FrederickNaftolinMDPhD, FACOG, FRCOG (hon)

PubMed

• Cardiometabolic outcomes in Kronos Early Estrogen Prevention Study continuation: 14-year follow-up of a hormone therapy trial.
  Kejal Kantarci, Nirubol Tosakulwong, Timothy G Lesnick, Firat Kara, June Kendall-Thomas, Ekta Kapoor, Julie A Fields, Taryn T James, Rogerio A Lobo, JoAnn E Manson, Lu...> ;Menopause. 2024 Jan 1
• 1 citations
  Associations between pituitary-ovarian hormones and cognition in recently menopausal women independent of type of hormone therapy.
  Juliana M Kling, N Maritza Dowling, Heather Bimonte-Nelson, Carey E Gleason, Kejal Kantarci, Cynthia M Stonnington, S Mitch Harman, Frederick Naftolin, Lubna Pal, Marc...> ;Maturitas. 2023 Jan 1
• 31 citations
  Menopause and the Skin: Old Favorites and New Innovations in Cosmeceuticals for Estrogen-Deficient Skin
  Frederick Naftolin, Edwin D. Lephart> ;Dermatology and Therapy. 2021 Feb 1
• 6 citations
  Lessons from KEEPS: the Kronos Early Estrogen Prevention Study
  Virginia M. Miller, Hugh S. Taylor, Frederick Naftolin, JoAnn E. Manson, Carey E. Gleason, Eliot A. Brinton, Juliana M. Kling, Marcelle I. Cedars, N. M. Dowling, Kejal...> ;Climacteric. 2021 Mar 4
• 14 citations
  Granulosa-Lutein Cell Sirtuin Gene Expression Profiles Differ between Normal Donors and Infertile Women.
  Rebeca González-Fernández, Rita Martín-Ramírez, Deborah Rotoli, Frederick Naftolin, Pablo Martín-Vasallo, Angela Palumbo, Julio Ávila> ;International Journal of Molecular Sciences. 2019 Dec 31
• 11 citations
  Impact of menopausal hormone formulations on pituitary-ovarian regulatory feedback
  Juliana M. Kling, N. Maritza Dowling, Heather A. Bimonte-Nelson, Carey E. Gleason, Kejal Kantarci, JoAnn E. Manson, Hugh S. Taylor, Eliot A. Brinton, Rogerio A. Lobo, ...> ;American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 2019 Oct 30
• 44 citations
  Cardiovascular health and the menopausal woman: the role of estrogen and when to begin and end hormone treatment.
  Frederick Naftolin, Jenna Friedenthal, Richard Nachtigall, Lila E. Nachtigall> ;F1000research. 2019 Sep 3
• Aromatase and estrogen receptor immunoreactivity in the coronary arteries of monkeys and human subjects.
  Diano, S.,Horvath, T. L.,Mor, G.,Register, T.,Adams, M.,Harada, N.,Naftolin, F.> ;Menopause. 2018 Oct 26
• 11 citations
  A multicentre evaluation of an opioid patient–provider agreement
  Joseph V. Pergolizzi, Frederick A. Curro, Nanada Col, Mary Papa Ghods, Don Vena, Frederick Naftolin, Jo Ann LeQuang> ;Postgraduate Medical Journal. 2017 Oct 1
• 38 citations
  Longitudinal changes in menopausal symptoms comparing women randomized to low-dose oral conjugated estrogens or transdermal estradiol plus micronized progesterone vers...
  Nanette Santoro, Amanda A. Allshouse, Genevieve Neal-Perry, Lubna Pal, Rogerio A. Lobo, Frederick Naftolin, Dennis M. Black, Eliot A. Brinton, Matthew J. Budoff, Marce...> ;Menopause. 2017 Mar 1
• 11 citations
  Bisphenol A influences oestrogen- and thyroid hormone-regulated thyroid hormone receptor expression in rat cerebellar cell culture.
  Virág Somogyi, Tamas L. Horvath, István János Tóth, Tibor Bartha, Laszlo V. Frenyo, Dávid Sándor Kiss, Gergely Jocsak, Frederick Naftolin, Attila Zsarnovszky> ;Acta Veterinaria Hungarica. 2016 Dec 1
• 5 citations
  Sex Steroids Block the Initiation of Atherosclerosis.
