GeorgeKarpouzasMDFACR

PubMed

• Publisher Correction: Efficacy and safety of JAK inhibitors in rheumatoid arthritis: update for the practising clinician.
  Szekanecz, Z., Buch, M., Galloway, J., Kristensen, L., Hamar, A., Charles-Schoeman, C., Karpouzas, G., Ytterberg, S., Fleischmann, R.> ;Nature Reviews. Rheumatology. 2024 Mar 1
• 1 citations
  Efficacy and safety of JAK inhibitors in rheumatoid arthritis: update for the practising clinician.
  Zoltán Szekanecz, Maya H Buch, Christina Charles-Schoeman, James Galloway, George A Karpouzas, Lars Erik Kristensen, Steven R Ytterberg, Attila Hamar, Roy Fleischmann> ;Nature Reviews. Rheumatology. 2024 Feb 1
• 1 citations
  Inflammation and immunomodulatory therapies influence the relationship between ATP-binding cassette A1 membrane transporter-mediated cholesterol efflux capacity and co...
  George A Karpouzas, Bianca Papotti, Sarah R Ormseth, Marcella Palumbo, Elizabeth Hernandez, Maria Pia Adorni, Francesca Zimetti, Matthew J Budoff, Nicoletta Ronda> ;Journal of Translational Autoimmunity. 2023 Dec 1
• Statins influence the relationship between ATP-binding cassette A1 membrane transporter-mediated cholesterol efflux capacity and coronary atherosclerosis in rheumatoid...
  George A Karpouzas, Bianca Papotti, Sarah R Ormseth, Marcella Palumbo, Elizabeth Hernandez, Maria Pia Adorni, Francesca Zimetti, Matthew J Budoff, Nicoletta Ronda> ;Journal of Translational Autoimmunity. 2023 Dec 1
• Decision Impact Analysis to Measure the Influence of Molecular Signature Response Classifier Testing on Treatment Selection in Rheumatoid Arthritis.
  Jeffrey R Curtis, Vibeke Strand, Steven J Golombek, George A Karpouzas, Lixia Zhang, Angus Wong, Krishna Patel, Jennifer Dines, Viatcheslav R Akmaev> ;Rheumatology and Therapy. 2024 Feb 1
• 1 citations
  Cardiovascular risk in vasculitis.
  Durga Prasanna Misra, Aman Sharma, George A Karpouzas, George D Kitas> ;Best Practice & Research. Clinical Rheumatology. 2023 Mar 1
• 3 citations
  ATP-binding cassette G1 membrane transporter-mediated cholesterol efflux capacity influences coronary atherosclerosis and cardiovascular risk in Rheumatoid Arthritis.
  George A Karpouzas, Bianca Papotti, Sarah R Ormseth, Marcella Palumbo, Elizabeth Hernandez, Maria Pia Adorni, Francesca Zimetti, Matthew J Budoff, Nicoletta Ronda> ;Journal of Autoimmunity. 2023 Apr 1
• Cardiovascular Comorbidities in Inflammatory Rheumatic Diseases.
  George A Karpouzas, M Elaine Husni> ;Rheumatic Diseases Clinics of North America. 2023 Feb 1
• 1 citations
  Atherosclerotic Cardiovascular Risk Stratification in the Rheumatic Diseases:: An Integrative, Multiparametric Approach.
  Durga Prasanna Misra, Ellen M Hauge, Cynthia S Crowson, George D Kitas, Sarah R Ormseth, George A Karpouzas> ;Rheumatic Diseases Clinics of North America. 2023 Feb 1
• 1 citations
  Role of Lipoprotein Levels and Function in Atherosclerosis Associated with Autoimmune Rheumatic Diseases.
  Nicoletta Ronda, Francesca Zimetti, Maria Pia Adorni, Marcella Palumbo, George A Karpouzas, Franco Bernini> ;Rheumatic Diseases Clinics of North America. 2023 Feb 1
• 2 citations
  Coronary plaque progression is greater in systemic lupus erythematosus than rheumatoid arthritis.
