GiovanniMelilloMD

PubMed

• 2 citations
  Association of PD-L1 Expression on Tumor and Immune Cells with Survival in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma and Assay Validation.
  Sophie Wildsmith, Jiabu Ye, April Franks, Giovanni Melillo, Jon Armstrong, Jessica Whiteley, Karina Schnittker, Fangru Lian, Bryan Roland, Constantine Sabalos, Payam A...> ;Cancer Research Communications. 2022 Jan 1
• 9 citations
  Curative-Intent Treatment with Durvalumab in Early-Stage Cancers.
  Giovanni Melillo, Vikram Chand, Alejandro Javier Yovine, Ashok K. Gupta, Cristian Massacesi> ;Advances in Therapy. 2021 Apr 21
• 4 citations
  SUPREME-HN: a retrospective biomarker study assessing the prognostic value of PD-L1 expression in patients with recurrent and/or metastatic squamous cell carcinoma of ...
  Sara I. Pai, Ezra E.W. Cohen, Derrick T. Lin, George Fountzilas, Edward S. Kim, Holger Mehlhorn, Neus Baste, Daniel R. Clayburgh, Loren Lipworth, Carlo Resteghini, Naw...> ;Journal of Translational Medicine. 2019 Dec 26
• 206 citations
  Safety and Efficacy of Durvalumab With or Without Tremelimumab in Patients With PD-L1-Low/Negative Recurrent or Metastatic HNSCC: The Phase 2 CONDOR Randomized Clinica...
  Lillian L. Siu, Caroline Even, Ricard Mesia, Éva Remenár, Amaury Daste, Jean Pierre Delord, Jürgen Krauss, Nabil F. Saba, Lisle Nabell, Neal Ready, Irene Brana, Nuria ...> ;JAMA Oncology. 2019 Feb 1
• 162 citations
  Durvalumab for recurrent or metastatic head and neck squamous cell carcinoma: Results from a single-arm, phase II study in patients with ≥25% tumour cell PD-L1 express...
  Dan P. Zandberg, Alain Algazi, Antonio Jimeno, J. Good, Jérôme Fayette, Nathaniel Bouganim, Neal Ready, Paul Clement, Caroline Even, Raymond Woo-Jun Jang, Stuart J. Wo...> ;European Journal of Cancer. 2019 Jan 1
• 60 citations
  NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction
  Agnes Juhasz, Susan Markel, Shikha Gaur, Han Liu, Jiamo Lu, Guojian Jiang, Xiwei Wu, Smitha Antony, Yongzhong Wu, Giovanni Melillo, Jennifer L. Meitzler, Diana C. Hain...> ;The Journal of Biological Chemistry. 2017 May 12
• 282 citations
  Human Monocytes Undergo Functional Re-programming during Sepsis Mediated by Hypoxia-Inducible Factor-1α
  Irina N. Shalova, Jyue Yuan Lim, Manesh Chittezhath, Annelies S. Zinkernagel, Federico C. Beasley, Enrique Hernández-Jiménez, Victor Toledano, Carolina Cubillos-Zapata...> ;Immunity. 2015 Mar 17
• 14 citations
  A phase I and pharmacokinetic study of oral perifosine with different loading schedules in patients with refractory neoplasms
  William D. Figg, Manish Monga, Donna Headlee, Avni A. Shah, Cindy H. Chau, Cody J. Peer, Richard Messman, Yusri A. Elsayed, Anthony J. Murgo, Giovanni Melillo, Qin C. ...> ;Cancer Chemotherapy and Pharmacology. 2014 Sep 3
• 33 citations
  HIF factors cooperate with PML-RARα to promote acute promyelocytic leukemia progression and relapse.
  Nadia Coltella, Stefano Percio, Roberta Valsecchi, Roberto Cuttano, Jlenia Guarnerio, Maurilio Ponzoni, Pier Paolo Pandolfi, Giovanni Melillo, Linda Pattini, Rosa Bern...> ;EMBO Molecular Medicine. 2014 May 1
• 21 citations
  Weekly EZN-2208 (PEGylated SN-38) in combination with bevacizumab in patients with refractory solid tumors
  Woondong Jeong, Sook Ryun Park, Annamaria Rapisarda, Nicole Fer, Robert J. Kinders, Alice P. Chen, Giovanni Melillo, Baris Turkbey, Seth M. Steinberg, Peter L. Choyke,...> ;Investigational New Drugs. 2014 Apr 1
• 111 citations
  Pilot trial of EZN-2968, an antisense oligonucleotide inhibitor of hypoxia-inducible factor-1 alpha (HIF-1α), in patients with refractory solid tumors
  Woondong Jeong, Annamaria Rapisarda, Sook Ryun Park, Robert J. Kinders, Alice P. Chen, Giovanni Melillo, Baris Turkbey, Seth M. Steinberg, Peter L. Choyke, James H. Do...> ;Cancer Chemotherapy and Pharmacology. 2014 Feb 1
• 61 citations
  Autocrine production of IL-11 mediates tumorigenicity in hypoxic cancer cells
  Barbara Onnis, Nicole Fer, Annamaria Rapisarda, Victor S. Perez, Giovanni Melillo> ;The Journal of Clinical Investigation. 2013 Apr 1
• 127 citations
  Overcoming disappointing results with antiangiogenic therapy by targeting hypoxia
  Annamaria Rapisarda, Giovanni Melillo> ;Nature Reviews. Clinical Oncology. 2012 Apr 24
• 126 citations
  Role of the VEGF/VEGFR axis in cancer biology and therapy.
