GeorgeMMartinMD

PubMed

• 3 citations
  Accelerated epigenetic aging and DNA methylation alterations in Berardinelli-Seip congenital lipodystrophy.
  Abeer Qannan, Yosra Bejaoui, Mahmoud Izadi, Noha A Yousri, Aleem Razzaq, Colette Christiansen, George M Martin, Jordana T Bell, Steve Horvath, Junko Oshima, Andre Mega...> ;Human Molecular Genetics. 2023 May 18
• 27 citations
  TNF-α/IFN-γ synergy amplifies senescence-associated inflammation and SARS-CoV-2 receptor expression via hyper-activated JAK/STAT1.
  Renuka Kandhaya-Pillai, Xiaomeng Yang, Tamar Tchkonia, George M Martin, James L Kirkland, Junko Oshima> ;Aging Cell. 2022 Jun 1
• 12 citations
  Targeted long-read sequencing identifies missing pathogenic variants in unsolved Werner syndrome cases.
  Danny E Miller, Lin Lee, Miranda Galey, Renuka Kandhaya-Pillai, Marc Tischkowitz, Deepak Amalnath, Avadh Vithlani, Koutaro Yokote, Hisaya Kato, Yoshiro Maezawa, Aki Ta...> ;Journal of Medical Genetics. 2022 May 9
• 14 citations
  DNA methylation signatures in Blood DNA of Hutchinson-Gilford Progeria syndrome.
  Yosra Bejaoui, Aleem Razzaq, Noha A Yousri, Junko Oshima, Andre Megarbane, Abeer Qannan, Ramya Potabattula, Tanvir Alam, George M Martin, Henning F Horn, Thomas Haaf, ...> ;Aging Cell. 2022 Feb 1
• 10 citations
  Cell-to-cell variation in gene expression and the aging process
  Alexander Mendenhall, George M. Martin, Matt Kaeberlein, Rozalyn M. Anderson> ;Geroscience. 2021 Feb 17
• 6 citations
  Review of How Genetic Research on Segmental Progeroid Syndromes Has Documented Genomic Instability as a Hallmark of Aging But Let Us Now Pursue Antigeroid Syndromes
  George M. Martin, Fuki M. Hisama, Junko Oshima> ;The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2021 Jan 18
• 6 citations
  SMAD4 mutations and cross-talk between TGF-β/IFNγ signaling accelerate rates of DNA damage and cellular senescence, resulting in a segmental progeroid syndrome-the Myh...
  Renuka Kandhaya-Pillai, Deyin Hou, Jiaming Zhang, Xiaomeng Yang, Goli Compoginis, Takayasu Mori, Tamara Tchkonia, George M. Martin, Fuki M. Hisama, James L. Kirkland, ...> ;Geroscience. 2021 Jan 5
• 3 citations
  Cell-to-Cell Variation in Gene Expression for Cultured Human Cells Is Controlled in Trans by Diverse Genes: Implications for the Pathobiology of Aging
  Jiaming Zhang, Nikolay Burnaevskiy, James Annis, Wenyan Han, Deyin Hou, Paula D. Ladd, Lin Lee, Alexander Mendenhall, Junko Oshima, George M. Martin> ;The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2020 Nov 13
• 3 citations
  Novel LMNA mutations in Greek and Myanmar Patients with Progeroid Features and Cardiac Manifestations.
  Renuka Kandhaya-Pillai, Fuki M. Hisama, Stephanie A. Bucks, Soe Yarzar, Haroula Korovou, George M. Martin, Junko Oshima> ;Aging Pathobiology and Therapeutics. 2020 Jun 29
• 4 citations
  Lessons for aging from Werner syndrome epigenetics.
  George M. Martin, Martin Poot, Thomas Haaf> ;Aging. 2020 Feb 5
• 4 citations
  Inactivating Mutations in Exonuclease and Polymerase Domains in DNA Polymerase Delta Alter Sensitivities to Inhibitors of dNTP Synthesis
  Jiaming Zhang, Deyin Hou, James Annis, Forough Sargolzaeiaval, Julia Appelbaum, Eishi Takahashi, George M. Martin, Alan J. Herr, Junko Oshima> ;DNA and Cell Biology. 2020 Jan 8
• 19 citations
  Epigenetic signatures of Werner syndrome occur early in life and are distinct from normal epigenetic aging processes
  Anna Maierhofer, Julia Flunkert, Junko Oshima, George M. Martin, Martin Poot, Indrajit Nanda, Marcus Dittrich, Tobias Müller, Thomas Haaf> ;Aging Cell. 2019 Jul 1
• 17 citations
  CTC1 mutations in a Brazilian family with progeroid features and recurrent bone fractures.
