GeorgeJChiuMD

PubMed

• 3 citations
  Synthesis, In Vitro Activities of (2-Cyclopropoxyphenyl)piperidine Derivatives for α1a and α1d Adrenergic Receptor Inhibitors
  Shengjian Li, George Chiu, Virginia L. Pulito, Jingchun Liu, Peter J. Connolly, Steven A. Middleton> ;Medicinal Chemistry. 2009 Jan 1
• (Phenylpiperazinyl)cyclohexylureas: discovery of alpha1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower urinary t...
  Chiu, G.,Li, S.,Connolly, P. J.,Pulito, V.,Liu, J.,Middleton, S. A.> ;Bioorg. Med. Chem. Lett.. 2007 Dec 07
• 3 citations
  Aminocyclohexylsulfonamides : Discovery of metabolically stable α1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lowe...
  George Chiu, Shengjian Li, Hong Cai, Peter J. Connolly, Sean Peng, Kathe Stauber, Virginia L. Pulito, Jingchun Liu, Steven A. Middleton> ;Bioorganic & Medicinal Chemistry Letters. 2007 Nov 15
• 50 citations
  Design, synthesis, and evaluation of 3,4-disubstituted pyrazole analogues as anti-tumor CDK inhibitors
  Ronghui Lin, George Chiu, Yang Yu, Peter J. Connolly, Shengjian Li, Yanhua Lu, Mary Adams, Angel R. Fuentes-Pesquera, Stuart Emanuel, Lee M. Greenberger> ;Bioorganic & Medicinal Chemistry Letters. 2007 Aug 15
• 33 citations
  Synthesis and evaluation of pyrazolo[3,4-b]pyridine CDK1 inhibitors as anti-tumor agents.
  Ronghui Lin, Peter J. Connolly, Yanhua Lu, George Chiu, Shengjian Li, Yang Yu, Shenlin Huang, Xun Li, Stuart Emanuel, Steven A. Middleton, Robert H. Gruninger, Mary Ad...> ;Bioorganic & Medicinal Chemistry Letters. 2007 Aug 1
• (Phenylpiperidinyl)cyclohexylsulfonamides: development of alpha1a/1d-selective adrenergic receptor antagonists for the treatment of benign prostatic hyperplasia/lower ...
  Chiu G, Li S, Connolly PJ, Pulito V, Liu J, Middleton SA> ;Bioorg. Med. Chem. Lett.. 2007-07-15
• (Arylpiperazinyl)cyclohexylsufonamides: discovery of alpha(1a/1d)-selective adrenergic receptor antagonists for the treatment of Benign Prostatic Hyperplasia/Lower Uri...
  Chiu G, Li S, Connolly PJ, Pulito V, Liu J, Middleton SA> ;Bioorg. Med. Chem. Lett.. 2007-06-15
• 11 citations
  1-Arylpiperazinyl-4-cyclohexylamine derived isoindole-1,3-diones as potent and selective α-1a/1d adrenergic receptor ligands
  Shengjian Li, George Chiu, Virginia L. Pulito, Jingchun Liu, Peter J. Connolly, Steven A. Middleton> ;Bioorganic & Medicinal Chemistry Letters. 2007 Mar 15
• 33 citations
  Synthesis of 3-(1H-benzimidazol-2-yl)-5-isoquinolin-4-ylpyrazolo[1,2-b]pyridine, a potent cyclin dependent kinase 1 (CDK1) inhibitor.
  Shenlin Huang, Ronghui Lin, Yang Yu, Yanhua Lu, Peter J. Connolly, George Chiu, Shengjian Li, Stuart Emanuel, Steven A. Middleton> ;Bioorganic & Medicinal Chemistry Letters. 2007 Mar 1
• 16 citations
  Synthesis and evaluation of furo[3,4-d]pyrimidinones as selective α1a-Adrenergic receptor antagonists
  Bharat Lagu, Dake Tian, George Chiu, Dhanapalan Nagarathnam, James Fang, Quanrong Shen, Carlos Forray, Richard W. Ransom, Raymond S.L. Chang, Kamlesh P. Vyas, Kanyin Z...> ;Bioorganic & Medicinal Chemistry Letters. 2000 Jan 17
• 19 citations
  Design and Synthesis of Novel α1a Adrenoceptor-Selective Antagonists. 3. Approaches To Eliminate Opioid Agonist Metabolites by Using Substituted Phenylpiperazine Side ...
  Bharat Lagu, Dake Tian, Dhanapalan Nagarathnam, Mohammad R. Marzabadi, Wai C. Wong, Miao Shou Wu, Fengqi Zhang, Wanying Sun, George Chiu, James Fang, Carlos Forray, Ra...> ;Journal of Medicinal Chemistry. 1999 Oct 27
• 27 citations
  Design and synthesis of novel alpha(1)(a) adrenoceptor-selective antagonists. 2. Approaches to eliminate opioid agonist metabolites via modification of linker and 4-me...
  T. G. Murali Dhar, Dhanapalan Nagarathnam, Mohammad R. Marzabadi, Bharat Lagu, Wai C. Wong, George Chiu, Sriram Tyagarajan, Shou Wu Miao, Fengqi Zhang, Wanying Sun, Da...> ;Journal of Medicinal Chemistry. 1999 Oct 27
• 48 citations
  Design and Synthesis of Novel α1a Adrenoceptor-Selective Antagonists. 1. Structure−Activity Relationship in Dihydropyrimidinones
  Dhanapalan Nagarathnam, Shou Wu Miao, Bharat Lagu, George Chiu, James Fang, T. G. Murali Dhar, Jack Zhang, Sriram Tyagarajan, Mohammad R. Marzabadi, Fengqi Zhang, Wai ...> ;Journal of Medicinal Chemistry. 1999 Oct 27
• 3 citations
  Design and synthesis of novel dihydropyridine alpha-1a antagonists.
  Mohammad R. Marzabadi, Xingfang Hong, Dhanapalan Nagarathnam, ShouWu Miao, George Chiu, Wai C. Wong, John M. Wetzel, James Fang, Carlos Forray, Tsing B. Chen, Stacey O...> ;Bioorganic & Medicinal Chemistry Letters. 1999 Oct 4
• 25 citations
  Design and Synthesis of Novel α1a Adrenoceptor-Selective Dihydropyridine Antagonists for the Treatment of Benign Prostatic Hyperplasia
  Dhanapalan Nagarathnam, John M. Wetzel, Shou Wu Miao, Mohammad R. Marzabadi, George Chiu, Wai C. Wong, Xingfang Hong, James Fang, Carlos Forray, T. A. Branchek, Willia...> ;Journal of Medicinal Chemistry. 1998 Nov 20
• 18 citations
  Identification of a Dihydropyridine as a Potent α1a Adrenoceptor-Selective Antagonist That Inhibits Phenylephrine-Induced Contraction of the Human Prostate
  Wai C. Wong, George Chiu, John M. Wetzel, Mohammad R. Marzabadi, Dhanapalan Nagarathnam, Diana Wang, James Fang, Shou Wu Miao, Xingfang Hong, Carlos Forray, Pierre J.-...> ;Journal of Medicinal Chemistry. 1998 Jun 16
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