  Jeff Moore, Suvasini Lakshmanan, Venkat Sanjay Manubolu, April Kinninger, George Stojan, Daniel W Goldman, Michelle Petri, Matthew Budoff, George A Karpouzas> ;Coronary Artery Disease. 2023 Jan 1
• Rheumatoid arthritis disease activity and adverse events in patients receiving tofacitinib or tumor necrosis factor inhibitors: aanalysis of ORAL Surveillance.
  George A Karpouzas, Zoltán Szekanecz, Eva Baecklund, Ted R Mikuls, Deepak L Bhatt, Cunshan Wang, Gosford A Sawyerr, Yan Chen, Sujatha Menon, Carol A Connell, Steven R ...> ;Therapeutic Advances in Musculoskeletal Disease. 2023 Jan 1
• 3 citations
  Serum cholesterol loading capacity on macrophages is linked to coronary atherosclerosis and cardiovascular event risk in rheumatoid arthritis.
  George Athanasios Karpouzas, Bianca Papotti, Sarah Ormseth, Marcella Palumbo, Elizabeth Hernandez, Maria Pia Adorni, Francesca Zimetti, Matthew Budoff, Nicoletta Ronda> ;RMD Open. 2022 Sep 1
• 4 citations
  Serum cholesterol loading capacity of macrophages is regulated by seropositivity and C-reactive protein in rheumatoid arthritis patients.
  George A Karpouzas, Bianca Papotti, Sarah R Ormseth, Marcella Palumbo, Elizabeth Hernandez, Cinzia Marchi, Francesca Zimetti, Matthew J Budoff, Nicoletta Ronda> ;Rheumatology. 2023 Mar 1
• 6 citations
  Lipoprotein oxidation may underlie the paradoxical association of low cholesterol with coronary atherosclerotic risk in rheumatoid arthritis.
  George A Karpouzas, Sarah R Ormseth, Nicoletta Ronda, Elizabeth Hernandez, Matthew J Budoff> ;Journal of Autoimmunity. 2022 May 1
• 11 citations
  The impact of statins on coronary atherosclerosis progression and long-term cardiovascular disease risk in rheumatoid arthritis.
  George Karpouzas, Sarah R. Ormseth, Elizabeth Hernandez, Matthew J. Budoff> ;Rheumatology. 2021 Aug 9
• 1 citations
  Doppler ultrasound impacts response to intravenous tocilizumab in rheumatoid arthritis patients
  Nicolette T. Morris, Jenny Brook, Ami Ben-Artzi, William J. Martin, Tanaz A. Kermani, Lynette Avedikian-Tatosyan, George Karpouzas, Geraldine Navarro, Soo Choi, Mihael...> ;Clinical Rheumatology. 2021 Jul 16
• 8 citations
  An international audit of the management of dyslipidaemia and hypertension in patients with rheumatoid arthritis-results from 19 countries.
  Silvia Rollefstad, Eirik Ikdahl, Grunde Wibetoe, Joseph O. Sexton, Cynthia S. Crowson, Piet L. C. M. van Riel, George D. Kitas, Ian D. Graham, Solbritt Rantapää Dahlqv...> ;European Heart Journal. Cardiovascular Pharmacotherapy. 2021 Jul 7
• 12 citations
  Diabetes mellitus and cardiovascular risk management in patients with rheumatoid arthritis: an international audit.
  Anne Grete Semb, Silvia Rollefstad, Eirik Ikdahl, Grunde Wibetoe, Joseph O. Sexton, Cynthia S. Crowson, Piet L. C. M. van Riel, George D. Kitas, Ian D. Graham, Solbrit...> ;RMD Open. 2021 Jul 1
• 9 citations
  Biologics and atherosclerotic cardiovascular risk in rheumatoid arthritis: a review of evidence and mechanistic insights
  George Karpouzas, Viet L Bui, Nicoletta Ronda, Ivana Hollan, Sarah R. Ormseth> ;Expert Review of Clinical Immunology. 2021 Apr 15
• 6 citations
  Epicardial adipose tissue volume is a marker of subclinical coronary atherosclerosis in Rheumatoid arthritis.
