FlavioG.VincentiMD

Nephrology • San Francisco, CA

Professor, Medicine, UCSF School of Medicine

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Office
505 Parnassus Ave
San Francisco, CA 94143
Phone+1 415-353-1889

Fax+1 415-353-8974
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Education & Training

University of California (San Francisco)Fellowship, Nephrology, 1975 - 1976
American University of Beirut Faculty of MedicineClass of 1971

Certifications & Licensure

CA State Medical License 1976 - 2024
GA State Medical License 1974 - 1977
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Nephrology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2012-2013

Clinical Trials

Study of ISA247 (Voclosporin) in De Novo Renal Transplantation Start of enrollment: 2006 Jan 01
Completed
Phase 2
Belatacept to Prevent Organ Rejection in Kidney Transplant Patients Start of enrollment: 2006 Dec 01
Terminated
Phase 2
The Effect of Rituximab on the Development of Anti-Donor Antibodies Start of enrollment: 2004 Aug 01
Completed
Not Applicable
Pilot Trial to Assess Effect of CNI Conversion of Efalizumab on T Reg Cells Start of enrollment: 2008 Dec 01
Withdrawn
Phase 1, Phase 2
NFAT-Dependent Cytokine Gene Expression for Immune Monitoring in Kidney Transplant Patients Start of enrollment: 2013 May 02
Completed
Not Applicable
Efficacy and Safety of Eculizumab for Treatment of Antibody-mediated Rejection Following Renal Transplantation Start of enrollment: 2013 Nov 01
Terminated
Phase 2
Treg Adoptive Therapy for Subclinical Inflammation in Kidney Transplantation Start of enrollment: 2014 Mar 01
Completed
Phase 1
Tocilizumab for Renal Graft Inflammation Start of enrollment: 2014 Jun 01
Completed
Phase 2
Precision Medicine Offers Belatacept Monotherapy Start of enrollment: 2019 Feb 01
Withdrawn
Phase 4
Immune Monitoring in Sensitized Patients at Risk of Rejection Start of enrollment: 2015 Aug 20
Completed
Treg Modulation With CD28 and IL-6 Receptor Antagonists Start of enrollment: 2019 Dec 11
Completed
Phase 1, Phase 2
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Publications & Presentations

