GeorgeWilliamFarrMD

Anesthesiology • Knoxville, TN

Physician

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Office
501 20th St
Ste 606
Knoxville, TN 37916
Phone+1 865-546-8040

Fax+1 865-541-2787
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Summary

Dr. George Farr, MD is a board certified anesthesiologist in Knoxville, Tennessee. He is currently licensed to practice medicine in Tennessee and Alabama. He is affiliated with Vanderbilt Tullahoma Harton Hospital.

Education & Training

University of Alabama Medical CenterResidency, Anesthesiology, 1995 - 1998
University of Tennessee College of Medicine at ChattanoogaInternship, Transitional Year, 1994 - 1995
University of Tennessee Health Science Center College of MedicineClass of 1994

Certifications & Licensure

TN State Medical License 1998 - 2025
AL State Medical License 1995 - 2021
American Board of Anesthesiology Anesthesiology

Publications & Presentations

PubMed

20 citations
Increased cerebral vascularization and decreased water exchange across the blood-brain barrier in aquaporin-4 knockout mice
Yifan Zhang, Kui Xu, Yuchi Liu, Bernadette O. Erokwu, Pan Zhao, Christopher A Flask, Ciro Ramos-Estebanez, George W. Farr, Joseph C. LaManna, Walter F. Boron, Xin Yu> ;Plos One. 2019 Jun 20
12 citations
Aquaporin 4 inhibition alters chemokine receptor expression and T cell trafficking.
Michael Nicosia, Satoshi Miyairi, Ashley Beavers, George W. Farr, Paul Robert Mcguirk, Marc F. Pelletier, Anna Valujskikh> ;Scientific Reports. 2019 May 15
32 citations
Functionalized Phenylbenzamides Inhibit Aquaporin-4 Reducing Cerebral Edema and Improving Outcome in Two Models of CNS Injury.
George W. Farr, Christopher H. Hall, Susan Farr, Ramon Wade, Joshua M. Detzel, Amielia G. Adams, Jasen M. Buch, Derek L. Beahm, Christopher A Flask, Kui Xu, Joseph C. ...> ;Neuroscience. 2019 Apr 15
17 citations
The aquaporin-4 inhibitor AER-271 blocks acute cerebral edema and improves early outcome in a pediatric model of asphyxial cardiac arrest.
Jessica Wallisch, Keri Janesko-Feldman, Henry Alexander, Ruchira M. Jha, George W. Farr, Paul Robert Mcguirk, Anthony E. Kline, Travis C. Jackson, Marc F. Pelletier, R...> ;Pediatric Research. 2019 Mar 1
7 citations
A two-domain folding intermediate of RuBisCO in complex with the GroEL chaperonin.
Ramanathan Natesh, Daniel K. Clare, George W. Farr, Arthur L. Horwich, Helen R. Saibil> ;International Journal of Biological Macromolecules. 2018 Jun 27
15 citations
Aquaporin 4 blockade improves survival of murine heart allografts subjected to prolonged cold ischemia.
Katayoun Ayasoufi, Naoki Kohei, Michael Nicosia, Ran Fan, George W. Farr, Paul Robert Mcguirk, Marc F. Pelletier, Robert L. Fairchild, Anna Valujskikh> ;American Journal of Transplantation. 2018 May 1
24 citations
Arterial spin labeling‐fast imaging with steady‐state free precession (ASL‐FISP): a rapid and quantitative perfusion technique for high‐field MRI
Ying Gao, Candida L. Goodnough, Bernadette O. Erokwu, George W. Farr, Rebecca J. Darrah, Lan Lu, Katherine MacRae Dell, Xin Yu, Christopher A Flask> ;NMR in Biomedicine. 2014 Aug 1
25 citations
Yeast Gis2 and its human ortholog CNBP are novel components of stress-induced RNP granules.
Marta Rojas, George W. Farr, Cesar F. Fernandez, Laura Lauden, John C. McCormack, Sandra L. Wolin> ;Plos One. 2012 Dec 21
129 citations
ATP-Triggered Conformational Changes Delineate Substrate-Binding and -Folding Mechanics of the Groel Chaperonin.
Daniel K. Clare, Daven Vasishtan, Scott M. Stagg, Joel Quispe, George W. Farr, Maya Topf, Arthur L. Horwich, Helen R. Saibil> ;Cell. 2012 Mar 30
12 citations
Hydrogen-deuterium exchange in vivo to measure turnover of an ALS-associated mutant SOD1 protein in spinal cord of mice.
George W. Farr, Zheng Ying, Wayne A. Fenton, Arthur L. Horwich> ;Protein Science. 2011 Oct 1
108 citations
Progressive aggregation despite chaperone associations of a mutant SOD1-YFP in transgenic mice that develop ALS.
