Frederick H Hausheer MD PhD(hon), FACP

PubMed

• 9 citations
  Cysteine specific targeting of the functionally distinct peroxiredoxin and glutaredoxin proteins by the investigational disulfide BNP7787.
  Aulma Parker, Pavankumar Petluru, Vicki L. Nienaber, John Badger, Betsy D. Leverett
  Molecules. 2015-03-18
• 5 citations
  Novel covalent modification of human anaplastic lymphoma kinase (ALK) and potentiation of crizotinib-mediated inhibition of ALK activity by BNP7787.
  Aulma Parker, Pavankumar Petluru, Vicki L. Nienaber, Min Zhao, P. Y. Ayala
  Oncotargets and Therapy. 2015-02-04
• 4 citations
  Stabilization of the Karenitecin ® lactone by alpha-1 acid glycoprotein
  Shijie Yao, Pavankumar Petluru, Aulma Parker, Daoyuan Ding, Xinghai Chen
  Cancer Chemotherapy and Pharmacology. 2015-01-30

Journal Articles

• Novel Covalent Modification of Human Anaplastic Lymphoma Kinase (ALK) And Potentiation of Crizotinib Mediated Inhibition of ALK Activity by BNP7787  
  Aulma R Parker, Pavankumar N Petluru, Vicki L Nienaber, Min Zhao, Philippe Y Ayala, John Badger, Barbara Chie-Leon, Vandana Sridhar, Cheyenne Logan, Harry Kochat, Fred..., Onco Targets and Therapy, 1/1/2015
• Stabilization of the Karenitecin(R) Lactone by Alpha 1 Acid Glycoprotein  
  Shijie Yao, Pavankumar Petluru, Aulma Parker, Daoyuan Ding, Xinghai Chen, Qiuli Huang, Harry Kochat, Frederick Hausheer, Cancer Chemotherapy and Pharmacology, 1/1/2015
• Comprehensive Comparative Analysis of the Morphological Changes in a 12-mer DNA Oligonucleotide upon Platination by Cisplatin, Oxaliplatin and BNP3029 (a Substituted C...  
  Pavankumar PNV, Ayala PY, Parker AR, Zhao M, Jair K, Chen X, Kochat H and Hausheer FH, J Physical Chemistry and Biophysics, 1/1/2014
• Novel Covalent Modification of Human ALK and Potentiation of Crizotinib-mediated Inhibition of ALK Activity by BNP7787  
  Parker AR, Petluru PN, Nienaber VL, Zhao M, Ayala PY, Badger J, Chie-Leon B, Sridhar V, Logan C, Kochat H, Hausheer, FH, OncoTargets and Therapy, 1/1/2014
• Comprehensive Comparative Study Using Ab Initio Computational Approaches on the Structures of Cisplatin, Oxaliplatin and BNP3029 (A Novel Substituted Cyano Ligand -bas...  
  P.N.V. Pavankumar, P.Y. Ayala, A.R. Parker, M. Zhao, K. Jair, X. Chen, H. Kochat, and F.H. Hausheer, J Phys Chem and Biophys, 1/1/2014
• Tavocept Forms Novel Covalent Adducts on HumanThioredoxin and Modulates Activity  
  Parker, A, Vicki L. Nienauber, Pavankumar, Petluru, Vandan Sridhar, Philippe Y. Ayala, Min Zhao, Barbara Chie-Leon, Kam Wing Jair, Jon Badjer, and Frederick H. Hausheer, J. Pharmacol. Clin. Toxicity: Special Issue, 1/1/2014
• Taxane-induced Peripheral Neuropathy and Health-related Quality of Life in Postoperative Breast Cancer Patients Undergoing Adjuvant Chemotherapy: N-SAS BC 02, a Random...  
