GeroldBeplerMD

Oncology • Detroit, MI

Physician

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Office
4100 John R
HW02EA
Detroit, MI 48201
Phone+1 313-576-8670

Fax+1 313-576-8628
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Education & Training

Duke University HospitalFellowship, Hematology and Medical Oncology, 1987 - 1991
Philipps University of Marburg Faculty of MedicineClass of 1983

Certifications & Licensure

MI State Medical License 2010 - 2024
FL State Medical License 2001 - 2011
NC State Medical License 1989 - 1999

Clinical Trials

Safety and Efficacy Study of Glufosfamide in Patients With Recurrent Sensitive Small Cell Lung Carcinoma Start of enrollment: 2007 Feb 01
Terminated
Phase 2
A Study of Emibetuzumab in Non Small Cell Lung Cancer (NSCLC) Participants Start of enrollment: 2013 Aug 01
Completed
Phase 2
Gene Expression Levels in Predicting Treatment Response in Patients With Stage IV Non-small Cell Lung Cancer Start of enrollment: 2014 Jun 01
Terminated
Not Applicable
Comprehensive Genomic Analysis in Tissue Samples From Patients With Recurrent or Stage IV Non-small Cell Lung Cancer Start of enrollment: 2014 Jun 01
Recruiting
Not Applicable
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Publications & Presentations