  Frederick Naftolin, Holly Mehr, Ahmed Fadiel> ;Reproductive Sciences. 2016 Dec 1
• 36 citations
  The Ovarian Renin-Angiotensin System (OVRAS): A Major Factor in Ovarian Function and Disease.
  Angela Palumbo, Frederick Naftolin> ;Reproductive Sciences. 2016 Nov 7
• 15 citations
  Opioid, NSAID, and OTC Analgesic Medications for Dental Procedures: PEARL Network Findings.
  Ying Jo Wong, James R Keenan, Keith Hudson, Frederick Naftolin, Van P. Thompson, Ronald G. Craig, Don Vena, Damon Collie, Hongyu Wu, Abigail G. Matthews, Ashley C Gril...> ;Compendium of Continuing Education in Dentistry. 2016 Nov 1
• 7 citations
  Expression of Ezrin and Estrogen Receptors During Cervical Carcinogenesis.
  Ahmed Fadiel, Seung Do Choi, Bora Park, Tae-Hee Kim, J. Buldo-Licciardi, Mitra Ahmadi, Alan A. Arslan, Khushbakhat Mittal, Frederick Naftolin> ;Reproductive Sciences. 2017 May 1
• 102 citations
  Aromatase: Contributions to Physiology and Disease in Women and Men
  Jennifer K. Blakemore, Fredrick Naftolin> ;Physiology. 2016 Jul 1
• 21 citations
  Human Milk Bacterial and Glycosylation Patterns Differ by Delivery Mode.
  Marina Hoashi, Lawrence Meche, Lara K. Mahal, Elizabeth Bakacs, Frederick Naftolin, Naomi Bar-Yam, Maria Gloria Dominguez-Bello, Deanna Nardella> ;Reproductive Sciences. 2016 Jul 1
• 13 citations
  Hormone therapy and ovarian cancer.
  Joseph Onwude> ;Lancet. 2015 Sep 12
• Hormone therapy and ovarian cancer.
  Frederick Naftolin, Jenna Friedenthal, Jennifer Blakemore, Lila Nachtigall> ;Lancet. 2015 Sep 12
• 253 citations
  Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women: Findings from the Randomized, Controlled KEEPS–Cognitive and Affective Study
  Carey E. Gleason, N. Maritza Dowling, Whitney Wharton, JoAnn E. Manson, Virginia M. Miller, Craig S. Atwood, Eliot A. Brinton, Marcelle I. Cedars, Rogerio A. Lobo, Geo...> ;Plos Medicine. 2015 Jun 2
• Defining Periodontitis for "Person-Centered Care".
  Frederick A. Curro, Frederick Naftolin, Ashley C Grill, Van P. Thompson> ;Compendium of Continuing Education in Dentistry. 2015 Jun 1
• 1 citations
  Case Presentations Demonstrating Periodontal Treatment Variation: PEARL Network.
  Frederick A. Curro, Ashley C Grill, Abigail G. Matthews, John A. Martin, Elisabeth Kalenderian, Frederick Naftolin, Van P. Thompson> ;Compendium of Continuing Education in Dentistry. 2015 Jun 1
• 3 citations
  Person-centric clinical trials: defining the N-of-1 clinical trial utilizing a practice-based translational network
  Frederick A. Curro, Frederick Naftolin, Ashley C Grill, Don Vena, Louis Terracio> ;Clinical Investigation. 2015 Feb 13
• 9 citations
  Phenytoin Is an Estrogen Receptor α-Selective Modulator That Interacts With Helix 12:
  Ahmed Fadiel, J. Song, D. Tivon, Adel Hamza, Frederick Naftolin> ;Reproductive Sciences. 2015 Feb 1
• 1 citations
  Abnormal fingernail beds following carbon monoxide poisoning: a case report and review of the literature.