  Shimozuma, K., Ohashi, Y., Takeuchi, A., Aranishi, T., Morita, S., Kuroi, K., Ohsumi, S., Makino, H., Katsumata, N., Kuranami, M., Suemasu, K., Watanabe, T., Hausheer,..., Supportive Care in Cancer, 1/1/2012
• Accumulation of BNP7787 in Human Renal Proximal Tubule Cells  
  Hausheer F.H., Ding D., Shanmugarajah, D., Leverett, B. D., Huang, Q., Chen, X., Kochat H., Ayala, P. Y., Petluru, P.N. and Parker, A. R., Journal of Pharmaceutical Sciences, 1/1/2011
• Mechanistic Study of BNP7787-mediated Cisplatin Nephroprotection: Modulation of Human Aminopeptidase N  
  Hausheer, F.H., Parker, A.R., Petluru, P.N., Jair, K.W., Chen, S., Huang, Q., Chen, X., Ayala, P.Y., Shanmugarajah, D., Kochat, H., Cancer Chemother Pharmacol, 1/1/2011
• Cancer Neuropathic Pain: Overview of Current Status and Future Objectives  
  Hausheer, F.H. and Foley, K., The Oncologist, 1/1/2010
• Types and Epidemiology of Cancer-Related Neuropathic Pain: The Intersection of Cancer Pain and Neuropathic Pain  
  Lema, M.J., Foley, K.M. and Hausheer, F.H., The Oncologist, 1/1/2010
• Assessment of Cancer-Related Neuropathy and Neuropathic Pain  
  Cleeland, C.S., Farrar, J.T., and Hausheer, F.H., The Oncologist, 1/1/2010
• Mechanistic Study of BNP7787-Mediated Cisplatin Nephroprotection: Modulation of Gamma-Glutamyl Transpeptidase  
  Hausheer, F.H., Shanmugarajah D., Chen X., Huang Q., Kochat H., Petluru P. N. and Parker A. R., Cancer Chemother Pharmacol, 1/1/2010
• Comprehensive Meta-Analysis of Survival Outcomes from Two Randomized Multicenter Trials in First Line Advanced Non-Small Cell Lung Cancer in Patients Treated with the ...  
  Hausheer, F.H., Bain, S., Perry, M., Du, L., Ohashi, Y., Ariyoshi, Y., and Fukuoka, M., EJCMO, 1/1/2010
• Analysis of BNP7787 Thiol-disulfide Exchange Reactions in Phosphate Buffer and Human Plasma Using Microscale Electrochemical High Performance Liquid Chromatography  
  Shanmugarajah, D, Ding, D, Huang, Q, Chen, X, Kochat, H, Petluru, PN, Ayala, PY, Parker, AR, Hausheer, FH, J Chromatogr B Analyt Technol Biomed Life Sci, 1/1/2009
• Feasibility and Validity of the Patient Neurotoxicity Questionnaire (PNQ) During Taxane Chemotherapy in a Phase III Randomized Trial in Patients with Breast Cancer: N-...  