PubMed

1 citations
Acetylation of MLH1 by CBP increases cellular DNA mismatch repair activity.
Mu Zhang, Jiawei Zhao, Peter M Glazer, Wenlong Bai, Gerold Bepler, Xiaohong Mary Zhang> ;Journal of Biochemistry. 2023 Jul 31
1 citations
Identification of actionable targets for breast cancer intervention using a diversity outbred mouse model.
Jennifer B Jacob, Kuang-Chung Wei, Gerold Bepler, Joyce D Reyes, Andi Cani, Lisa Polin, Kathryn White, Seongho Kim, Nerissa Viola, Julie McGrath, Anthony Guastella, Co...> ;Iscience. 2023 Apr 21
1 citations
ATR inhibition overcomes platinum tolerance associated with ERCC1- and p53-deficiency by inducing replication catastrophe.
Joshua R Heyza, Elmira Ekinci, Jacob Lindquist, Wen Lei, Christopher Yunker, Vilvanathan Vinothkumar, Rachelle Rowbotham, Lisa Polin, Natalie G Snider, Eric Van Buren,...> ;NAR Cancer. 2023 Mar 1
5 citations
The Mechanisms of Zinc Action as a Potent Anti-Viral Agent: The Clinical Therapeutic Implication in COVID-19.
Ananda S Prasad, Agnes Malysa, Gerold Bepler, Andrew Fribley, Bin Bao> ;Antioxidants. 2022 Sep 21
10 citations
A Randomized, Open-Label Phase II Study Evaluating Emibetuzumab Plus Erlotinib and Emibetuzumab Monotherapy in MET Immunohistochemistry Positive NSCLC Patients with Ac...
D Ross Camidge, Teresa Moran, Ingel Demedts, Heidrun Grosch, Kathryn Mileham, Julian Molina, Oscar Juan-Vidal, Gerold Bepler, Jonathan W Goldman, Keunchil Park, Johan ...> ;Clinical Lung Cancer. 2022 Jun 1
3 citations
Role of novel cancer gene SLITRK3 to activate NTRK3 in squamous cell lung cancer
Aliccia Bollig-Fischer, Bin Bao, Morenci Manning, Greg Dyson, Sharon K. Michelhaugh, Sandeep Mittal, Gerold Bepler, Hirva Mamdani> ;Molecular Biomedicine. 2021 Dec 1
13 citations
The Effects of HER2 Alterations in EGFR Mutant Non-small Cell Lung Cancer.
Misako Nagasaka, Vijendra Singh, Yasmine Baca, Ammar Sukari, Chul Kim, Hirva Mamdani, Alexander I. Spira, Dipesh Uprety, Gerold Bepler, Edward S. Kim, Luis E. Raez, Sa...> ;Clinical Lung Cancer. 2021 Oct 18
2 citations
Impact of XPO1 mutations on survival outcomes in metastatic non-small cell lung cancer (NSCLC)
Misako Nagasaka, Mohammad Fahad Bin Asad, Mohammed Najeeb Al Hallak, Hafiz Uddin, Ammar Sukari, Yasmine Baca, Joanne Xiu, Dan Magee, Hirva Mamdani, Dipesh Uprety, Chul...> ;Lung Cancer. 2021 Aug 27
2 citations
Implications of the USP10-HDAC6 axis in lung cancer - A path to precision medicine.
Xiaohong Mary Zhang, Navnath Gavande, Prahlad Parajuli, Gerold Bepler> ;Journal of Cancer Biology. 2021 Jan 1
9 citations
HDAC6 Regulates Radiosensitivity of Non-Small Cell Lung Cancer by Promoting Degradation of Chk1.
Niko Moses, Mu Zhang, Jheng Yu Wu, Chen Hu, Shengyan Xiang, Xinran Geng, Yue Chen, Wenlong Bai, You Wei Zhang, Gerold Bepler, Xiaohong Mary Zhang> ;Cells. 2020 Oct 4
36 citations
The USP10-HDAC6 axis confers cisplatin resistance in non-small cell lung cancer lacking wild-type p53.
Chen Hu, Mu Zhang, Niko Moses, Cong li Hu, Lisa Polin, Wei Chen, Hyejeong Jang, Joshua Heyza, Agnes Malysa, Joseph A. Caruso, Shengyan Xiang, Steve M. Patrick, Paul M....> ;Cell Death & Disease. 2020 May 7
24 citations
Physical activity and quality of life in African American cancer survivors: The Detroit Research on Cancer Survivors study
Jennifer L. Beebe-Dimmer, Julie J. Ruterbusch, Felicity W. K. Harper, Tara M. Baird, David G. Finlay, Andrew Rundle, Stephanie S. Pandolfi, Theresa A. Hastert, Kendra ...> ;Cancer. 2020 May 1
14 citations
Profiling the mutational landscape in known driver genes and novel genes in African American non-small cell lung cancer patients
Christine M. Lusk, Donovan Watza, Gregory Dyson, Douglas B. Craig, Valerie Ratliff, Angela S. Wenzlaff, Fulvio Lonardo, Aliccia Bollig-Fischer, Gerold Bepler, Kristen ...> ;Clinical Cancer Research. 2019 Jul 15
13 citations
Identification and Characterization of Synthetic Viability with ERCC1 Deficiency in Response to Interstrand Crosslinks in Lung Cancer.
Joshua Heyza, Wen Lei, Donovan Watza, Hao Zhang, Wei Chen, Jessica B. Back, Ann G. Schwartz, Gerold Bepler, Steve M. Patrick> ;Clinical Cancer Research. 2019 Apr 15