  George Karpouzas, Panteha Rezaeian, Sarah R. Ormseth, Ivana Hollan, Matthew J. Budoff> ;Arthritis & Rheumatology. 2021 Feb 14
• 7 citations
  Beta-2-glycoprotein-I IgA antibodies predict coronary plaque progression in rheumatoid arthritis
  George Karpouzas, Sarah Ormseth, Elizabeth Hernandez, Viet L. Bui, Matthew J. Budoff> ;Seminars in Arthritis and Rheumatism. 2021 Feb 1
• 9 citations
  Long-term safety and efficacy of sirukumab for patients with rheumatoid arthritis who previously received sirukumab in randomised controlled trials (SIRROUND-LTE).
  Daniel Aletaha, Clifton O. Bingham, George Karpouzas, Tsutomu Takeuchi, Carter Thorne, Androniki Bili, Prasheen Agarwal, Benjamin Hsu, Ravi Rao, Kurt Brown, Yoshiya Ta...> ;RMD Open. 2021 Jan 1
• 48 citations
  Biologics may prevent cardiovascular events in rheumatoid arthritis by inhibiting coronary plaque formation and stabilizing high‐risk lesions
  George Karpouzas, Sarah Ormseth, Elizabeth Hernandez, Matthew J. Budoff> ;Arthritis & Rheumatology. 2020 Sep 1
• 24 citations
  Smoking cessation is associated with lower disease activity and predicts cardiovascular risk reduction in rheumatoid arthritis patients
  Ida Kristiane Roelsgaard, Eirik Ikdahl, Silvia Rollefstad, Grunde Wibetoe, Bente Appel Esbensen, George D. Kitas, Piet L. C. M. van Riel, Sherine E. Gabriel, Tore K Kv...> ;Rheumatology. 2020 Aug 1
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Journal Articles

• Highly sensitive cardiac troponin-I predicts occult coronary plaque burden, composition and cardiovascular events in patients with rheumatoid arthritis  
  Karpouzas GA, Estis J, Rezaeian P, Todd J, Budoff MJ, Rheumatology (Oxford), 1/1/2018
• Reply  
  Grossman JM, McMahon MA, Fitzgerald JD, Karpouzas GA, Chen W, Hahn BH, Merrill JT, Wallace DJ, Yazdany J, Ramsey-Goldman R, Arthritis Care Res (Hoboken), 1/1/2012
• Shortness of Breath and Hemoptysis in a 35-Year-Old Man with Extensive Perihilar Infiltrates  
  Jung C, Stringer W, Karpouzas GA, Chest, 1/1/2005
• Regulation of autoantibody production by multiple mechanisms in immune tolerance  
  Hahn BH, Ebling F, Singh RR, Singh RP, Dubey S, Kalsi J, Karpouzas GA, La Cava A, Autoimmunity Reviews, 1/1/2004
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Books/Book Chapters

• Dubois� Lupus Erythematosus and Related Syndromes 
  Chapter: Chapter 34, Hematologic and Lymphoid Manifestations in Systemic Lupus Erythematosus. 
  Page 426 - 438Karpouzas GAEditors: Wallace and Hahn.ElsevierEdition 8th,2013
• Dubois Lupus Erythematosus 
  Chapter: Chapter 51, The mother in lupus pregnancy. 
  Page 992 - 1039Karpouzas GA, Kitridou RCEditors: Wallace and Hahn.Edition 7th,2007
• Kelley�s Textbook of Rheumatology 
  Chapter: Pathogenesis of SLE 
  Tsao BP, Karpouzas GA, and Hahn BHEditors: Budd, R.C..W.B. Saunders Company, Philadelphia, PA2003
• Targeted Therapies in Rheumatology 
  Chapter: Chapter 34, Systemic Lupus Erythematosus: Targets for innovative therapies. 