  Frederick Naftolin, M. Khatamee> ;Journal of Medical Case Reports. 2014 Jul 29
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Journal Articles

• The Women's Health Initiative trial and related studies: 10 years later: a clinician's view  
  Gurney EP, Nachtigall MJ, Nachtigall LE, Naftolin F, J Steroid Biochem Mol Biol, 7/1/2014
• Hypothalamic Sidedness in Mitochondrial Metabolism: New Perspectives  
  Toth I, Kiss DS, Goszleth G, Bartha T, Frenyo LV, Naftolin F, Horvath TL, Zsarnovszky A, Reprod Sci, 4/1/2014
• Neonatal insulin action impairs hypothalamic neurocircuit formation in response to maternal high-fat feeding  
  Vogt MC, Paeger L, Hess S, Steculorum SM, Awazawa M, Hampel B, Neupert S, Nicholls HT, Mauer J, Hausen AC, Predel R, Kloppenburg P, Horvath TL, Bruning JC, Cell, 1/1/2014
• The KEEPS-Cognitive and Affective Study: baseline associations between vascular risk factors and cognition  
  Wharton W, Gleason CE, Dowling NM, Carlsson CM, Brinton EA, Santoro MN, Neal-Perry G, Taylor H, Naftolin F, Lobo RA, Merriam G, Manson JE, Cedars MI, Miller VM, Black ..., J Alzheimer Dis, 1/1/2014
• Brain health and cognitive and mood disorders in ageing women Review  
  Silva I, Naftolin F, Best Pract Res Clin Obstet Gynaecol, 10/1/2013
• Bioinformatic analysis of benzo-alpha-pyrene-induced damage to the human placental insulin-like growth factor-1 gene  
  Fadiel A, Epperson B, Shaw MI, Hamza A, Petito J, Naftolin F, Reprod Sci, 8/1/2013
• Ectopic fat and adipokines in metabolically benign overweight/obese women: the Kronos Early Estrogen Prevention Study  
  Ogorodnikova AD, Khan UI, McGinn AP, Zeb I, Budoff MJ, Harman SM, Miller VM,Brinton EA, Manson JE, Hodis HN, Merriam GR, Cedars MI, Taylor HS, Naftolin F, Lobo RA, San..., Obesity (Silver Spring), 8/1/2013
• Characterization of vascular disease risk in postmenopausal women and its association with cognitive performance  
  Dowling NM, Gleason CE, Manson JE, Hodis HN, Miller VM, Brinton EA, Neal-Perry G, Santoro MN, Cedars M, Lobo R, Merriam GR, Wharton W, Naftolin F, Taylor H, Harman SM,..., PLoS One, 7/1/2013
• Practice based research networks impacting periodontal care: PEARL Initiative  
  Curro FA, Thompson VP, Grill A, Vena D, Terracio L, Naftolin F, J Periodontol, 5/1/2013
• Self-reported menopausal symptoms, coronary artery calcification, and carotid intima-media thickness in recently menopausal women screened for the Kronos early estroge...  
  Wolff EF, He Y, Black DM, Brinton EA, Budoff MJ, Cedars MI, Hodis HN, Lobo RA, Manson JE, Merriam GR, Miller VM, Naftolin F, Pal L, Santoro N, Zhang H, Harman SM, Tayl..., Fertil Steril, 4/1/2013
• Genetic polymorphisms associated carotid artery intima-media thickness and coronary artery calcification in women of the Kronos Early Estrogen Prevention Study  
  Miller VM, Petterson TM, Jeavons EN, Lnu AS, Rider DN, Heit JA, Cunningham JM, Huggins GS, Hodis HN, Budoff MJ, Santoro N, Hopkins PN, Lobo RA, Manson JE, Naftolin F, ..., Physiol Genomics, 11/27/2012
• Protein flexibility and conformational states of Leishmania antigen eIF-4A: identification of a novel plausible protein adjuvant using comparative genomics and molecul...  
  Wei NN, Hamza A, Hao C, Johnson-Scalise T, Xiu Z, Naftolin F, Zhan CG, J Biomol Struct Dyn, 9/10/2012
• Ezrin over-expression by transformed human ovarian surface epithelial cells, ovarian cleft cells and serous ovarian adenocarcinoma  
  Fadiel A, Chen Z, Ulukus E, Ohtani K, Hatami M, Naftolin F, Reprod Sc Reprod Sci, 8/1/2012
• The PBRN Initiative: Transforming new technologies to improve patient care  
  Curro FA, Vena D, Naftolin F, Terracio L, Thompson VP, J Dent Res, 7/1/2012
• Practice Based Research Networks Impacting Periodontal Care  
  Curro FA, Thompson VP, Grill A, Vena D, Terracio L, Naftolin F, J Periodontol, 6/15/2012
• Associations between retinol-binding protein 4 and cardiometabolic risk factors and subclinical atherosclerosis in recently postmenopausal women: Cross-sectional analy...  