  Annamaria Rapisarda, Giovanni Melillo> ;Advances in Cancer Research. 2012 Jan 1
• 185 citations
  Phase I Study of PARP Inhibitor ABT-888 in Combination with Topotecan in Adults with Refractory Solid Tumors and Lymphomas
  Shivaani Kummar, Alice P. Chen, Jiuping Ji, Yiping Zhang, Joel M. Reid, Matthew M. Ames, Lee Jia, Marcie K. Weil, Giovanna Speranza, Anthony J. Murgo, Robert J. Kinder...> ;Cancer Research. 2011 Sep 1
• 88 citations
  Multihistology, Target-Driven Pilot Trial of Oral Topotecan as an Inhibitor of Hypoxia-Inducible Factor-1α in Advanced Solid Tumors
  Shivaani Kummar, Mark Raffeld, Lamin Juwara, Yvonne Horneffer, Agnes Strassberger, Deborah Allen, Seth M. Steinberg, Annamaria Rapisarda, Shawn D. Spencer, William D. ...> ;Clinical Cancer Research. 2011 Aug 1
• 20 citations
  Phase I trial of vandetanib and bevacizumab evaluating the VEGF and EGF signal transduction pathways in adults with solid tumours and lymphomas
  Shivaani Kummar, Martin Gutierrez, Alice P. Chen, Ismail B. Turkbey, Deborah Allen, Yvonne Horneffer, Lamin Juwara, Liang Cao, Yunkai Yu, Yeong Sang Kim, Jane B. Trepe...> ;European Journal of Cancer. 2011 May 1
• 14 citations
  Hypoxia: jump-starting inflammation
  Giovanni Melillo> ;Blood. 2011 Mar 3
• 46 citations
  Hypoxia: a double-edged sword of immunity.
  Antonio Sica, Giovanni Melillo, Luigi Varesio> ;Journal of Molecular Medicine. 2011 Feb 19
• 156 citations
  Hypoxia potentiates glioma-mediated immunosuppression.
  Jun Wei, Adam Wu, Ling Yuan Kong, Yongtao Wang, Gregory N. Fuller, Izabela Fokt, Giovanni Melillo, Waldemar Priebe, Amy B. Heimberger> ;Plos One. 2011 Jan 20
• 73 citations
  Aminoflavone, a Ligand of the Aryl Hydrocarbon Receptor, Inhibits HIF-1α Expression in an AhR-Independent Fashion
  Erika Terzuoli, Maura Puppo, Annamaria Rapisarda, Badarch Uranchimeg, Liang Cao, Angelika M. Burger, Marina Ziche, Giovanni Melillo> ;Cancer Research. 2010 Sep 1
• 46 citations
  Inhibition of Hypoxia Inducible Factor-1α by Dihydroxyphenylethanol, a Product from Olive Oil, Blocks Microsomal Prostaglandin-E Synthase-1/Vascular Endothelial Growth...
  Erika Terzuoli, Sandra Donnini, Antonio Giachetti, Miguel A. Iñiguez, Manuel Fresno, Giovanni Melillo, Marina Ziche> ;Clinical Cancer Research. 2010 Aug 15
• 1 citations
  Editorial: T cells, not "immune" from HIF.
  Giovanni Melillo> ;Journal of Leukocyte Biology. 2010 Mar 1
• 94 citations
  Phase I trial of 17-dimethylaminoethylamino-17-demethoxygeldanamycin (17-DMAG), a heat shock protein inhibitor, administered twice weekly in patients with advanced mal...
  Shivaani Kummar, Martin Gutierrez, Erin R. Gardner, Xiaohong Chen, William D. Figg, Maria Zajac-Kaye, Min Chen, Seth M. Steinberg, Christine A. Muir, Mary Ann Yancey, ...> ;European Journal of Cancer. 2010 Jan 1
• 20 citations
  A phase I trial of UCN-01 and prednisone in patients with refractory solid tumors and lymphomas.
  Shivaani Kummar, Martin Gutierrez, Erin R. Gardner, William D. Figg, Giovanni Melillo, Janet Dancey, Edward A. Sausville, Barbara A. Conley, Anthony J. Murgo, James H....> ;Cancer Chemotherapy and Pharmacology. 2010 Jan 1
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