GlennLeglerMD

PubMed

• N1-alkyl-D-gluconamidines: are they 'perfect' mimics of the first transition state of glucosidase action?
  Legler G, Finken MT> ;Carbohydr. Res.. 1996-10-04
• A novel approach to the 1-deoxynojirimycin system: synthesis from sucrose of 2-acetamido-1, 2-dideoxynojirimycin, as well as some 2-N-modified derivatives.
  Gradnig G, Legler G, Stütz AE> ;Carbohydr. Res.. 1996-06-07
• Mechanism of enzymic glycoside hydrolysis and of glycosyl transfer by glycosidases and glycosyltransferases.
  Legler G> ;Carbohydr. Res.. 1993-12-16
• Bovine N-acetyl-beta-D-glucosaminidase: affinity purification and characterization of its active site with nitrogen containing analogs of N-acetylglucosamine.
  Legler G, Lüllau E, Kappes E, Kastenholz F> ;Biochim. Biophys. Acta. 1991-10-25
• Human acid beta-glucosidase: inhibition studies using glucose analogues and pH variation to characterize the normal and Gaucher disease glycon binding sites.
  Osiecki-Newman K, Legler G, Grace M, Dinur T, Gatt S, Desnick RJ, Grabowski GA> ;Enzyme. 1988-01-01
• Human acid beta-glucosidase: use of inhibitors, alternative substrates and amphiphiles to investigate the properties of the normal and Gaucher disease active sites.
  Osiecki-Newman K, Fabbro D, Legler G, Desnick RJ, Grabowski GA> ;Biochim. Biophys. Acta. 1987-09-02
• Further studies on the catalytic mechanism of human liver alpha-L-fucosidase.
  White WJ, Schray KJ, Legler G, Alhadeff JA> ;Biochim. Biophys. Acta. 1987-03-18
• Synthesis of 5-amino-5-deoxy-D-galactopyranose and 1,5-dideoxy-1,5-imino-D-galactitol, and their inhibition of alpha- and beta-D-galactosidases.
  Legler G, Pohl S> ;Carbohydr. Res.. 1986-11-01
• Active-site-directed inactivation of human liver alpha-L-fucosidase by conduritol C trans-epoxide.
  White WJ, Schray KJ, Legler G, Alhadeff JA> ;Biochim. Biophys. Acta. 1986-09-26
• Characterization of calf liver glucosidase I and its inhibition by basic sugar analogs.
  Schweden J, Borgmann C, Legler G, Bause E> ;Arch. Biochem. Biophys.. 1986-07-01
• Human acid beta-glucosidase. Use of conduritol B epoxide derivatives to investigate the catalytically active normal and Gaucher disease enzymes.
  Grabowski GA, Osiecki-Newman K, Dinur T, Fabbro D, Legler G, Gatt S, Desnick RJ> ;J. Biol. Chem.. 1986-06-25
• Purification and characterization of a neutral processing mannosidase from calf liver acting on (Man)9(GlcNAc)2 oligosaccharides.
  Schweden J, Legler G, Bause E> ;Eur. J. Biochem.. 1986-06-16
• Human acid beta-glucosidase: affinity purification of the normal placental and Gaucher disease splenic enzymes on N-alkyl-deoxynojirimycin-sepharose.
  Osiecki-Newman KM, Fabbro D, Dinur T, Boas S, Gatt S, Legler G, Desnick RJ, Grabowski GA> ;Enzyme. 1986-01-01
• Cell type dependent inhibition of transport of cathepsin D in HepG2 cells and fibroblasts exposed to deoxy-manno-nojirimycin and deoxynojirimycin.
  Nauerth A, Lemansky P, Hasilik A, von Figura K, Bause E, Legler G> ;Biol. Chem. Hoppe-Seyler. 1985-11-01
• Influence of asparagine-linked oligosaccharides on tumor cell recognition in the mixed lymphocyte reaction.
  Powell LD, Bause E, Legler G, Molyneux RJ, Hart GW> ;J. Immunol.. 1985-07-01
• Purification by affinity chromatography of glucosidase I, an endoplasmic reticulum hydrolase involved in the processing of asparagine-linked oligosaccharides.
  Hettkamp H, Legler G, Bause E> ;Eur. J. Biochem.. 1984-07-02
• Synthesis of 5-amino-5-deoxy-D-mannopyranose and 1,5-dideoxy-1,5-imino-D-mannitol, and inhibition of alpha- and beta-D-mannosidases.
  Legler G, Jülich E> ;Carbohydr. Res.. 1984-05-15
• Inhibition of N-linked oligosaccharide trimming does not interfere with surface expression of certain integral membrane proteins.
  Burke B, Matlin K, Bause E, Legler G, Peyrieras N, Ploegh H> ;EMBO J.. 1984-03-01
• Novel mannosidase inhibitor blocking conversion of high mannose to complex oligosaccharides.
  Fuhrmann U, Bause E, Legler G, Ploegh H> ;Nature. 1984-01-01
• Effects of the glucosidase inhibitors nojirimycin and deoxynojirimycin on the biosynthesis of membrane and secretory glycoproteins.
  Peyrieras N, Bause E, Legler G, Vasilov R, Claesson L, Peterson P, Ploegh H> ;EMBO J.. 1983-01-01
• Inhibition by nojirimycin and 1-deoxynojirimycin of microsomal glucosidases from calf liver acting on the glycoprotein oligosaccharides Glc1-3Man9GlcNAc2.
  Hettkamp H, Bause E, Legler G> ;Biosci. Rep.. 1982-11-01
• Conformational aspects of N-glycosylation of proteins. Studies with linear and cyclic peptides as probes.
  Bause E, Hettkamp H, Legler G> ;Biochem. J.. 1982-06-01
• The effect of flavomycin on the synthesis and transfer of lipid-linked saccharides in pig brain.
  Bause E, Legler G> ;Biochem. J.. 1982-03-01
• The Gaucher mouse.
  Kanfer JN, Stephens MC, Singh H, Legler G> ;Prog. Clin. Biol. Res.. 1982-01-01
• The role of the hydroxy amino acid in the triplet sequence Asn-Xaa-Thr(Ser) for the N-glycosylation step during glycoprotein biosynthesis.
  Bause E, Legler G> ;Biochem. J.. 1981-06-01
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