GailA.HechtMD

PubMed

• 1 citations
  Recommendations to Improve Quality of Probiotic Systematic Reviews With Meta-Analyses.
  Lynne V McFarland, Gail Hecht, Mary E Sanders, Debra A Goff, Ellie J C Goldstein, Colin Hill, Stuart Johnson, Maryam R Kashi, Ravina Kullar, Maria L Marco, Daniel J Me...> ;JAMA Network Open. 2023 Dec 1
• Two-year durability of REBYOTA™ (RBL), a live biotherapeutic for the prevention of recurrentinfections.
  Robert Orenstein, Gail Hecht, Adam Harvey, Glenn Tillotson, Sahil Khanna> ;Open Forum Infectious Diseases. 2023 Sep 1
• Presentation of the AGA Distinguished Achievement Award in Basic Science to James R. Goldenring, MD, PhD, AGAF.
  Jason C Mills, James E Casanova, Gail Hecht> ;Gastroenterology. 2023 Jul 1
• 1 citations
  Transmission of the Potential Pathogen Atypical Enteropathogenic Escherichia coli by Fecal Microbiota Transplant.
  Sarah E Kralicek, Celeste Jenkins, Jessica R Allegretti, James D Lewis, Majdi Osman, Gail A Hecht> ;Gastroenterology. 2023 Jul 1
• 3 citations
  Clinical Manifestations and Stool Load of Atypical Enteropathogenic Escherichia coli Infections in United States Children and Adults.
  Sarah E Kralicek, Lalitha M Sitaraman, Paulius V Kuprys, Amanda T Harrington, Bharat Ramakrishna, Majdi Osman, Gail A Hecht> ;Gastroenterology. 2022 Nov 1
• 3 citations
  Spef1/CLAMP binds microtubules and actin-based structures and regulates cell migration and epithelia cell polarity.
  Rocio Tapia, Gail A Hecht> ;Annals of the New York Academy of Sciences. 2022 Sep 1
• 36 citations
  Durable reduction of Clostridioides difficile infection recurrence and microbiome restoration after treatment with RBX2660: results from an open-label phase 2 clinical...
  Robert Orenstein, Erik R Dubberke, Sahil Khanna, Christine H Lee, David Yoho, Stuart Johnson, Gail Hecht, Herbert L DuPont, Dale N Gerding, Ken F Blount, Sarah Mische,...> ;BMC Infectious Diseases. 2022 Mar 12
• 3 citations
  Quantitative analysis and virulence phenotypes of atypical enteropathogenic Escherichia coli (EPEC) acquired from diarrheal stool samples from a Midwest US hospital.
  Maximillian J. Carlino, Sarah E. Kralicek, SA Santiago, Lalitha Sitaraman, AT Harrington, Gail Hecht> ;Gut Microbes. 2020 Nov 1
• 26 citations
  The Efficacy and Safety of Fecal Microbiota Transplant for Recurrent Clostridium difficile Infection: Current Understanding and Gap Analysis.
  Mark H. Wilcox, Barbara H. McGovern, Gail Hecht> ;Open Forum Infectious Diseases. 2020 Apr 11
• 7 citations
  Enteropathogenic Escherichia coli (EPEC) Recruitment of PAR Polarity Protein Atypical PKCζ to Pedestals and Cell-Cell Contacts Precedes Disruption of Tight Junctions i...
  Rocio Tapia, Sarah E. Kralicek, Gail Hecht> ;International Journal of Molecular Sciences. 2020 Jan 14
• 3 citations
  2019 Gut Microbiota for Health World Summit
  Gwenny M. Fuhler, Gail Hecht, Sage E. Foley, Angelica Cruz Lebron, Keith Hazleton> ;Gastroenterology. 2019 Sep 6
• 5 citations
  Sperm Flagellar 1 Binds Actin in Intestinal Epithelial Cells and Contributes to Formation of Filopodia and Lamellipodia.