PubMed

The hepatocyte growth factor mimetic, ANG-3777, in kidney transplant recipients with delayed graft function: Results from a randomized phase 3 trial.
Flavio Vincenti, Jonathan Bromberg, Jim Kim, Arman Faravardeh, Nicolae Leca, Gabriela Alperovich, Philipp Andreas Csomor, Shakil Aslam, John Neylan> ;American Journal of Transplantation. 2024 Feb 20
2 citations
Isatuximab Monotherapy for Desensitization in Highly Sensitized Patients Awaiting Kidney Transplant.
Flavio Vincenti, Oriol Bestard, Amarpali Brar, Josep M Cruzado, Daniel Seron, A Osama Gaber, Nicole Ali, Anat R Tambur, Helen Lee, Giovanni Abbadessa, Jo-Anne Paul, Ma...> ;Journal of the American Society of Nephrology. 2024 Mar 1
Perturbations in podocyte transcriptome and biological pathways induced by FSGS associated circulating factors.
Priyanka Rashmi, Tara K Sigdel, Dmitry Rychkov, Izabella Damm, Andrea Alice Da Silva, Flavio Vincenti, Andre L Lourenco, Charles S Craik, Jochen Reiser, Minnie M Sarwal> ;Annals of Translational Medicine. 2023 Jun 30
7 citations
Understanding heterogeneity of human bone marrow plasma cell maturation and survival pathways by single-cell analyses.
Meixue Duan, Doan C Nguyen, Chester J Joyner, Celia L Saney, Christopher M Tipton, Joel Andrews, Sagar Lonial, Caroline Kim, Ian Hentenaar, Astrid Kosters, Eliver Ghos...> ;Cell Reports. 2023 Jul 25
2 citations
Open letter to Bristol Myers Squibb: Belatacept; we aren't done yet.
Flavio Vincenti, Klemens Budde, Josep Grinyo, Lionel Rostaing, Allan D Kirk, Christian P Larsen> ;American Journal of Transplantation. 2023 Oct 1
36 citations
Letermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-Risk Kidney Transplant Recipients: A Randomized Clinical Trial.
Ajit P Limaye, Klemens Budde, Atul Humar, Flavio Vincenti, Dirk R J Kuypers, Robert P Carroll, Nicole Stauffer, Yoshihiko Murata, Julie M Strizki, Valerie L Teal, Chri...> ;JAMA. 2023 Jul 3
4 citations
Race-free estimated glomerular filtration rate equation in kidney transplant recipients: development and validation study.
Marc Raynaud, Solaf Al-Awadhi, Ivana Juric, Gillian Divard, Yannis Lombardi, Nikolina Basic-Jukic, Olivier Aubert, Laurence Dubourg, Ingrid Masson, Christophe Mariat, ...> ;BMJ. 2023 May 31
1 citations
Obinutuzumab Effectively Depletes Key B-cell Subsets in Blood and Tissue in End-stage Renal Disease Patients.
Cary M Looney, Aaron Schroeder, Erica Tavares, Jay Garg, Thomas Schindler, Flavio Vincenti, Robert R Redfield, Stanley C Jordan, Stephan Busque, E Steve Woodle, Jared ...> ;Transplantation Direct. 2023 Feb 1
5 citations
Burden of neutropenia and leukopenia among adult kidney transplant recipients: A systematic literature review of observational studies.
Amit D Raval, Kristin D Kistler, Yuexin Tang, Flavio Vincenti> ;Transplant Infectious Disease. 2023 Feb 1
2 citations
State of the art in childhood nephrotic syndrome: concrete discoveries and unmet needs.
Flavio Vincenti, Andrea Angeletti, Gian Marco Ghiggeri> ;Frontiers in Immunology. 2023 Jan 1
6 citations
Infliximab Induction Lacks Efficacy and Increases BK Virus Infection in Deceased Donor Kidney Transplant Recipients: Results of the CTOT-19 Trial.
Donald E Hricik, Brian Armstrong, Tarek Alhamad, Daniel C Brennan, Jonathan S Bromberg, Suphamai Bunnapradist, Sindhu Chandran, Robert L Fairchild, David P Foley, Rich...> ;Journal of the American Society of Nephrology. 2023 Jan 1
8 citations
Outcomes among CMV-mismatched and highly sensitized kidney transplants recipients who develop neutropenia.
Sandeep Brar, Reyoot Berry, Amit D Raval, Yuexin Tang, Flavio Vincenti, Nikolaos Skartsis> ;Clinical Transplantation. 2022 Apr 1
34 citations
Conversion from Calcineurin Inhibitor to Belatacept-based Maintenance Immunosuppression in Renal Transplant Recipients: a Randomized Phase 3b Trial.
Klemens Budde, Rohini Prashar, Hermann Haller, M Rial, Nassim Kamar, Avinash Agarwal, Johan W. de Fijter, Lionel Rostaing, Stefan P Berger, Arjang Djamali, Nicolae Lec...> ;Journal of the American Society of Nephrology. 2021 Oct 27
