GeorgeIGorodeskiMD

Obstetrics & Gynecology • Beachwood, OH

Reproductive Endocrinology & Infertility

Physician

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Office
25154 Bridgeton Dr
Beachwood, OH 44122
Phone+1 216-831-2751
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Education & Training

Mount Sinai Medical Center of ClevelandInternship, Transitional Year, 1988 - 1990
Tel Aviv University SacklerClass of 1973

Certifications & Licensure

OH State Medical License 1988 - 2025
PA State Medical License 1987 - 2008

Clinical Trials

Clinical Trial for the Use of a Novel Cell Collector Device to Retrieve Cells From the Uterine Cervix Start of enrollment: 1999 Aug 01
Completed

Publications & Presentations

PubMed

22 citations
Purinergic Signalling in the Reproductive System.
George I. Gorodeski> ;Autonomic Neuroscience. 2015 Sep 1
1 citations
Effects of estrogen on vaginal innervation: denervation or remodeling?
George I. Gorodeski> ;Menopause. 2012 Jun 1
34 citations
P2X7-mediated chemoprevention of epithelial cancers
George I. Gorodeski> ;Expert Opinion on Therapeutic Targets. 2009 Oct 22
21 citations
Regulation of P2X7 gene transcription
Lingyin Zhou, Liping Luo, Xiaoping Qi, Xin Li, George I. Gorodeski> ;Purinergic Signalling. 2009 Jul 16
23 citations
P2X 7 receptor expression is decreased in epithelial cancer cells of ectodermal, uro-genital sinus, and distal paramesonephric duct origin
Xin Li, Xiaoping Qi, Lingyin Zhou, Wen Fu, Fadi W. Abdul-Karim, Gregory T. MacLennan, George I. Gorodeski> ;Purinergic Signalling. 2009 Apr 28
61 citations
Activation of P2X7-mediated apoptosis Inhibits DMBA/TPA-induced formation of skin papillomas and cancer in mice
Wen Fu, Thomas S. McCormick, Xiaoping Qi, Liping Luo, Lingyin Zhou, Xin Li, Bingcheng Wang, Heidi E. Gibbons, Fadi W. Abdul-Karim, George I. Gorodeski> ;BMC Cancer. 2009 Apr 20
114 citations
MicroRNAs miR-186 and miR-150 Down-regulate Expression of the Pro-apoptotic Purinergic P2X7 Receptor by Activation of Instability Sites at the 3′-Untranslated Region o...
Lingyin Zhou, Xiaoping Qi, Judith A. Potashkin, Fadi W. Abdul-Karim, George I. Gorodeski> ;The Journal of Biological Chemistry. 2008 Oct 17
23 citations
Estrogen modulation of epithelial permeability in cervical-vaginal cells of premenopausal and postmenopausal women.
George I. Gorodeski> ;Menopause. 2007 Nov 1
35 citations
Decreased expression of P2X7 in endometrial epithelial pre-cancerous and cancer cells
Xin Li, Xiaoping Qi, Lingyin Zhou, Deborah Catera, Neal S. Rote, Judith A. Potashkin, Fadi W. Abdul-Karim, George I. Gorodeski> ;Gynecologic Oncology. 2007 Jul 1
56 citations
Estrogen Decrease in Tight Junctional Resistance Involves Matrix-Metalloproteinase-7-Mediated Remodeling of Occludin
George I. Gorodeski> ;Endocrinology. 2007 Jan 1
33 citations
Endogenously expressed truncated P2X7 receptor lacking the C-terminus is preferentially upregulated in epithelial cancer cells and fails to mediate ligand-induced pore...
Ying-Hong Feng, X. Li, R. Zeng, George I. Gorodeski> ;Nucleosides, Nucleotides & Nucleic Acids. 2006 Nov 22
4 citations
Apically sorted P2X7 receptors mediate purinergic-induced pore formation preferentially in apical domains of the plasma membrane.
X. Li, George I. Gorodeski> ;Nucleosides, Nucleotides & Nucleic Acids. 2006 Nov 22
2 citations
Non-muscle myosin-II-B filament regulation of paracellular resistance in cervical epithelial cells is associated with modulation of the cortical acto-myosin.
Xin Li, George I. Gorodeski> ;Journal of the Society for Gynecologic Investigation. 2006 Nov 7
14 citations
