GeoffreyJ.GorseMD

Infectious Disease • Saint Louis, MO

Professor, Internal Medicine, St Louis University School of Medicine

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Office
915 N Grand Blvd
Saint Louis, MO 63106
Phone+1 913-578-4409
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Education & Training

University of California (Irvine)Fellowship, Infectious Disease, 1981 - 1983
University of California (Irvine)Fellowship, Infectious Disease, 1980 - 1981
University of California (San Francisco)/FresnoResidency, Internal Medicine, 1977 - 1980
David Geffen School of Medicine at UCLAClass of 1977

Certifications & Licensure

MO State Medical License 1989 - 2025
CA State Medical License 1978 - 2024
WV State Medical License 1983 - 1992
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Infectious Disease

Clinical Trials

A Phase I Safety and Immunogenicity Trial of UBI SynVac (HIV-1 MN Octameric V3 Peptide Vaccine)
Completed
Phase 1
A Multicenter, Randomized, Placebo-Controlled, Double-Blind Trial to Evaluate the Safety and Immunogenicity of an HIV-1 Pseudovirion Vaccine
Withdrawn
A Phase II Safety and Immunogenicity Trial of Live Recombinant Canarypox ALVAC-HIV vCP205 With or Without HIV-1 SF-2 RGP120 in HIV-1 Uninfected Adult Volunteers
Completed
Phase 2
A Phase I, Multicenter, Clinical Trial to Evaluate the Safety and Immunogenicity of Vaccinia-Derived MN HIV-1 Recombinant Envelope Glycoprotein (rgp160) of Human Immunodeficiency Virus at Two Different Vaccination Schedules
Completed
Phase 1
A Phase I, Multicenter, Randomized Trial to Evaluate the Safety and Immunogenicity of Vaccinia-Derived MN HIV-1 Recombinant Envelope Glycoprotein (rgp160) of Human Immunodeficiency Virus at Two Different Vaccination Schedules
Completed
Phase 1
Safety of and Immune System Response to an HIV Vaccine (EP HIV-1090) in HIV Uninfected Adults
Completed
Phase 1
Safety of and Immune Response to a DNA Vaccine and a Recombinant HIV-1-MVA Vaccine, Separately and in Combination, in Healthy Adults Start of enrollment: 2007 Apr 01
Completed
Phase 1
MAS-1 Adjuvanted Compared to Unadjuvanted Influenza Vaccines in the Elderly Start of enrollment: 2012 Oct 01
Withdrawn
Phase 1, Phase 2
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Publications & Presentations

