GouthamNarlaMDPHD

PubMed

• Integrated stress response plasticity governs normal cell adaptation to chronic stress via the PP2A-TFE3-ATF4 pathway.
  Rita A Avelar, Riya Gupta, Gracie Carvette, Felipe da Veiga Leprevost, Jose Colina, Jessica Teitel, Alexey I Nesvizhskii, Caitlin M O'Connor, Maria Hatzoglou, Shirish ...> ;Research Square. 2024 Mar 28
• Cooperativity of c-MYC with Krüppel-Like Factor 6 Splice Variant 1 induces phenotypic plasticity and promotes prostate cancer progression and metastasis.
  Izadmehr, S., Fernandez-Hernandez, H., Lee-Poturalski, C., Tavassoli, P., Yao, S., Schlatzer, D., Difeo, A., Mosquera, J., Cordon-Cardo, C., Wiredja, D., Kirschenbaum,...> ;Biorxiv. 2024 Feb 1
• Protein Phosphatase 2A Activation Promotes Heart Transplant Acceptance in Mice.
  Zhou, X., Xu, Q., Li, W., Dong, N., Lin, Z., Stomberski, C., Narla, G.> ;Transplantation. 2024 Mar 1
• 3 citations
  Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance.
  Reyaz Ur Rasool, Caitlin M O'Connor, Chandan Kanta Das, Mohammed Alhusayan, Brijesh Kumar Verma, Sehbanul Islam, Ingrid E Frohner, Qu Deng, Erick Mitchell-Velasquez, J...> ;Nature Communications. 2023 Aug 29
• 1 citations
  Regulation and role of the PP2A-B56 holoenzyme family in cancer.
  Irene Peris, Silvia Romero-Murillo, Carmen Vicente, Goutham Narla, Maria D Odero> ;Biochimica Et Biophysica Acta. Reviews on Cancer. 2023 Sep 1
• 3 citations
  PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis.
  Kallesh D Jayappa, Brian Tran, Vicki L Gordon, Christopher Morris, Shekhar Saha, Caroline C Farrington, Caitlin M O'Connor, Kaitlin P Zawacki, Krista M Isaac, Mark Kes...> ;The Journal of Clinical Investigation. 2023 Jul 3
• 6 citations
  Small-Molecule-Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell Death.
  Rita A Avelar, Amy J Armstrong, Gracie Carvette, Riya Gupta, Noah Puleo, Jose A Colina, Peronne Joseph, Alexander M Sobeck, Caitlin M O'Connor, Brynne Raines, Agharnan...> ;Molecular Cancer Therapeutics. 2023 May 4
• 1 citations
  Mistletoe lectin inhibits growth of Myc-amplified small-cell lung cancer.
  Mohammad A Shatat, Betsy Gauthier, Suzy Yoon, Eric Yuan, Peiying Yang, Goutham Narla, Afshin Dowlati, Richard T Lee> ;Cancer Medicine. 2023 Apr 1
• 5 citations
  Activation of the PP2A-B56α heterocomplex synergizes with venetoclax therapies in AML through BCL2 and MCL1 modulation.
  Irene Peris, Silvia Romero-Murillo, Elena Martínez-Balsalobre, Caroline C Farrington, Elena Arriazu, Nerea Marcotegui, Marta Jiménez-Muñoz, Cristina Alburquerque-Priet...> ;Blood. 2023 Mar 2
• 5 citations
  Biased holoenzyme assembly of protein phosphatase 2A (PP2A): From cancer to small molecules.
  Terrance J Haanen 3rd, Caitlin M O'Connor, Goutham Narla> ;The Journal of Biological Chemistry. 2022 Dec 1
• Integrating Medical Genetics Into Precision Oncology Practice in the Veterans Health Administration: The Time Is Now.
  Anthony Scott, Arathi Mohan, Sarah Austin, Erika Amini, Shelby Raupp, Brittany Pannecouk, Michael J Kelley, Goutham Narla, Nithya Ramnath> ;JCO Oncology Practice. 2022 Jun 1
• 3 citations
  Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous Carcinoma.
  Caitlin M O'Connor, Sarah E Taylor, Kathryn M Miller, Lauren Hurst, Terrance J Haanen, Tahra K Suhan, Kaitlin P Zawacki, Fallon K Noto, Jonida Trako, Arathi Mohan, Jay...> ;Cancer Research. 2022 Feb 15
• 2 citations
  Allosteric Activation of PP2A Inhibits Experimental Abdominal Aortic Aneurysm.
