Francis J Miller Jr. MD FAHA

Cardiac Critical Care

Professor, Vanderbilt University Medical Center Chief of Cardiology, Nashville VA Medical Center

Summary

I am a physician-scientist with a clinical interest in general and critical care cardiology and a research interest in redox-mediated mechanisms of vascular disease. My research program utilizes molecular and cellular approaches to understand the regulation and the function of NADPH oxidases in the blood vessel, and to identify approaches for vascular wall targeting of therapeutic molecules.

University of Iowa Health Care Medical CenterFellowship, Cardiovascular Disease, 1992 - 1995
University of Texas Southwestern Medical CenterResidency, Internal Medicine, 1989 - 1992
University of Iowa Roy J. and Lucille A. Carver College of MedicineClass of 1989
University of IowaB.S., Biology, 1984

Nominated, Distinguished Mentor Award Iowa Center for Research by Undergraduates (ICRU), 2013
Nominated, Faculty Teacher of the Year for Internal Medicine Residents University of Iowa, 2007-2008
Fellow American Heart Association

PubMed

Cardiomyocyte-Restricted Expression of Progerin Confers Cardiac Hypertrophy.
Tuerdi Subati, Dennis P Buehler, Lin Zhong, Francis J Miller, Vineet Agrawal
Circulation Research. 2025-11-07
22 citations
The endothelial-enriched lncRNA LINC00607 mediates angiogenic function.
Frederike Boos, James A Oo, Timothy Warwick, Stefan Günther, Judit Izquierdo Ponce
Basic Research in Cardiology. 2023-01-26
12 citations
Comparative study between apocynin and protocatechuic acid regarding antioxidant capacity and vascular effects.
Murilo E Graton, Bruno H S H Ferreira, Jéssica A Troiano, Simone R Potje, Gabriel T Vale
Frontiers in Physiology. 2022-01-01

Journal Articles

Gene transfer extracellular but not cytosolic superoxide dismutase protects against oxidant-mediated endothelial dysfunction
Foresman EL and Miller FJ, Biology, 1/1/2013
CaMKII is essential for the pro-asthmatic effects of oxidation
Sanders PN, Koval OM, Jaffer OA, Prasad AM, Businga TR, Scott JA, Hayden PJ, Luczak ED, Dickey DD, Allamargot C, Olivier AK, Meyerholz DK, Robison AJ, Winder DG, Black..., Sci. Transl. Med, 1/1/2013
Inhibition of NADPH Oxidase by Apocynin Attenuates Progression of Atherosclerosis
Kinkade K, Streeter J, Miller Jr FJ, Int J Mol. Sci, 1/1/2013

Research Interestsvascular biology, NADPH oxidases, smooth muscle cells, atherosclerosis, restenosis, superoxide, reactive oxygen species, redox state, RNA aptamers, extracellular histones.