  Shimozuma, K., Ohashi, Y., Takeuchi, A., Aranishi, T., Morita, S., Kuroi, K., Ohsumi, S., Makino, H., Mukai, F., Katsumata, N., Sunada, Y., Watanabe, T., Hausheer, F.H., Support Care Cancer, 1/1/2009
• Potentiation of a Topoisomerase I inhibitor, Karenitecin, by the Histone Deacetylase inhibitor Valproic Acid in Melanoma: Translational and Phase I/II Clinical Trial  
  Daud, A.I., Dawson, J., DeConti, R.C., Bicak, E., Marchion, D., Bastien, S., Neuger, A., Hausheer, F.H.H., Sullivan, D.M., Munster, P.N., Clin Cancer Res, 1/1/2009
• A Questionnaire Survey of Physicians' Perspectives regarding the Assessment of Chemotherapy-induced Peripheral Neuropathy in Patients with Breast Cancer  
  Kuroi, K, Shimozuma, K, Ohashi, Y, Takeuchi, A, Aranishi, T, Morita, S, Ohsumi, S, Watanabe, T, Bain, S, Hausheer, FH, Jpn. J. Clin. Oncol, 1/1/2008
• New Approaches to Brain Tumor Therapy CNS Consortium Phase I and Pharmacokinetic Study of Karenitecin in Patients with Recurrent Malignant Gliomas  
  Grossman, S.A., Carson, K.A., Phuphanich, S., Batchelor, T., Peereboom, D., Nabors, B.L., Lesser, G., Hausheer, F.H., Supko, J.G., Neuro Oncol, 1/1/2008
• Stereoselectivity in Diels-Alder Reactions of Diene-Substituted N-Alkoxycarbonyl-1,2-dihydropyridines  
  Krow, G.R., Huang, Q., Szczepanski, S.W., Hausheer, F.H., Carroll, P.J., J. Org. Chem, 1/1/2007
• Diagnosis, Management and Evaluation of Chemotherapy-induced Peripheral Neuropathy  
  Hausheer, F.H., Schilsky, R.L., Bain, S., Berghorn, E., Lieberman, F., Seminars in Oncology, 1/1/2006
• Phase II Trial of Karenitecin in Patients with Malignant Melanoma: Clinical and Translational Study  
  Daud A, Valkov N, Centeno B, Derderian J, Sullivan P, Munster P, Urbas P, Deconti RC, Berghorn E, Liu Z, Hausheer F, Sullivan D., Clin Cancer Res, 1/1/2005
• Phase 1 Study of Karenitecin in the Treatment of Recurrent Malignant Gliomas  
  Lesser GJ, Grossman, SA, Carson, K, Phupanich, S, Batchelor, T, Peereboom, D, Nabors, LB, Supko, J, Hausheer, F, JCO (ASCO Annual Meeting Proceedings), 1/1/2005
• Phase 1 Clinical Trial and Pharmacokinetic Study of Karenitecin in the Treatment of Recurrent Malignant Gliomas: A Study of the NABTT CNS Consortium  
  Grossman, S, Supko, J, Carson, K, Phuphanich, S, Batchelor, T, Peereboom, D, Nabors, B, Lesser, G, Desideri, S, Hausheer, F, Neuro-Oncology, 1/1/2005
• Pharmacokinetic Behaviour of the Chemoprotectants BNP7787 and Mesna After an IV Bolus Injection in Rats  
  Vershraagen, M., Boven, E., Torun, E., Erkelens, C.A., Hausheer, F.H., and van der Vijgh, W.J., Br. J. Cancer, 1/1/2004
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Books/Book Chapters

• (Chapter): Diagnosis and Management of Chemotherapy Induced Peripheral Neuropathy 
  Chapter: Chemotherapy Source Book 
  Hausheer, F.H., Bain, S.H.Editors: Michael C. Perry.Lippincott Williams & WilkinsEdition 5th,2012
• Chemotherapy Source Book 
  Chapter: Chapter 25: Diagnosis and Management of Chemotherapy Induced Peripheral Neuropathy 
  Hausheer, F.H.Editors: Michael C. Perry.Lippincott Williams & WilkinsEdition 4th,2008
• Series in Discrete Mathematics and Theoretical Computer Science 
  Chapter: Specifications of Parallel Algorithms 
  DeBoni, T., Feo, J., Caffey, H., Hausheer, F.H.Editors: Guy E. Blelloch, K.M. Chandy and S. Jagannathan.1995
• Developments in Antisense Technology for Commercial Applications in Human Therapy and Agriculture 
  Chapter: Rational Design of DNA-Targeted Antisense Oligomers by Supercomputer 
  Hausheer, F.H.1994
• Cytotoxic Anticancer Drugs: Models and Concepts for Drug Discovery and Development 
  Chapter: Supercomputer Aided Drug Design: Applications in Oncology and AIDS 
  Hausheer, F.H., Singh, U.C., Saxe, J.D., Weis, A.L.Kluwer Academic Publishers1992
• Management of Malignant Pleural Effusions 
  Bitran, J., Brown, C., Feun, L.H., Hausheer, F.H., Ostrowski, M., Moores, D., Thurer, R.T., Yarbro, J.W.Editors: John Ruckdeschel.Bristol-Meyers-Squibb1992
• Progress in Clinical and Biologic Research 
  Chapter: Malignant Effusions as Oncologic Emergencies. Chapter 9: Oncologic Emergencies 
  Hausheer, F.H., and Yarbro, J.W.Editors: Mirand, E.A., Hutchinson, W.B., Mihich, E. et. al..Wiley-Liss, Inc., New York1983
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Abstracts/Posters

• Phase I Safety and Pharmacokinetic Trial of BNP7787 in Patients Receiving Cisplatin (CDDP) And Paclitaxel (PTX) For Advanced Non-small Cell Lung Cancer (NSCLC): An Osa...