  Rocio Tapia, Eloy Andrés Pérez-Yépez, Maximillian J. Carlino, Umesh C. Karandikar, Sarah E. Kralicek, Mary K. Estes, Gail Hecht> ;Gastroenterology. 2019 Dec 1
• 7 citations
  Targeting Gut Microbiome Interactions in Service-Related Gastrointestinal and Liver Diseases of Veterans
  J.S. Bajaj, Arun Sharma, Pradeep K. Dudeja, Zafar Iqbal, Amar B. Singh, Keith T. Wilson, Yvette Taché, Joseph R. Pisegna, Beverley Greenwood-Van Meerveld, R. Balfour S...> ;Gastroenterology. 2019 Aug 9
• 89 citations
  Results From a Randomized, Placebo-Controlled Clinical Trial of a RBX2660-A Microbiota-Based Drug for the Prevention of Recurrent Clostridium difficile Infection.
  Erik R. Dubberke, Christine H. Lee, Robert Orenstein, Sahil Khanna, Gail Hecht, Dale N. Gerding> ;Clinical Infectious Diseases. 2018 Sep 28
• 7 citations
  EPEC NleH1 is significantly more effective in reversing colitis and reducing mortality than NleH2 via differential effects on host signaling pathways
  Sarah E. Kralicek, Mai Nguyen, Ki Jong Rhee, Rocio Tapia, Gail Hecht> ;Laboratory Investigation; a Journal of Technical Methods and Pathology. 2018 Feb 2
• 16 citations
  Modulation of epithelial cell polarity by bacterial pathogens.
  Rocio Tapia, Sarah E. Kralicek, Gail Hecht> ;Annals of the New York Academy of Sciences. 2017 Jun 19
• 21 citations
  EPEC effector EspF promotes Crumbs3 endocytosis and disrupts epithelial cell polarity.
  Rocio Tapia, Sarah E. Kralicek, Gail Hecht> ;Cellular Microbiology. 2017 Jul 27
• 13 citations
  Role of SHP2 protein tyrosine phosphatase in SERT inhibition by enteropathogenic E. coli (EPEC).
  Megha Singhal, Christopher R. Manzella, Vinay Soni, Waddah A. Alrefai, Seema Saksena, Gail Hecht, Pradeep K. Dudeja, Ravinder K. Gill> ;American Journal of Physiology. Gastrointestinal and Liver Physiology. 2017 Feb 16
• 9 citations
  Gut Microbiota Developments With Emphasis on Inflammatory Bowel Disease: Report From the Gut Microbiota for Health World Summit 2016
  Hester Eppinga, Gwenny M. Fuhler, Maikel P. Peppelenbosch, Gail Hecht> ;Gastroenterology. 2016 Aug 1
• 15 citations
  Mechanisms of DRA recycling in Intestinal Epithelial Cells: Effect of Enteropathogenic E. coli
  Tarunmeet Gujral, Anoop Kumar, Shubha Priyamvada, Seema Saksena, Ravinder K. Gill, Kim Hodges, Waddah A. Alrefai, Gail Hecht, Pradeep K. Dudeja> ;American Journal of Physiology. Cell Physiology. 2015 Dec 15
• 11 citations
  Expression of Enteropathogenic Escherichia coli Map Is Significantly Different than That of Other Type III Secreted Effectors In Vivo
  Mai Nguyen, Jason Rizvi, Gail Hecht> ;Infection and Immunity. 2015 Jan 1
• 22 citations
  Actin Pedestal Formation by Enterohemorrhagic Escherichia coli Enhances Bacterial Host Cell Attachment and Concomitant Type III Translocation
  Scott E. Battle, Michael John Brady, Sivapriya Kailasan Vanaja, John M. Leong, Gail Hecht> ;Infection and Immunity. 2014 Sep 1
• 24 citations
  Enteropathogenic E. coli effectors EspG1/G2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration
  Lila G. Glotfelty, Anita Zahs, Kimberley Hodges, Kuangda Shan, Neal M. Alto, Gail Hecht> ;Cellular Microbiology. 2014 Dec 1
• 36 citations
  Microtubules Are Required for Efficient Epithelial Tight Junction Homeostasis and Restoration.
  Lila G. Glotfelty, Anita Zahs, Catalin Iancu, Le Shen, Gail Hecht> ;American Journal of Physiology. Cell Physiology. 2014 Aug 1
• 1 citations
  AGA's approach to the microbiome.
