FrederickANunesMD

Gastroenterology • Philadelphia, PA

Advanced Endoscopic Interventional, Hepatology & Liver Transplantation

Clinical Professor of Medicine, University of Pennsylvania

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Office
230 W Washington Sq
Farm Journal Building, Fl 4
Philadelphia, PA 19106
Phone+1 215-829-3561

Fax+1 215-829-5654
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Education & Training

University of Pennsylvania Health SystemFellowship, Gastroenterology, 1992 - 1994
New York Presbyterian Hospital (Cornell Campus)Residency, Internal Medicine, 1988 - 1991
Weill Cornell MedicineClass of 1988

Certifications & Licensure

PA State Medical License 1991 - 2024
CT State Medical License 1991 - 1997
NY State Medical License 1989 - 1992
American Board of Internal Medicine Gastroenterology
American Board of Internal Medicine Transplant Hepatology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
Fellow (AGAF) American Gastroenterological Association, 2007

Publications & Presentations

PubMed

54 citations
Positive Early Patient and Clinician Experience with Telemedicine in an Academic Gastroenterology Practice During the COVID-19 Pandemic.
Marina Serper, Frederick A. Nunes, Nuzhat A. Ahmad, Divya Roberts, David C. Metz, Shivan J. Mehta> ;Gastroenterology. 2020 Jun 18
Hepatoid Adenocarcinoma Presenting as Pancreatitis.
Rahul B. Chaudhari, Katherine Murphy, Stephen Schwartz, Immanuel Ho, Frederick Nunes, Jigisha Chaudhari> ;ACG Case Reports Journal. 2020 May 7
To avoid Hep B reactivation, screen before immunosuppression.
Ronan Farrell, Kyley Leroy, Frederick A. Nunes> ;The Journal of Family Practice. 2019 Mar 1
34 citations
The gRNA-miRNA-gRNA Ternary Cassette Combining CRISPR/Cas9 with RNAi Approach Strongly Inhibits Hepatitis B Virus Replication.
Jie Wang, Ran Chen, Ruiyang Zhang, Shanlong Ding, Tianying Zhang, Quan Yuan, Guiwen Guan, Xiangmei Chen, Ting Zhang, Hui Zhuang, Frederick A. Nunes, Timothy M. Block, ...> ;Theranostics. 2017 Jul 22
15 citations
Distinct features in natural history and outcomes of acute hepatitis C.
Chalermrat Bunchorntavakul, Lisa M. Jones, Masahiro Kikuchi, Mary E. Valiga, David E. Kaplan, Frederick A. Nunes, Ayse Aytaman, K. Rajender Reddy, Kyong-Mi Chang> ;Journal of Clinical Gastroenterology. 2015 Apr 1
4 citations
Flushing Out Antibodies to Make AAV Gene Therapy Available to More Patients
Steven E. Raper, James M. Wilson, Frederick A. Nunes> ;Molecular Therapy. 2013 Feb 1
42 citations
Racial differences in hepatitis C treatment eligibility
Michael T. Melia, Andrew J. Muir, Jonathan McCone, Mitchell L. Shiffman, John W. King, Steven K. Herrine, Greg Galler, Joseph R. Bloomer, Frederick A. Nunes, Kimberly ...> ;Hepatology. 2011 Jul 1
59 citations
Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis.
David E. Kaplan, Fusao Ikeda, Yun Li, Nobuhiro Nakamoto, Sutharsan Ganesan, Mary E. Valiga, Frederick A. Nunes, K. Rajender Reddy, Kyong-Mi Chang> ;Journal of Hepatology. 2008 Jun 1
118 citations
Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C.
David E. Kaplan, Kazushi Sugimoto, Kimberly Newton, Mary E. Valiga, Fusao Ikeda, Ayse Aytaman, Frederick A. Nunes, Michael R. Lucey, Barbara A. Vance, Robert H. Vonder...> ;Gastroenterology. 2007 Feb 1
35 citations
Strain-Specific T-Cell Suppression and Protective Immunity in Patients with Chronic Hepatitis C Virus Infection
Kazushi Sugimoto, David E. Kaplan, Fusao Ikeda, Jin Ding, Jonathan M. Schwartz, Frederick A. Nunes, Harvey J. Alter, Kyong-Mi Chang> ;Journal of Virology. 2005 Jun 1
288 citations