  Koji Takeda, Shunichi Negoro, Kaoru Matsui, Shinzoh Kudoh, Kazuhiko Nakagawa, Masahiro Fukuoka, Takuya Katsura, Satoshi Nonaka, Frederick H Hausheer, ASCO Proceedings, 1/1/2002
• High Performance Computing in Pharmaceutical Research and Development: Past, Present and an Exciting Future
  Hausheer, F.H., RCI Annual Conference, Alexandria, VA, 1/1/1999
• The Role of Supercomputing in Pharmaceutical Research and Development: Past, Present and an Exciting Future
  Hausheer, F.H., Supercomputing, Portland OR, 1/1/1999
• Addressing the Pharmaceutical Innovation Deficit by the Use of Supercomputing and a New Parallel Research and Development Operations Model
  Hausheer, F.H., Cray Executive Users Group, Scottsdale, Arizona, 1/1/1997
• Three Supercomputing Pioneers Talk About the History and Future of Supercomputing and Related Applications
  Michaels, G., Wong, A., Hausheer, F.H., Hirsch Foundation Lecture, University of Southern Colorado, 1/1/1997
• A Novel HPLC Assay Using Fluorescence Detection for Quantitation of Plasma gamma-Methylene-10-Deazaaminopterin (MDAM) and its Major Metabolite, 7-Hydroxy-gamma-Methele...
  Su, H., Chen, T.L., Hausheer, F.H., Rowinsky, E.K., ASCO, 1/1/1996
• Differential Activity of Topoisomerase I Inhibitors in Multidrug Resistance Protein (MRP) and P170-Glycoprotein (Pgp) Mediated Multidrug Resistance
  Voight, W., Vanhoefer, U., Yin, M.B., Hausheer, F.H., Rustum, Y.M., American Association for Cancer Research, 1/1/1996
• The Future of Parallel High Performance Computing, Grand Challenge Pharmaceutical Discovery Research, and Medicine
  Hausheer, F.H., The Salishan Conference on High Performance Computing, Glenedon Beach, Oregon, 1/1/1996
• High Performance Parallel Computing and the Future of Pharmaceutical Discovery Research, and Medicine
  Hausheer, F.H., Supercomputing 97, Pittsburgh, Pennsylvania, 1/1/1996
• Antitumor Activity of Classical Non-polyglutamylatable Analogs of 10-deazaaminopterins
  Abraham, A., Nair, M.G., Hausheer, F.H., American Association for Cancer Research, 1/1/1994
• Hybridization (Gibbs) Free Energy and Molecular Dynamics Studies of d[5mC+T]10 versus d[C+T]10 Oligomers in DNA Triple Helices
  Hausheer, F.H., Singh, U.C., Saxe, J.D.,Weis, A.L, Flory, J.P., Tufto, K., Proceedings of the American Association for Cancer Research, 1/1/1991
• The Prospective Analysis and Design of Therapeutic Agents for Cancer and AIDS by Supercomputers
  Hausheer, F.H., Fourth International Conference on Supercomputing and Third World Supercomputing Exhibition, Santa Clara, California, 1/1/1989
• Molecular Dynamics Analysis of Lamda Repressor-DNA Binding
  Sarai, A., Hausheer, F.H., Takeda, M., UCLA Biophysical Research Colloquium, 1/1/1988
• Prospective Analysis and Design of Anticancer Agents Using Advanced Computational Methods and the CRAY X-MP
  Hausheer, F.H., Barnett, G., Colvin. O.M., and Maizel, J.V., Third International Conference on Supercomputing and Second World Supercomputing Exhibition, Boston, Massachusetts, 1/1/1988