  Gail Hecht> ;Gastroenterology. 2014 Apr 1
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Journal Articles

• Gut Microbiota Developments With Emphasis on Inflammatory Bowel Disease: Report From the Gut Microbiota for Health World Summit 2016  
  Eppinga H, Fuhler GM, Peppelenbosch MP, and Hecht GA, Gastroenterology, 1/1/2016
• Expression of enteropathogenic Escherichia coli map is significantly different than that of other type III secreted effectors in vivo  
  Nguyen M, Rizvi J, and Hecht G, Infect Immun, 1/1/2015
• Mechanisms of DRA recycling in Intestinal Epithelial Cells: Effect of Enteropathogenic E coli  
  Gujral T, Kumar A, Priyamvada S, Saksena S, Gill RK, Hodges K, Alrefai WA, Hecht GA and Dudeja PK, Am. J. Physiol. Cell Physiol., 1/1/2015
• What is the value of a Food and Drug Administration Investigational New Drug application for fecal microbiota transplantation to treat Clostridium difficile infection?  
  Hecht GA, Blaser MJ, Gordon J, Kaplan LM, Knight R, Laine L, Peek R, Sanders ME, Sartor B, Wu GD, Yang VW, Clin Gastroenterol Hepatol, 1/1/2014
• Microtubules are required for efficient epithelial tight junction homeostasis and restoration  
  Glotfelty LA, Zahs A, Iancu C, Shen L, Hecht GA, Am J Physiol Cell Physiol, 1/1/2014
• Enteropathogenic E coli effectors EspG1/2 disrupt microtubules, contribute to tight junction perturbation and inhibit restoration  
  Glotfelty LG, Zahs A, Hodges K, Shan K, Alto NM, Hecht GA, Cell Microbiol, 1/1/2014
• Actin pedestal formation by enterohemorrhagic E coli enhances bacterial host attachment and concomitant type III translocation  
  Battle SE, Brady MJ, Vanaja SK, Leong JM, Hecht GA, Infect Immun, 1/1/2014
• Bacterial Infections of the Small Intestine  
  Hodges K and Hecht G, Current Opinion in Gastroenterology, 1/1/2013
• The intestinal microbiome, probiotics and prebiotics in neurogastroenterology  
  Saulnier DM, Ringel Y, Heyman MB, Foster JA, Bercik P, Shulman RJ, Versalovic J, Verdu EF, Dinan TG, Hecht G, Guarner F, Gut Microbes, 1/1/2013
• Enteropathogenic E coli inhibits ileal sodium-dependent bile acid transporter ASBT  
  Annaba F, Sarwar Z, Gill RK, Ghosh A, Saksena S, Bothakur A, Hecht GA, Dudeja PK, Alrefai WA, Am J Physiol Gastrointest Liver Physiol, 1/1/2012
• Interspecies communication in the gut, from bacterial delivery to host-cell response  
  Hodges K and Hecht G, J Physiol, 1/1/2012
• The bacterial virulence factor NleA is required for the disruption of intestinal tight junctions by enteropathogenic E coli  
  Thanabalasuriar A, Koutsouris A, Weflen A, Hecht G, and Gruenheid S, Cellular Microbiology, 1/1/2010
• E coli secreted protein F promotes invasion of intestinal epithelial cells via an SNX9-dependent mechanism  
  Weflen AW, Alto NM, Viswanathan VK, and Hecht G, Cell Microbiol, 1/1/2010
• Enterohemorrhagic E coli alters murine intestinal epithelial tight junction protein expression and barrier function in Shiga toxin indendent manner  
  Roxas JL, Koutsouris A, Bellmeyer A, Tesfay S, Royan S, Falzari D, Harris A, Cheng H, Rhee KJ, and Hecht G, J Lab Invest, 1/1/2010
• The bacterial virulence factor NleA's involvement in intestinal tight junction disruption during Enteropathogenic E coli infection is independent of its putative PDZ b...  
