GaryEGilbertMD

Oncology • Boston, MA

Hematologic Oncology

Associate Professor of Medicine, Brigham and Women's Hospital

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Office
150 S Huntington Ave
Boston, MA 02130
Phone+1 617-232-9500

Fax+1 857-364-4343
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Education & Training

Tufts Medical CenterFellowship, Hematology and Medical Oncology, 1985 - 1988
Loma Linda University Health Education ConsortiumResidency, Internal Medicine, 1982 - 1985
Loma Linda University Health Education ConsortiumResidency, Internal Medicine, 1981 - 1981
Loma Linda University School of MedicineClass of 1980

Certifications & Licensure

CA State Medical License 1982 - Present
MA State Medical License 1987 - 2025
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Hematology
American Board of Internal Medicine Medical Oncology

Publications & Presentations

PubMed

Factor VIII-antibody structure and membrane binding.
Gary E. Gilbert> ;Blood. 2021 May 27
1 citations
Factor V mutation illuminates the dominant anticoagulant role and importance of an unidentified platelet modifier.
Josefin Ahnström, Gary E. Gilbert> ;Journal of Thrombosis and Haemostasis. 2021 May 1
6 citations
Procoagulant activities of skeletal and cardiac muscle myosin depend on contaminating phospholipid
Valerie A. Novakovic, Gary E. Gilbert> ;Blood. 2020 Nov 19
1 citations
Discordance between platelet-supported and vesicle-supported factor VIII activity in the presence of anti-C2 domain inhibitory antibodies
Madhumouli Chatterjee, Shannon L. Meeks, Valerie A. Novakovic, Gary E. Gilbert> ;Journal of Thrombosis and Haemostasis. 2020 Jun 17
2 citations
Unexpected enhancement of FVIII immunogenicity by endothelial expression in lentivirus-transduced and transgenic mice.
Qizhen Shi, Christopher V. Carman, Yingyu Chen, Peter T. Sage, Feng Xue, Xin M. Liang, Gary E. Gilbert> ;Blood Advances. 2020 May 26
6 citations
The evolving understanding of factor VIII binding sites and implications for the treatment of hemophilia A
Gary E. Gilbert> ;Blood Reviews. 2019 Jan 1
53 citations
A microengineered vascularized bleeding model that integrates the principal components of hemostasis.
Yumiko Sakurai, Elaissa T. Hardy, Byungwook Ahn, Reginald Tran, Meredith E. Fay, Jordan C. Ciciliano, Robert G. Mannino, David R. Myers, Yongzhi Qiu, Marcus A. Carden,...> ;Nature Communications. 2018 Feb 6
Inhibitory antibodies against factor VIII C1 domain.
Gary E. Gilbert> ;Blood. 2016 Oct 20
34 citations
Thrombotic Role of Blood and Endothelial Cells in Uremia through Phosphatidylserine Exposure and Microparticle Release
Chunyan Gao, Rui Xie, Chengyuan Yu, Ruishuang Ma, Weijun Dong, Huan Meng, Yan Zhang, Yu Si, Zhuo Zhang, Valerie A. Novakovic, Yong Zhang, Junjie Kou, Yayan Bi, Baoxin ...> ;Plos One. 2015 Nov 16
27 citations
Platelet binding sites for factor VIII in relation to fibrin and phosphatidylserine
Gary E. Gilbert, Valerie A. Novakovic, Jialan Shi, Jan T. Rasmussen, Steven W. Pipe> ;Blood. 2015 Sep 3
8 citations
Changes in the Factor VIII C2 domain upon membrane binding determined by hydrogen-deuterium exchange MS.
Dionysios Pantazatos, Christopher R. Gessner, Virgil L. Woods, Gary E. Gilbert> ;The Biochemical Journal. 2014 Aug 1
2 citations
Factor VIII inhibitor epitopes and an enigma
Gary E. Gilbert> ;Blood. 2013 Dec 19
4 citations
Lactadherin Inhibits Secretory Phospholipase A2 Activity on Pre-Apoptotic Leukemia Cells
Steffen Nyegaard, Valerie A. Novakovic, Jan T. Rasmussen, Gary E. Gilbert> ;Plos One. 2013 Oct 23
31 citations
Endothelial cell phagocytosis of senescent neutrophils decreases procoagulant activity