20 citations
Application of the iBox prognostication system as a surrogate endpoint in the TRANSFORM randomised controlled trial: proof-of-concept study.
Olivier Aubert, Gillian Divard, Julio Pascual, Federico Oppenheimer, Claudia Sommerer, Franco Citterio, H. Tedesco, Steve Chadban, Mitchell L. Henry, Flavio Vincenti, ...> ;BMJ Open. 2021 Oct 1
5 citations
A Comparison of Ex Vivo Expanded Human Regulatory T Cells Using Allogeneic Stimulated B Cells or Monocyte-Derived Dendritic Cells.
Linda M. Lee, Hong Zhang, Karim Lee, Horace Liang, Alexander A. Merleev, Flavio Vincenti, Emanual Michael Maverakis, Angus W. Thomson, Qizhi Tang> ;Frontiers in Immunology. 2021 Jun 18
3 citations
Tests for the noninvasive diagnosis of kidney transplant rejection should be evaluated by kidney transplant programs.
Gabriel M. Danovitch, Suphamai Bunnapradist, David Cohen, Sundaram Hariharan, Dianne B. McKay, Lloyd E. Ratner, Mark D. Stegall, Robert W. Steiner, Peter G. Stock, Fla...> ;American Journal of Transplantation. 2021 Jun 3
14 citations
Optimization of de novo belatacept-based immunosuppression administered to renal transplant recipients
Allan D. Kirk, Andrew B. Adams, Antoine Durrbach, Mandy L. Ford, David A. Hildeman, Christian P. Larsen, Flavio Vincenti, David Wojciechowski, E. Steve Woodle> ;American Journal of Transplantation. 2021 May 1
8 citations
Phase 3 trial Design of the Hepatocyte Growth Factor Mimetic ANG-3777 in Renal Transplant Recipients With Delayed Graft Function.
Flavio Vincenti, Jim Kim, Deborah Gouveia, Gabrielle Pelle, Tracy J. Mayne, John F. Neylan> ;Kidney International Reports. 2021 Feb 1
31 citations
Interleukin-6 blockade with tocilizumab increases Tregs and reduces T effector cytokines in renal graft inflammation: A randomized controlled trial.
Sindhu Chandran, Joey Leung, Crystal Hu, Zoltan Laszik, Qizhi Tang, Flavio Vincenti> ;American Journal of Transplantation. 2021 Jan 21
4 citations
Single-Cell RNA Sequencing of Tocilizumab-Treated Peripheral Blood Mononuclear Cells as an in vitro Model of Inflammation
Arya Zarinsefat, George C. Hartoularos, Dmitry Rychkov, Priyanka Rashmi, Sindhu Chandran, Flavio Vincenti, Chun J. Yee, Minnie M. Sarwal> ;Frontiers in Genetics. 2021 Jan 5
19 citations
IL-6 and TNFα Drive Extensive Proliferation of Human Tregs Without Compromising Their Lineage Stability or Function.
Nikolaos Skartsis, Yani Peng, Leonardo M R Ferreira, Vinh Nguyen, Emilie Ronin, Yannick D Muller, Flavio Vincenti, Qizhi Tang> ;Frontiers in Immunology. 2021 Jan 1
1 citations
The impact of belatacept on the phenotypic heterogeneity of renal T cell‐mediated alloimmune response: the critical role of maintenance treatment and inflammatory load
Dejan Dobi, Flavio Vincenti, Sindhu Chandran, John R. Greenland, Christopher Bowman, Adeline Chen, Henrik Junger, Zoltan Laszik> ;Clinical Transplantation. 2020 Sep 16
42 citations
A urine score for noninvasive accurate diagnosis and prediction of kidney transplant rejection.
Joshua Y. C. Yang, Reuben D. Sarwal, Tara K. Sigdel, Izabella Damm, Ben Rosenbaum, Juliane Liberto, Chitranon Chan-on, José M. Arreola-Guerra, Josefina Alberú, Flavio ...> ;Science Translational Medicine. 2020 Mar 18
21 citations
A randomized, phase 1b study of the pharmacokinetics, pharmacodynamics, safety, and tolerability of bleselumab, a fully human, anti‐CD40 monoclonal antibody, in kidney...
Flavio Vincenti, Goran B. Klintmalm, Harold Yang, V. Ram Peddi, Paul Blahunka, Angela Conkle, Vicki Santos, John Holman> ;American Journal of Transplantation. 2020 Jan 1
12 citations
Further Evidence That the Soluble Urokinase Plasminogen Activator Receptor Does Not Directly Injure Mice or Human Podocytes.
Efrat Harel, Jun Shoji, Vivek Abraham, Loan Miller, Zoltan Laszik, Andy J. King, Dejan Dobi, Gyula Szabo, Byron Hann, Minnie M. Sarwal, Charles S. Craik, Flavio Vincenti> ;Transplantation. 2020 Jan 1
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