Gayle(Pageau)PouliotMD

PubMed

• A phase 2 study of AZD4635 in combination with durvalumab or oleclumab in patients with metastatic castration-resistant prostate cancer.
  Gerald S Falchook, James Reeves, Sunil Gandhi, David R Spigel, Edward Arrowsmith, Daniel J George, Janet Karlix, Gayle Pouliot, Maureen M Hattersley, Eric T Gangl, Gar...> ;Cancer Immunology, Immunotherapy. 2024 Mar 2
• First-in-human Study of AZD5153, A Small-molecule Inhibitor of Bromodomain Protein 4, in Patients with Relapsed/Refractory Malignant Solid Tumors and Lymphoma.
  Erika P Hamilton, Judy S Wang, Amit M Oza, Manish R Patel, Susanna V Ulahannan, Todd Bauer, Janet L Karlix, Jorge Zeron-Medina, Giulia Fabbri, Paola Marco-Casanova, Ga...> ;Molecular Cancer Therapeutics. 2023 Oct 2
• Comprehensive clinical pharmacology characterization of AZD4635 in healthy participants to support dosing considerations.
  Ganesh Moorthy, Gayle Pageau Pouliot, Lorraine Graham, Elizabeth Pilling, Lindsey Jung, Rachael Alcobi, Yali Zhu, Yan Li, Sharan Sidhu, Pablo Forte, Ganesh Mugundu> ;British Journal of Clinical Pharmacology. 2023 Sep 1
• 17 citations
  Phase Ia/b, Open-Label, Multicenter Study of AZD4635 (an Adenosine A2A Receptor Antagonist) as Monotherapy or Combined with Durvalumab, in Patients with Solid Tumors.
  Emerson A Lim, Johanna C Bendell, Gerald S Falchook, Todd M Bauer, Charles G Drake, Jennifer H Choe, Daniel J George, Janet L Karlix, Susanna Ulahannan, Kris F Sachsen...> ;Clinical Cancer Research. 2022 Nov 14
• 8 citations
  Evaluation of Combination Strategies for the A2AR Inhibitor AZD4635 Across Tumor Microenvironment Conditions via a Systems Pharmacology Model.
  Veronika Voronova, Kirill Peskov, Yuri Kosinsky, Gabriel Helmlinger, Lulu Chu, Alexandra Borodovsky, Richard Woessner, Kris Sachsenmeier, Wenlin Shao, Rakesh Kumar, Ga...> ;Frontiers in Immunology. 2021 Mar 2
• 47 citations
  Adenosine Signaling Is Prognostic for Cancer Outcome and Has Predictive Utility for Immunotherapeutic Response.
  Ben Sidders, Pei Zhang, Kelly Goodwin, Greg O'Connor, Deanna L. Russell, Alexandra Borodovsky, Joshua Armenia, Robert McEwen, Bolan Linghu, Johanna C. Bendell, Todd M....> ;Clinical Cancer Research. 2020 Jan 1
• 17 citations
  Fanconi-BRCA pathway mutations in childhood T-cell acute lymphoblastic leukemia.
  Gayle P. Pouliot, James Degar, Laura Hinze, Bose Kochupurakkal, Chau D. Vo, Melissa A. Burns, Lisa A. Moreau, Chirag Ganesa, Justine E. Roderick, Sofie Peirs, Björn Me...> ;Plos One. 2019 Nov 13
• 48 citations
  MEF2C Phosphorylation Is Required for Chemotherapy Resistance in Acute Myeloid Leukemia
  Fiona C. Brown, Eric Still, Richard Koche, Christina Y. Yim, Sumiko Takao, Paolo Cifani, Casie Reed, Shehana Gunasekera, Scott B. Ficarro, Peter Romanienko, Willie Mar...> ;Cancer Discovery. 2018 Apr 1
• 43 citations
  Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia.
  Melissa A. Burns, Zi Wei Liao, Natsuko Yamagata, Gayle P. Pouliot, Kristen E. Stevenson, Donna Neuberg, Aaron R. Thorner, Matthew D. Ducar, Emily A. Silverman, Stephen...> ;Leukemia. 2018 Mar 20
• 67 citations
  Demethylated HSATII DNA and HSATII RNA Foci Sequester PRC1 and MeCP2 into Cancer-Specific Nuclear Bodies
  Lisa L. Hall, Meg Byron, Dawn M. Carone, Troy W. Whitfield, Gayle P. Pouliot, Andrew H. Fischer, Peter L. Jones, Jeanne B. Lawrence> ;Cell Reports. 2017 Mar 21
• Thymocyte transformation enhanced
  Gayle P. Pouliot, Alejandro Gutierrez> ;Nature Medicine. 2014 Oct 1
• Aberrant silencing of cancer-related genes by CpG hypermethylation occurs independently of their spatial organization in the nucleus.
  Easwaran HP Van Neste L Cope L Sen S Mohammad HP Pageau GJ Lawrence JB Herman JG Schuebel KE Baylin SB> ;Cancer Res. 2010 Oct 15
• 91 citations
  The disappearing Barr body in breast and ovarian cancers
  Gayle Jeannette Pageau, Lisa L. Hall, Shridar Ganesan, David M. Livingston, Jeanne B. Lawrence> ;Nature Reviews. Cancer. 2007 Aug 1
• 47 citations
  BRCA1 does not paint the inactive X to localize XIST RNA but may contribute to broad changes in cancer that impact XIST and Xi heterochromatin
  Gayle Jeannette Pageau, Lisa L. Hall, Jeanne B. Lawrence> ;Journal of Cellular Biochemistry. 2007 Mar 1
• 39 citations
  BRCA1 foci in normal S-phase nuclei are linked to interphase centromeres and replication of pericentric heterochromatin
  Gayle Jeannette Pageau, Jeanne B. Lawrence> ;The Journal of Cell Biology. 2006 Dec 4
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Journal Articles

• BRCA1 does not paint the inactive X to localize XIST RNA but may contribute to broad changes in cancer that impact XIST and Xi heterochromatin.  
  Pageau, G.J., Hall, L.L., Lawrence, J.B., J, Cell Biochem, 3/1/2007