GaryTongMD

PubMed

• 252 citations
  Treatment Combinations for Alzheimer’s Disease: Current and Future Pharmacotherapy Options
  Jeffrey L. Cummings, Gary Tong, Clive Ballard> ;Journal of Alzheimer's Disease. 2019 Jan 1
• 318 citations
  Current state of Alzheimer's fluid biomarkers.
  José Luis Molinuevo, Scott Ayton, Richard Batrla, Martin M. Bednar, Tobias Bittner, Jeffrey L. Cummings, Anne M. Fagan, Harald Hampel, Michelle M. Mielke, Alvydas Miku...> ;Acta Neuropathologica. 2018 Nov 28
• 2 citations
  Corrigendum: Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease.
  Hiroto Takahashi, Peng Xia, Jiankun Cui, Maria Talantova, Karthik Bodhinathan, Wenjun Li, Sofiyan Saleem, Emily A. Holland, Gary Tong, Juan C. Piña-Crespo, Dongxian Zh...> ;Scientific Reports. 2016 Feb 12
• 38 citations
  Pharmacologically targeted NMDA receptor antagonism by NitroMemantine for cerebrovascular disease
  Hiroto Takahashi, Peng Xia, Jiankun Cui, Maria Talantova, Karthik Bodhinathan, Wenjun Li, Sofiyan Saleem, Emily A. Holland, Gary Tong, Juan C. Piña-Crespo, Dongxian Zh...> ;Scientific Reports. 2015 Oct 19
• 419 citations
  Aβ induces astrocytic glutamate release, extrasynaptic NMDA receptor activation, and synaptic loss
  Maria Talantova, Sara Sanz-Blasco, Xiaofei Zhang, Peng Xia, Mohd Waseem Akhtar, Shu-ichi Okamoto, Gustavo Dziewczapolski, Tomohiro Nakamura, Gang Cao, Alexander E. Pra...> ;Proceedings of the National Academy of Sciences of the United States of America. 2013 Jul 2
• 53 citations
  Pharmacodynamics of Selective Inhibition of γ-Secretase by Avagacestat
  Charles F. Albright, Randy C. Dockens, Jere E. Meredith, Richard E. Olson, Randy Slemmon, Kimberley A. Lentz, Jun-Sheng Wang, Rex Denton, Gary Pilcher, Paul Rhyne, Jos...> ;The Journal of Pharmacology and Experimental Therapeutics. 2013 Mar 1
• 42 citations
  The advantages of frontotemporal degeneration drug development (part 2 of frontotemporal degeneration: The next therapeutic frontier)
  Adam L. Boxer, Michael Gold, Edward D. Huey, William T. Hu, Howard J. Rosen, Joel H. Kramer, Fen-Biao Gao, Edward A. Burton, Tiffany W. Chow, Aimee W. Kao, Blair R. Le...> ;Alzheimer's & Dementia. 2013 Mar 1
• 12 citations
  A contrast in safety, pharmacokinetics and pharmacodynamics across age groups after a single 50 mg oral dose of the γ-secretase inhibitor avagacestat.
  Gary Tong, Jun Sheng Wang, Oleksandr Sverdlov, Shu-Pang Huang, Randy Slemmon, Robert Croop, Lorna Castaneda, Huidong Gu, Oi Wong, Hewei Li, Robert M. Berman, Christina...> ;British Journal of Clinical Pharmacology. 2013 Jan 1
• Frontotemporal degeneration, the next therapeutic frontier: Molecules and animal models for frontotemporal degeneration drug development.
  Boxer, A. L., Gold, M., Huey, E., Gao, F. B., Burton, E. A., Chow, T., Kao, A., Leavitt, B. R., Lamb, B., Grether, M., Knopman, D., Cairns, N. J., Mackenzie, I. R., Mi...> ;Alzheimers Dement. 2013 Mar
• 29 citations
  Effects of single doses of avagacestat (BMS-708163) on cerebrospinal fluid Aβ levels in healthy young men.
  Gary Tong, Lorna Castaneda, Jun-Sheng Wang, Oleksandr Sverdlov, Shu-Pang Huang, Randy Slemmon, Huidong Gu, Oi Wong, Hewei Li, Robert M. Berman, Christina Smith, Charle...> ;Clinical Drug Investigation. 2012 Sep 14
• 53 citations
  Multicenter, randomized, double-blind, placebo-controlled, single-ascending dose study of the oral γ-secretase inhibitor BMS-708163 (Avagacestat): tolerability profile...
  Gary Tong, Jun-Sheng Wang, Oleksandr Sverdlov, Shu-Pang Huang, Randy Slemmon, Robert Croop, Lorna Castaneda, Huidong Gu, Oi Wong, Hewei Li, Robert M. Berman, Christina...> ;Clinical Therapeutics. 2012 Mar 1
• Association of β-cell function and insulin sensitivity with fasting and 2-h plasma glucose in a large Chinese population.
