Gilbert D. A.PadulaMD

Radiation Oncology • Avon, OH

Breast Cancer, Head & Neck

Chief Medical Officer and Market Medical Director, Case Management

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Office
UH Seidman Cancer Center
2075 Healthway Dr UH Avon Health Center, 1st Fl
Avon, OH 44011
Phone+1 440-517-9000

Fax+1 216-201-5978
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Summary

Dr. Gilbert D. A. Padula is a highly experienced Radiation Oncologist based in Avon, OH, with subspecialties in Breast Cancer and Head & Neck Oncology. His education includes a medical degree from Michigan State University College of Human Medicine, an internship at St Joseph Mercy Ann Arbor, and residency at Memorial Sloan Kettering Cancer Center. He served as Chief Medical Officer at University Hospitals St. John Medical Center and held academic positions at Michigan State University College of Human Medicine, where he continues to contribute as a Clinical Professor. Dr. Padula has extensive experience in clinical research, clinical protocols, and neoplasm staging, among other areas. He is also a published author with several influential papers to his credit and has led numerous clinical trials. His work has been recognised with prestigious honours, including the Platinum Award for Clinical Trial Accrual from the National Cancer Institute and the Alpha Omega Alpha.

Education & Training

Memorial Sloan Kettering Cancer CenterResidency, Radiation Oncology, 1988 - 2002
St Joseph Mercy Ann ArborInternship, Transitional Year, 1997 - 1998
Michigan State University College of Human MedicineClass of 1997

Certifications & Licensure

OH State Medical License 2017 - 2026
MI State Medical License 2002 - 2024
PA State Medical License 2016 - 2021
NY State Medical License 1999 - 2002
American Board of Radiology Radiation Oncology

Awards, Honors, & Recognition

Platinum Award for Clinical Trial Accrual National Cancer Institute (NCI)
Alpha Omega Alpha

