GeorgeLiweiChenMD

Hematology • Buffalo, NY

Hematologic Oncology, Myeloproliferative Disorder Hematology-Oncology

Roswell Park Cancer Institute

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Office
Elm And Carlton St
Buffalo, NY 14263
Phone+1 716-845-2300

Fax+1 716-845-3423
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Education & Training

Baylor College of MedicineFellowship, Hematology and Medical Oncology, 2001 - 2004
Baylor College of MedicineResidency, Internal Medicine, 1998 - 2001
The University of Texas Health Science Center at San AntonioClass of 1998

Certifications & Licensure

CA State Medical License 2002 - Present
TX State Medical License 2000 - 2026
NY State Medical License 2010 - 2023
American Board of Internal Medicine Hematology

Clinical Trials

Phase 1 Nilotinib in Steroid Dependent/Refractory Chronic Graft Versus Host Disease Start of enrollment: 2010 Aug 01
Completed
Phase 1
Safety Study of Gene Modified Donor T-cells Following Partially Mismatched Stem Cell Transplant Start of enrollment: 2013 Mar 01
Active, not recruiting
Phase 1, Phase 2
Novel Approaches for Graft-versus-Host Disease Prevention Compared to Contemporary Controls (BMT CTN 1203) Start of enrollment: 2014 Aug 01
Completed
Phase 2
Acalabrutinib for the Treatment of Chronic Graft Versus Host Disease Start of enrollment: 2020 Dec 12
Recruiting
Phase 2
Roles: Principal Investigator, Contact
Predicting the Quality of Response to Specific Treatments in Patients With cGVHD, PQRST Study Start of enrollment: 2020 Jun 29
Recruiting
Ustekinumab for the Prevention of Acute Graft-versus-Host Disease After Unrelated Donor Hematopoietic Cell Transplant Start of enrollment: 2021 May 14
Recruiting
Phase 2
Roles: Contact, Principal Investigator
A Study to Compare T-Guard vs Ruxolitinib for Treatment of Steroid-Refractory Acute Graft-vs-Host Disease (BMT CTN 2002) Start of enrollment: 2022 Jun 16
Terminated
Phase 3
Roles: Contact
Close Assessment and Testing for Chronic Graft Versus Host Disease, CATCH Study Start of enrollment: 2019 Sep 13
Recruiting
Roles: Contact, Principal Investigator
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Publications & Presentations