  Forough Sargolzaeiaval, Jiaming Zhang, Jennifer Schleit, Davor Lessel, Christian Kubisch, Débora Rossi Precioso, David Sillence, Fuki M. Hisama, Michael O. Dorschner, ...> ;Molecular Genetics & Genomic Medicine. 2018 Nov 1
• 297 citations
  Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies
  Steve Horvath, Junko Oshima, George M. Martin, Ake T. Lu, Austin Quach, Howard Cohen, Sarah Felton, Mieko Matsuyama, Donna Lowe, Sylwia Kabacik, James G. Wilson, Alexa...> ;Aging. 2018 Jul 1
• 21 citations
  ERCC4 variants identified in a cohort of patients with segmental progeroid syndromes.
  Takayasu Mori, Matthew J. Yousefzadeh, Maryam Faridounnia, Jessica X. Chong, Fuki M. Hisama, Louanne Hudgins, Gabriela Mercado, Erin A. Wade, Amira S. Barghouthy, Lin ...> ;Human Mutation. 2018 Feb 1
• 50 citations
  Dysfunction of the MDM2/p53 axis is linked to premature aging
  Davor Lessel, Danyi Wu, Carlos Trujillo, Thomas Ramezani, Ivana Lessel, Mohammad Khalid Alwasiyah, Bhaskar Saha, Fuki M. Hisama, Katrin Rading, Ingrid Goebel, Petra Sc...> ;The Journal of Clinical Investigation. 2017 Aug 28
• 9 citations
  Geroscience: Addressing the mismatch between its exciting research opportunities, its economic imperative and its current funding crisis.
  George M. Martin> ;Experimental Gerontology. 2017 Aug 1
• 110 citations
  Accelerated epigenetic aging in Werner syndrome.
  Anna Maierhofer, Julia Flunkert, Junko Oshima, George M. Martin, Thomas Haaf, Steve Horvath> ;Aging. 2017 Apr 1
• 11 citations
  High incidence of BSCL2 intragenic recombinational mutation in Peruvian type 2 Berardinelli-Seip syndrome.
  Nelson Purizaca-Rosillo, Takayasu Mori, Yamalí Benites-Cóndor, Fuki M. Hisama, George M. Martin, Junko Oshima> ;American Journal of Medical Genetics. Part A. 2017 Feb 1
• 44 citations
  Mitochondrial-Targeted Catalase: Extended Longevity and the Roles in Various Disease Models
  Dao-Fu Dai, Ying Ann Chiao, George M. Martin, David J. Marcinek, Nathan Basisty, Ellen Quarles, Peter S. Rabinovitch> ;Progress in Molecular Biology and Translational Science. 2017 Jan 1
• 63 citations
  WRN Mutation Update: Mutation Spectrum, Patient Registries, and Translational Prospects
  Koutaro Yokote, Sirisak Chanprasert, Lin Lee, Katharina Eirich, Minoru Takemoto, Aki Watanabe, Naoko Koizumi, Davor Lessel, Takayasu Mori, Fuki M. Hisama, Paula D. Lad...> ;Human Mutation. 2017 Jan 1
• 1 citations
  Views on the ethical struggle for universal, high quality, affordable health care and its relevance for gerontology.
  George M. Martin> ;Experimental Gerontology. 2017 Jan 1
• Ageing: Dietary protection for genes
  Junko Oshima, George M. Martin> ;Nature. 2016 Sep 15
• 25 citations
  Mitochondrial‐targeted catalase is good for the old mouse proteome, but not for the young: ‘reverse’ antagonistic pleiotropy?
  Nathan Basisty, Dao-Fu Dai, Arni Gagnidze, Lemuel Gitari, Jeanne Fredrickson, Yvonne Maina, Richard P. Beyer, Mary J. Emond, Edward J. Hsieh, Michael J. MacCoss, Georg...> ;Aging Cell. 2016 Aug 1
• 13 citations
  How Research on Human Progeroid and Antigeroid Syndromes Can Contribute to the Longevity Dividend Initiative
  Fuki M. Hisama, Junko Oshima, George M. Martin> ;Cold Spring Harbor Perspectives in Medicine. 2016 Apr 1
• Join now to see all

Journal Articles

• "Rapamycin decreases DNA damage accumulation and enhances cell growth of WRN deficient human fibroblasts"  
  Saha B, Cypro A, Martin GM, Oshima J, Aging Cell, 1/1/2014
• "Atypical Aicardi-Goutieres syndrome: Is the WRN locus a modifier?"  
