GeorgeThalodyMD

PubMed

• 11 citations
  Discovery of ()-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally...
  Guanglin Luo, Ling Chen, Walter A Kostich, Brian Hamman, Jason Allen, Amy Easton, Clotilde Bourin, Michael Gulianello, Jonathan Lippy, Susheel Nara, Tarun Kumar Maisha...> ;Journal of Medicinal Chemistry. 2022 Mar 24
• 9 citations
  Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) ...
  Guanglin Luo, Ling Chen, Walter A Kostich, Brian Hamman, Jason Allen, Amy Easton, Clotilde Bourin, Michael Gulianello, Jonathan Lippy, Susheel Nara, Sreenivasulu Naidu...> ;Journal of Medicinal Chemistry. 2022 Mar 24
• 10 citations
  Azepino-indazoles as calcitonin gene-related peptide (CGRP) receptor antagonists.
  Stephen E. Mercer, Chaturvedula Prasad, Charles M. Conway, Deborah A. Cook, Carl Davis, Sokhom S. Pin, Robert Macci, Richard Schartman, Laura J. Signor, Kimberly A. Wi...> ;Bioorganic & Medicinal Chemistry Letters. 2021 Jan 1
• 23 citations
  Assessing seizure liability using multi-electrode arrays (MEA).
  Jingsong Fan, George Thalody, Jae Kwagh, Elisabeth Burnett, Hong Shi, Geoff Lewen, Shen-Jue Chen, Paul Levesque> ;Toxicology in Vitro. 2019 Mar 1
• 22 citations
  Discovery of (R)-N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-carboxamide (BMS-742413...
  Chaturvedula Prasad, Stephen E. Mercer, Sokhom S. Pin, George Thalody, Cen Xu, Charlie M. Conway, Deborah Keavy, Laura J. Signor, Glenn H. Cantor, Neil Mathias, Paul M...> ;Bioorganic & Medicinal Chemistry Letters. 2013 Jun 1
• 4 citations
  The synthesis and SAR of calcitonin gene-related peptide (CGRP) receptor antagonists derived from tyrosine surrogates. Part 2.
  Xiaojun Han, Rita L. Civiello, Charles M. Conway, Deborah A. Cook, Carl D. Davis, Andrew P. Degnan, Xiang-Jun Jiang, Robert Macci, Neil Mathias, Paul Moench, Sokhom S....> ;Bioorganic & Medicinal Chemistry Letters. 2013 Mar 15
• 44 citations
  Discovery of (R)-4-(8-fluoro-2-oxo-1,2-dihydroquinazolin-3(4H)-yl)-N-(3-(7-methyl-1H-indazol-5-yl)-1-oxo-1-(4-(piperidin-1-yl)piperidin-1-yl)propan-2-yl)piperidine-1-c...
  Andrew P. Degnan, Chaturvedula Prasad, Charles M. Conway, Deborah A. Cook, Carl D. Davis, Rex Denton, Xiaojun Han, Robert Macci, Neil Mathias, Paul Moench, Sokhom S. P...> ;Journal of Medicinal Chemistry. 2008 Jul 30
• 28 citations
  Chemical genetics reveals an RGS/G-protein role in the action of a compound.
  Kevin Fitzgerald, Svetlana Tertyshnikova, Lisa Moore, Lynn Margaret Bjerke, Ben Burley, Jian Cao, Pamela M. Carroll, Robert Choy, Steve Doberstein, Yves Dubaquie, Yvon...> ;Plos Genetics. 2006 Apr 21
• 45 citations
  BL-1249 [(5,6,7,8-Tetrahydro-naphthalen-1-yl)-[2-(1H-tetrazol-5-yl)-phenyl]-amine]: A Putative Potassium Channel Opener with Bladder-Relaxant Properties
  Svetlana Tertyshnikova, Ronald J. Knox, Mary Jane Plym, George Thalody, Corinne Griffin, Torben R. Neelands, David G. Harden, Laura J. Signor, David Weaver, Robert A. ...> ;The Journal of Pharmacology and Experimental Therapeutics. 2005 Apr 1
• 25 citations
  The synthesis and structure–activity relationships of 1,3-diaryl 1,2,4-(4H)-triazol-5-ones: A new class of calcium-dependent, large conductance, potassium (maxi-k) cha...
  Piyasena Hewawasam, Matthew Erway, George Thalody, Harvey Weiner, Christopher G. Boissard, Valentin K. Gribkoff, Nicholas A. Meanwell, Nicholas J. Lodge, John E. Starrett> ;Bioorganic & Medicinal Chemistry Letters. 2002 Apr 8
• 3 citations
  Kinetic characterization of adenosine A2 receptor-mediated relaxation in isolated rabbit aorta.
  Harvey L. Wiener, George P. Thalody> ;European Journal of Pharmacology. 1993 Jul 6
• 8 citations
  Interactions between responses mediated by activation of adenosine A2 receptors and alpha 1-adrenoceptors in the rabbit isolated aorta.
  Harvey L. Wiener, George P. Thalody, Saul Maayani> ;British Journal of Pharmacology. 1993 Jun 1
• 7 citations
  Kinetics of relaxation responses to vasorelaxants in isolated rabbit aorta.
  Harvey L. Wiener, Jacinta Murray, George P. Thalody, Saul Maayani> ;European Journal of Pharmacology. 1992 Sep 22
• Partially purified Grammostola spatulata venom inhibits stretch activated calcium signaling in bladder myocytes and improves bladder compliance in an in vitro rat whol...
  Tertyshnikova, S., Matson, J. A., Thalody, G., Lodge, N. J.> ;J Urol. 2003 Feb
• Differential attenuation of the responses to adenosine and methoxamine in isolated rabbit aorta.
  Wiener, H. L., Thalody, G. P.> ;J Pharmacol Exp Ther. 1993 Nov
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