22 citations
HDAC6 regulates DNA damage response via deacetylating MLH1
Mu Zhang, Chen Hu, Niko Moses, Joshua Haakenson, Shengyan Xiang, Daniel Quan, Bin Fang, Zhe Yang, Wenlong Bai, Gerold Bepler, Guo Min Li, Xiaohong Mary Zhang> ;The Journal of Biological Chemistry. 2019 Apr 12
36 citations
Randomized-controlled phase II trial of salvage chemotherapy after immunization with a TP53-transfected dendritic cell-based vaccine (Ad.p53-DC) in patients with recur...
Alberto Chiappori, Charles C. Williams, Jhanelle E. Gray, Tawee Tanvetyanon, Eric B. Haura, Ben C. Creelan, Ram Thapa, Dung-Tsa Chen, George R. Simon, Gerold Bepler, D...> ;Cancer Immunology, Immunotherapy. 2019 Mar 1
4 citations
Prognostic modeling of the immune-centric transcriptome reveals interleukin signaling candidates contributing to differential patient outcomes
Donovan Watza, Christine M. Lusk, Gregory Dyson, Kristen S. Purrington, Kang Chen, Angela S. Wenzlaff, Valerie Ratliff, Christine Neslund-Dudas, Gerold Bepler, Ann G. ...> ;Carcinogenesis. 2018 Dec 31
7 citations
Chronic p27 Kip1 Induction by Dexamethasone Causes Senescence Phenotype and Permanent Cell Cycle Blockade in Lung Adenocarcinoma Cells Over-expressing Glucocorticoid R...
Mugdha Patki, Thomas McFall, Rayna Rosati, Yanfang Huang, Agnes Malysa, Lisa Polin, Abigail Fielder, Mike R. Wilson, Fulvio Lonardo, Jessica B. Back, Jing Li, Larry H....> ;Scientific Reports. 2018 Oct 30
10 citations
A CARP-1 functional mimetic compound is synergistic with BRAF-targeting in non-small cell lung cancers.
Vino T. Cheriyan, Hashem O. Alsaab, Sreeja C. Sekhar, Jaganathan Venkatesh, Arindam Mondal, Imran Vhora, Samaresh Sau, Magesh Muthu, Lisa Polin, Edi Levi, Gerold Beple...> ;Oncotarget. 2018 Jul 3
12 citations
RUMI is a novel negative prognostic marker and therapeutic target in non-small-cell lung cancer
May Chammaa, Agnes Malysa, Carlos Redondo, Hyejeong Jang, Wei Chen, Gerold Bepler, Rodrigo Fernandez-Valdivia> ;Journal of Cellular Physiology. 2018 Jun 28
94 citations
SMARCA4/BRG1 Is a Novel Prognostic Biomarker Predictive of Cisplatin-Based Chemotherapy Outcomes in Resected Non-Small Cell Lung Cancer.
Erica Hlavin Bell, Arup R. Chakraborty, Xiaokui Mo, Ziyan Liu, Konstantin Shilo, Simon Kirste, Petra Stegmaier, Maureen McNulty, Niki Karachaliou, Rafael Rosell, Gerol...> ;Clinical Cancer Research. 2016 May 15
26 citations
Histone deacetylase 6 (HDAC6) deacetylates extracellular signal-regulated kinase 1 (ERK1) and thereby stimulates ERK1 activity.
Jheng-Yu Wu, Shengyan Xiang, Mu Zhang, Bin Fang, He Huang, Oh Kwang Kwon, Yingming Zhao, Zhe Yang, Wenlong Bai, Gerold Bepler, Xiaohong Mary Zhang> ;The Journal of Biological Chemistry. 2017 Dec 19
7 citations
Precision Medicine and Pancreatic Cancer: A Gemcitabine Pathway Approach.
James J. Farrell, Jennifer Moughan, Jonathan L. Wong, William F. Regine, Paul L. Schaefer, Al B. Benson, Xiyong Liu, Yun Yen, Raymond Lai, Zhong Zheng, Gerold Bepler, ...> ;Pancreas. 2016 Nov 1
A small molecule inhibits Akt through direct binding to Akt and preventing Akt membrane translocation.
Kim D, Sun M, He L, Zhou Q, Chen J, Sun X, Bepler G, Sebti SM, Cheng JQ> ;J. Biol. Chem.. 2016-10-21
42 citations
Identification of small molecule inhibitors of ERCC1-XPF that inhibit DNA repair and potentiate cisplatin efficacy in cancer cells
Sanjeevani Arora, Joshua Heyza, Hao Zhang, Vivian Kalman-Maltese, Kristin Tillison, Ashley M. Floyd, Elaine M. Chalfin, Gerold Bepler, Steve M. Patrick> ;Oncotarget. 2016 Sep 16
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Press Mentions

McLaren Health Care and Karmanos Cancer Institute CEOs Listed on DBusiness Magazine’s “Detroit 500” For the Second Consecutive YearAugust 10th, 2022
Brian Gamble Named President of Barbara Ann Karmanos Cancer HospitalJuly 26th, 2022
Wayne State University and Karmanos Cancer Institute Express Gratitude for $100 Million from State for New Medical Education-Research SiteJuly 25th, 2022
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