  Huang G, Wang D, Khan UI, Zeb I, Manson JE, Miller V, Hodis HN, Budoff MJ,vMerriam GR, Harman SM, Brinton EA, Cedars MI, Lobo RA, Naftolin F, Santoro N, Taylor HS, Wil..., Cardiovasc Diabetol, 5/1/2012
• The International Society of Gynecological Endocrinology and its president  
  Naftolin F, Petraglia F, Simoncini T, Gynecol Endocrinol, 3/1/2012
• Neuroendocrine control of ovulation  
  Berga S, Naftolin F, Gynecol Endocrinol, 1/1/2012
• Dehydroepiandrosterone (DHEA) inhibition of monocyte binding by vascular endothelium is associated with sialylation of neural cell adhesion molecule  
  Curatola A-M, Huang K, Naftolin F, Reprod Sci, 1/1/2012
• Unveiling the unfolding pathway of F5F8D disorder-associated D81H/V100D mutant of MCFD2 via multiple molecular dynamics simulations  
  Hamza A, Wei1 N-N, Johnson-Scalise T, Zhan C-G, Naftolin F, J Biomol Struct Dyn, 1/1/2012
• Intra-thoracic fat, cardiometabolic risk factors, and subclinical cardiovascular disease in healthy, recently menopausal women screened for the Kronos Early Estrogen P...  
  Huang G, Wang D, Zeb I, Budoff MJ, Harman SM, Miller V, Brinton EA, El Khoudary SR, Manson JE, Sowers MR, Hodis HN, Merriam GR, Cedars MI, Taylor HS, Naftolin F, Lobo ..., Atherosclerosis, 1/1/2012
• How we almost discovered LH receptors, but didn't  
  Lunenfeld B, Naftolin F, Gynecol Endocrinol, 1/1/2012
• Expression and activation of the membrane-cytoskeletal protein ezrin during the normal endometrial cycle  
  Tan O, Ornek T, Fadiel A, Carrick K, Arici A, Doody K, Carr BR, Naftolin F, Fertil Steril, 1/1/2012
• Updated IMS recommendations on postmenopausal hormone therapy and preventive strategies for midlife health  
  Sturdee DW, Pines A; International Menopause Society Writing Group, Archer DF, Baber RJ, Barlow D, Birkhauser MH, Brincat M, Cardozo L, de Villiers TJ, Gambacciani M, ..., Climacteric, 6/1/2011
• Timing and duration of menopausal hormone treatment may affect cardiovascular outcomes  
  Harman SM, Vittinghoff E, Brinton EA, Budoff MJ, Cedars MI, Lobo RA, Merriam GR, Miller VM, Naftolin F, Pal L, Santoro N, Taylor HS, Black DM, Am J Med, 3/1/2011
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Books/Book Chapters

• Proceedings of the IEEE International Conference on Computer Systems and Applications. 
  Chapter: Computational Analysis of Mass Spectrometry Data Using Novel Combinatorial Methods. 
  Page 266 - 273Fadiel A, Langston MA, Peng X, Perkins AD, Taylor HS, Tuncalp O, Vitello D, Pevsner P, Naftolin FIEEE Computer Society, Washington, DC2006
• Informacion y Formacion para el Manejo Actual de la Mujer en su Climaterio. 
  Chapter: Prologo a la Primera Edicion. 
  Naftolin FEditors: N Siseles.Ascune2005
• Climacteric Medicine – where do we go? 
  Chapter: Menopause: lack of Darwinian adaptation drives its physiology. 
  Page 4 - 8Naftolin F, Richman SEditors: Schneider HPG, Naftolin F.Parthenon Publishing, Abingdon, UK2005
• Informacion y Formacion para el Manejo Actual de la Mujer en su Climaterio 
  Chapter: A Comprehensive Holistic Approach to Health Management of the Post-reproductive Woman in the 21st Century (Un Enfoque Holistico e Integral para el Manejo de la Salud de la Mujer Posmenopausica del Sig 
  Page 23 - 28Scalise T, Lee H H, Naftolin FEditors: N Siseles.Ascune2005
• ISM Pisa Workshop on Bone 
  Chapter: Understanding the role of aromatizable androgens in bone-sparing 
  Page 239 - 246Tuncalp O, Edusa V, Fadiel A, Naftolin FEditors: Genazzani A.Taylor and Francis, London2005
• Immunology of Pregnancy. 