Jiou Wang, George W. Farr, Caroline J. Zeiss, Diego J. Rodriguez-Gil, Jean H. Wilson, Krystyna Furtak, D. Thomas Rutkowski, Randal J. Kaufman, Cristian I. Ruse, John R...> ;Proceedings of the National Academy of Sciences of the United States of America. 2009 Feb 3
15 citations
A small molecule inhibitor selective for a variant ATP-binding site of the chaperonin GroEL.
Eli Chapman, George W. Farr, Krystyna Furtak, Arthur L. Horwich> ;Bioorganic & Medicinal Chemistry Letters. 2009 Feb 1
139 citations
An ALS-Linked Mutant SOD1 Produces a Locomotor Defect Associated with Aggregation and Synaptic Dysfunction When Expressed in Neurons of Caenorhabditis elegans
Jiou Wang, George W. Farr, David H. Hall, Fei Li, Krystyna Furtak, Lars Dreier, Arthur L. Horwich> ;Plos Genetics. 2009 Jan 23
25 citations
Requirement for binding multiple ATPs to convert a GroEL ring to the folding-active state.
Eli Chapman, George W. Farr, Wayne A. Fenton, Steven M. Johnson, Arthur L. Horwich> ;Proceedings of the National Academy of Sciences of the United States of America. 2008 Dec 9
32 citations
Multiple states of a nucleotide-bound group 2 chaperonin.
Daniel K. Clare, Scott M. Stagg, Joel Quispe, George W. Farr, Arthur L. Horwich, Helen R. Saibil> ;Structure. 2008 Apr 8
295 citations
Two Families of Chaperonin: Physiology and Mechanism
Arthur L. Horwich, Wayne A. Fenton, Eli Chapman, George W. Farr> ;Annual Review of Cell and Developmental Biology. 2007 Oct 18
85 citations
Topologies of a substrate protein bound to the chaperonin GroEL.
Nadav Elad, George W. Farr, Daniel K. Clare, Elena V. Orlova, Arthur L. Horwich, Helen R. Saibil> ;Molecular Cell. 2007 May 11
41 citations
Perturbed ATPase activity and not close confinement of substrate in the cis cavity affects rates of folding by tail-multiplied groel
George W. Farr, Wayne A. Fenton, Arthur L. Horwich> ;Proceedings of the National Academy of Sciences of the United States of America. 2007 Mar 27
111 citations
Global aggregation of newly translated proteins in an Escherichia coli strain deficient of the chaperonin GroEL
Eli Chapman, George W. Farr, Renata Usaite, Krystyna Furtak, Wayne A. Fenton, Tapan K. Chaudhuri, Elise R. Hondorp, Rowena G. Matthews, Sharon G. Wolf, John R. Yates, ...> ;Proceedings of the National Academy of Sciences of the United States of America. 2006 Oct 24
58 citations
GroEL-GroES-mediated protein folding.
Horwich, A. L., Farr, G. W., Fenton, W. A.> ;Chemical reviews. 2006 May 11
121 citations
Allosteric signaling of ATP hydrolysis in GroEL-GroES complexes.
Neil A. Ranson, Daniel K. Clare, George W. Farr, David Houldershaw, Arthur L. Horwich, Helen R. Saibil> ;Nature Structural & Molecular Biology. 2006 Jan 22
195 citations
Loops in the central channel of ClpA chaperone mediate protein binding, unfolding, and translocation.
Jörg Hinnerwisch, Wayne A. Fenton, Krystyna Furtak, George W. Farr, Arthur L. Horwich> ;Cell. 2005 Jul 1
33 citations
A mutant chaperonin with rearranged inter-ring electrostatic contacts and temperature-sensitive dissociation.
B. Trevor Sewell, Robert B. Best, Shaoxia Chen, Alan M. Roseman, George W. Farr, Arthur L. Horwich, Helen R. Saibil> ;Nature Structural & Molecular Biology. 2004 Nov 1
64 citations
Substrate polypeptide presents a load on the apical domains of the chaperonin GroEL
Fumihiro Motojima, Charu Chaudhry, Wayne A. Fenton, George W. Farr, Arthur L. Horwich> ;Proceedings of the National Academy of Sciences of the United States of America. 2004 Oct 19
108 citations
Role of the gamma-phosphate of ATP in triggering protein folding by GroEL-GroES: function, structure and energetics.
Charu Chaudhry, George W. Farr, Matthew J. Todd, Hayes S. Rye, Axel T. Brunger, Paul D. Adams, Arthur L. Horwich, Paul B. Sigler> ;The EMBO Journal. 2003 Oct 1
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Hospital Affiliations

Vanderbilt Tullahoma Harton HospitalTullahoma, Tennessee