GeorgeDossMD

PubMed

• 11 citations
  Structure-activity-relationship of amide and sulfonamide analogs of omarigliptin.
  Ping Chen, Dennis Feng, Xiaoxia Qian, James M. Apgar, Robert R. Wilkening, Jeffrey T. Kuethe, Ying-Duo Gao, Giovanna Scapin, Jason M. Cox, George A. Doss, George J. Ei...> ;Bioorganic & Medicinal Chemistry Letters. 2015 Dec 15
• 102 citations
  Omarigliptin (MK-3102): A Novel Long-Acting DPP-4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes.
  Tesfaye Biftu, Ranabir SinhaRoy, Ping Chen, Xiaoxia Qian, Dennis Feng, Jeffrey T. Kuethe, Giovanna Scapin, Ying-Duo Gao, Youwei Yan, Davida Krueger, Annette Bak, Georg...> ;Journal of Medicinal Chemistry. 2014 Apr 2
• 4 citations
  2-[(3aR,4R,5S,7aS)-5-{(1S)-1-[3,5-bis(trifluoromethyl)phenyl]-2-hydroxyethoxy}-4-(2-methylphenyl)octahydro-2H-isoindol-2-yl]-1,3-oxazol-4(5H)-one: a potent human NK1 r...
  Andrew J. Kassick, Jinlong Jiang, Jaime Lynn Bunda, David Wilson, Jianming Bao, Huagang Lu, Peter Lin, Richard G. Ball, George A. Doss, Xinchun Tong, Kwei-Lan C. Tsao,...> ;Journal of Medicinal Chemistry. 2013 Jul 9
• 7 citations
  Design of a novel pyrrolidine scaffold utilized in the discovery of potent and selective human β3 adrenergic receptor agonists.
  Gregori J. Morriello, Harvey R. Wendt, Alka Bansal, Jerry Di Salvo, Scott D. Feighner, Jiafang He, Amanda L. Hurley, Donna L. Hreniuk, Gino Salituro, Marat Vijay Reddy...> ;Bioorganic & Medicinal Chemistry Letters. 2011 Mar 15
• 3 citations
  In vitro and in vivo metabolism of a novel cannabinoid-1 receptor inverse agonist, taranabant, in rats and monkeys.
  Vijay Bhasker G. Reddy, George A. Doss, Bindhu V. Karanam, Koppara Samuel, Thomas J. Lanza, Linus S. Lin, Nathan X. Yu, Andy Shiqiang Zhang, Conrad E. Raab, Ralph A. S...> ;Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 2010 Aug 12
• 8 citations
  Glutathione S-transferase catalyzed desulfonylation of a sulfonylfuropyridine.
  Thomas Bateman, John S. Debenham, Christina B. Madsen-Duggan, Richard B. Toupence, Thomas F. Walsh, Quang Truong, Scott A. Bradley, George A. Doss, Sanjeev Kumar, Vija...> ;Drug Metabolism and Disposition. 2010 Jan 1
• 30 citations
  Conformational analysis and receptor docking of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propan...
  Linus S. Lin, Sookhee Ha, Richard G. Ball, Nancy N. Tsou, Laurie A. Castonguay, George A. Doss, Tung M. Fong, Chun-Pyn Shen, Jing Chen Xiao, Mark T. Goulet, William K....> ;Journal of Medicinal Chemistry. 2008 Mar 12
• 13 citations
  Fused bicyclic pyrrolizinones as new scaffolds for human NK1 antagonists.
  Gregori J. Morriello, Robert J. DeVita, Sander G. Mills, Jonathan R. Young, Peter Lin, George A. Doss, Gary G. Chicchi, Julie A. DeMartino, Marc M. Kurtz, Kwei-Lan C. ...> ;Bioorganic & Medicinal Chemistry. 2008 Mar 1
• 7 citations
  Conformational studies of 3-amino-1-alkyl-cyclopentane carboxamide CCR2 antagonists leading to new spirocyclic antagonists
  Alexander Pasternak, Stephen D. Goble, George A. Doss, Nancy N. Tsou, Gabor Butora, Pasquale P. Vicario, Julia M. Ayala, Mary Struthers, Julie A. DeMartino, Sander G. ...> ;Bioorganic & Medicinal Chemistry Letters. 2008 Feb 15
• 41 citations
  Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin.
  Tesfaye Biftu, Giovanna Scapin, Suresh B. Singh, Dennis Feng, Joe W. Becker, George J. Eiermann, Huaibing He, Kathy Lyons, Sangita B. Patel, Aleksandr Petrov, Ranabir ...> ;Bioorganic & Medicinal Chemistry Letters. 2007 Jun 15
• 8 citations
  Highly constrained bicyclic VLA-4 antagonists.
