GlennJLesserMD

Oncology • Winston Salem, NC

Hematologic Oncology, Neuro-Oncology

Professor of Hematology & Oncology, Wake Forest University

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Office
Medical Center Blvd
Wake Forest Univ-Div Hematolgy/Oncology
Winston Salem, NC 27157
Phone+1 336-713-5440
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Education & Training

Johns Hopkins UniversityFellowship, Hematology and Medical Oncology, 1991 - 1994
Wake Forest University School of MedicineResidency, Internal Medicine, 1987 - 1991
Pennsylvania State University College of MedicineClass of 1987

Certifications & Licensure

NC State Medical License 1995 - 2025
VA State Medical License 1994 - 2012
MD State Medical License 1991 - 1996
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2009-2024
America's Top Doctors for Cancer Castle Connolly, 2005-2021
CMS Meaningful Use Stage 1 Certification EpicCare Inpatient - Core EMR, Epic Systems Corporation, 2013

Clinical Trials

Pyrazoloacridine Followed by Radiation Therapy in Treating Adults With Newly Diagnosed Supratentorial Glioblastoma Multiforme Start of enrollment: 2000 May 01
Completed
Phase 1, Phase 2
Oxandrolone Compared With Megestrol in Preventing Weight Loss in Patients Receiving Chemotherapy for Cancer Start of enrollment: 2004 Mar 01
Completed
Phase 3
Thalidomide and Procarbazine in Treating Patients With Recurrent or Progressive Malignant Glioma Start of enrollment: 2004 Jan 01
Completed
Phase 2
Coenzyme Q10 in Relieving Treatment-Related Fatigue in Women With Breast Cancer Start of enrollment: 2004 Aug 27
Completed
Phase 1
Temozolomide and Radiation Therapy in Treating Patients With Gliomas Start of enrollment: 2005 Jan 01
Completed
Phase 2
Changes in Semen or Sperm Caused by Temozolomide in Patients With Newly Diagnosed, Progressive, or Recurrent Primary Malignant Brain Tumors Start of enrollment: 2004 Aug 01
Completed
Safety and Dose-Finding Study of TM-601 in Adults With Recurrent Malignant Glioma Start of enrollment: 2008 Feb 01
Unknown status
Phase 1
ABT-888, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme Start of enrollment: 2009 Jul 13
Completed
Phase 1
Ramucirumab or Anti-PDGFR Alpha Monoclonal Antibody IMC-3G3 in Treating Patients With Recurrent Glioblastoma Multiforme Start of enrollment: 2010 Jul 01
Completed
Phase 2
Erlotinib Hydrochloride and Isotretinoin in Treating Patients With Recurrent Malignant Glioma Start of enrollment: 2010 May 01
Terminated
Phase 1
Mibefradil Dihydrochloride and Temozolomide in Treating Patients With Recurrent Glioma Start of enrollment: 2012 May 31
Completed
Phase 1
A Study of Rindopepimut/GM-CSF in Patients With Relapsed EGFRvIII-Positive Glioblastoma Start of enrollment: 2011 Dec 01
Completed
Phase 2
Bovine Lactoferrin in Reducing Taste Disturbances in Patients With Colorectal Cancer Receiving Oxaliplatin-Based Chemotherapy Start of enrollment: 2013 Jan 01
Completed
Not Applicable
Adavosertib, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma Start of enrollment: 2013 Aug 19
Active, not recruiting
Phase 1
Bovine Lactoferrin Supplement in Improving Taste in Patients With Cancer Receiving Chemotherapy Start of enrollment: 2014 Feb 01
Completed
Not Applicable
Sapanisertib Before and After Surgery in Treating Patients With Recurrent Glioblastoma Start of enrollment: 2014 Jul 02
Terminated
Phase 1
Electronic Medical Record Review in Monitoring the Effects of Adherence on Myelosuppression and Morbidity in Patients With Newly Diagnosed Brain Tumors Receiving Temozolomide and Radiation Therapy Start of enrollment: 2010 Oct 01
Completed
Terameprocol in Treating Patients With Recurrent High Grade Glioma Start of enrollment: 2018 May 03
Completed
Phase 1
Study of the Effect NT-I7 on CD4 Counts in Patients With High Grade Gliomas Start of enrollment: 2018 Oct 30
Terminated
Phase 1
Testing Ramipril to Prevent Memory Loss in People With Glioblastoma Start of enrollment: 2019 Mar 25
Active, not recruiting
Phase 2
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer Start of enrollment: 2019 Sep 23
Recruiting
An Internet-based Program to Help Cancer Survivors Manage Pain Start of enrollment: 2021 May 13
Recruiting
Not Applicable
Pivotal, Randomized, Open-label Study of Optune® (Tumor Treating Fields) Concomitant With RT & TMZ for the Treatment of Newly Diagnosed GBM Start of enrollment: 2020 Dec 08
Active, not recruiting
Not Applicable
Roles: Contact
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Publications & Presentations