• Recognition of the Operator DNA Sequence by Cro Repressor
  Takeda, Y., Sarai, A., and Hausheer, F.H., Cold Spring Harbor Laboratory, 1/1/1988
• The Utility of High Resolution Graphics in the Analysis and Design of Anticancer Agents in the Supercomputer Environment
  Hausheer, F.H., Third Annual International Supercomputer and Networking Conference. Naval Research Laboratory and National Science Foundation, 1/1/1987
• Multidisciplinary Analysis and Design of Anticancer Agents in the Supercomputer Environment
  Hausheer, F.H., Colvin, O.M., Barnett, G., Baylin, S., Crum, C. and Maizel, J.V., The Third International Science and Engineering Symposium on Supercomputers, Minneapolis, Minnesota, 1/1/1987
• Diagnosis and Treatment of Malignant Pleural Effusion
  Hausheer, F.H., and Ettinger, D.N., Topics in Clinical Medicine, The Johns Hopkins Hospital, 1/1/1986
• Supercomputer Guided Rational Drug Design: Applications in Oncology and AIDS
  Hausheer, F.H., Singh, U. C., Weis, A.L., Flory, J. W., Saxe, J.D., and Tufto, K, Fifth International Science and Engineering Symposium on Supercomputers, Comput. Mech. Publications, London, UK, 1/22/1990
• Prospective Supercomputer Aided Drug Design
  Hausheer, F.H., Second International Computational Chemistry Symposium on Cray Supercomputers, Chicago, Illinois, 1/13/1988
• The Analysis and Design of Anticancer and AIDS Drugs using Advanced Molecular Computational Methods
  Hausheer, F.H., Computational Chemistry and Supercomputer Symposium. Center for High Performance Computing. The University of Texas System, 1/5./1988
• Enhanced Binding of Methylphosphonate (ODN) In Triple-Stranded Poly (dT) Poly (dA) Poly (dT) Demonstrated by Molecular Dynamics
  Hausheer, F.H., Singh, U.C., Saxe, J.D., Colvin, O.M., and Ts'o, P.O.P., Proceedings of the American Association for Cancer Research, 1/24/1989
• The Application of Supercomputers and Advanced Molecular Computational Methods in the Prospective Design and Rapid Development of Therapeutic Agents for the Treatment ...
  Hausheer, F.H., University Grand Rounds, University Grand Rounds, 1/12/1989
• The Application of Supercomputers and Advanced Molecular Computational Methods in the Prospective Design and Rapid Development of Therapeutic Agents for the Treatment ...
  Hausheer, F.H., The Johns Hopkins School of Medicine, Baltimore, Maryland, 1/20/1989
• The Application of Quantum Mechanics, Statistical Mechanics, and Supercomputers Toward the Prospective Design and Rapid Development of Therapeutic Agents for the Treat...
  Hausheer, F.H., Sandia National Laboratories, Livermore, California, 1/13/1989
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Lectures

• Anticancer and AIDS Drug Design. The Impact of Supercomputing Capabilities on U.S. Materials Science and Technology, Report of the Committee on Computer Simulation and... 
  Washington, D.C. - 1/1/1988