  Thanabalasuriar A, Koutsouris A, Hecht G, and Gruenheid S, Gut Microbes, 1/1/2010
• Enterohemorrhagic E coli required N-WASP for efficient type III translocation but not for EspFU-mediated actin pedestal formation  
  Vingadassalom D, Campellone KG, Brady MJ, Skehan B, Battle SE, Robbins D, Kapoor A, Hecht G, Snapper SB, Leong JM, PLoS Pathog, 1/1/2010
• Enteropathogenic E coli non-LEE encoded effectors NleH1 and NleH2 attenuate NF-kB activation  
  Royan SV, Jones RM, Koutsouris A, Roxas JL, Falzari K, Weflen A, Kim A, Bellmeyer A, Turner JR, Neish A, Rhee KJ, Viswanathan VK, Hecht GA, Mol Micro, 1/1/2010
• Enterohemorrhagic E coli suppress inflammatory response to cytokines and its own toxin  
  Bellmeyer AA, Cotton C, Kanteti R, Koutsouris A, Viswanathan VK, Hecht G, Am J Physiol Gastrointest Liver Physiol, 1/1/2009
• Enteropathogenic E coli inhibits intestinal vitamin B1 (thiamin) uptake: Studies with human derived intestinal epithelial Caco-2 cells  
  Ashokkumar B, Kumar JS, Hecht GA, Said HM, Am J Physiol Gastrointest Liver Physiol, 1/1/2009
• Modulation apical Cl-/OH exchange activity in human intestinal epithelial cells by enteropathogenic E coli  
  Gill RK, Borthakur A, Hodges K. Saksena S, Ramaswamy K, Hecht G, and Dudeja PK, . Clin. Invest., 1/1/2007
• Absence of bacterially induced RELM-Beta reduces injury in the DSS model of colitis  
  McVay LD, Keilbaugh SA, Wong TMH, Kierstein S, Shin ME, Lehrke M, Lefterova MI, Shifflett DE, Barnes SL, Cominelli F, Cohn SM, Hecht G, Lazar MA, Haczku A, and Wu GD, J Clin Invest, 1/1/2006
• A murine model for enteropathogenic E coli infection  
  Savkovic SD, Villanueva J, Matkowskyj K, and Hecht G, Infect Immun, 1/1/2005
• Enterohemorrhagic and enteropathogenic E coli alters intestinal epithelial tight junctions by distinct mechanisms  
  Viswanathan VK, Koutsouris, Lukic S, Hecht G, Infect Immun, 1/1/2004
• Enteropathogenic Escherichia coli induced alterations in epithelial barrier function  
  Viswanathan VK and G Hecht, Archives of Hellenic Medicine, 1/1/2003
• Disruption of cell polarity by enteropathogenic Escherichia coli enables basolateral membrane proteins to migrate apically and to potentiate physiological consequences  
  Muza M, Koutsouris A, Hecht G, Infection & Immunity, 1/1/2003
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Books/Book Chapters

• Yamada Textbook of Gastroenterololgy 
  Chapter: Approach to the Patient with Diarrhea. 
  Hecht G, Gaspar J, and Malespin M2016
• Foodborne Infections and Intoxications 
  Chapter: Pathogenic E. coli. 
  Hodges K and Hecht GEditors: John Glenn Morris and Morris Potter.ElsevierEdition 4th,2012
• Atlas of Gastroenterology 
  Chapter: Bacterial viral, and toxic causes of diarrhea, gastroenteritis, and anorectal infections. 
  Hecht GA and Tarr PIEditors: T. Yamada.Edition 4th,2009
• Textbook of Gastroenterology 
  Chapter: Bacterial viral, and toxic causes of diarrhea, gastroenteritis, and anorectal infections. 
  Tarr PI, Bass DM, and Hecht GAEditors: T. Yamada.Edition 5th,2008
• Bacterial-Epithelial Cell Cross-Talk: Molecular Mechanisms in Pathogenesis 
  Chapter: Gastrointestinal Infections: Interactions of Enteric Bacteria with the Intestinal Mucosa. 
  Tesfay SY, Shifflett DE, and Hecht GAEditors: BA McCormick.Cambridge Press2007
• Physiology of the Gastrointestinal Tract 
  Chapter: Physiology of Host-Pathogen Interactions. 
  Hodges K, Viswanathan VK, and Hecht GEditors: LR Johnson, KE Barrett.2006
• Textbook of Gastroenterology 
  Chapter: Bacterial infections of the colon. 
  Page 1864 - 1882Hecht, GEditors: T. Yamada.J. B. Lippincott Co., Philadelphia, PAEdition 4th,2003
• Atlas of Gastroenterology 
  Chapter: Bacterial infections of the colon. 
  Page 428 - 432Hecht, GEditors: T. Yamada.J. B. Lippincott Co., Philadelphia, PAEdition 4th,2003
• Microbial Pathogenesis and the Intestinal Epithelial Cell 
  Chapter: Enteric pathogens that affect intestinal epithelial tight junctions. 