Clinical Trials

Cytogenetic Studies in Acute Leukemia and Multiple Myeloma Start of enrollment: 1984 Jun 01
Active, not recruiting
Radiation Therapy (WBI Versus PBI) in Treating Women Who Have Undergone Surgery For Ductal Carcinoma In Situ or Stage I or Stage II Breast Cancer Start of enrollment: 2005 Mar 01
Completed
Not Applicable
Chemotherapy With or Without Bevacizumab in Treating Patients With Stage IB, Stage II, or Stage IIIA Non-small Cell Lung Cancer That Was Removed By Surgery Start of enrollment: 2007 Jun 01
Active, not recruiting
Phase 3
Surgery With or Without Docetaxel and Leuprolide or Goserelin in Treating Patients With High-Risk Localized Prostate Cancer Start of enrollment: 2007 May 08
Active, not recruiting
Phase 3
S0535, Gemtuzumab and Combination Chemotherapy in Treating Patients With Previously Untreated Acute Promyelocytic Leukemia Start of enrollment: 2007 Nov 15
Completed
Phase 2
Carboplatin, Paclitaxel and Gemcitabine Hydrochloride With or Without Bevacizumab After Surgery in Treating Patients With Recurrent Ovarian, Epithelial, Primary Peritoneal, or Fallopian Tube Cancer Start of enrollment: 2007 Dec 06
Active, not recruiting
Phase 3
Chemotherapy With or Without Bevacizumab in Treating Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma Start of enrollment: 2008 Aug 08
Active, not recruiting
Phase 3
Diet and Physical Activity Change or Usual Care in Improving Progression-Free Survival in Patients With Previously Treated Stage II, III, or IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer Start of enrollment: 2012 Jun 18
Recruiting
Phase 3
Radiation Therapy With or Without Trastuzumab in Treating Women With Ductal Carcinoma In Situ Who Have Undergone Lumpectomy Start of enrollment: 2008 Nov 10
Active, not recruiting
Phase 3
S0816 Fludeoxyglucose F 18-PET/CT Imaging and Combination Chemotherapy With or Without Additional Chemotherapy and G-CSF in Treating Patients With Stage III or Stage IV Hodgkin Lymphoma Start of enrollment: 2009 Jul 01
Completed
Phase 2
S0702: Osteonecrosis of the Jaw in Patients With Cancer Receiving Zoledronic Acid for Bone Metastases Start of enrollment: 2008 Dec 01
Completed
Radiation Therapy With Concomitant and Adjuvant Temozolomide Versus Radiation Therapy With Adjuvant PCV Chemotherapy in Patients With Anaplastic Glioma or Low Grade Glioma Start of enrollment: 2009 Sep 01
Recruiting
Phase 3
Studying Tissue and Blood Samples From Patients With Acute Myeloid Leukemia Start of enrollment: 2008 Jun 01
Active, not recruiting
Image-Guided Radiosurgery or Stereotactic Body Radiation Therapy in Treating Patients With Localized Spine Metastasis Start of enrollment: 2009 Nov 01
Completed
Phase 2, Phase 3
Radiation Therapy With or Without Androgen-Deprivation Therapy in Treating Patients With Prostate Cancer Start of enrollment: 2009 Sep 01
Active, not recruiting
Phase 3
Gemcitabine Hydrochloride and Cisplatin With or Without Bevacizumab in Treating Patients With Advanced Urinary Tract Cancer Start of enrollment: 2009 Jul 15
Completed
Phase 3
S0819: Carboplatin and Paclitaxel With or Without Bevacizumab and/or Cetuximab in Treating Patients With Stage IV or Recurrent Non-Small Cell Lung Cancer Start of enrollment: 2009 Jul 15
Terminated
Phase 3
Paclitaxel and Carboplatin or Ifosfamide in Treating Patients With Newly Diagnosed, Persistent or Recurrent Uterine, Ovarian, Fallopian Tube, or Peritoneal Cavity Cancer Start of enrollment: 2009 Aug 17
Active, not recruiting
Phase 3
Lymphedema After Surgery in Patients With Endometrial Cancer, Cervical Cancer, or Vulvar Cancer Start of enrollment: 2012 Jun 01
Unknown status
Not Applicable