  Lessel D, Saha B, Hisama F, Kaymakamzade B, Nurlu G, Gursoy-Ozdemir Y, Thiele H, Numberg P, Martin GM, Kubuisch C, Oshima J, American Journal of Medical Genetics, 1/1/2014
• "An encouraging progress report on the treatment of progeria and its implications for atherogenesis"  
  Oshima J, Martin GM, Hisama F, Circulation, 1/1/2014
• Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features"  
  Lessel D, Vaz B, Halder S, Lockhart PJ, Marinovic-Terric I, et al, Nature Genetics, 1/1/2014
• "Ethnic specific WRN mutations in South Asian Werner syndrome patients: Potential founder effect in patients with Indian or Pakistani ancestry"  
  Saha B, Lessel D, Nampoothiri S, Rao AS, Dincy P, Bennett C, Nurnberg G, Nurnberg P, Hisama FM, Martin GM, Kubisch C, Oshima J, Molecular Genetics and Genomic Medicine, 1/1/2013
• "DNA damage accumulation and TRF2 degradation in atypical Werner syndrome fibroblasts with LMNA mutations"  
  Saha B, Zitnik G, Johnson S, Nguyen Q, Risques RA, Martin GM, Oshima J, Frontiers in the Genetics of Aging, 1/1/2013
• "Preserving Youth: Does Rapamycin Deliver?"  
  Johnson SC, Martin GM, Rabinovitch PS, Kaeberlein M, Science Translational Medicine, 1/1/2013
• "Commentary: A gerontological perspective on Klaus Gartner's discovery that phenotypic variability of mammals is driven by stochastic events"  
  Martin GM, International Journal of Epidemiology, 1/1/2012
• "Clinical utility gene card for: Werner syndrome"  
  Hisama F, Oshima J, Kubisch C, Martin GM, European Journal of Human Genetics, 1/1/2012
• "Lecture Presentation: Epigenetic gambling & epigenetic drift as potential mechanisms underlying the quasi-stochastic distributions of late life neurodegenerative diso...  
  Martin GM, Molecular Neurodegeneration, 1/1/2012
• "Stochastic Modulations of the Pace and Patterns of Ageing: Impacts on Quasi-Stochastic Distributions of Multiple Geriatric Pathologies"  
  Martin GM, Mechanisms of Ageing and Development, 1/1/2012
• "A novel functional low-density lipoprotein receptor-related protein 6 gene alternative splice variant is associated with Alzheimer's disease"  
  Alarcon MA, Medina MA, Hu Q, Avila ME, Bustos BI, Perez-Palma E, Peralta A, Salazar P, Ugarte GD, Reyes AE, Martin GM, Opazo C, Moon RT, De Ferrari GV, Neurobiology of Aging, 1/1/2012
• Book Review: "Aging and Age-Related Disorders, edited by S Bondy and K Maiese, New York, Springer, 2010"  
  Martin, G.M., Journal of Alzheimer's Disease, 1/1/2011
• "The biology of aging: 1985-2010 and beyond"  
  Martin GM, Federation of American Societies for Experimental Biology Journal, 1/1/2011
• "Editorial"  
  Antebi A, Cuervo AM, Kennedy B, Martin GM, Sedivy J, Aging Cell, 1/1/2011
• "Coronary Artery Disease in a Werner Syndrome-like Form of Progeria Characterized by Low Levels of Progerin, a Splice Variant of Lamin A"  
  Hisama FM, Lessel D, Leistritz D, Friedrich K, McBride K, Pastore M, Gottesman GS, Saha B, Martin GM, Kubisch C, Oshima J, American Jouranl of Medical Genetics, 1/1/2011
• "Structural and functional characterization of a novel FE65 protein product up-regulated in cognitively impaired FE65 knockout mice"  
  Cool BH, Zitnik G, Martin GM, Hu Q, Journal of Neurochemistry, 1/1/2010
• "A Flanking Gene Problem Leads to the Discovery of a Gprc5b Splice Variant Predominantly Expressed in C57Bl/6J Mouse Brain and in Maturing Neurons"  
  Cool BH, Chan GC, Lee L, Oshima J, Martin GM, Hu Q, PloS One, 1/1/2010
• "The Demographic and Biomedical Case for Late-Life Interventions in Aging"  
  Rae MJ, Butler RJ, Campisi J, et al, Science Translational Medicine, 1/1/2010
• "WRN mutations in Werner syndrome patients: genomic rearrangements, unusual intronic mutations and ethnic-specific alterations"  
  Friedrich K, Lee L, Leistritz DF, Nurnberg G, Saha B, Hisama FM, Eyman DK, Lessel D, et al, Human Genetics, 1/1/2010
• "Leukocyte Telomere Length Is Associated with Disability in Older US Population"  
  Risques RA, Arbeev KG, Yashin AI, Ukraintseva SV, Rabinovitch PS, Martin GM, Oshima J, Journal of American Geriatrics Society, 1/1/2010
• "A novel LMNA mutation causes altered nuclear morphology and symptoms of familial partial lipodystrophy (Dunnigan Variety) with progeroid features"  
  Saha B, Lessel D, Hisama FM, Leistritz DF, Friedrich K, Martin GM, Oshima J, Molecular Syndromology, 1/1/2010
• "Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging"  
  Dai D, Santana LF, Vermulst M, Tomazela DM, Emond MJ, MacCoss MJ, Gollahon K, Martin GM, Loeb LA, Ladiges WC, Rabinovitch PS, Circulation Research, 1/1/2009
• "The 2008 American Federation For Aging Annual Research Conference: Aging and Cancer: Two Sides of the Same Coin?"  