PubMed

Preschool-Aged Household Contacts as a Risk Factor for Viral Respiratory Infections in Healthcare Personnel.
Zachary M Most, Ann-Christine Nyquist, Lewis J Radonovich, Maria C Rodriguez-Barradas, Connie Savor Price, Michael S Simberkoff, Mary T Bessesen, Derek A T Cummings, S...> ;Open Forum Infectious Diseases. 2023 Feb 1
1 citations
MAS-1, a novel water-in-oil adjuvant/delivery system, with reduced seasonal influenza vaccine hemagglutinin dose may enhance potency, durability and cross-reactivity o...
Geoffrey J Gorse, Stephen Grimes, Helen Buck, Hussain Mulla, Peter White, Heather Hill, Jeanine May, Sharon E Frey, Peter Blackburn> ;Vaccine. 2022 Mar 1
4 citations
A phase 1 dose-sparing, randomized clinical trial of seasonal trivalent inactivated influenza vaccine combined with MAS-1, a novel water-in-oil adjuvant/delivery system.
Geoffrey J Gorse, Stephen Grimes, Helen Buck, Hussain Mulla, Peter White, Heather Hill, Jeanine May, Sharon E Frey, Peter Blackburn> ;Vaccine. 2022 Feb 23
Influence of Pre-Season Antibodies against Influenza Virus on Risk of Influenza Infection among Health Care Personnel.
Geoffrey J. Gorse, Susan M Rattigan, Alexander Kirpich, Michael S. Simberkoff, Mary T. Bessesen, Cynthia L. Gibert, Ann-Christine Nyquist, Connie S. Price, Charlotte A...> ;The Journal of Infectious Diseases. 2021 Sep 17
5 citations
Impact of mandatory vaccination of healthcare personnel on rates of influenza and other viral respiratory pathogens.
Michael S. Simberkoff, Susan M Rattigan, Charlotte A. Gaydos, Cynthia L. Gibert, Geoffrey J. Gorse, Ann-Christine Nyquist, Connie S. Price, Nicholas G. Reich, Maria C....> ;Infection Control and Hospital Epidemiology. 2021 Aug 5
1 citations
Outpatient healthcare personnel knowledge and attitudes towards infection prevention measures for protection from respiratory infections.
Mary T. Bessesen, Susan M Rattigan, John Frederick, Derek A. T. Cummings, Charlotte A. Gaydos, Cynthia L. Gibert, Geoffrey J. Gorse, Ann-Christine Nyquist, Connie S. P...> ;American Journal of Infection Control. 2021 Jun 25
1 citations
Take-home kits to detect respiratory viruses among healthcare personnel: Lessons learned from a cluster randomized clinical trial.
Jenna Los, Charlotte A. Gaydos, Cynthia L. Gibert, Geoffrey J. Gorse, Jacquelyn Lykken, Ann-Christine Nyquist, Connie S. Price, Lewis J. Radonovich, Susan M Rattigan, ...> ;American Journal of Infection Control. 2021 Feb 10
13 citations
Risk Factors for Healthcare Personnel Infection with Endemic Coronaviruses (HKU1, OC43, NL63, 229E): Results from the Respiratory Protection Effectiveness Clinical Tri...
Derek A. T. Cummings, Lewis J. Radonovich, Geoffrey J. Gorse, Charlotte A. Gaydos, Mary T. Bessesen, Alexandria C. Brown, Cynthia L. Gibert, Matthew D. Hitchings, Just...> ;Clinical Infectious Diseases. 2020 Jul 9
101 citations
Antibodies to coronaviruses are higher in older compared with younger adults and binding antibodies are more sensitive than neutralizing antibodies in identifying coro...
Geoffrey J. Gorse, Mary M. Donovan, Gira B. Patel> ;Journal of Medical Virology. 2020 May 1
277 citations
N95 respirators vs medical masks for preventing influenza among health care personnel: A randomized clinical trial
Lewis J. Radonovich, Michael S. Simberkoff, Mary T. Bessesen, Alexandria C. Brown, Derek A. T. Cummings, Charlotte A. Gaydos, Jenna Los, Amanda Krosche, Cynthia L. Gib...> ;JAMA. 2019 Sep 3
38 citations
Protecting Healthcare Personnel in Outpatient Settings: The Influence of Mandatory Versus Nonmandatory Influenza Vaccination Policies on Workplace Absenteeism During M...
John Frederick, Alexandria C. Brown, Derek A. T. Cummings, Charlotte A. Gaydos, Cynthia L. Gibert, Geoffrey J. Gorse, Jenna Los, Ann-Christine Nyquist, Trish M. Perl, ...> ;Infection Control and Hospital Epidemiology. 2018 Mar 8
5 citations
Interpatient mutational spectrum of human coronavirus-OC43 revealed by illumina sequencing
Geoffrey J. Gorse, Gira B. Patel, Xiaofeng Fan> ;Journal of Medical Virology. 2017 Mar 14
22 citations
The Respiratory Protection Effectiveness Clinical Trial (ResPECT): a cluster-randomized comparison of respirator and medical mask effectiveness against respiratory inf...
