FrancisSLeeMDPhD

PubMed

• Synaptic plasticity via receptor tyrosine kinase/G-protein-coupled receptor crosstalk.
  Lao-Peregrin, C., Xiang, G., Srivastava, I., Fall, A., Gerhard, D., Kohtala, P., Kim, D., Song, M., Garcia-Marcos, M., Levitz, J., Kim, J., Lee, F.> ;Cell Reports. 2024 Jan 23
• 6 citations
  The role of neurotrophic factors in novel, rapid psychiatric treatments.
  Jihye Kim, Michelle J He, Alina K Widmann, Francis S Lee> ;Neuropsychopharmacology. 2024 Jan 1
• Developmental age and fatty acid amide hydrolase genetic variation converge to mediate fear regulation in female mice.
  Danielle M Gerhard, Nathaniel Tse, Francis S Lee, Heidi C Meyer> ;Developmental Psychobiology. 2023 Sep 1
• Intermixed safety cues facilitate extinction retention in adult and adolescent mice.
  Heidi C Meyer, Francis S Lee> ;Physiology & Behavior. 2023 Nov 1
• 22 citations
  Towards a youth mental health paradigm: a perspective and roadmap.
  Peter J Uhlhaas, Christopher G Davey, Urvakhsh Meherwan Mehta, Jai Shah, John Torous, Nicholas B Allen, Shelli Avenevoli, Tolulope Bella-Awusah, Andrew Chanen, Eric Y ...> ;Molecular Psychiatry. 2023 Aug 1
• Immune activation of the p75 neurotrophin receptor: implications in neuroinflammation.
  Danelon, V., Garret-Thomson, S., Almo, S., Hempstead, B., Lee, F.> ;Frontiers in Molecular Neuroscience. 2023 Jan 1
• 8 citations
  Control of Gαsignaling dynamics and GPCR cross-talk by GRKs.
  Guoqing Xiang, Amanda Acosta-Ruiz, Arthur Radoux-Mergault, Melanie Kristt, Jihye Kim, Jared D Moon, Johannes Broichhagen, Asuka Inoue, Francis S Lee, Miriam Stoeber, J...> ;Science Advances. 2022 Nov 25
• 3 citations
  Human immunomodulatory ligand B7-1 mediates synaptic remodeling via the p75 neurotrophin receptor.
  Nicholas C Morano, Roshelle S Smith, Victor Danelon, Ryan Schreiner, Uttsav Patel, Natalia G Herrera, Carla Smith, Steven M Olson, Michelle K Laerke, Alev Celikgil, Sc...> ;The Journal of Clinical Investigation. 2022 Nov 15
• 3 citations
  The role of BDNF in mediating the prophylactic effects of (R,S)-ketamine on fear generalization and extinction.
  James D Ryan, Nathaniel Tse, Chienchun Huang, Ruirong Yang, Francis S Lee> ;Translational Psychiatry. 2022 Aug 25
• 7 citations
  Acute stress induces an aberrant increase of presynaptic release of glutamate and cellular activation in the hippocampus of BDNFmice.
  Laura Musazzi, Paolo Tornese, Nathalie Sala, Francis S Lee, Maurizio Popoli, Alessandro Ieraci> ;Journal of Cellular Physiology. 2022 Oct 1
• 10 citations
  Enhancing exposure therapy for posttraumatic stress disorder (PTSD): a randomized clinical trial of virtual reality and imaginal exposure with a cognitive enhancer.
  JoAnn Difede, Barbara O Rothbaum, Albert A Rizzo, Katarzyna Wyka, Lisa Spielman, Christopher Reist, Michael J Roy, Tanja Jovanovic, Seth D Norrholm, Judith Cukor, Mega...> ;Translational Psychiatry. 2022 Jul 27
• 14 citations
  Identification of potential blood biomarkers associated with suicide in major depressive disorder.
  Firoza Mamdani, Matthieu D Weber, Blynn Bunney, Kathleen Burke, Preston Cartagena, David Walsh, Francis S Lee, Jack Barchas, Alan F Schatzberg, Richard M Myers, Stanle...> ;Translational Psychiatry. 2022 Apr 14
• 9 citations
  Corticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated Nr3c1 gene.
  Salvatore G Caradonna, Nathan R Einhorn, Vikram Saudagar, Huzefa Khalil, Gordon H Petty, Axel Lihagen, Claire LeFloch, Francis S Lee, Huda Akil, Alessandro Guidotti, B...> ;Translational Psychiatry. 2022 Mar 16
• 3 citations
  The α-adrenergic receptor pathway modulating depression influences the risk of arterial thrombosis associated with BDNFVal66Met polymorphism.
  Leonardo Sandrini, Patrizia Amadio, Alessandro Ieraci, Alessandro Malara, José P Werba, Paolo M Soprano, Alessandra Balduini, Marta Zarà, Alice Bonomi, Fabrizio Veglia...> ;Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 2022 Feb 1
• A Common Human Brain-Derived Neurotrophic Factor Polymorphism Leads to Prolonged Depression of Excitatory Synaptic Transmission by Isoflurane in Hippocampal Cultures.