PubMed

Galectin-3 predicts acute GvHD and overall mortality post reduced intensity allo-HCT: a BMT-CTN biorepository study.
Philip L McCarthy, Kristopher M Attwood, Xiaojun Liu, George L Chen, Hans Minderman, Amin Alousi, Asad Bashey, Robert Lowsky, David B Miklos, John Hansen, Peter Wester...> ;Bone Marrow Transplantation. 2024 Mar 1
3 citations
Patient-reported treatment response in chronic graft--host disease.
Annie Im, Iskra Pusic, Lynn Onstad, Carrie L Kitko, Betty K Hamilton, Amin M Alousi, Mary E Flowers, Stefanie Sarantopoulos, Paul Carpenter, Jennifer White, Sally Arai...> ;Haematologica. 2024 Jan 1
3 citations
NCCN Guidelines® Insights: Hematopoietic Cell Transplantation, Version 3.2022.
Ayman Saad, Alison Loren, Javier Bolaños-Meade, George Chen, Daniel Couriel, Antonio Di Stasi, Areej El-Jawahri, Hany Elmariah, Sherif Farag, Krishna Gundabolu, Jonath...> ;Journal of the National Comprehensive Cancer Network. 2023 Feb 1
6 citations
Cytomegalovirus reactivation after CD19 CAR T-cell therapy is clinically significant.
George Chen, Megan Herr, Jan Nowak, Christine Ho, Nikolaos Almyroudis, Kristopher Attwood, John Bonnewell, Marissa Walsh, Brahm Segal, Maureen Ross, Philip McCarthy, T...> ;Haematologica. 2023 Feb 1
Short-Term Storage of Mobilized Peripheral Blood Stem Cells in a Closed System Changes the Microenvironment and May Affect the Quantity of CD34Cells.and CD34CD38CD45RA...
Amro Elshoury, Orla Maguire, Alexis Conway, Joseph Tario, Kah Teong Soh, Maureen Ross, Theresa Hahn, Joanne Becker, Paul Wallace, Philip L McCarthy, Hans Minderman, Ge...> ;Transplantation and Cellular Therapy. 2023 Feb 1
2 citations
Durable discontinuation of systemic therapy in patients affected by chronic graft--host disease.
George L Chen, Lynn Onstad, Paul J Martin, Paul Carpenter, Joseph Pidala, Sally Arai, Corey Cutler, Betty K Hamilton, Stephanie J Lee, Mukta Arora> ;Haematologica. 2023 Feb 1
8 citations
Identification of Neurotoxicity after Chimeric Antigen Receptor (CAR) T Cell Infusion without Deterioration in the Immune Effector Cell Encephalopathy (ICE) Score.
Megan M. Herr, George Chen, Maureen Ross, Hillary Jacobson, Renee McKenzie, Laura Markel, Sophia R. Balderman, Christine M. Ho, Theresa Hahn, Philip L. McCarthy> ;Biology of Blood and Marrow Transplantation. 2020 Nov 1
4 citations
Low-Level Cytomegalovirus Antigenemia Promotes Protective Cytomegalovirus Antigen-Specific T Cells after Allogeneic Hematopoietic Cell Transplantation
George Chen, Paul K. Wallace, Yali Zhang, Joseph D. Tario, Amanda C. Przespolewski, Joanne Becker, Nikolaos G. Almyroudis, Maureen Ross, Marcie L. Riches, Brahm H. Seg...> ;Biology of Blood and Marrow Transplantation. 2020 Nov 1
12 citations
β2-Adrenergic receptor activation on donor cells ameliorates acute GvHD
Hemn Mohammadpour, Cameron R. MacDonald, George Chen, Jingxin Qiu, Umesh C. Sharma, Xuefang Cao, Megan M. Herr, Theresa Hahn, Bruce R. Blazar, Elizabeth A. Repasky, Ph...> ;JCI Insight. 2020 Jun 18
6 citations
Ixazomib for Treatment of Refractory Chronic Graft-versus-Host Disease: A Chronic GVHD Consortium Phase II Trial.
Joseph Pidala, Vijaya R Bhatt, Betty Hamilton, Iskra Pusic, William A Wood, Lynn Onstad, Anne M Hall, Barry Storer, Stephanie J Lee> ;Biology of Blood and Marrow Transplantation. 2020 Sep 1
51 citations
Hematopoietic cell transplantation, Version 2.2020
Ayman Saad, Marcos de Lima, Sarah Anand, Vijaya Raj Bhatt, Ryan Bookout, George Chen, Daniel R. Couriel, Antonio Di Stasi, Areej El-Jawahri, Sergio Giralt, Jonathan A....> ;Journal of the National Comprehensive Cancer Network. 2020 May 1
14 citations
Disability Related to Chronic Graft-Versus-Host Disease
Betty K. Hamilton, Barry E. Storer, William A. Wood, Joseph Pidala, Corey Cutler, Paul J. Martin, George Chen, Mary E.D. Flowers, Stephanie J. Lee> ;Biology of Blood and Marrow Transplantation. 2020 Apr 1
1 citations
Carfilzomib for Treatment of Refractory Chronic Graft-versus-Host Disease: A Chronic GVHD Consortium Pilot Phase II Trial.
Joseph Pidala, Samantha Jaglowski, Annie Im, George Chen, Lynn Onstad, Barry Storer, Chareeni Kurukulasuriya, Stephanie J Lee> ;Biology of Blood and Marrow Transplantation. 2020 Feb 1
3 citations
Immune profiling in diffuse large B-cell lymphoma and mantle cell lymphoma patients treated with autologous hematopoietic cell transplant.
Megan M Herr, Pallawi Torka, Yali Zhang, Paul K Wallace, Joseph D Tario Jr, Elizabeth A Repasky, George L Chen, Christine M Ho, Sophia R Balderman, Maureen Ross, Bruno...> ;Bone Marrow Transplantation. 2020 Jan 1