  Martin GM, The Journals of Gerontology: Series A-Biological Sciences and Medical Sciences, 1/1/2009
• "The APP-interacting protein FE65 is required for hippocampus-dependent learning and long-term potentiation"  
  Wang Y, Zhang M, Moon C, Hu Q, Wang B, Martin GM, Sun Z, Wang H, Learning Memory, 1/1/2009
• Join now to see all

Books/Book Chapters

• Annual Review of Gerontology and Genetics 
  Chapter: "Nature, Nurture, and Chance: Their Roles in Interspecific and Intraspecific Modulations of Aging." 
  GM MartinEditors: Sprott R.Springer Publishing Co., New York2014
• Harrison's Principles of Internal Medicine 
  Chapter: "The Biology of Aging." 
  GM MartinEditors: Longo D, Fauci A, Kasper D, Jameson J, and Loscalzso J, Hauser ES.Edition 18th,2012
• Clinical Genomics: Practical Applications in Adult Patient Care 
  Chapter: "Werner Syndrome" 
  GM Martin, L Dru, J OshimaMcGraw Hill and the American College of Physicians, New York2010
• Handbook of Theories of Aging 
  Chapter: "Modalities of Gene Action Predicted by the Classical Evolutionary Theory of Aging." 
  Page 226 - 250Martin GMEditors: Bengston V, Silverstein M, Norella P, Gans D.2008
• Encyclopedia of Gerontology: Age, Aging, and the Aged 
  Chapter: "Premature Aging." 
  Page 379 - 384Martin GMElsevier Inc.Edition 2nd,2007
• Global Health and Global Aging 
  Chapter: "The Biology of Aging: Current Research and Expected Future Gains." 
  Page 249 - 256Martin GM, Lederberg JEditors: Robinson M, Novelli W, Pearson C, Norris L.Jossey-Bass2007
• Cecil Textbook of Medicine 
  Chapter: "Biology of Aging." 
  Page 103 - 105Martin GMEditors: Lee Goldman and Dennis Ausiello.Saunders, PhiladelphiaEdition 22nd,2004
• The NORD Guide to Rare Disorders 
  Chapter: "Werner syndrome." 
  Oshima J, Martin GMLippincott, Williams & Wilkins, Philadelphia2003
• Chromosomal Instability and Aging: Basic Science and Clinical Implications 
  Chapter: "Introduction." 
  Page 1 - 8Martin GMEditors: Hisama FM, Weissman SM, Martin GM.Marcel Dekker, New York2003
• Chromosomal Instability and Aging: Basic Science and Clinical Implications 
  Chapter: "Conclusions and Future Directions." 
  Page 565 - 573Hisama FM, Weissman SM, Martin GMEditors: Hisama FM, Weissman SM, Martin GM.Marcel Dekker, New York2003
• National Academy of Sciences Biographical Memoirs 
  Chapter: "Earl Philip Bendit, 1916-1996." 
  Page 1 - 24Lagunoff D, Martin GMThe National Academy Press2002
• The Genetic Basis of Common Disease 
  Chapter: "Genetic Modulation of Aging and Longevity." 
  Page 964 - 974Martin GMEditors: King RA, Rotter JI, Motulsky AG.Oxford University Press, New YorkEdition 2nd,2002
• Vulnerability and aging: can they be prevented, delayed or controlled? (Les colloques de L'Institut Servier) 
  Chapter: "Role of genetics in the modulation of longevity." 