Estrogen Regulates Epithelial Cell Deformability by Modulation of Cortical Actomyosin through Phosphorylation of Nonmuscle Myosin Heavy-Chain II-B Filaments
Xin Li, Lingying Zhou, George I. Gorodeski> ;Endocrinology. 2006 Aug 10
55 citations
The P2X7 Receptor: A Novel Biomarker of Uterine Epithelial Cancers
Xin Li, Lingying Zhou, Ying-Hong Feng, Fadi W. Abdul-Karim, George I. Gorodeski> ;Cancer Epidemiology, Biomarkers & Prevention. 2006 Oct 1
5 citations
Estrogen Modulation of MgATPase Activity of Nonmuscle Myosin-II-B Filaments
George I. Gorodeski> ;Endocrinology. 2007 Jan 1
121 citations
A Truncated P2X7 Receptor Variant (P2X7-j) Endogenously Expressed in Cervical Cancer Cells Antagonizes the Full-length P2X7 Receptor through Hetero-oligomerization
Ying-Hong Feng, Xin Li, Liqin Wang, Lingying Zhou, George I. Gorodeski> ;The Journal of Biological Chemistry. 2006 Jun 23
23 citations
Changes in Tight Junctional Resistance of the Cervical Epithelium Are Associated with Modulation of Content and Phosphorylation of Occludin 65-Kilodalton and 50-Kiloda...
Ling Zhu, Xin Li, Robin Zeng, George I. Gorodeski> ;Endocrinology. 2006 Feb 1
13 citations
Effects of estrogen on proton secretion via the apical membrane in vaginal-ectocervical epithelial cells of postmenopausal women.
George I. Gorodeski> ;Menopause. 2005 Nov 1
54 citations
ATP stimulates GRK-3 phosphorylation and β-arrestin-2-dependent internalization of P2X7 receptor
Ying-Hong Feng, Liqin Wang, Qifang Wang, Xin Li, Robin Zeng, George I. Gorodeski> ;American Journal of Physiology. Cell Physiology. 2005 Feb 23
63 citations
Estrogen acidifies vaginal pH by up-regulation of proton secretion via the apical membrane of vaginal-ectocervical epithelial cells.
George I. Gorodeski, Ulrich Hopfer, Chung Chiun Liu, Ellen Margles> ;Endocrinology. 2005 Feb 1
20 citations
Epidermal Growth Factor Facilitates Epinephrine Inhibition of P2X7-Receptor-Mediated Pore Formation and Apoptosis: A Novel Signaling Network
Liqin Wang, Ying-Hong Feng, George I. Gorodeski> ;Endocrinology. 2005 Jan 1
22 citations
Aging and Estrogen Effects on Transcervical-Transvaginal Epithelial Permeability
George I. Gorodeski> ;The Journal of Clinical Endocrinology and Metabolism. 2005 Jan 1
11 citations
Estrogen attenuates P2X7-R-mediated apoptosis of uterine cervical cells by blocking calcium influx
George I. Gorodeski> ;Nucleosides, Nucleotides & Nucleic Acids. 2004 Dec 31
100 citations
P2X7 receptor-mediated apoptosis of human cervical epithelial cells.
Qifang Wang, Liqin Wang, Ying-Hong Feng, Xin Li, Robin Zeng, George I. Gorodeski> ;American Journal of Physiology. Cell Physiology. 2004 Nov 1
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Grant Support

Estrogen And Aging Effects On Transvaginal TransportNational Institute On Aging2003–2007
Estrogen And Aging Effects On Transvaginal TranspoetNational Institute On Aging2004–2006
Aging Effects On Transvaginal TransportNational Institute On Aging1999–2002
Transepithelial Transport In Cultured Uterine CellsEunice Kennedy Shriver National Institute Of Child Health &Human Development1995–1999
Aging Effects On Transvaginal TransportNational Institute On Aging1998
Electrolyte Transport In Cultured Cervical CellsEunice Kennedy Shriver National Institute Of Child Health &Human Development1994–1996
Electrolyte Transport In Cultured Human Cervical CellsEunice Kennedy Shriver National Institute Of Child Health &Human Development1992–1993

GeorgeIGorodeskiMD

Dr. Gorodeski is on Doximity

Education & Training

Certifications & Licensure

Clinical Trials

Publications & Presentations

Grant Support

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