Correction: Immune profiling in diffuse large B-cell lymphoma and mantle cell lymphoma patients treated with autologous hematopoietic cell transplant.
Megan M Herr, Pallawi Torka, Yali Zhang, Paul K Wallace, Joseph D Tario Jr, Elizabeth A Repasky, George L Chen, Christine M Ho, Sophia R Balderman, Maureen Ross, Bruno...> ;Bone Marrow Transplantation. 2020 Jan 1
4 citations
The Chronic Graft-versus-Host Disease Failure-Free Survival (cGVHD-FFS) Index
Joseph Pidala, Betty K. Hamilton, Paul J. Martin, Lynn Onstad, Barry E. Storer, Jeanne Palmer, Amin M. Alousi, Corey Cutler, Madan Jagasia, George Chen, Mukta Arora, M...> ;Biology of Blood and Marrow Transplantation. 2019 Dec 1
3 citations
Organ Changes Associated with Provider-Assessed Responses in Patients with Chronic Graft-versus-Host Disease
Paul J. Martin, Barry E. Storer, Jeanne Palmer, Madan Jagasia, George Chen, Raewyn Broady, Mukta Arora, Joseph Pidala, Betty K. Hamilton, Stephanie J. Lee> ;Biology of Blood and Marrow Transplantation. 2019 Sep 1
7 citations
Reduced-Intensity Conditioning with Fludarabine, Melphalan, and Total Body Irradiation for Allogeneic Hematopoietic Cell Transplantation: The Effect of Increasing Melp...
, , , , , , , , , , , , , , , > ;Biology of Blood and Marrow Transplantation. 2019 Apr 1
18 citations
Employment, Insurance, and Financial Experiences of Patients with Chronic Graft-versus-Host Disease in North America
Nandita Khera, Betty K. Hamilton, Joseph Pidala, William A. Wood, Vicky Wu, Jenna M. Voutsinas, Lynn Onstad, Amin M. Alousi, Raewyn Broady, George Chen, Mukta Arora, C...> ;Biology of Blood and Marrow Transplantation. 2019 Mar 1
Impact of conditioning regimen on peripheral blood hematopoietic cell transplant.
Anurag K. Singh, Carrie C Hoefer, Yali Zhang, Paul K. Wallace, George Chen, A. Platek, Timothy B. Winslow, Austin J. Iovoli, Christopher Choi, Maureen Ross, Philip L. ...> ;World Journal of Clinical Oncology. 2019 Feb 24
26 citations
Amphiregulin modifies the Minnesota Acute Graft-versus-Host Disease Risk Score: results from BMT CTN 0302/0802.
Shernan G. Holtan, Todd E. DeFor, Angela Panoskaltsis-Mortari, Nandita Khera, John E. Levine, Mary E.D. Flowers, Stephanie J. Lee, Yoshihiro Inamoto, George Chen, Seba...> ;Blood Advances. 2018 Aug 14
14 citations
Anti-Platelet-Derived Growth Factor Receptor Alpha Chain Antibodies Predict for Response to Nilotinib in Steroid-Refractory or -Dependent Chronic Graft-Versus-Host Dis...
George Chen, Paul A. Carpenter, Raewyn Broady, Tara K. Gregory, Laura Johnston, Barry E. Storer, Jan H. Beumer, Jingxin Qiu, Kiara Cerda, Ryan Le, Joanne Otani, Hong L...> ;Biology of Blood and Marrow Transplantation. 2018 Feb 1
1 citations
BPX-501 T cells interfere with minimal residual disease evaluation of B-cell acute lymphoblastic leukemia.
Amro Elshoury, Paul K. Wallace, Michael J. Borowitz, Angela Kader, Christopher Choi, Christine M. Ho, Sophia R. Balderman, Maureen Ross, Theresa Hahn, Vince O'Neill, P...> ;Bone Marrow Transplantation. 2018 Jan 17
28 citations
T Cell-Derived CD70 Delivers an Immune Checkpoint Function in Inflammatory T Cell Responses.
Rachel E. O’Neill, Wei Du, Hemn Mohammadpour, Emad Alqassim, Jingxin Qiu, George Chen, Philip L. McCarthy, Kelvin P. Lee, Xuefang Cao> ;Journal of Immunology. 2017 Nov 15
9 citations
Host-Derived CD70 Suppresses Murine Graft-versus-Host Disease by Limiting Donor T Cell Expansion and Effector Function.
Nicholas D. Leigh, Rachel E. O’Neill, Wei Du, Chuan Chen, Jingxin Qiu, Jonathan D. Ashwell, Philip L. McCarthy, George Chen, Xuefang Cao> ;Journal of Immunology. 2017 May 26
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Abstracts/Posters

Equate, a Phase 1b/2 Study Evaluating the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of a Novel Targeted Anti-CD6 Therapy, Itolizu...
George L. Chen, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
_2- Adrenergic Signaling Regulates Graft Versus Host Disease after Allogenic Transplantation While Preserving Graft Versus Leukemia Effect
George L. Chen, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019

Press Mentions

$Phase III SIERRA Trial Finds Iomab-B Promising for Relapsed/Refractory AML$
Phase III SIERRA Trial Finds Iomab-B Promising for Relapsed/Refractory AMLApril 8th, 2019

Hospital Affiliations

Roswell Park Comprehensive Cancer CenterBuffalo, New York