GlennJaffeMD

Ophthalmology • Durham, NC

Cataract Related, Retinal Disease, Uveitis

Professor, Ophthalmology, Duke University School of Medicine

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Office
2351 Erwin Rd
Durham, NC 27705
Phone+1 919-681-3937
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Education & Training

Medical College of Wisconsin Affiliated HospitalsResidency, Ophthalmology, 1987 - 1989
University of California (San Francisco)Residency, Ophthalmology, 1984 - 1987
University of California (San Francisco)/Mount ZionInternship, Internal Medicine, 1983 - 1984
University of California San Francisco School of MedicineClass of 1983

Certifications & Licensure

NC State Medical License 1989 - 2024
WI State Medical License 1987 - 1989
American Board of Ophthalmology Ophthalmology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
Fellow (FAAO) American Academy of Ophthalmology

Clinical Trials

Re-implantation of a Fluocinolone Acetonide Implant for Non-infectious Uveitis Affecting the Posterior Segment Start of enrollment: 2004 Mar 01
Completed
Phase 4
Retisert and Cataract Surgery in Patients With Severe Uveitis Start of enrollment: 2006 Sep 01
Completed
Not Applicable
Comparison of Age-related Macular Degeneration Treatments Trials: Lucentis-Avastin Trial Start of enrollment: 2008 Feb 01
Completed
Phase 3
Diagnostic Yield of Vitreous Biopsy in Sarcoid Uveitis Start of enrollment: 2007 Jan 01
Completed
Not Applicable
Fluocinolone Acetonide Implant for Retinal Vein Occlusion (RVO) Start of enrollment: 2002 Oct 01
Completed
Early Phase 1
A Study of a Sustained Release Fluocinolone Implant for Treatment of Central Retinal Vein Occlusion Start of enrollment: 2002 Oct 01
Completed
Not Applicable
Pilot Study of a Fluocinolone Acetonide Intravitreal Insert (FA-i) to Treat Intermediate-, Posterior-, or Panuveitis Start of enrollment: 2012 Jun 01
Completed
Phase 1
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Publications & Presentations