  Chapter: Evolution of the mammalian reproductive tract and placentation. 
  Page 1 - 8Richman S, Naftolin FEditors: Mor G.Eurekah.com2004
• International Menopause Society Expert Workshop, 15-18 March 2003, Pisa, Italy. 
  Chapter: Controversial issues in climacteric medicine III: Hormone replacement thereapy in the climacteric and aging brain. 
  Page 188 - 203Alt J, Angst J, Backstrom T et alEditors: Genazzani AR, Gambacciani M, Simoncini T and Schneider HPG.Climacteric2003
• Hormone Replacement Therapy and the Brain: The Current Status of Research and Practice 
  Chapter: Unsolved and controversial issues regarding neuroprotection by estrogen. 
  Page 177 - 181Azcoitia I, Ciriza I, Garcia-Ovejero D, Mendez P, Sierra A, Veiga S, Naftolin F, Garcia-Segura LMEditors: Genazzani AR.Parthenon Publishing Group, New York2003
• Hormone Replacement Therapy and The Brain: The Current Status of Research and Practice. Controversial Issues in Climacteric Medicine Series. 
  Chapter: The immune system, estrogen and brain aging. 
  Page 25 - 31Silva I, Mor G, Bechmann I, Naftolin FEditors: Genazzani AR.Parthenon Publishing Group, New York2003
• Women’s Health and Menopause: New Strategies – Improved Quality of Life (Proceedings of the 4th International Symposium on Women’s Health and Menopause, 2001, Washington, DC) 
  Chapter: Sex steroid-sensitive reproductive tissues in women during reproduction and menopause. 
  Naftolin F, Rinaudo P, Abushahin F, Sze EEditors: Lobo RA, Crosignani PG, Paoletti R, Bruschi F.Kluwer, Boston2002
• Menopause: The State of the Art – in Research and Management, The Official Proceedings of the 10th World Congress on the Menopause 
  Chapter: Estrogen Effects on Microglia and Immune Checkpoint Proteins in the Brain. 
  Page 186 - 190Silva I, Nilsen J, Williams S, Bechmann I, Garcia-Segura LM, Mor G, Naftolin FEditors: HPG Schneider.Parthenon Publishing, Boca Raton2002
• Endocrine therapy of breast cancer. 
  Chapter: Aromatase inhibitors in breast cancer. 
  Page 75 - 106Yue W, Mor G, Naftolin F, Pauley R, Shim W-S, Harvey HA, Santen RJEditors: JFR Robertson, RI Nicholson, DF Hayes.Martin Dunitz Ltd., London2002
• A Change in Paradigms in Family Planning. 
  Chapter: Menopause: Controversies in hormone replacement therapy. 
  Naftolin FSalud Reproductiva, Juntos por la salud2001
• New Pharmacological Approaches to Reproductive Health and Healthy Ageing, Symposium on the Occasion of the 80th Birthday of Professor Egon Diczfalusy. 
  Chapter: The elderly and hormone replacement. 
  Naftolin F, Aso T, Balogh A, Limpaphayom KK, Landgren B-M, Mancuso S, Schneider HPG, Segars JH, Swerdloff RSEditors: WK Raff, MF Fathalla, F Saad.Springer, Berlin2001
• The Physiologic Basis of Gynecology and Obstetrics 
  Chapter: Neuroendocrine control of reproduction. 
  Page 63 - 74Naftolin F, Zreik TG, Garcia-Segura LM, Horvath TLEditors: DB Seifer, P Samuels, DA Kniss.Lippencott, Williams and Wilkins, Philadelphia2001
• Proceedings of the 5th International Conference on the Control of the Onset of Puberty, September 26-28, 1999 Liege, Belgium 
  Chapter: Fetal hypothalamic development events presage adult function. 