PubMed

Hypertension Severity and Declines in Left Ventricular Ejection Fraction Among Women Receiving Adjuvant Chemotherapy for Breast Cancer (WF-97415 UPBEAT).
Riya Garg, Ralph B D'Agostino Jr, Nathaniel O'Connell, Anika L Hines, Giselle C Meléndez, Jennifer H Jordan, Bonnie Ky, Lynne I Wagner, Arnethea L Sutton, Kristine Ols...> ;Hypertension. 2024 Apr 18
Strategies to Assess and Manage Frailty among Patients Diagnosed with Primary Malignant Brain Tumors.
Alayna E Ernster, Heidi D Klepin, Glenn J Lesser> ;Current Treatment Options in Oncology. 2024 Jan 1
A multi-site phase I trial of Veliparib with standard radiation and temozolomide in patients with newly diagnosed glioblastoma multiforme (GBM).
Lawrence Kleinberg, Xiaobu Ye, Jeff Supko, Glen H J Stevens, Hui-Kuo Shu, Tom Mikkelsen, Frank Lieberman, Glenn J Lesser, Emerson Lee, Stuart A Grossman> ;Journal of Neuro-Oncology. 2023 Dec 1
A Retrospective Genomic Landscape of 661 Young Adult Glioblastomas Diagnosed Using 2016 WHO Guidelines for Central Nervous System Tumors.
James F Haberberger, Worthy Pegram, Nicholas Britt, Kelsie Schiavone, Eric Severson, Radwa Sharaf, Lee A Albacker, Erik Williams, Mirna Lechpammer, Amanda Hemmerich, D...> ;The Oncologist. 2024 Jan 5
15 citations
BRAF-MEK Inhibition in Newly Diagnosed Papillary Craniopharyngiomas.
Priscilla K Brastianos, Erin Twohy, Susan Geyer, Elizabeth R Gerstner, Timothy J Kaufmann, Shervin Tabrizi, Brian Kabat, Julia Thierauf, Michael W Ruff, Daniela A Bota...> ;The New England Journal of Medicine. 2023 Jul 13
Endometrial cancer survivors' perceptions of their cardiovascular disease risk (results from WF-1804CD AH-HA).
Joseph A DeMari, Emily V Dressler, Randi E Foraker, Brian J Wells, Sydney Smith, Heidi Klepin, William G Hundley, Glenn J Lesser, David I Shalowitz, Chandylen L Nighti...> ;Gynecologic Oncology. 2023 Jul 1
2 citations
The Optimizing Lung Screening Trial (WF-20817CD): Multicenter Randomized Effectiveness Implementation Trial to Increase Tobacco Use Cessation for Individuals Undergoin...
Kristie L Foley, Emily V Dressler, Kathryn E Weaver, Erin L Sutfin, David P Miller Jr, Christina Bellinger, Carol Kittel, Rebecca J Stone, W Jeffrey Petty, Stephanie R...> ;Chest. 2023 Aug 1
4 citations
Genomic Profiling Reveals Differences in Primary Central Nervous System Lymphoma and Large B-Cell Lymphoma, With Subtyping Suggesting Sensitivity to BTK Inhibition.
Eric A Severson, James Haberberger, Amanda Hemmerich, Richard S P Huang, Claire Edgerly, Kelsie Schiavone, Adib Najafian, Matthew Hiemenz, Mirna Lechpammer, Jo-Anne Ve...> ;The Oncologist. 2023 Jan 18
5 citations
A transformer-based deep-learning approach for classifying brain metastases into primary organ sites using clinical whole-brain MRI images.
Qing Lyu, Sanjeev V Namjoshi, Emory McTyre, Umit Topaloglu, Richard Barcus, Michael D Chan, Christina K Cramer, Waldemar Debinski, Metin N Gurcan, Glenn J Lesser, Hui-...> ;Patterns. 2022 Nov 11