PubMed

1 citations
Gene therapy for neovascular age-related macular degeneration by subretinal delivery of RGX-314: a phase 1/2a dose-escalation study.
Robert Avery, David M Brown, Jeffrey S Heier, Stephen Pakola, Charles C Wykoff, Sherri Van Everen, Peter A Campochiaro, Allen C Ho, Stephen M Huddleston, Glenn J Jaffe...> ;Lancet. 2024 Mar 27
LIGHTSITE III: 13-Month Efficacy and Safety Evaluation of Multiwavelength Photobiomodulation in Nonexudative (Dry) Age-Related Macular Degeneration Using the Lumithera...
Boyer, D., Hu, A., Warrow, D., Xavier, S., Gonzalez, V., Lad, E., Rosen, R., Do, D., Schneiderman, T., Ho, A., Munk, M., Jaffe, G., Tedford, S., Croissant, C., Walker,...> ;Retina. 2024 Mar 1
Two studies to learn if avacincaptad pegol works and is safe in people with geographic atrophy: a plain language summary of the GATHER1 and GATHER 2 studies.
Jaffe, G., Khanani, A.> ;Immunotherapy. 2024 Mar 1
Faricimab Treat-and-Extend for Diabetic Macular Edema: Two-Year Results from the Randomized Phase 3 YOSEMITE and RHINE Trials.
Wong, T., Haskova, Z., Asik, K., Baumal, C., Csaky, K., Eter, N., Ives, J., Jaffe, G., Korobelnik, J., Lin, H., Murata, T., Ruamviboonsuk, P., Schlottmann, P., Seres, ...> ;Ophthalmology. 2023 Dec 28
5 citations
Retinal Vasculitis After Intravitreal Pegcetacoplan: Report From the ASRS Research and Safety in Therapeutics (ReST) Committee.
Andre J Witkin, Glenn J Jaffe, Sunil K Srivastava, Janet L Davis, Judy E Kim> ;Journal of Vitreoretinal Diseases. 2023 Dec 21
Reticular Pseudodrusen: Interreader Agreement of Evaluation on OCT Imaging in Age-Related Macular Degeneration.
Zhichao Wu, Steffen Schmitz-Valckenberg, Barbara A Blodi, Frank G Holz, Glenn J Jaffe, Sandra Liakopoulos, Srinivas R Sadda, Mari Bonse, Tyler Brown, John Choong, Bail...> ;Ophthalmology Science. 2023 Dec 1
Bilateral Panuveitis in an Adolescent with Autoimmune Lymphoproliferative Syndrome Due to CTLA4 Haploinsufficiency.
Richmond Woodward, Andrew Gross, Grant A Justin, Glenn J Jaffe, Dilraj S Grewal> ;Ocular Immunology and Inflammation. 2023 Sep 13
15 citations
Efficacy and safety of avacincaptad pegol in patients with geographic atrophy (GATHER2): 12-month results from a randomised, double-masked, phase 3 trial.
Arshad M Khanani, Sunil S Patel, Giovanni Staurenghi, Ramin Tadayoni, Carl J Danzig, David A Eichenbaum, Jason Hsu, Charles C Wykoff, Jeffrey S Heier, David R Lally, J...> ;Lancet. 2023 Oct 21
1 citations
Joint Multimodal Deep Learning-based Automatic Segmentation of Indocyanine Green Angiography and OCT Images for Assessment of Polypoidal Choroidal Vasculopathy Biomark...
Jessica Loo, Kelvin Y C Teo, Chinmayi H Vyas, Janice Marie N Jordan-Yu, Amalia B Juhari, Glenn J Jaffe, Chui Ming Gemmy Cheung, Sina Farsiu> ;Ophthalmology Science. 2023 Sep 1
Gradeability and Reproducibility of Geographic Atrophy Measurement in GATHER-1, a Phase II/III Randomized Interventional Trial.
Angela S Li, Justin Myers, Sandra S Stinnett, Dilraj S Grewal, Glenn J Jaffe> ;Ophthalmology Science. 2023 Aug 13
Imaging Features of Retinal Vasculitis and/or Retinal Vascular Occlusion after Brolucizumab Treatment in the Postmarketing Setting.
Dilraj S Grewal, Charles C Wykoff, Divya D'Souza, Valentine Jehl, Iulian Alecu, Glenn J Jaffe> ;Ophthalmology Science. 2023 Jul 1
Potential for Treatment Interval Extension in Eyes with nAMD Disease Activity Post Loading Phase in HAWK and HARRIER.
Ramin Tadayoni, Glenn J Jaffe, Frank G Holz, Ursula Schmidt-Erfurth, Kanji Takahashi, Chui Ming Gemmy Cheung, Seenu M Hariprasad, Kinfemichael Gedif, Rasmus Olsen, Cat...> ;Ophthalmology and Therapy. 2023 Aug 1
4 citations
Macular Telangiectasia Type 2: A Classification System Using MultiModal Imaging MacTel Project Report Number 10.
Emily Y Chew, Tunde Peto, Traci E Clemons, Ferenc B Sallo, Daniel Pauleikhoff, Irene Leung, Glenn J Jaffe, Tjebo F C Heeren, Catherine A Egan, Peter Charbel Issa, Kons...> ;Ophthalmology Science. 2023 Jun 1
2 citations
Correction: Avacincaptad pegol for geographic atrophy secondary to age-related macular degeneration: 18-month findings from the GATHER1 trial.
Sunil S Patel, David R Lally, Jason Hsu, Charles C Wykoff, David Eichenbaum, Jeffrey S Heier, Glenn J Jaffe, Keith Westby, Dhaval Desai, Liansheng Zhu, Arshad M Khanani> ;Eye. 2023 Dec 1
Primary Vitreoretinal Lymphoma Masquerading as Post-Operative Endophthalmitis in a Pregnant Patient with Longstanding Idiopathic Panuveitis.
Jordan D Deaner, Alan D Proia, Glenn J Jaffe, Sri Meghana Konda> ;Retinal Cases & Brief Reports. 2023 Apr 7
24 citations
Avacincaptad pegol for geographic atrophy secondary to age-related macular degeneration: 18-month findings from the GATHER1 trial.
Sunil S Patel, David R Lally, Jason Hsu, Charles C Wykoff, David Eichenbaum, Jeffrey S Heier, Glenn J Jaffe, Keith Westby, Dhaval Desai, Liansheng Zhu, Arshad M Khanani> ;Eye. 2023 Dec 1
1 citations
Prediction for 2-Year Vision Outcomes Using Early Morphologic and Functional Responses in the Comparison of Age-related Macular Degeneration Treatments Trials.
Katie Xue, Peiying Hua, Maureen G Maguire, Ebenezer Daniel, Glenn J Jaffe, Juan E Grunwald, Gui-Shuang Ying> ;Ophthalmology. Retina. 2023 Jul 1
1 citations
0.18 MG FLUOCINOLONE ACETONIDE INSERT FOR THE TREATMENT OF CHRONIC POSTOPERATIVE PSEUDOPHAKIC CYSTOID MACULAR EDEMA.
Jordan D Deaner, Danny Mammo, Sumit Sharma, Sunil K Srivastava, Glenn J Jaffe, Dilraj S Grewal, Lee, J. "., Andrew Gross, Terry Lee> ;Retina. 2023 Jun 1
Recurrence rates in ocular non-infectious uveitis according to US FDA criteria or Rest of World criteria.
Glenn J Jaffe, Carlos E Pavesio> ;Journal of Ophthalmic Inflammation and Infection. 2022 Sep 14
5 citations
Baseline Microperimetry and OCT in the RUSH2A Study: Structure-Function Association and Correlation With Disease Severity.
Eleonora M Lad, Jacque L Duncan, Wendi Liang, Maureen G Maguire, Allison R Ayala, Isabelle Audo, David G Birch, Joseph Carroll, Janet K Cheetham, Todd A Durham, Abigai...> ;American Journal of Ophthalmology. 2022 Dec 1
5 citations
VALIDATION OF A DEEP LEARNING-BASED ALGORITHM FOR SEGMENTATION OF THE ELLIPSOID ZONE ON OPTICAL COHERENCE TOMOGRAPHY IMAGES OF AN USH2A-RELATED RETINAL DEGENERATION CL...
Jessica Loo, Glenn J Jaffe, Jacque L Duncan, David G Birch, Sina Farsiu> ;Retina. 2022 Jul 1
3 citations
Impact of Baseline Quantitative OCT Features on Response to Risuteganib for the Treatment of Dry Age-Related Macular Degeneration: The Importance of Outer Retinal Inte...
Joseph R Abraham, Glenn J Jaffe, Peter K Kaiser, Stephanie J Chiu, Jessica Loo, Sina Farsiu, Laurens Bouckaert, Vicken Karageozian, Melvin Sarayba, Sunil K Srivastava,...> ;Ophthalmology. Retina. 2022 Nov 1
20 citations
MERLIN: Phase 3a, Multicenter, Randomized, Double-Masked Trial of Brolucizumab in Participants with Neovascular Age-Related Macular Degeneration and Persistent Retinal...
Arshad M Khanani, David M Brown, Glenn J Jaffe, Charles C Wykoff, Eser Adiguzel, Randall Wong, Xiangyi Meng, Jeffrey S Heier> ;Ophthalmology. 2022 Sep 1
Thiazolidinedione use and retinal fluid in the comparison of age-related macular degeneration treatments trials.
Jason Q Core, Peiying Hua, Ebenezer Daniel, Juan E Grunwald, Glenn Jaffe, Maureen G Maguire, Gui-Shuang Ying> ;The British Journal of Ophthalmology. 2023 Jul 1
1 citations
Prevalence and Progression of Macular Atrophy in Eyes with Neovascular Age-Related Macular Degeneration in the Phase 2 Ladder Trial of the Port Delivery System with Ra...
Glenn J Jaffe, Briana Cameron, David Kardatzke, Jane Ives, Giulio Barteselli, Shamika Gune> ;Ophthalmology. Retina. 2022 Sep 1
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Journal Articles