  Linda L. Chang, Quang Truong, George A. Doss, Malcolm MacCoss, Kathryn A. Lyons, Ermengilda McCauley, Richard A. Mumford, Gail Forrest, Stella H. Vincent, John A. Schm...> ;Bioorganic & Medicinal Chemistry Letters. 2007 Feb 1
• 11 citations
  Short Synthesis of Octosyl Nucleosides
  Spencer Knapp, Vinay V. Thakur, Machender R. Madduru, Krishnan Malolanarasimhan, Gregori J. Morriello, George A. Doss> ;Organic Letters. 2006 Mar 30
• 17 citations
  Synthesis of functionalized 1,8-naphthyridinones and their evaluation as novel, orally active CB1 receptor inverse agonists
  John S. Debenham, Christina B. Madsen-Duggan, Thomas F. Walsh, Junying Wang, Xinchun Tong, George A. Doss, Julie Lao, Tung M. Fong, Marie-Therese Schaeffer, Jing Chen ...> ;Bioorganic & Medicinal Chemistry Letters. 2006 Feb 1
• 26 citations
  Dipeptidyl peptidase IV inhibitors derived from β-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole
  Wallace T. Ashton, Rosemary Sisco, Hong Dong, Kathryn A. Lyons, Huaibing He, George A. Doss, Barbara Leiting, Reshma A. Patel, Joseph K. Wu, Frank Marsilio, Nancy A. T...> ;Bioorganic & Medicinal Chemistry Letters. 2005 May 2
• 17 citations
  2-Piperazinecarboxamides as potent and selective melanocortin subtype-4 receptor agonists
  Palucki Brenda, Min K. Park, Ravi P. Nargund, Rui Tang, Tanya MacNeil, David H. Weinberg, Aurawan Vongs, Charles Rosenblum, George A. Doss, Randall R. Miller, Ralph A....> ;Bioorganic & Medicinal Chemistry Letters. 2005 Apr 15
• 33 citations
  Synthesis and activity of 4,5-diarylimidazoles as human CB1 receptor inverse agonists.
  Christopher W. Plummer, Paul E. Finke, Sander G. Mills, Junying Wang, Xinchun Tong, George A. Doss, Tung M. Fong, Julie Z. Lao, Marie-Therese Schaeffer, Jing Chen, Chu...> ;Bioorganic & Medicinal Chemistry Letters. 2005 Mar 1
• 12 citations
  Potent Kv1.3 inhibitors from correolide-modification of the C18 position.
  Jianming Bao, Shouwu Miao, Frank Kayser, Andrew Kotliar, Robert K. Baker, George A. Doss, John P. Felix, Randal M. Bugianesi, Robert S. Slaughter, Gregory J. Kaczorows...> ;Bioorganic & Medicinal Chemistry Letters. 2005 Jan 17
• 33 citations
  Discovery of (2S)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-4-methyl-2-piperazinecarboxamide...
  Palucki Brenda, Min K. Park, Ravi P. Nargund, Zhixiong Ye, Iyassu K. Sebhat, Patrick G. Pollard, Rubana N. Kalyani, Rui Tang, Tanya MacNeil, David H. Weinberg, Aurawan...> ;Bioorganic & Medicinal Chemistry Letters. 2005 Jan 3
• 14 citations
  Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibi...
  Wallace T. Ashton, Hong Dong, Rosemary Sisco, George A. Doss, Barbara Leiting, Reshma A. Patel, Joseph K. Wu, Frank Marsilio, Nancy A. Thornberry, Ann E. Weber> ;Bioorganic & Medicinal Chemistry Letters. 2004 Feb 23
• 2 citations
  Novel fragmentation reaction of correolide.
  Jianming Bao, Robert K. Baker, George A. Doss, Frank Kayser, Andrew Kotliar, Shouwu Miao, William H. Parsons, Kathleen M. Rupprecht> ;Organic Letters. 2002 May 9
• 19 citations
  CCR5 antagonists: bicyclic isoxazolidines as conformationally constrained N-1-substituted pyrrolidines.
  Christopher L. Lynch, Amy Gentry, Jeffrey J. Hale, Sander G. Mills, Malcolm MacCoss, Lorraine Malkowitz, Martin S. Springer, Sandra L. Gould, Julie A. DeMartino, Salva...> ;Bioorganic & Medicinal Chemistry Letters. 2002 Feb 25
• 20 citations
  Synthesis of the Liposidomycin Diazepanone Nucleoside
  Spencer Knapp, Gregori J. Morriello, George A. Doss> ;Organic Letters. 2002 Jan 26
• 7 citations
  Synthesis of griseolic acid B by π-face-dependent radical cyclization
  Spencer Knapp, Machender R. Madduru, Zhijian Lu, Gregori J. Morriello, Thomas J. Emge, George A. Doss> ;Organic Letters. 2001 Nov 1
• 15 citations
  Assignment of the liposidomycin diazepanone stereochemistry.
  Spencer Knapp, Gregori J. Morriello, Santosh R. Nandan, Thomas J. Emge, George A. Doss, Ralph T. Mosley, Lijian Chen> ;The Journal of Organic Chemistry. 2001 Jul 26
• 39 citations
  Synthesis of apicidin-derived quinolone derivatives: parasite-selective histone deacetylase inhibitors and antiproliferative agents.
  Peter T. Meinke, Steven L. Colletti, George A. Doss, Robert W. Myers, Anne Gurnett, Paula M. Dulski, Sandra J. Darkin-Rattray, John J. Allocco, Stefan Galuska, Dennis ...> ;Journal of Medicinal Chemistry. 2000 Dec 14
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