  Page 267 - 284Hecht, GEditors: G. Hecht.ASM Press, Baltimore, MD2003
• Microbial Pathogenesis and the Intestinal Epithelial Cell 
  Chapter: Epithelial response to enteric pathogens: activation of chloride secretory pathways. 
  Page 285 - 300Hecht, GEditors: G. Hecht.ASM Press, Baltimore, MD2003
• Tight Junctions 
  Chapter: Effects of bacteria and bacterial toxins on tight junctions. 
  Page 493 - 515Hecht, GEditors: James Anderson and Marcelino Cereijido.CRC Press, Boca Raton, FL2001
• Conn's Current Therapy 
  Chapter: Constipation. 
  Page 17 - 19Robinson B, Hecht GAEditors: Robert E. Rakel.W.B. Saunders Co., Philadelphia, PA1992
• Modern Cell Biology: Functional Epithelial Cells in Culture 
  Chapter: Tight (occludin) junction in cultured (and native) epithelial cells. 
  Page 131 - 169Madara JL, Hecht GAEditors: Karl Matlin.Alan R. Liss, Inc., New York, NY1989
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Lectures

• Current Diagnosis and Management of C. difficile Infection. 
  Good Samaritan Hospital, Los Angeles, CA - 1/16/2016
• Impact of EPEC on Intestinal Epithelial Cell Polarity. 
  Berlin, Germany - 1/14/2016
• Impact of Enteric Pathogens on Tight Junctions. 
  Boston, MA - 1/24/2013
• Update on Gut Microbiome. 
  1/18/2013
• Understanding the Gut Microbiome. 
  San Diego, CA - 1/17/2013
• How Bugs Communicate with the Gut and What They Have To Say. 
  San Diego, CA - 1/22/2012
• Influence of EPEC on Intestinal Epithelial Cells. 
  University of Texas Southwestern, Dallas, TX - 1/1/2011
• Control of Host Responses by EPEC. 
  University of Wisconsin-Madison - 1/1/2010
• EPEC Regulation of Host Response. 
  Vanderbilt University - 1/1/2010
• Control of Host Responses by EPEC: A Tale of Two Effectors. 
  Northwestern University, Chicago, IL - 1/1/2010
• Role of EspF in EPEC Invasion of Intestinal Epithelial Cells. 
  Children's Hospital of LA, USC, Los Angeles, CA - 1/1/2010
• Ups and Downs of EPEC-Induced Inflammation. 
  Kyoto, Japan - 1/1/2009
• EPEC Modulation of Intestinal Inflammation. 
  Tokoyo, Japan - 1/1/2009
• EPEC Effects on Intestinal Epithelial Cell Function. 
  University of California, San Diego, San Diego, CA - 1/1/2008
• Effects of EPEC on Intestinal Epithelial Cells: Probing activity of EPEC EspF. 
  University of Maryland, Baltimore, MD - 1/1/2008
• Interference of Intestinal Epithelial Cell Function by Bacterial Proteins: EPEC as an Example. 
  Vanderbilt University, Nashville, TN - 1/26/2007
• Effect of EPEC EspF on Intestinal Epithelial Function. 
  Johns Hopkins University - 1/1/2007
• Impact of EPEC on IEC Transport. 
  Baltimore, MD - 1/1/2007
• Effects of EPEC on intestinal epithelial function. 
  Medical College of Virginia, Richmond, VA - 1/12/2006
• Regulation of Intestinal Inflammation by Non-Invasive Pathogens: Softening the Blow. 
  San Francisco, CA - 1/1/2006
• Anti-inflammatory effects of EPEC on intestinal epithelial cells. 
  1/1/2005
• Mechanisms of EPEC alteration of host intestinal functions. 
  University of Florida, Gainesville, FL - 1/1/2005
• Physiological alterations of intestinal epithelial cells by infection with enteropathogenic E. coli. 
  University of Virginia, Charlottesville, VA - 1/27/2003
• Enteropathogenic E. coli and intestinal epithelial cells. 
  Milwaukee, WI - 1/18/2003
• Disruption of Tight Junctions by Enteropathogenic E. coli. 
  San Francisco, CA - 1/13/2003
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Other

• A transformation assay of herpes simplex type II strain MS in GM347 cells. 
  Hecht GA, Masters Thesis (Medical Microbiology)
  1/1/1979