  Page 233 - 246Nilsen J, Horvath TL, Levy A, Chowen J, Garcia-Segura LM, Naftolin FEditors: Bourguignon JP and Plant TM.Elsevier Science B.V., Amsterdam2000
• Biology of Menopause 
  Chapter: Putting the menopause into perspective: Lessons learned from the Biology of Menopause 
  Page 273 - 277Naftolin FEditors: Bellino.Springer-Verlag, New York2000
• Treatment of the postmenopausal woman: Basic and clinical aspects. 
  Chapter: Clinical effects of sex steroids on the brain. 
  Page 247 - 262Cela V and Naftolin FEditors: Rogerio A. Lobo.Lippincott Williams & Wilkins, PhiladelphiaEdition 2nd,1999
• Contemporary Endocrinology: Neurosteroids: A New Regulatory Function in the Nervous System 
  Chapter: Steroid effects on brain plasticity: Role of glial cells and trophic factors. 
  Page 255 - 268Garcia-Segura LM, Chowen JA, Naftolin F, Torres-Aleman IEditors: Baulieu EE, Robel P, Schumacher M.Humana Press, Inc., Totowa, NJ1999
• Menopause: Comprehensive Management 
  Chapter: Book foreward. 
  Naftolin FEditors: B.A. Eskin.Parthenon Publishing, New York, NYEdition 4th,1999
• Neurobiology of Mental Illness. 
  Chapter: Neurobiology of human sexuality. 
  Wood RI, Naftolin FEditors: DS Charney, EJ Nestler, BS Bunney.Oxford UP, New York1999
• Estrogens and Progestogens in Clinical Practice 
  Chapter: Effects of estrogen and progesterone on the central nervous system 
  Polcz T, Horvath T, Naftolin FEditors: Fraser IS, Jansen RPS, Lobo RA, Whitehead MI.Churchill Livingstone, United Kingdom1998
• The Brain: Source and target for sex steroid hormones. 
  Chapter: Glial cells and estrogen-induced synaptogenesis and synaptic plasticity. 
  Page 191 - 200Garcia-Segura LM, Chowen JA, Parducz A and Naftolin FEditors: Genazzani AR, Petraglia F and Purdy RH.Parthenon Publishing, New York1996
• CNS Neurotransmitters and Neuromodulators:Neuroactive Steroids 
  Chapter: Chapter 6: Estrogen effects on neuronal ultrastructure and synaptic plasticity. 
  Page 103 - 111Leedom L, Garcia-Segura LM, Naftolin FCRC Press1996
• Polycystic Ovary Syndrome 
  Chapter: Chapter 5: Potential role of the renin-angiotensin system in polycystic ovaries. 
  Page 71 - 88Naftolin F, Palumbo A, Pepperell JREditors: R. Jeffrey Chang, M.D..Springer-Verlag Inc., New York1996
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Abstracts/Posters

• Estradiol (E2, Raloxifene (R) and Tamoxifen (T) Cause Rapid and Profound Changes in Astrocytes in Living Human Brain Slices
  Naftolin F, NAMS 13th Annual Meeting, 1/1/2002

Lectures

• The Hypothalamus (Lecturer) 
  1/1/2005
• Advances in Medicine in Reproduction (Visiting Professor, “Extraordinary Professor” and Chair) 
  Complutense University, Madrid, Spain - 1/1/1998
• Keynote Speaker 
  1/1/1988
• Plenary Lecturer 
  1/1/1988
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Other

• Faculty of 1000 Biology 
  Naftolin F, Tan O
  http://www.f1000biology.com/article/id/1148120/evaluation
  2/16/2009
• Guidelines for the hormone treatment of women in the menopausal transition and beyond. 
  Naftolin F, Schneider HP, Sturdee DW; Executive Committee of the International Menopause Society.
  1/1/2004
• Guidelines for the hormone treatment of women in the menopausal transition and beyond. Position statement by the Executive Committee of the International Menopause Soc... 
  Wright J, Naftolin F, Schneider HP, Sturdee DW; Executive Committee of the International Menopause Society
  1/1/2004
• The Brain, Biochemistry, and Behavior 
  Wahby VS, Naftolin F, Proceedings of the Sixth Arnold O. Beckman Conference in Clinical Chemistry. Book Review.
  1/1/1984
• Application of radioimmunoassay and competitive protein binding methodology to the study of neuroendocrine function. (Ph D Thesis) 
  Naftolin F, St. Catherine's College, University of Oxford
  1/1/1970
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