Carboplatin, Paclitaxel, and Bevacizumab With or Without Everolimus in Treating Patients With Metastatic Malignant Melanoma Start of enrollment: 2010 Apr 01
Completed
Phase 2
Lisinopril or Coreg CR® in Reducing Side Effects in Women With Breast Cancer Receiving Trastuzumab Start of enrollment: 2010 Mar 01
Completed
Phase 2
Gemcitabine Hydrochloride and Docetaxel With or Without Bevacizumab in Treating Patients With Advanced or Recurrent Uterine Leiomyosarcoma Start of enrollment: 2009 Nov 01
Terminated
Phase 3
Phase III Randomized Trial of Clofarabine as Induction and Post-Remission Therapy vs. Standard Daunorubicin & Cytarabine Induction and Intermediate Dose Cytarabine Post-Remission Therapy, Followed by Decitabine Maintenance vs. Observation in Newly-Diagnos Start of enrollment: 2011 Jan 01
Gemcitabine Hydrochloride or Pemetrexed Disodium and Carboplatin With or Without Celecoxib in Treating Patients With Advanced Non-Small Cell Lung Cancer Start of enrollment: 2010 Feb 01
Terminated
Phase 3
Radiation Therapy in Treating Patients With Extensive Stage Small Cell Lung Cancer Start of enrollment: 2010 Mar 01
Completed
Phase 2
S0931, Everolimus in Treating Patients With Kidney Cancer Who Have Undergone Surgery Start of enrollment: 2011 Apr 01
Active, not recruiting
Phase 3
Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Celecoxib in Treating Patients With Stage III Colon Cancer Previously Treated With Surgery Start of enrollment: 2010 Jun 01
Active, not recruiting
Phase 3
Ofatumumab in Treating Patients With Previously Untreated Stage II, Stage III, or Stage IV Follicular Non-Hodgkin Lymphoma Start of enrollment: 2011 Aug 01
Completed
Phase 2
Vitamin D and Breast Cancer Biomarkers in Female Patients Start of enrollment: 2010 Oct 01
Completed
Phase 3
Diet in Altering Disease Progression in Patients With Prostate Cancer on Active Surveillance Start of enrollment: 2011 Jan 01
Completed
Phase 3
Early Surgery or Standard Palliative Therapy in Treating Patients With Stage IV Breast Cancer Start of enrollment: 2011 May 16
Completed
Not Applicable
Tamoxifen Citrate, Letrozole, Anastrozole, or Exemestane With or Without Chemotherapy in Treating Patients With Invasive RxPONDER Breast Cancer Start of enrollment: 2011 Jan 15
Active, not recruiting
Phase 3
Chemotherapy With or Without Trastuzumab After Surgery in Treating Women With Invasive Breast Cancer Start of enrollment: 2011 Jan 06
Active, not recruiting
Phase 3
Study of Biomarkers Associated With Fatigue in Patients With Early-Stage Breast Cancer Treated With Metformin or Placebo on NCIC-CTG-MA.32 Start of enrollment: 2011 Jul 01
Unknown status
Ofatumumab and Bendamustine Hydrochloride With or Without Bortezomib in Treating Patients With Untreated Follicular Non-Hodgkin Lymphoma Start of enrollment: 2011 Apr 08
Active, not recruiting
Phase 2
Combination of BKM120 and Bevacizumab in Refractory Solid Tumors and Relapsed/Refractory Glioblastoma Multiforme Start of enrollment: 2011 Dec 01
Completed
Phase 1, Phase 2
S0820, Adenoma and Second Primary Prevention Trial Start of enrollment: 2013 Aug 23
Active, not recruiting
Phase 3
Cisplatin and Radiation Therapy With or Without Carboplatin and Paclitaxel in Patients With Locally Advanced Cervical Cancer Start of enrollment: 2012 Jan 09
Completed
Phase 3
Relating Clinical Outcomes in Multiple Myeloma to Personal Assessment of Genetic Profile Start of enrollment: 2011 Jul 01
Completed
S1201: Combination Chemo for Patients W/Advanced or Metastatic Esophageal, Gastric, or Gastroesophageal Junction Cancer Start of enrollment: 2012 Feb 01
Completed
Phase 2