  Page 161 - 166Martin GMElsevier SAS, Paris2002
• Drug Discovery and Development for Alzheimer's Disease 
  Chapter: "Novel tricyclic pyrone compounds prevent intracellular APP C99-induced cell death." 
  Jin LW, Hua DH, Shie FS, Maezawa I, Sopher B, Martin GMEditors: HM Fillit, AW O'Connell.Springer, New York2002
• The Metabolic and Molecular Bases of Inherited Disease 
  Chapter: "Genetics and aging." 
  Page 215 - 223Martin GMEditors: Scriver, C.R., Beaudet, A.L., Sly, W.S., Valle, D..McGraw-Hill Pub. Co., New York, NYEdition 8th,2001
• From Premature Gray Hair to Helicase-Werner Syndrome: Implications for Aging and Cancer 
  Chapter: "A Brief History of Research on the Werner Syndrome." 
  Page 1 - 10Martin GMEditors: M. Goto and R. Miller.Japan Scientific Societies Press, Tokyo, Japan2001
• The Science of Geriatrics 
  Chapter: "Genetic determinants of aging." 
  Page 46 - 56Martin GMEditors: J.E. Morley, H.J. Armbrecht, R.M. Coe, and B. Vellas.SERDI; Springer Pub. Co., Paris; New York2000
• Cell and Surveys: Should Biological Measures be Included in Social Science Research? 
  Chapter: "Opportunities for Population-Based Reasearch on Aging Human Subjects: Pathology and Genetics." 
  Page 133 - 158Martin GM, Hu QNational Academy Press (NAP)2000
• Molecular Biology of Aging, Alfred Benzon Symposium 44 
  Chapter: "Genetic approaches to aging research: opportunities for progress utilizing avian, murine and human species." 
  Page 17 - 24Martin GMEditors: Bohr V, Clark B, Stevnsner T.Copenhagen1999
• Paradoxes of Longevity 
  Chapter: "Genes that modulate longevity and senescence." 
  Page 11 - 21Martin GMEditors: Robine JM, et al.Berlin1999
• The Role of DNA Damage and Repair in Cell Aging 
  Chapter: "Gene Action at the Werner helicase locus: its role in the pathobiology of Aging." 
  Oshima J, Martin GM, Gray MD, Poot M, Rabinovitch PSEditors: Gilchrest BA, Bohr VA.JAI Press, Stamford, CT1999
• Handbook of the Aging Brain 
  Chapter: "Toward a genetic analysis of unusually successful neural aging." 
  Page 125 - 134Martin GMEditors: Wang E, Snyder DS.Academic Press, San Diego1998
• Evolution of Health and Disease 
  Chapter: "Evolution, Senescence, and health in old age." 
  Page 219 - 230Kirkwood TBL, Martin GM, Partridge LEditors: Stearns SC.1998
• Health Care for the Older Woman 
  Chapter: "The biology of aging." 
  Page 21 - 353Martin GMEditors: Stenchever MA.Chapman & Hall, New York1996
• Alzheimer's Disease: Cause(s), Diagnosis, Treatment, and Care 
  Chapter: "Intrinsic biological aging as underlying pathogenic mechanisms." 
  Page 177 - 185Martin GMEditors: Khachaturian ZS, Radebaugh TS.CRC Press1996
• Join now to see all

Abstracts/Posters

• The Roles of Nature, Nurture and Chance in the Genesis of Variable Trajectories of Aging.
  Martin, G.M., Japanese Journal of Geriatrics, 1/1/2013
• Age-related cataract in anti-oxidant altered mice.
  Wolf, N.S., Pendergrass, W., VanRemmen, H., Bartke, A., Rabinovitch, P.S., Martin, G.M., Investigative Ophthamology & Visual Science, 1/1/2005
• Genetic, environmental and stochastic modulations of biological aging and its sequelae of geriatric disorders.
  Martin, G.M., Neurobiology of Aging, 1/1/2004
• Female mice transgenic for mitochondrial-directed catalase have altered glutathione redox cycle enzyme activities coincident with tissue specific catalase expression.
  Shi, S., Hendsch, M.B., Ogburn, C.E., Rabinovitch, P.S., Martin, G.M., Kavanagh, T., Toxicological Sciences, 1/1/2003
• Novel tricyclic pyrone compounds prevent intracellular A-beta-related cell death.
  Maezawa, I., Hua, D.H., Shie, F., Alvord, E., Martin, G.M., Jin, L-W., J Neuropath Exp Neurol, 1/1/2002
• Modeling a Concept-Based Information System to Promote Scientific Disovery: The Telemakus System.