Suppression of HCV-specific T cells without differential hierarchy demonstrated ex vivo in persistent HCV infection.
Kazushi Sugimoto, Fusao Ikeda, Jason Stadanlick, Frederick A. Nunes, Harvey J. Alter, Kyong-Mi Chang> ;Hepatology. 2003 Dec 1
61 citations
The outcome of liver grafts procured from hepatitis C-positive donors.
Ergun Velidedeoglu, Niraj M. Desai, Louis Campos, Kim M. Olthoff, Abraham Shaked, Frederick A. Nunes, Gillian Zeldin, Charmaine A. Stewart, Emily A. Blumberg, J. Abram...> ;Transplantation. 2002 Feb 27
4 citations
Effect of donor hepatitis C on liver graft survival.
Ergun Velidedeoglu, Niraj M. Desai, Luis Campos, Kim M. Olthoff, Abraham Shaked, F. Nunes, G. Zeldin, C. Stewart, Emily A. Blumberg, J. Abrams, James F. Markmann> ;Transplantation Proceedings. 2001 Nov 1
2 citations
Searching for a balance when applying immunosuppression after liver transplantation.
Frederick A. Nunes, Michael R. Lucey> ;Transplantation. 2001 Feb 27
27 citations
Combination Therapy with Lamivudine and Adenovirus Causes Transient Suppression of Chronic Woodchuck Hepatitis Virus Infections
Tianlun Zhou, Juo-Tao Guo, Frederick A. Nunes, Katherine L. Molnar-Kimber, James M. Wilson, Carol E. Aldrich, Jeffry Saputelli, Sam Litwin, Lynn D. Condreay, Christoph...> ;Journal of Virology. 2000 Dec 15
68 citations
Fatal Hyperammonemia after Orthotopic Lung Transplantation
Gary R. Lichtenstein, Yu-Xiao Yang, Frederick A. Nunes, James D. Lewis, Mendel Tuchman, Gregory Tino, Larry R. Kaiser, Harold I. Palevsky, Robert M. Kotloff, Emma E. F...> ;Annals of Internal Medicine. 2000 Feb 15
102 citations
Gene transfer into the liver of nonhuman primates with E1-deleted recombinant adenoviral vectors: safety of readministration.
Frederick A. Nunes, Emma E. Furth, James M. Wilson, Steven E. Raper> ;Human Gene Therapy. 1999 Oct 10
3 citations
GASTROINTESTINAL COMPLICATIONS OF IMMUNOSUPPRESSION
Frederick A. Nunes, Michael R. Lucey> ;Gastroenterology Clinics of North America. 1999 Mar 1
1 citations
Liver transplantation at the University of Pennsylvania and the Children's Hospital of Philadelphia.
Gideon Zamir, Kim M. Olthoff, Fredrick A. Nunes, James F. Markmann, Gillian Zeldin, Charmaine A. Stewart, Weinreib Rm, Elizabeth B. Rand, Maller Es, Michael R. Lucey, ...> ;Clinical Transplants. 1999 Jan 1
14 citations
LIVER-DIRECTED GENE THERAPY
Frederick A. Nunes, Steven E. Raper> ;The Medical Clinics of North America. 1996 Sep 1
25 citations
Chemiluminescent measurement of increased free radical formation after ischemia/reperfusion : mechanisms of free radical formation in the liver
Frederick A. Nunes, Chellappa Kumar, Britton Chance, Clifford A. Brass> ;Digestive Diseases and Sciences. 1995 May 1
366 citations
Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis.
Yiping Yang, Frederick A. Nunes, Klara Berencsi, Eva Gonczol, John F. Engelhardt, James M. Wilson> ;Nature Genetics. 1994 Jul 1
1296 citations
Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy
Yiping Yang, Frederick A. Nunes, Klara Berencsi, Emma E. Furth, Eva Gonczol, James M. Wilson> ;Proceedings of the National Academy of Sciences of the United States of America. 1994 May 10
The fate of liver grafts declined for subjective reasons and transplanted out of a local organ procurement organization.
Gideon Zamir, James F. Markmann, J. Abrams, Michelle R. Macatee, Fredrick A. Nunes, Abraham Shaked, Kim M. Olthoff> ;Transplantation. 1999 May 1
Mesenteric ischemia.
Anzengruber, F., Ramzan, Z., Carasquillo, J., Nunes, F.> ;Isr Med Assoc J. 2011 Jan
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