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Fredric Gorin, MD, Neurology, Sacramento, CA

FredricAustinGorinMDPhD

Neurology • Sacramento, CA

Professor and Chairperson Neurology, UC, Davis School of Medicine

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  • Office

    4860 Y St Ste 3700
    Dept Of Neurology UC Davis Health System
    Sacramento, CA 95817
    Phone+1 916-734-6284
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Summary

  • PROFESSIONAL SUMMARY :
    •    First correctly predictive pharmacophore for opioid peptides binding to the mu opioid receptor.
    •    First human muscle disorder cloned and chromosomally mapped (glycogen phosphorylase, McArdles Disease).
    •    Demonstration of an acquired metabolic myopathy of glycogenolysis of fast twitch skeletal muscle following nerve regeneration. Metabolic myopathy explains clinically observed rhabdomyolysis in high intensity muscular activity.
    •    Identified that neural activity in fast-twitch skeletal muscle alters metabolic gene expression by regulating their transcript stability via calcium flux of the sarcoplasmic reticulum
    •    Designed, co-developed, and implemented a JAVA software tool that generates neuroanatomical metadata indexing and reconciling the names of thalamic structures from different mammalian species. A novel, concept-based vector space model (VSM) employed automated relevance feedback adapted from genomic sequence alignment algorithms. The categorized metadata was applied to archive and retrieve semi-structured graphical neuroscientific information as part of the NIH-funded Human Brain Project.
    •    Identified a new class of anti-cancer small molecules that cause a previously unreported form of programmed necrosis in proliferating and non-proliferating, hypoxically transformed cancer initiator cells (CICs). Patented by University of California, these small molecules kill independently of cell cycle by initiating selective endosomal mis-trafficking.
    * New class of small molecules that inhibit nitric oxide release from macrophages and microglia
    •    As Chairperson, implemented first Telestroke and TeleNeurology programs in the UC Davis Health System. TeleNeurology outreach includes public health initiatives with Central Valley hospital facilities.

Education & Training

  • University of California (San Francisco)
    University of California (San Francisco)Residency, Neurology, 1980 - 1983
  • Washington University/B-JH/SLCH Consortium
    Washington University/B-JH/SLCH ConsortiumInternship, Internal Medicine, 1979 - 1980
  • Washington U. Med. School
    Washington U. Med. SchoolPhD, Physiology and Biophysics, 1973 - 1979
  • Washington University in St. Louis School of Medicine
    Washington University in St. Louis School of MedicineClass of 1979
  • University of California, Davis
    University of California, DavisBS, Biochemistry, 1969 - 1973

Certifications & Licensure

  • CA State Medical License
    CA State Medical License 1981 - 2025
  • American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

  • member Phi Kappa Phi, 1972
  • Phi Beta Kappa 1972
  • UC Davis Graduation with Highest Honors 1973
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Publications & Presentations

PubMed

Journal Articles

  • Size-stable solid lipid nanoparticles loaded with Gd-DOTA for magnetic resonance imaging  
    Andreozzi E, Wang P, Valenzuela A, Tu C, Gorin F, Dhenain M, Louie A, Bioconjug Chem, 9/1/2013
  • 5’-Benzylglycinyl-Amiloride Kills Proliferating and Nonproliferating Malignant Glioma Cells through Caspase-Independent Necroptosis Mediated by Apoptosis-Inducing Factor  
    Pasupuleti N, Leon L, Carraway KL 3rd, Gorin F, J Pharmacol Exp Ther, 3/1/2013
  • 2-Amidino Analogs of Glycine-Amiloride Conjugates: Inhibitors of Urokinase-type Plasminogen Activator  
    Massey, AP, Harley, WR, NagaRekha Pasupuleti, Gorin, FA, Nantz MH, Bioorg Med Chem Lett, 4/1/2012
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Grant Support

  • Novel Glioma Upa Inhibitor Design Guided By Intracellular Signaling PathwaysNational Institute Of Neurological Disorders And Stroke2009–2010
  • Novel Amiloride Conjugates Selectively Kill GliomasNational Institute Of Neurological Disorders And Stroke2005–2007
  • Inhibition Of NA-H Exchanger Selectively Kills GliomasNational Institute Of Neurological Disorders And Stroke2001–2003
  • Brain Glycogen Phosphorylase In Hypoxic-Ischemic EventsNational Institute Of Neurological Disorders And Stroke1985–1986

Professional Memberships

  • American Neurological Association
    Fellow
  • Society for Neuro-Oncology
    Member
  • American Chemical Society
    Member
  • American Society for Pharmacology and Experimental Therapeutics
    Member

Dr. Fredric Gorin, Dr. Fredric Gorin, MD, Dr. F Gorin, Dr. Fredric Austin Gorin