  Page 563 - 582Karpouzas GA, Hahn, B.H.Editors: Smolen and Lipsky.2002
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Abstracts/Posters

• Impact of Inflammation and Biologic Treatments on Generation and Progression to Advanced Calcified Coronary Plaques in Rheumatoid Arthritis
  Karpouzas G, Ormseth S, Hernandez E, Budoff M, Arthritis Rheumatol, 1/1/2018
• Implications of Coronary Artery Calcium Score and Its Change over Time As Markers of Coronary Plaque Vulnerability and Patient Risk in Rheumatoid Arthritis
  Karpouzas G, Ormseth S, Hernandez E, Budoff M, Arthritis Rheumatol, 1/1/2018
• Low Inflammatory Burden and Statin Exposure Inhibit Progression and Induce Regression of Early Coronary Plaques in Rheumatoid Arthritis
  Karpouzas G, Ormseth S, Hernandez E, Budoff M, Arthritis Rheumatol, 1/1/2018
• Predictors of Change in Coronary Plaque Burden and Composition in Patients with Rheumatoid Arthritis
  Karpouzas G, Ormseth S, Hernandez E, Budoff M, Arthritis Rheumatol, 1/1/2018
• Highly Sensitive Cardiac Troponin-I in peripheral blood predicts Cardiovascular Events in patients with Rheumatoid Arthritis.
  Karpouzas GA, Estis J, Todd J, Budoff MJ, Arthritis Rheumatol, 1/1/2017
• Occult coronary plaque presence and burden predict Cardiovascular Events in patients with Rheumatoid Arthritis.
  Karpouzas GA, Estis J, Todd J, Budoff MJ, Arthritis Rheumatol, 1/1/2017
• A Cluster Analysis approach to Patient-Physician Discordance in Rheumatoid Arthritis Activity Evaluations optimally differentiates and predicts Clinical, Functional an...
  Karpouzas GA, Ormseth SR, Arthritis Rheumatol, 1/1/2017
• Discordant Patient-Physician Assessments of Disease Activity and its Persistence Adversely Impact Quality of Life and Work Productivity in United States Hispanics with...
  Karpouzas GA, Ramadan S, Cost C, Draper T, Hernandez E, Ormseth SR, Arthritis Rheumatol, 1/1/2017
• Long-Term Effect of Sirukumab, an Anti�IL-6 Cytokine Monoclonal Antibody, on Radiographic Progression in Patients with Active Rheumatoid Arthritis Despite Disease-Modi...
  Karpouzas GA, Takeuchi T, Thorne C, Sheng S, Kurrasch R, Fei K, Hsu B, Arthritis Rheumatol, 1/1/2017
• Effect Size Comparison of Ultrasound Measures in Rheumatoid Arthritis.
  Ranganath VK, Elashoff DA, Brook J, Ben-Artzi A, Navarro J, Tatosyan L, Karpouzas GA, Martin W, Kermani T, Choi S, Kaeley G, Arthritis Rheumatol, 1/1/2017
• Change in self-reported pain reflects psychological and functional state rather than inflammatory burden in United States Latinos with established Rheumatoid arthritis.
  Karpouzas GA, Hernandez E, Cost C, Ormseth SR, EULAR, 1/1/2017
• Does preconsult Electronic exchange affect postconsult diagnosis?
  Miller GD, Chou B, Karpouzas GA, EULAR, 1/1/2017
• Response and radiographic progression in biologic-naive and biologic-experienced patients with RA treated with Sirukumab.
  C. Thorne, G. Karpouzas, T. Takeuchi, S. Sheng, W. Xu, S. Xu, R. Kurrasch, K. Fei, B. Hsu, Ann Rheum Dis, 1/1/2016
• Favorable effects of Silukumab treatment on physical function and reductions in morning stiffness in patients with active RA and inadequate response to disease modifyi...
  C. Thorne, T. Takeuchi, G. Karpouzas, K. McQuarrie, S. Sheng, W. Xu, S. Peterson, R. Ganguly, C. Han, K. Fei, B. Hsu, Ann Rheum Dis, 1/1/2016
• RA-specific cardiovascular risk calculators are not superior to risk calculators established for the general population: A validation analysis in a cohort of RA patien...
  C.S. Crowson, S.E. Gabriel, A.G. Semb, P.L. van Riel, G. Karpouzas, P.H. Dessein, C. Hitchon, V. Pascual Ramos, G.D. Kitas, Ann Rheum Dis, 1/1/2016
• Health-related physical and emotional well-being and fatigue improve significantly with sirukumab treatment: Results of a phase 3 study in patients with active RA refr...