  Fuller S, Revere D, Soderland S, Bugni P, Kadiyska Y, Reber L, Fuller H, Martin G, AMIA 2002 Annual Symposium Proceedings, 1/1/2002
• Public and private genetic modulations of the pathobiology of senescence.
  Martin, G.M., Am J Phys Anthropol, 1/1/2000
• Expression of X11 mRNA, a modulator of the production of beta amyloid, in neurons, non-neuronal cells and Alzheimer brains.
  LoGerfo, S.E., Hu, Q., Martin, G.M., J Invest Med, 1/1/2000
• Complementation of 4NQO sensitivity in SGS1 mutant yeast by human Werner syndrome protein.
  Rowe, E.V., Martin, G.M., J. Invest. Med., 1/1/1999
• Mitochondrial genetic variants and Alzheimer's disease: Whale genome sequencing of ten pedigrees with a matrilineal pattern of inheritance.
  Edland, S.D., Rieder, M.J., Poot, M., et al., Neurology, 1/1/1999
• Emerging paradigms and new perspectives for human geneticists interested in the biology of aging.
  Martin, G.M., AGE, 1/1/1999
• Werner Syndrome and Genetic Instability.
  Shen, J.C., Kamath-Loeb, A.S., Blank, A., Martin, G.M., Oshima, J., Gray, M.D., Loeb, L.A., Proceedings of the Innovative Approaches to the Prevention, Diagnosis and Therapy of Cancer, 4th Joint Conference of the American Association for Cancer Research and the Japanese Cancer Association, Maui, HI, 1/16/1998
• Aging Theories.
  Martin, G.M., European Archives of Psychiatry and Clinical Neuroscience, Aging 2000 Joint Meeting, Munich, Germany, 1/13/1998
• What proportion of the human genome has the potential to modulate the pathobiology of aging?
  Martin, G.M., Meeting on the Genetics of Aging, Cold Spring Harbor Laboratory, New York, 1/2/1998
• Functional and biochemical studies of the WRN helicase defective in Werner syndrome, a human premature aging disorder.
  Nehlin, J.O., Orren, D.K., Brosh, R.B. Jr., Machwe, A., Balajee, A.S., Gray, M.D., Martin, G.M., Bohr, V.A., 29th Annual Conference of the Environmental Mutagen Society, Annaheim, CA, 1/1/1998
• Many Mutations in Cancer.
  Gray, M.D., Shen, J.C., Kamath-Loeb, A.S., Blank, A., Sopher, B. L., Martin, G.M., Oshima, J., Loeb, L.A., Proceedings of the Workshop on DNA Repair and Genome Instability, 68 Centro De Reuiniones Internacionales Sobre Biologia, Madride, Spain, 1/9/1997
• The pathobiology of the Werner syndrome.
  Martin, G.M., FASEB J, 1/1/1997
• Investigation of FE65 and its potential role in the etiology of Alzheimer's disease.
  Bressler, S.L., Gray, M.D., Sopher, B.L., Hu, Q., Hearn, M.G., Pham, D.G., Sisodia, S.S., Fukuchi, K., Deeb, S.S., Martin, G.M., Fifth International Conference on Alzheimer's Disease and Related Disorders, Osaka, Japan, 1/1/1996
• Baiting the yeast interaction trap with the minimal neuroprotective domain of secreted bPP's receptor.
  Sopher, B.L., Pham, D.G., Mattson, M.P., Martin, G.M., Soc Neurosci Abst, 1/1/1996
• Alzheimer's Ps-1 L286V Mutation increases neuronal vulnerability to Ab toxicity and trophic factor withdrawal-induiced apoptosis.
  Guo, Q., Sopher, B.L., Furukawa, K., Robinson, N., Martin, G.M., Mattson, M.P., Soc Neurosci Abst, 1/1/1996
• Progress in understanding the activity regulating and neuroprotective signal transduction pathway of secreted APP.
  Mattson, M.P., Furukawa, K., Sopher, B., Mark, R.J. and Martin, G.M., Soc Neurosci Abst, 1/1/1996
• Dominant Neuroprotective efficacy of a-secretase derived secreted-APP mediated by heparin-binding domain of Ab.
  Furukawa, K., Sopher, B.L., Rydel, R.E., Martin, G.M., Fox, M., Mattson, M.P., Soc Neurosci Abst, 1/1/1996
• Isolation and characterization of mouse cDNA fusion-proteins that interact with human-amyloid.
  Bressler, S.L., Gray, M.D., Fukuchi, K.-I., Martin, G.M., Soc Neurosci Abst, 1/1/1995
• Isolation and characterization of mouse cDNA fusion-proteins that interact with human beta-amyloid precursor protein.