Chunyan Gao, R. Xie, W. Li, J. Zhou, S. Liu, F. Cao, Y. Liu, R. Ma, Y. Si, Y. Bi, Gary E. Gilbert, Jialan Shi> ;Thrombosis and Haemostasis. 2013 Apr 4
Backbone resonance assignments of the C2 domain of coagulation factor VIII
Kristin M. Nuzzio, David B. Cullinan, Valerie A. Novakovic, John M. Boettcher, Chad M. Rienstra, Gary E. Gilbert, James D. Baleja> ;Biomolecular NMR Assignments. 2013 Apr 1
25 citations
Conservative mutations in the C2 domains of factor VIII and factor V alter phospholipid binding and cofactor activity
Gary E. Gilbert, Valerie A. Novakovic, Randal J. Kaufman, Hongzhi Miao, Steven W. Pipe> ;Blood. 2012 Aug 30
45 citations
Lactadherin binds to phosphatidylserine-containing vesicles in a two-step mechanism sensitive to vesicle size and composition.
Daniel E. Otzen, Kristine Blans, Huabing Wang, Gary E. Gilbert, Jan T. Rasmussen> ;Biochimica Et Biophysica Acta. 2012 Apr 1
38 citations
Phagocytosis by macrophages and endothelial cells inhibits procoagulant and fibrinolytic activity of acute promyelocytic leukemia cells
Rui Xie, Chunyan Gao, Wen Li, Jiuxin Zhu, Valerie A. Novakovic, Jing Wang, Ruishuang Ma, Jin Zhou, Gary E. Gilbert, Jialan Shi> ;Blood. 2012 Mar 8
71 citations
Procoagulant activity of erythrocytes and platelets through phosphatidylserine exposure and microparticles release in patients with nephrotic syndrome
Chunyan Gao, R. Xie, C. Yu, Q. Wang, F. Shi, C. Yao, J. Zhou, Gary E. Gilbert, J. Shi> ;Thrombosis and Haemostasis. 2012 Feb 28
2 citations
Curbing an inhibitor for hemostasis
Gary E. Gilbert, Alan E. Mast> ;Blood. 2011 May 19
25 citations
Membrane-binding properties of the Factor VIII C2 domain.
Valerie A. Novakovic, David B. Cullinan, Hironao Wakabayashi, Philip J. Fay, James D. Baleja, Gary E. Gilbert> ;The Biochemical Journal. 2011 Apr 1
42 citations
A membrane-interactive surface on the factor VIII C1 domain cooperates with the C2 domain for cofactor function
Junhong Lü, Steven W. Pipe, Hongzhi Miao, Marc Jacquemin, Gary E. Gilbert> ;Blood. 2011 Mar 17
49 citations
Lactadherin functions as a probe for phosphatidylserine exposure and as an anticoagulant in the study of stored platelets
J. Hou, Y. Fu, J. Zhou, W. Li, R. Xie, F. Cao, Gary E. Gilbert, J. Shi> ;Vox Sanguinis. 2011 Feb 1
36 citations
Daunorubicin induces procoagulant activity of cultured endothelial cells through phosphatidylserine exposure and microparticles release
Yueyue Fu, Jin Zhou, Huibo Li, Fenglin Cao, Yanhua Su, Shengjin Fan, Yinghua Li, Shuye Wang, Limin Li, Gary E. Gilbert, Jialan Shi> ;Thrombosis and Haemostasis. 2010 Sep 30
45 citations
Phosphatidylserine exposure and procoagulant activity in acute promyelocytic leukemia
J. Zhou, Jialan Shi, J. Hou, F. Cao, Y. Zhang, Jan T. Rasmussen, Christian W. Heegaard, Gary E. Gilbert> ;Journal of Thrombosis and Haemostasis. 2010 Apr 1
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Press Mentions

Research Recap for July 2: Hemophilia and the Restoration of the Elwha Valley ForestsJuly 2nd, 2021

Grant Support

Phospholipid Binding Structures Of Factor VIIINational Heart, Lung, And Blood Institute1996–2002
Function Of Factor VIII On The Platelet MembraneNational Heart, Lung, And Blood Institute1998–2001
Phospholipid Binding Structures Of Factor VIIINational Heart, Lung, And Blood Institute1995–1997
Coordinate Function Of Enzyme Complexes In HemostasisNational Heart, Lung, And Blood Institute1991–1995
Platelet Proteins Associated With Platelet ActivationNational Heart, Lung, And Blood Institute1986–1988

Hospital Affiliations

Veterans Affairs Boston Healthcare System - Jamaica PlainJamaica Plain, Massachusetts