  Riley A Williams, Kenneth W Johnson, Francis S Lee, Hugh C Hemmings Jr, Jimcy Platholi> ;Frontiers in Molecular Neuroscience. 2022 Jan 1
• 11 citations
  Genomic modules and intramodular network concordance in susceptible and resilient male mice across models of stress.
  Salvatore G. Caradonna, Tie-Yuan Zhang, Nicholas O’Toole, Mojun Shen, Huzefa Khalil, Nathan R. Einhorn, Xianglan Wen, Carine Parent, Francis S. Lee, Huda Akil, Michael...> ;Neuropsychopharmacology. 2021 Nov 30
• 3 citations
  Genetic Variants of Fatty Acid Amide Hydrolase Modulate Acute Inflammatory Responses to Colitis in Adult Male Mice
  Haley A. Vecchiarelli, Robert J. Aukema, Catherine Hume, Vincent Chiang, Maria Morena, Catherine M. Keenan, Andrei S. Nastase, Francis S. Lee, Quentin J. Pittman, Keit...> ;Frontiers in Cellular Neuroscience. 2021 Nov 22
• 15 citations
  SLITRK5 is a negative regulator of hedgehog signaling in osteoblasts.
  Jun Sun, Dong Yeon Shin, Mark Eiseman, Alisha R. Yallowitz, Na Li, Sarfaraz Lalani, Zan Li, Michelle Cung, Seoyeon Bok, Shawon Debnath, Sofia Jenia Marquez, Tommy E. W...> ;Nature Communications. 2021 Jul 29
• 7 citations
  Scn2a severe hypomorphic mutation decreases excitatory synaptic input and causes autism-associated behaviors.
  Hong-Gang Wang, Charlotte C. Bavley, Anfei Li, Rebecca M. Jones, Jonathan E. Hackett, Yared Bayleyen, Francis S. Lee, Anjali M. Rajadhyaksha, Geoffrey S. Pitt> ;JCI Insight. 2021 Sep 29
• 23 citations
  An Adolescent Sensitive Period for Threat Responding: Impacts of Stress and Sex.
  Danielle M. Gerhard, Heidi C. Meyer, Francis S. Lee> ;Biological Psychiatry. 2021 Apr 1
• 18 citations
  SorCS2 is required for social memory and trafficking of the NMDA receptor.
  Jianmin Yang, Iva Dincheva, Joanna Giza, Deqiang Jing, Tina Marinic, Teresa A. Milner, Anjali M. Rajadhyaksha, Francis S. Lee, Barbara L. Hempstead> ;Molecular Psychiatry. 2021 Mar 1
• SorCS is highly expressed in the CA2 region of the hippocampus and is enriched in the postsynaptic region
  Jianmin Yang, Qian Ma, Iva Dincheva, Joanna Giza, Deqiang Jing, Tina Marinic, Teresa A. Milner, Anjali M. Rajadhyaksha, Francis S. Lee, Barbara L. Hempstead> ;Molecular Psychiatry. 2021 Mar 1
• 14 citations
  Pre-adolescent stress disrupts adult, but not adolescent, safety learning.
  Heidi C. Meyer, Danielle M. Gerhard, Paia A. Amelio, Francis S. Lee> ;Behavioural Brain Research. 2021 Feb 26
• 1 citations
  TrkB deubiquitylation by USP8 regulates receptor levels and BDNF-dependent neuronal differentiation.
  Carlos Martín-Rodríguez, Minseok Song, Begoña Anta, Francisco J González-Calvo, Rubén Deogracias, Deqiang Jing, Francis S Lee, Juan Carlos Arevalo> ;Journal of Cell Science. 2020 Dec 23
• 48 citations
  mGreenLantern: a bright monomeric fluorescent protein with rapid expression and cell filling properties for neuronal imaging.
  Benjamin C. Campbell, Elisa M. Nabel, Mitchell H. Murdock, Cristina Lao-Peregrin, Pantelis Tsoulfas, Murray Blackmore, Francis S. Lee, Conor Liston, Hirofumi Morishita...> ;Proceedings of the National Academy of Sciences of the United States of America. 2020 Nov 18
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Journal Articles

• Splice-Break: Exploiting an RNA-Seq Splice Junction Algorithm to Discover Mitochondrial DNA Deletion Breakpoints and Analyses of Psychiatric Disorders  
  Francis S Lee, Alan F Schatzberg, Jack D Barchas, Virginia Kimonis, Elizabeth C Chao, Nucleic Acids Research
• Epigenetic Intersection of BDNF Val66Met Genotype with Premenstrual Dysphoric Disorder Transcriptome in a Cross-Species Model of Estradiol Add-Back  
  Francis S Lee, Karen F Berman, Nature
• Protective Effects of Elevated Anandamide on Stress and Fear-Related Behaviors: Translational Evidence from Humans and Mice  
  Francis Lee, MD, Nature
• Acetyl-L-carnitine Deficiency in Patients with Major Depressive Disorder  
  James W Murrough, James H Kocsis, Francis S Lee, Proceedings of the National Academy of Sciences
• Role for Fatty Acid Amide Hydrolase (FAAH) in the Leptin-Mediated Effects on Feeding and Energy Balance  
  Francis Lee, MD, Proceedings of the National Academy of Sciences
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