  Bressler, S.L., Gray, M.D., Sopher, B.L., Hearn, M.G., Hu, Q., Fukuchi, K.I., Martin, G.M., Am J Hum Genet, 1/1/1995
• Enhancement of glutathione content in glutathione cynthetase-deficient fibroblasts from a patient with 5-oxoprolinuria via metabolic cooperation with normal fibroblasts.
  Kavanagh, T.J., Raghu, G., White, C.C., Martin, G.M., Rabinovitch, P.S., Eaton, D.L., Exp Cell Res, 1/1/1994
• Join now to see all

Lectures

• "The Roles of Nature, Nurture and Chance in the Genesis of Variable Trajectories of Aging" 
  Osaka, Japan - 1/1/2013
• Ellison Lecture, "How important are stochastic variations in gene expression in explaining intra-specific differences in the pace and patterns of aging?" 
  Hyderabad, India - 1/1/2011
• "Taking a Chance on Life: Epigenetic Gambling, Epigenetic Drift and Somatic Mutation Modulate Lifespan and Healthspan" 
  Andrus School of Gerontology, University of Southern California, Los Angeles, CA - 1/1/2011
• Summer Course, "The Biology of Aging" 
  Leyden Academy, Leiden, Netherlands - 1/1/2011
• NIA Summer Training Course, "The Biology of Aging" 
  Seattle, WA - 1/1/2011
• "Epigenetic gambling, epigenetic drift and the quasi-stochastic distributions of geriatric pathologies" 
  Shanghai, China - 1/1/2011
• "Elite Ageing: The Roles of Nature, Nurture and Chance & an Agenda for Discovering Relevant Gene Actions in People" 
  Rochester, MN - 1/1/2010
• "New Insights into Healthspan and Diseases of Aging: From Molecular to Functional Senescence, Human Diseases of Ageing and Their Evolutionary Substrates" 
  Tahoe City, CA - 1/1/2010
• "Some New Opportunities for Genetic Research on the Biology of Aging | Stochastic Modulations of Healthspan & Lifespan: Somatic Mutations & Epigenetic Gambling" 
  Boulder, CO - 1/1/2010
• "Some Unanswered Questions Regarding the Pathogenesis of the Vascular Pathology associated with Normative Aging and Progeria" 
  Boston, MA - 1/1/2010
• Keynote Lecture, "Twelve modalities of Gene Action that escape the force of natural selection and thus contribute to senescent phenotypes" 
  Les Diablerets, Switzerland - 1/1/2010
• Keynote Lecture, "Nature, Nature and Chance: Their Relative Contributions to Intra-Specific versus Inter-Specific Variations in Life Span and Health Span" 
  Copenhagen, Denmark - 1/1/2010
• Keynote Lecture, "Dr. Olivia Pereira-Smith's Retirement Reception" 
  University of Texas Health Science Center, San Antonio, TX - 1/1/2010
• Plenary Session: "Genetic and Epigenetic Control of Aging" 
  Hong Kong, China - 1/1/2009
• "Classes of gene action with the potential to modulate the times of onset and the rates of progression of neurodegenerative disorders" 
  Xiamen, China - 1/1/2009
• "Some Thoughts on Future Directions of Research on Lifespan and Healthspan" 
  New York, NY - 1/1/2009
• Keynote Lecture, "Systems Biology and the Biology of Aging" 
  Baltimore, MD - 1/1/2009
• "Workshop on Aging-From Molecules to Populations" 
  Copenhagen, Denmark - 1/1/2008
• "Biology of Ageing: Gerontogenes, Gerontogens and Luck" 
  Jonkoping, Sweden - 1/1/2008
• "Segmental and Unimodal Progeroid Syndromes of Homo sapiens" 
  Jonkoping, Sweden - 1/1/2008
• "Elite Aging" 
  Jonkoping, Sweden - 1/1/2008
• "Genome Dynamics & Instability in the Ageing Brain" 
  Asilomar Conference Center, Pacific Grove, CA - 1/1/2008
• "Summer Training Course on the Biology of Ageing" 
  Seattle, WA - 1/1/2008
• Keynote Lecture, "Pathology Retreat" 
  Seattle, WA - 1/1/2008
• "International Symposium Tissue Ageing: From Molecular Biology to Clinical Perspectives" 
  Halle, Germany - 1/1/2007
• Join now to see all

Other

• "Responses to George Martin's 2009 Aging Cell Paper on Epigenetic Gambling and Aging" 
  Martin, G.M., Yates, F.E., Promislow, D. and Rose, M.R., American Aging Association Web Forum 1 (eds. GM Martin and RJ Martin)
  http://www.americanaging.org/Forum/1/
  1/1/2010
• "HR 676 holds promise for a successful national health program" 
  Martin, G.M., Seattle Times
  http://seattletimes.nwsource.com/html/northwestvoices/2009470964_health-care_reform_national_pl.html
  1/14/2009
• "How is the evolutionary biological theory of aging holding up against mounting attacks? (With commentaries and responses by Dr. Martin)." 