Morphotek Investigation in Colorectal Cancer: Research of MORAb-004 (MICRO) Start of enrollment: 2012 Mar 27
Terminated
Phase 2
Trial of Eribulin/Cyclophosphamide or Docetaxel/Cyclophosphamide as Neoadjuvant Therapy in Locally Advanced HER2-Negative Breast Cancer Start of enrollment: 2012 Jun 01
Completed
Phase 2
Erlotinib Hydrochloride With or Without Bevacizumab in Treating Patients With Stage IV Non-small Cell Lung Cancer With Epidermal Growth Factor Receptor Mutations Start of enrollment: 2012 Mar 16
Completed
Phase 2
S1200: Acupuncture, Sham Acupuncture, or Wait List for Joint Symptoms Related to Aromatase Inhibitors in Pts W/Early-Stage Breast Cancer Start of enrollment: 2012 May 16
Completed
Not Applicable
Breast-Conserving Surgery and Radiation Therapy in Patients With Multiple Ipsilateral Breast Cancer Start of enrollment: 2012 Jul 01
Completed
Phase 2
Pazopanib Hydrochloride in Treating Patients With Metastatic Kidney Cancer Who Have No Evidence of Disease After Surgery Start of enrollment: 2012 Aug 08
Active, not recruiting
Phase 3
S1202: Duloxetine Hydrochloride for Muscle/Joint Pain in Early-Stage Breast Cancer Receiving Hormone Therapy Start of enrollment: 2013 May 15
Completed
Phase 3
Whole-Brain Radiation Therapy or Stereotactic Radiosurgery With or Without Lapatinib Ditosylate in Treating Patients With Brain Metastasis From HER2-Positive Breast Cancer Start of enrollment: 2012 Dec 06
Completed
Phase 2
Bevacizumab With or Without Anti-Endoglin Monoclonal Antibody TRC105 in Treating Patients With Recurrent Glioblastoma Multiforme Start of enrollment: 2012 Nov 01
Completed
Phase 1, Phase 2
Standard Versus Intensity-Modulated Pelvic Radiation Therapy in Treating Patients With Endometrial or Cervical Cancer Start of enrollment: 2012 Nov 01
Completed
Phase 3
Cytarabine and Daunorubicin Hydrochloride or Idarubicin and Cytarabine With or Without Vorinostat in Treating Younger Patients With Previously Untreated Acute Myeloid Leukemia Start of enrollment: 2013 Feb 12
Completed
Phase 3
S1216, Phase III ADT+TAK-700 vs. ADT+Bicalutamide for Metastatic Prostate Cancer Start of enrollment: 2013 Mar 08
Active, not recruiting
Phase 3
Cabozantinib-S-Malate Compared With Temozolomide or Dacarbazine in Treating Patients With Metastatic Melanoma of the Eye That Cannot Be Removed by Surgery Start of enrollment: 2013 Jul 31
Completed
Phase 2
Pazopanib Hydrochloride in Treating Patients With Progressive Carcinoid Tumors Start of enrollment: 2013 Sep 20
Active, not recruiting
Phase 2
Randomized Phase II Study of AB (Abraxane™, Bevacizumab) Versus Ipilimumab for 1st Line Therapy of Unresectable Stage IV Metastatic Malignant Melanoma (BRAF V600E Negative) Start of enrollment: 2013 Oct 01
Rituximab and Bendamustine Hydrochloride, Rituximab and Ibrutinib, or Ibrutinib Alone in Treating Older Patients With Previously Untreated Chronic Lymphocytic Leukemia Start of enrollment: 2013 Dec 09
Active, not recruiting
Phase 3
Trametinib or Combination Chemotherapy in Treating Patients With Refractory or Advanced Biliary or Gallbladder Cancer or That Cannot Be Removed by Surgery Start of enrollment: 2014 Feb 01
Completed
Phase 2
Paclitaxel and Carboplatin With or Without Metformin Hydrochloride in Treating Patients With Stage III, IV, or Recurrent Endometrial Cancer Start of enrollment: 2014 Mar 17
Active, not recruiting
Phase 2, Phase 3
Clofarabine or Daunorubicin Hydrochloride and Cytarabine Followed By Decitabine or Observation in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia Start of enrollment: 2011 Feb 04
Active, not recruiting
Phase 3
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Publications & Presentations