Development, Validation, and Innovation in Ophthalmic Laser-Based Imaging
Frank Brodie, Natalie Afshari, Jennifer E Thorne, Albert Vitale, David Myung, Mark S Blumenkranz, Elmer Tu, David Sarraf, Glenn J Jaffe, Malvina Eydelman, JAMA Ophthalmology
Development, Validation, and Innovation in Ophthalmic Laser-Based Imaging
Frank Brodie, Natalie Afshari, Jennifer E Thorne, Albert Vitale, David Myung, Mark S Blumenkranz, Elmer Tu, David Sarraf, Glenn J Jaffe, Malvina Eydelman, JAMA Ophthalmology
Incidence and Progression of Nongeographic Atrophy in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Clinical Trial
Glenn Jaffe, MD, JAMA Ophthalmology
Incidence and Progression of Nongeographic Atrophy in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT) Clinical Trial
Glenn Jaffe, MD, JAMA Ophthalmology
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Press Mentions

Researchers Discover Therapeutic Target to Aid in Glaucoma TreatmentMarch 16th, 2023
LumiThera Announces Sustained Vision Improvement for 24 Months in Dry Age-Related Macular Degeneration Subjects from US LIGHTSITE III Clinical Trial DataMarch 15th, 2023
EyePoint Pharmaceuticals Announces Renowned Scientists to Join New Executive Scientific Advisory BoardAugust 2nd, 2021
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