1 citations
Outcomes of radiation-induced meningiomas treated with stereotactic radiosurgery.
Niema B Razavian, Corbin A Helis, Adrian Laxton, Stephen Tatter, J Daniel Bourland, Ryan Mott, Glenn J Lesser, Roy Strowd, Jaclyn J White, Michael D Chan, Christina K ...> ;Journal of Neuro-Oncology. 2023 Jan 1
Clinical outcomes of dose-escalated re-irradiation in patients with recurrent high-grade glioma.
Corbin A Helis, Shih-Ni Prim, Christina K Cramer, Roy Strowd, Glenn J Lesser, Jaclyn J White, Stephen B Tatter, Adrian W Laxton, Christopher Whitlow, Hui-Wen Lo, Walde...> ;Neuro-Oncology Practice. 2022 Oct 1
Smoking and Radiation-induced Skin Injury: Analysis of a Multiracial, Multiethnic Prospective Clinical Trial.
Ryan T Hughes, Edward H Ip, James J Urbanic, Jennifer J Hu, Kathryn E Weaver, Mark O Lively, Karen M Winkfield, Edward G Shaw, Luis Baez Diaz, Doris R Brown, Jon Stras...> ;Clinical Breast Cancer. 2022 Dec 1
22 citations
Statins and Left Ventricular Ejection Fraction Following Doxorubicin Treatment.
W Gregory Hundley, Ralph D'Agostino Jr, Teresa Crotts, Karen Craver, Mary Helen Hackney, Jennifer H Jordan, Bonnie Ky, Lynne I Wagner, David M Herrington, Joseph Yeboa...> ;NEJM Evidence. 2022 Sep 1
mutant small cell glioblastoma in a patient with Gorlin syndrome: A case report.
John T Dorsey, Ryan T Mott, Christopher M Lack, Nicholas Britt, Shakti H Ramkissoon, Bonny B Morris, Annette Carter, Alisha T Detroye, Michael Chan, Stephen Tatter, Gl...> ;Oncology Letters. 2022 Sep 1
5 citations
HSP90-CDC37 functions as a chaperone for the oncogenic FGFR3-TACC3 fusion.
Tao Li, Farideh Mehraein-Ghomi, M Elizabeth Forbes, Sanjeev V Namjoshi, E Ashley Ballard, Qianqian Song, Ping-Chieh Chou, Xuya Wang, Brittany C Parker Kerrigan, Freder...> ;Molecular Therapy. 2022 Apr 6
Treatment of Radiation-Induced Meningiomas With Non-Invasive Stereotactic Radiosurgery.
N Razavian, Corbin A. Helis, Adrian W. Laxton, Stephen Tatter, J.D. Bourland, Ryan T. Mott, Glenn J. Lesser, Roy E. Strowd, Michael D. Chan, Christina K. Cramer> ;International Journal of Radiation Oncology Biology Physics. 2021 Nov 1
A Review on the Surgical Management of Insular Gliomas.
Jaclyn J. Renfrow, Bao-Quynh Julian, Desmond A. Brown, Stephen Tatter, Adrian W. Laxton, Glenn J. Lesser, Roy E. Strowd, Ian F. Parney> ;The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques. 2021 Oct 29
1 citations
Assessment of Oral Chemotherapy Nonadherence in Chronic Myeloid Leukemia Patients Using Brief Measures in Community Cancer Clinics: A Pilot Study.
Terry C. Davis, Connie L. Arnold, Glenn Mills, Glenn J. Lesser, W. Mark Brown, Richard M. Schulz, Kathryn E. Weaver, Pamala A Pawloski> ;International Journal of Environmental Research and Public Health. 2021 Oct 21
5 citations