PubMed

2 citations
Exploratory Analysis of Associations Between Whole Blood Mitochondrial Gene Expression and Cancer-Related Fatigue Among Breast Cancer Survivors.
Amber S Kleckner, Ian R Kleckner, Eva Culakova, Andrew P Wojtovich, N Jennifer Klinedinst, Sarah L Kerns, Sara J Hardy, Julia E Inglis, Gilbert D A Padula, Karen M Mus...> ;Nursing Research. 2022 Apr 13
8 citations
Nutritional Status Predicts Fatty Acid Uptake from Fish and Soybean Oil Supplements for Treatment of Cancer-Related Fatigue: Results from a Phase II Nationwide Study.
Amber S Kleckner, Eva Culakova, Ian R Kleckner, Elizabeth K Belcher, Wendy Demark-Wahnefried, Elizabeth A Parker, Gilbert D A Padula, Mary Ontko, Michelle C Janelsins,...> ;Nutrients. 2021 Dec 31
Adjuvant exemestane with ovarian suppression in premenopausal breast cancer.
Pagani O, Regan MM, Walley BA, Fleming GF, Colleoni M, Láng I, Gomez HL, Tondini C, Burstein HJ, Perez EA, Ciruelos E, Stearns V, Bonnefoi HR, Martino S, Geyer CE, Pin...> ;The New England journal of medicine. 2014-06-01
Assessment of an Elekta Versa HD linear accelerator for stereotactic radiosurgery with circular cone collimators.
Mutian Zhang, Qiyong Fan, Y Lei, Bishnu Thapa, Gilbert D. A. Padula> ;Journal of X-Ray Science and Technology. 2020 Jan 1
26 citations
Phase I/II study of bevacizumab with BKM120, an oral PI3K inhibitor, in patients with refractory solid tumors (phase I) and relapsed/refractory glioblastoma (phase II).
John D. Hainsworth, Kevin P. Becker, Tarek Mekhail, Sajeel A. Chowdhary, Janice Faulkner Eakle, David Wright, Robert M. Langdon, Kathleen Yost, Gilbert Darin Anthony P...> ;Journal of Neuro-Oncology. 2019 Aug 7
21 citations
Multicenter Randomized Controlled Trial of Omega-3 Fatty Acids Versus Omega-6 Fatty Acids for the Control of Cancer-Related Fatigue Among Breast Cancer Survivors.
Luke J. Peppone, Julia E Inglis, Karen M. Mustian, Charles E. Heckler, Gilbert D A Padula, Supriya G. Mohile, Charles Kamen, Eva Culakova, Po-Ju Lin, Sarah L. Kerns, S...> ;JNCI Cancer Spectrum. 2019 Feb 21
2 citations
Tailored postoperative treatment of prostate cancer: final results of a phase I/II trial.
Giovanna Mantini, Giambattista Siepe, Anna Rita Alitto, Milly Buwenge, Nam P. Nguyen, Andrea Farioli, Riccardo Schiavina, F. Catucci, Francesco Deodato, Bruno Fionda, ...> ;Prostate Cancer and Prostatic Diseases. 2018 Jul 23
Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer.
Francis PA, Pagani O, Fleming GF, Walley BA, Colleoni M, Láng I, Gómez HL, Tondini C, Ciruelos E, Burstein HJ, Bonnefoi HR, Bellet M, Martino S, Geyer CE, Goetz MP, St...> ;The New England journal of medicine. 2018-06-04
10 citations
Postresection CA19-9 and margin status as predictors of recurrence after adjuvant treatment for pancreatic carcinoma: Analysis of NRG oncology RTOG trial 9704.
William F. Regine, Kathryn Winter, Ross A. Abrams, Howard Safran, Ivan L. Kessel, Yuhchyau Chen, James A. Fugazzi, Eric D. Donnelly, Thomas A. DiPetrillo, Samir Naraya...> ;Advances in Radiation Oncology. 2018 Apr 1
42 citations
Unusual Thyroid Carcinoma Metastases: a Case Series and Literature Review.
E. Farina, Fabio Monari, Giovanni Tallini, Andrea Repaci, Renzo Mazzarotto, Francesca Giunchi, Riccardo Panzacchi, Silvia Cammelli, Gilbert D.A. Padula, Francesco Deod...> ;Endocrine Pathology. 2016 Mar 1
6 citations
Low-dose radiotherapy and concurrent FOLFIRI-bevacizumab: a Phase II study
Alessio G. Morganti, Francesco Cellini, S. Mignogna, Gilbert D.A. Padula, Luciana Caravatta, Francesco Deodato, Vincenzo Picardi, Gabriella Macchia, Savino Cilla, Mill...> ;Future Oncology. 2016 Feb 1
41 citations
A Phase III study of radiation therapy (RT) and O6-benzylguanine + BCNU versus RT and BCNU alone and methylation status in newly diagnosed glioblastoma and gliosarcoma...
Deborah T. Blumenthal, Cathryn Rankin, Keith J. Stelzer, Alexander M. Spence, Andrew E. Sloan, Dennis F. Moore, Gilbert D. A. Padula, Susan B. Schulman, Mark Wade, Eli...> ;International Journal of Clinical Oncology. 2015 Aug 1
9 citations
Results of a phase II study of Short-course Accelerated Radiation Therapy (SHARON) for multiple brain metastases.