  G. Karpouzas, C. Thorne, T. Takeuchi, K. McQuarrie, S. Sheng, W. Xu, S. Peterson, R. Ganguly, C. Han, K. Fei, B. Hsu, Ann Rheum Dis, 1/1/2016
• An analysis of laboratory results from 2 randomized, double-blind studies of sirukumab in patients with active RA refractory to disease modifying anti-rheumatic drug t...
  G. Karpouzas, C. Thorne, T. Takeuchi, Y. Tanaka, H. Yamanaka, M. Harigai, T. Ota, S. Sheng, W. Xu, S. Xu, R. Kurrasch, K. Fei, B. Hsu, Ann Rheum Dis, 1/1/2016
• Anti-b2Glycoprotein-1 IgA antibodies independently and differentially contribute to thrombotic risk in systemic lupus erythematosus above and beyond ACL and LA: Lesson...
  T. Aung, G. Miller, S. Ormseth, R. Moran, G. Karpouzas, Ann Rheum Dis, 1/1/2016
• Efficacy and safety of Sirukumab in patients with active RA despite disease modifying anti-rheumatic drug treatment: Results of a randomized, double blind, placebo con...
  T. Takeuchi, C. Thorne, G. Karpouzas, S. Sheng, W. Xu, R. Rao, K. Fei, B. Hsu, Ann Rheum Dis, 1/1/2016
• Improvements in measures of work productivity/ interference and general health status with sirukumab treatment in patients with active RA and inadequate response to di...
  T. Takeuchi, G. Karpouzas, C. Thorne, K. McQuarrie, S. Sheng, W. Xu, S. Peterson, R. Ganguly, C. Han, K. Fei, B. Hsu, Ann Rheum Dis, 1/1/2016
• Treatment with Sirukumab, an Anti-IL6 Cytokine Monoclonal Antibody, Improves Fatigue and Health-Related Physical and Emotional Well Being in Patients with Active Rheum...
  Clifton Bingham C, Tanaka Y, Karpouzas G, Takeuchi T, Aletaha D, Thorne C, Sheng S, Xu W, Rao R, Fei K, Hsu B, Agarwal P, Popik S, Kurrasch R, Peterson S, Ganguly R, H..., Arthritis Rheumatol, 1/1/2016
• Prediction of Inhibition of Radiographic Progression By Sirukumab, an Anti�IL-6 Cytokine Monoclonal Antibody, in Patients with Active Rheumatoid Arthritis Despite Dise...
  Karpouzas G, Takeuchi T, Thorne C, Sheng S, Li X, Rao R, Fei K, Hsu B, Arthritis Rheumatol, 1/1/2016
• Contribution of patient global assessment on loss and gain of disease remission in patients with established Rheumatoid arthritis in clinical practice.
  Karpouzas GA, Hernandez E, Cost C, Ormseth S, Arthritis Rheumatol, 1/1/2016
• Rates and determinants of persistent Patient-Physician Discordance in global assessment of disease activity in Latinos with Rheumatoid arthritis in the United States.
  Karpouzas GA, Hernandez E, Cost C, Ormseth S, Arthritis Rheumatol, 1/1/2016
• Reliability and validity of the Patient-Health Questionnaire-9 for assessment of depression in disadvantaged Latinos with Rheumatoid arthritis living in the United Sta...
  Ormseth S, Draper T, Hernandez E, Karpouzas GA, Arthritis Rheumatol, 1/1/2016
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Lectures

• Clinical Manifestations of Rapid Disease Progression in Moderate to Severe Rheumatoid Arthritis 
  Multiple Locations, 2017, 2018 - 1/1/2018
• Accelerated coronary Atherogenesis and cardiovascular risk stratification in Rheumatoid Arthritis, 
  UCLA Medical Center, Westwood, CA, 2014, 2018; Harbor-UCLA Medical Center, Torrance, CA, 2017 - 1/1/2018
• A New Treatment Option for Adult Patients with Moderately to Severely Actively Rheumatoid Arthritis 
  Multiple Locations, 2017, 2018 - 1/1/2018
• Biomarkers and risk of Rheumatoid Arthritis 
  Seattle, WA, 2017; Mission Viejo, CA, 2017 - 1/1/2017
• Physician and patient reported outcomes in Latinos with RA: Longitudinal trends and determinants of change. 
