 21st, 2022
Trial to Test Brain Stimulation Device for Balance ProblemsDecember 9th, 2021
Spaulding Rehabilitation Hospital at Harvard Medical School and Highland Instruments, Inc., Jointly Announce National Institutes of Health Funded Clinical Trial Investigating Highland's Electrosonic Stimulation Technology to Treat Postural Instability in Parkinson's DiseaseDecember 7th, 2021
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Grant Support

Investigation And Treatment Of Central Nervous System Dysfunction In Chronic PelvNational Institute Of Diabetes And Digestive And Kidney Diseases2009–2010
Investigation And Treatment Of Central Nervous System Dysfunction In Chronic PelvNational Institute Of Diabetes And Digestive And Kidney Diseases2009
Clinical Trial: TMS For The Treatment Of Severely Affected StrokeNational Center For Research Resources2008
Effect Of TMS On Abdominal Pain In Patients With Pancreatic CancerNational Center For Research Resources2007–2008