Lactoferrin supplementation for taste and smell abnormalities among patients receiving cancer chemotherapy
Glenn J. Lesser, Megan B. Irby, Richard Taylor, Anna Snavely, Douglas Case, Aili Wang, Andrea M. Dietrich, Susan E. Duncan> ;Supportive Care in Cancer. 2021 Oct 13
6 citations
Long-Term Report of a Comprehensive Molecular and Genomic Analysis in NRG Oncology/RTOG 0424: A Phase II Study of Radiation and Temozolomide in High-Risk Grade II Glioma
Jessica Fleming, Stephanie L. Pugh, Barbara Fisher, Glenn J. Lesser, David R. Macdonald, Erica Hlavin Bell, Joseph P. McElroy, Aline Paixão Becker, Cynthia D Timmers, ...> ;JCO Precision Oncology. 2021 Sep 1
14 citations
Clinicopathologic and Genomic Landscape of Breast Carcinoma Brain Metastases.
Richard S.P. Huang, James Haberberger, Kimberly McGregor, Douglas A. Mata, Brennan Decker, Matthew Hiemenz, Mirna Lechpammer, Natalie Danziger, Kelsie Schiavone, James...> ;The Oncologist. 2021 Jun 23
5 citations
Addressing cancer survivors’ cardiovascular health using the automated heart health assessment (AH-HA) EHR tool: Initial protocol and modifications to address COVID-19...
Randi E. Foraker, Eleanor C. Davidson, Emily V. Dressler, Brian J. Wells, Simon J. Craddock Lee, Heidi D. Klepin, Karen M. Winkfield, W. Gregory Hundley, Philip R. O. ...> ;Contemporary Clinical Trials Communications. 2021 Jun 1
4 citations
The Head and Neck Survivorship Tool (HN-STAR) Trial (WF-1805CD): A protocol for a cluster-randomized, hybrid effectiveness-implementation, pragmatic trial to improve t...
Talya Salz, Jamie S. Ostroff, Chandylen L Nightingale, Thomas M. Atkinson, Eleanor C. Davidson, Sankeerth R. Jinna, Anuja Kriplani, Glenn J. Lesser, Kathleen Lynch, De...> ;Contemporary Clinical Trials. 2021 May 21
7 citations
Real-Time Positron Emission Tomography Evaluation of Topotecan Brain Kinetics after Ultrasound-Mediated Blood–Brain Barrier Permeability
Andrei Molotkov, Patrick Carberry, Martin Dolan, Simon Joseph, Sidney Idumonyi, Shunichi Oya, John Castrillon, Elisa E. Konofagou, Mikhail Doubrovin, Glenn J. Lesser, ...> ;Pharmaceutics. 2021 Mar 18
4 citations
Clinical Experience using Osimertinib in Patients with Recurrent Malignant Gliomas ContainingAlterations.
Marin Abousaud, Naqeeb M Faroqui, Glenn Lesser, Roy E Strowd, Shakti H Ramkissoon, Madan Kwatra, Kristin S Houston, Fang-Chi Hsu, Annette Carter, Robin Petro, Alisha T...> ;Journal of Cancer Science and Clinical Therapeutics. 2021 Jan 1
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Press Mentions

Cancer Researchers at Wake Forest Baptist Receive $25 Million from National Cancer InstituteSeptember 23rd, 2019
What Are the Symptoms of Glioblastoma? Brain Cancer Treatment, Survival RatesJuly 17th, 2019
Novel Brain Tumor Vaccine Acts like Bloodhound to Locate Cancer CellsJanuary 6th, 2012
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