Luciana Caravatta, Francesco Deodato, Marica Ferro, Gabriella Macchia, Mariangela Massaccesi, Savino Cilla, Rosa Tambaro, S. Mignogna, Gilbert D.A. Padula, Michela Mus...> ;American Journal of Clinical Oncology. 2015 Aug 1
15 citations
North Central Cancer Treatment Group N10C2 (Alliance): a double-blind placebo-controlled study of magnesium supplements to reduce menopausal hot flashes.
Haeseong Park, Rui Qin, Thomas J. Smith, Pamela J. Atherton, Debra L. Barton, Keren Sturtz, Shaker R. Dakhil, Kathleen A. Flynn, Suneetha Puttabasavaiah, Nguyet A. Le-...> ;Menopause. 2015 Jun 1
21 citations
Short-Course Radiotherapy in Elderly Patients with Early Stage Non-Melanoma Skin Cancer: A Phase II Study
Marica Ferro, Francesco Deodato, Gabriella Macchia, Stefano Gentileschi, Savino Cilla, Gabriella Torre, Gilbert D.A. Padula, Marianna Nuzzo, Mariangela Massaccesi, Vin...> ;Cancer Investigation. 2015 Jan 22
7 citations
Incidence and management of noncancer pain in cancer patients referred to a radiotherapy center.
Mariangela Massaccesi, Francesco Deodato, Luciana Caravatta, Gabriella Macchia, Gilbert D.A. Padula, Sonia Di Rito, Aynalem A. Woldemariam, Marco Rossi, Carlo Di Falco...> ;The Clinical Journal of Pain. 2013 Nov 1
10 citations
A phase I study of short-course accelerated whole brain radiation therapy for multiple brain metastases
Luciana Caravatta, Francesco Deodato, Marica Ferro, Gabriella Macchia, Mariangela Massaccesi, Savino Cilla, Gilbert D.A. Padula, S. Mignogna, Rosa Tambaro, Francesco C...> ;International Journal of Radiation Oncology, Biology, Physics. 2012 Nov 15
17 citations
Neoadjuvant accelerated concomitant boost radiotherapy and multidrug chemotherapy in locally advanced rectal cancer: a dose-escalation study.
Luciana Caravatta, Vincenzo Picardi, Rosa Tambaro, Gilbert D.A. Padula, Gabriella Macchia, Francesco Deodato, Mariangela Massaccesi, Fabio Pacelli, Stefano Berardi, Ma...> ;American Journal of Clinical Oncology. 2012 Oct 1
19 citations
Short-Course Accelerated Radiotherapy in Palliative Treatment of Advanced Pelvic Malignancies: A Phase I Study
Luciana Caravatta, Gilbert D.A. Padula, Gabriella Macchia, Gabriella Ferrandina, Pierluigi Bonomo, Francesco Deodato, Mariangela Massaccesi, S. Mignogna, Rosa Tambaro,...> ;International Journal of Radiation Oncology, Biology, Physics. 2012 Aug 1
25 citations
Clinical target volume delineation including elective nodal irradiation in preoperative and definitive radiotherapy of pancreatic cancer.
Luciana Caravatta, Giuseppina Sallustio, Fabio Pacelli, Gilbert D.A. Padula, Francesco Deodato, Gabriella Macchia, Mariangela Massaccesi, Vincenzo Picardi, Savino Cill...> ;Radiation Oncology. 2012 Jun 12
36 citations
Intensity-modulated radiotherapy with simultaneous integrated boost to dominant intraprostatic lesion: preliminary report on toxicity.
Edy Ippolito, Giovanna Mantini, Alessio G. Morganti, Ercole Mazzeo, Gilbert D.A. Padula, Cinzia Digesù, Savino Cilla, Vincenzo Frascino, Stefano Luzi, Mariangela Massa...> ;American Journal of Clinical Oncology. 2012 Apr 1
3 citations
Mammography before post-operative radiotherapy in conservatively managed breast cancer patients: is it useful?
Macchia Massaccesi, Cinzia Digesù, Gabriella Macchia, Francesco Deodato, Matteo Ciuffreda, Eleonora Cucci, Luciana Caravatta, Giacomo Corrado, Gilbert D.A. Padula, R. ...> ;The British Journal of Radiology. 2012 Feb 14
Brain necrosis after enucleation, external beam cobalt radiotherapy, and systemic chemotherapy for retinoblastoma.
Gilbert D. A. Padula, Beryl McCormick, David H. Abramson> ;Archives of Ophthalmology. 2002 Jan 1
[Minimally invasive surgery and neoplasms of the inferior third of the rectum: personal technique].
Trignano, M., Sini, G., Padula, G., Occhioni, G., Mastino, G., Pisano, I., De Anna, D.> ;G Chir. 1997 Apr
318 citations
The relationship of pathologic tumor regression grade (TRG) and outcomes after preoperative therapy in rectal cancer.
Fabio Maria Vecchio, Vincenzo Valentini, Bruce D. Minsky, Gilbert D.A. Padula, Ennapadam Venkatraman, Mario Balducci, Francesco Miccichè, Riccardo Ricci, Alessio G. Mo...> ;International Journal of Radiation Oncology, Biology, Physics. 2005 Jul 1
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