Lewis J. Radonovich, Mary T. Bessesen, Derek A. T. Cummings, Aaron Eagan, Charlotte A. Gaydos, Cynthia L. Gibert, Geoffrey J. Gorse, Ann-Christine Nyquist, Nicholas G....> ;BMC Infectious Diseases. 2016 Jun 2
16 citations
Coronavirus and Other Respiratory Illnesses Comparing Older with Young Adults
Geoffrey J. Gorse, Mary M. Donovan, Gira B. Patel, Sumitra Balasubramanian, Rodney H. Lusk> ;The American Journal of Medicine. 2015 Nov 1
31 citations
Safety and immunogenicity of a quadrivalent intradermal influenza vaccine in adults.
Geoffrey J. Gorse, Ann R. Falsey, Ayca Ozol-Godfrey, Victoria Landolfi, Peter H. Tsang> ;Vaccine. 2015 Feb 25
5 citations
Phase I/II Randomized Trial of Safety and Immunogenicity of LIPO-5 Alone, ALVAC-HIV (vCP1452) Alone, and ALVAC-HIV (vCP1452) Prime/LIPO-5 Boost in Healthy, HIV-1-Uninf...
Sharon E. Frey, Laurence Peiperl, M. Juliana McElrath, Spyros A. Kalams, Paul A. Goepfert, Michael C. Keefer, Lindsey R. Baden, Michelle Lally, Kenneth H. Mayer, Willi...> ;Clinical and Vaccine Immunology. 2014 Nov 1
61 citations
Immunogenicity and safety of Fluzone(®) intradermal and high-dose influenza vaccines in older adults ≥65 years of age: a randomized, controlled, phase II trial.
Peter H. Tsang, Geoffrey J. Gorse, Cynthia Strout, Malcolm Sperling, David P. Greenberg, Ayca Ozol-Godfrey, Carlos A. DiazGranados, Victoria Landolfi> ;Vaccine. 2014 May 1
16 citations
Safety and immunogenicity of revaccination with reduced dose intradermal and standard dose intramuscular influenza vaccines in adults 18-64 years of age.
Geoffrey J. Gorse, Ann R. Falsey, Carol M. Johnson, Dennis Morrison, David Fried, John E. Ervin, David P. Greenberg, Ayca Ozol-Godfrey, Victoria Landolfi, Peter H. Tsang> ;Vaccine. 2013 Dec 5
28 citations
Intradermally-administered influenza virus vaccine is safe and immunogenic in healthy adults 18-64 years of age.
Geoffrey J. Gorse, Ann R. Falsey, John A. Fling, Terry L. Poling, Cynthia Strout, Peter H. Tsang> ;Vaccine. 2013 May 1
18 citations
DNA and modified vaccinia virus Ankara vaccines encoding multiple cytotoxic and helper T-lymphocyte epitopes of human immunodeficiency virus type 1 (HIV-1) are safe bu...
Geoffrey J. Gorse, Mark Newman, Allan C. deCamp, Christine M. Hay, Stephen C. De Rosa, Elizabeth A. Noonan, Brian D. Livingston, Jonathan D. Fuchs, Spyros A. Kalams, F...> ;Clinical and Vaccine Immunology. 2012 May 1
128 citations
Prevalence of Antibodies to Four Human Coronaviruses Is Lower in Nasal Secretions than in Serum
Geoffrey J. Gorse, Gira B. Patel, Joseph N. Vitale, Theresa Z. O'Connor> ;Clinical and Vaccine Immunology. 2010 Dec 1
287 citations
Randomized, Double-Blind Controlled Phase 3 Trial Comparing the Immunogenicity of High-Dose and Standard-Dose Influenza Vaccine in Adults 65 Years of Age and Older
Ann R. Falsey, John J. Treanor, Nadia Tornieporth, Jose Capellan, Geoffrey J. Gorse> ;The Journal of Infectious Diseases. 2009 Jul 15
69 citations
Human coronavirus and acute respiratory illness in older adults with chronic obstructive pulmonary disease.
Geoffrey J. Gorse, Theresa Z. O'Connor, Susan L. Hall, Joseph N. Vitale, Kristin L. Nichol> ;The Journal of Infectious Diseases. 2009 Mar 15
69 citations
Comparison of the Safety and Immunogenicity of 2 Respiratory Syncytial Virus (RSV) Vaccines—Nonadjuvanted Vaccine or Vaccine Adjuvanted with Alum—Given Concomitantly w...
Ann R. Falsey, Edward E. Walsh, Jose Capellan, Stefan Gravenstein, Maria Zambon, Eddy Yau, Geoffrey J. Gorse, Robert R. Edelman, Frederick G. Hayden, Janet E. McElhane...> ;The Journal of Infectious Diseases. 2008 Nov 1
17 citations
HIV-1 recombinant gp160 vaccine given in accelerated dose schedules
Geoffrey J. Gorse, David H. Schwartz, Barney S. Graham, T J Matthews, D. M. Stablein, Sharon E. Frey, Robert B. Belshe, Mary Lou Clements, Peter F. Wright, M M Eibl, P...> ;Clinical and Experimental Immunology. 2008 Jun 28
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Press Mentions

Quadrivalent vs. Trivalent Flu Vaccines Comparing Responses to B StrainsMarch 13th, 2015
Enhanced Flu Protection: Four Beats ThreeMarch 13th, 2015

Hospital Affiliations

John J. Cochran Veterans HospitalSaint Louis, Missouri
SSM Health Saint Louis University HospitalSaint Louis, Missouri