  Multiple Locations, 2016, 2017 - 1/1/2017
• New developments in understanding the IL-6 pathway and its role in Rheumatoid Arthritis 
  Chicago, IL, 2017; Seattle, WA, 2018; Bellevue, WA, 2018 - 1/1/2017
• Role of Rheumatoid Factor in the Immune System. 
  Loma Linda University, Loma Linda CA, 2016; Los Angeles, CA, 2016; Costa Mesa, CA, 2016 - 1/1/2016
• Principles for safe utilization of biologic agents in systemic autoimmune disease 
  Harbor-UCLA Medical Center, Torrance, CA - 1/1/2016
• Immunology of pregnancy and challenges in systemic autoimmune disease 
  Harbor-UCLA Medical Center, Torrance, CA - 1/1/2016
• ANCA-Associated Vasculitis: Clinical Manifestations and Immunopathogenesis 
  Multiple Locations, 2014, 2015, 2016 - 1/1/2016
• Development and Amplification of Immune Response in Rheumatoid Arthritis. 
  Multiple Locations, 2015, 2016 - 1/1/2016
• Emergencies in Rheumatology 
  Multiple Locations, 2007, 2008, 2009, 2011, 2015, 2016 - 1/1/2016
• From Prognosis to Pathogenesis: The Role of Autoantibodies in Rheumatoid Arthritis. 
  Multiple Locations, 2016 - 1/1/2016
• Pulmonary Hypertension in Systemic Sclerosis 
  Harbor-UCLA Medical Center, Torrance, CA, 2016; UCLA Medical Center, Westwood, CA, 2016 - 1/1/2016
• The Role of Autoantibodies in Rheumatoid Arthritis. 
  Loma Linda University, Loma Linda CA - 1/1/2015
• Coronary atherosclerosis and cardiovascular risk stratification in Rheumatoid arthritis 
  Los Angeles, CA, 2014; Harbor-UCLA Medical Center, Torrance, CA, 2015; UCLA Medical Center, Westwood - 1/1/2015
• Management of Comorbidities in Rheumatoid Arthritis 
  UCLA Medical Center, Westwood, CA - 1/1/2015
• The many faces of Rheumatoid Arthritis 
  UCLA Medical Center, Westwood, CA - 1/1/2015
• Rheumatoid Arthritis Therapeutics debate: TNFi cycling vs. MOA switch in RA 
  Tucson, AZ - 1/1/2015
• Early initiation of Abatacept in moderate to severe RA: Clinical evidence for use of Abatacept in patients with early, rapidly progressing disease and poor prognosis 
  Seattle, WA - 1/1/2015
• Pathophysiology of Rheumatoid Arthritis: The Role of Effector Immune Cells 
  Seattle, WA, 2015; Kaiser Permanente, Orange County, CA, 2015 - 1/1/2015
• Generation and Amplification of autoimmune response in RA 
  UCLA Medical Center, Westwood, CA, 2015; LAC-USC Medical Center, Los Angeles, CA, 2015 - 1/1/2015
• Rheumatology Board Review for the Internist: A smorgasbord of delights 
  Harbor-UCLA Medical Center, Torrance, CA - 1/1/2014
• Evolution of (auto)immune response in Rheumatoid arthritis: the pivotal role of TNFa 
  1/1/2014
• Ustekinumab (IL-12/23) blockade in Psoriatic Arthritis 
  Multiple Locations, 2014 - 1/1/2014
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Other

• Rheumatology circles: Role of Golimumab in the treatment of moderate to severe Rheumatoid arthritis 
  Karpouzas GA, Janssen National Faculty series National WebEx
  1/1/2012
• Thesis: ANCA vasculitis in Greece 
  Karpouzas GA
  National and Kapodistrian University of Athens, School of Medicine, Zografou, Greece - 1/1/1995