  Martin, G.M., American Aging Association: AGE Newsletter
  1/1/2005
• "A knowledgebase system to enhance scientific discovery: Telemakus." 
  Fuller, S.S., Revere, D., Bugni, P.F., Martin, G.M., Biomedical Digital Libraries
  http://www.bio-diglib.com/content/1/1/2
  1/1/2004
• "Our Future Selves: Research, Education, and Services for Early Development and Childhood in an Aging Society." (Theme of the Gerontological Society of America 2003 An... 
  Martin, G.M.
  http://www.eshow2000.com/geron/2003/theme.cfm
  1/1/2003
• "Chromosomal Instability and Aging: Basic Science and Clinical Implications, Marcel Dekker, New York" 
  F.M Hisama, S.M. Weissman, G.M. Martin (eds.)
  1/1/2003
• "Help Wanted: Physiologists for Research on Aging." 
  Martin, G.M.
  http://sageke.sciencemag.org/cgi/content/full/sageke;2002/9/vp2
  1/6/2002
• Werner syndrome. 
  Leistritz, D.F., Hanson, N.B., Martin, G.M., Oshima, J., GeneReviews at GeneTests·GeneClinics: Medical Genetics Information Resource (database online)
  https://www.genetests.org/
  1/1/2002
• "More kudos for our social science colleagues." 
  Martin, G.M.
  http://sageke.sciencemag.org/cgi/eletters/sageke;2001/2/vp4#EL1
  1/11/2001
• "SAGE KE: An Intellectual Home for Scientists Who Seek to Understand Why and How Organisms Age." 
  Martin, G.M.
  http://sageke.sciencemag.org/cgi/content/full/sageke;2001/1/vp2
  1/3/2001
• "Genetic Epidemiologic Studies on Age-Specified Traits." 
  Martin, G.M.
  http://www.nia.nih.gov/conferences/geneticreport111199.htm
  1/1/1999
• Editor: "Molecular Aspects of Aging: Life Sciences Research Report 56. John Wiley & Sons, Chichester, England" 
  Esser K, and Martin GM
  1/1/1995
• "Biological processes. Introduction." 
  Martin, G.M., The Threshold of Discovery: Future Directions for Research on Aging. Report of the Task force on Agi
  1/1/1995
• "Molecular Aspects of Aging: Life Sciences Research Report 56, John Wiley & Sons, Chichester, England" 
  K. Esser and G.M. Martin (eds.)
  1/1/1995
• "Definitions on aging. Background paper contributed to: Environmental Health Criteria 144: Principles for Evaluating Chemical Effects on the Aged Population." 
  Martin GM, World Health Organization
  Geneva - 1/1/1993
• "Proceedings of a United States-Japan Cooperative Seminar on Werner's Syndrome and Human Aging, December 10-12, 1982, Kobe, Japan. Advances in Experimental Medicine an... 
  Salk D, Fujiwara Y, and Martin GM (eds.)
  1/1/1985
• "Werner's Syndrome and Human Aging, Plenum Press, New York" 
  D. Salk, Y. Fujiwara, and G.M. Martin (eds.)
  1/1/1985
• "Integration of geriatric content in the basic sciences." 
  Martin GM, Proceedings of the Regional Institutes on Geriatrics and Medical Education, American Assocication of
  Washington, DC - 1/1/1983
• "Frontiers in molecular and genetic aspects of aging." 
  Martin GM, Biological and Behavior Science Frontiers in Aging Symposium Proceedings, pp. 23-35
  Washington State University - 1/12/1981
• "Looking at human chromosomes." 
  Hoehn H, Norwood TH, Martin GM, Northwest Health Team Approach
  1/1/1975
• "Resistance to mercurial diuretics in congestive heart failure." Medical Honors Thesis 
  Martin, G.M.
  University of Washington School of Medicine, Seattle, WA - 1/1/1953
• "Werner Syndrome." 
  Oshima J, Martin GM, Hisama FM, GeneTests·GeneClinics: Medical Genetics Information Resource (database online)
  http://www.genetests.org
• Join now to see all