  Bi Y, Zeng L, Zhu D, Yan J, Zhang Y, Tong G, Mu P, Shen S, Hu Y, Yu Q, Liang H, Weng J> ;Diabetes Obes Metab. 2012-02-01
• 73 citations
  Excitatory Glycine Responses of CNS Myelin Mediated by NR1/NR3 NMDA Receptor Subunits
  Juan C. Piña-Crespo, Maria Talantova, Ileana Micu, Bradley A. States, H-S Vincent Chen, Shichun Tu, Nobuki Nakanishi, Gary Tong, Dongxian Zhang, Stephen F. Heinemann, ...> ;The Journal of Neuroscience. 2010 Aug 25
• 16 citations
  Roles of KChIP1 in the regulation of GABA-mediated transmission and behavioral anxiety
  Kun Xia, Hui Xiong, Yeonsook Shin, Danling Wang, T. J. Deerinck, Hiroto Takahashi, Mark H. Ellisman, Stuart A. Lipton, Gang Tong, Giannina Descalzi, Dongxian Zhang, Mi...> ;Molecular Brain. 2010 Aug 2
• 323 citations
  Balance between synaptic versus extrasynaptic NMDA receptor activity influences inclusions and neurotoxicity of mutant huntingtin
  Shu-ichi Okamoto, Mahmoud A. Pouladi, Maria Talantova, Dongdong Yao, Peng Xia, Dagmar E. Ehrnhoefer, Rameez Zaidi, Arjay Clemente, Marcus Kaul, Rona K. Graham, Dongxia...> ;Nature Medicine. 2009 Dec 1
• 87 citations
  Neuroprotection by the NR3A Subunit of the NMDA Receptor
  Nobuki Nakanishi, Shichun Tu, Yeonsook Shin, Jiankun Cui, Toru Kurokawa, Dongxian Zhang, H.-S. Vincent Chen, Gary Tong, Stuart A. Lipton> ;The Journal of Neuroscience. 2009 Apr 22
• 67 citations
  Modulation of NMDA Receptor Properties and Synaptic Transmission by the NR3A Subunit in Mouse Hippocampal and Cerebrocortical Neurons
  Gary Tong, Hiroto Takahashi, Shichun Tu, Yeonsook Shin, Maria Talantova, Wagner M. Zago, Peng Xia, Zhiguo Nie, Thomas Goetz, Dongxian Zhang, Stuart A. Lipton, Nobuki N...> ;Journal of Neurophysiology. 2008 Jan 1
• 23 citations
  Takusan: a large gene family that regulates synaptic activity.
  Shichun Tu, Yeonsook Shin, Wagner M. Zago, Bradley A. States, Alexey Eroshkin, Stuart A. Lipton, Gary G. Tong, Nobuki Nakanishi> ;Neuron. 2007 Jul 5
• 229 citations
  Stem cells act through multiple mechanisms to benefit mice with neurodegenerative metabolic disease.
  Jean Pyo Lee, Mylvaganam Jeyakumar, Rodolfo Gonzalez, Hiroto Takahashi, Pei Jen Lee, Rena C. Baek, Dan Clark, Heather L. Rose, Gerald Fu, Jonathan Clarke, Scott R. McK...> ;Nature Medicine. 2007 Apr 1
• 90 citations
  Hypoxia Enhances S-Nitrosylation-Mediated NMDA Receptor Inhibition via a Thiol Oxygen Sensor Motif
  Hiroto Takahashi, Yeonsook Shin, Seung-Je Cho, Wagner M. Zago, Tomohiro Nakamura, Zezong Gu, Yuliang Ma, Hiroyasu Furukawa, Robert C. Liddington, Dongxian Zhang, Gary ...> ;Neuron. 2007 Jan 4
• 13 citations
  Tumor suppressor PTEN affects tau phosphorylation: deficiency in the phosphatase activity of PTEN increases aggregation of an FTDP-17 mutant Tau
  Xue Zhang, Yun-wu Zhang, Shijie Liu, Ayelen Bulloj, Gary G. Tong, Zhuohua Zhang, Francesca Fang Liao, Huaxi Xu> ;Molecular Neurodegeneration. 2006 Jul 31
• Genetic diversity of avian infectious bronchitis coronavirus strains isolated in China between 1995 and 2004.
  Liu SW, Zhang QX, Chen JD, Han ZX, Liu X, Feng L, Shao YH, Rong JG, Kong XG, Tong GZ> ;Arch. Virol.. 2006-06-01
• 46 citations
  Tumor-suppressor PTEN affects tau phosphorylation, aggregation, and binding to microtubules
  Xue Zhang, Feng Li, Ayelen Bulloj, Yun-wu Zhang, Gang Tong, Zhuohua Zhang, Francesca-Fang Liao, Huaxi Xu> ;FASEB Journal. 2006 Jun 1
• 75 citations
  Hypothalamic huntingtin-associated protein 1 as a mediator of feeding behavior
  Guoqing Sheng, Guo-Qing Chang, John Y. Lin, Zhao-Xue Yu, Zhi-Hui Fang, Juan Rong, Stuart A. Lipton, Shihua Li, Gang Tong, Sarah F. Leibowitz, Xiao-Jiang Li> ;Nature Medicine. 2006 Apr 9
• 695 citations
  A phase 1 clinical trial of nerve growth factor gene therapy for Alzheimer disease
  Mark H. Tuszynski, Leon J. Thal, Mary Pay, David P. Salmon, Hoi Sang U, Roy A.E. Bakay, Piyush M. Patel, Armin Blesch, H. Lee Vahlsing, Gilbert Ho, Gang Tong, Steven G...> ;Nature Medicine. 2005 Apr 24
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