  Xianming Zhou, Chao Zhang, Fei Xie, Wei Wei, Rui Li, Qian Xu, Yu Wang, Philip A. Klenotic, Goutham Narla, Nianguo Dong, Zhiyong Lin> ;Clinical Science. 2021 Sep 17
• 12 citations
  Targeting protein phosphatase PP2A for cancer therapy: development of allosteric pharmaceutical agents
  David L. Brautigan, Caroline Farrington, Goutham Narla> ;Clinical Science. 2021 Jul 16
• Food and science: Lessons learned from a great chef.
  Goutham Narla> ;American Journal of Hematology. 2021 Jul 31
• 17 citations
  CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis
  Anni Laine, Srikar G. Nagelli, Caroline Farrington, Umar Butt, Anna Cvrljevic, Julia P. Vainonen, Femke M. Feringa, Tove J. Grönroos, Prson Gautam, Sofia Khan, Harri S...> ;Cancer Research. 2021 Aug 15
• 3 citations
  Development and comparison of novel bioluminescent mouse models of pancreatic neuroendocrine neoplasm metastasis
  Courtney A. Kaemmer, Shaikamjad Umesalma, Chandra K. Maharjan, Devon L. Moose, Goutham Narla, Sarah L. Mott, Gideon K. D. Zamba, Patrick Breheny, Benjamin W. Darbro, A...> ;Scientific Reports. 2021 May 13
• 2 citations
  Mistletoe Extract Viscum Fraxini-2 for Treatment of Advanced Hepatocellular Carcinoma: A Case Series.
  Richard T. Lee, Peiying Yang, Asrar Alahmadi, Jennifer L. McQuade, Eric Yuan, Analisa DiFeo, Goutham Narla, Ahmed Kaseb> ;Case Reports in Oncology. 2021 Jan 1
• 10 citations
  PP2A-activating Drugs Enhance FLT3 Inhibitor Efficacy through AKT Inhibition-Dependent GSK-3β-Mediated c-Myc and Pim-1 Proteasomal Degradation
  Mario Scarpa, Prerna Singh, Christopher Bailey, Jonelle K. Lee, Shivani Kapoor, Rena G. Lapidus, Sandrine Niyongere, Jaya Sangodkar, Yin Wang, Danilo Perrotti, Goutham...> ;Molecular Cancer Therapeutics. 2021 Feb 10
• 21 citations
  Loss of hepatic aldolase B activates Akt and promotes hepatocellular carcinogenesis by destabilizing the Aldob/Akt/PP2A protein complex.
  Xuxiao He, Min Li, Hongming Yu, Guijun Liu, Ningning Wang, Chunzhao Yin, Qiaochu Tu, Goutham Narla, Yongzhen Tao, Shu-Qun Cheng, Huiyong Yin> ;Plos Biology. 2020 Dec 4
• 13 citations
  Targeting UHRF1-dependent DNA repair selectively sensitizes KRAS mutant lung cancer to chemotherapy
  Danmei Tian, Jinshan Tang, Xinran Geng, Qingwen Li, Fangfang Wang, Huadong Zhao, Goutham Narla, Xin-Sheng Yao, Youwei Zhang> ;Cancer Letters. 2020 Nov 28
• 6 citations
  The SRG rat, a Sprague-Dawley Rag2/Il2rg double-knockout validated for human tumor oncology studies.
  Fallon K. Noto, Jaya Sangodkar, Bisoye Towobola Adedeji, Sam Moody, Christopher B. McClain, Ming Tong, Eric M. Ostertag, Jack Crawford, Xiaohua Gao, Lauren Hurst, Cait...> ;Plos One. 2020 Oct 7
• 21 citations
  A Genome-Wide Pooled shRNA Screen Identifies PPP2R2A as a Predictive Biomarker for the Response to ATR and CHK1 Inhibitors.
  Zhaojun Qiu, Pengyan Fa, Tao Liu, Chandra Bhushan Prasad, Shanhuai Ma, Zhipeng Hong, Ernest R. Chan, Hongbing Wang, Zaibo Li, Kai He, Qi-En Wang, Terence M. Williams, ...> ;Cancer Research. 2020 Aug 15
• 50 citations
  Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells.
  Garry L. Coles, Sandra Cristea, James T. Webber, Rebecca S. Levin, Steven M. Moss, Andy He, Jaya Sangodkar, Yeonjoo C. Hwang, Julia Arand, Alexandros P. Drainas, Nanci...> ;Cancer Cell. 2020 Jul 13
• 1 citations
  Splice of Life for Cancer: Missplicing of PPP2R5A by Mutant SF3B1 Leads to MYC Stabilization and Tumorigenesis.
  Caitlin M. O’Connor, Goutham Narla> ;Cancer Discovery. 2020 Jun 1
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Journal Articles

• Targeted inhibition of the KLF6 splice variant KLF6SV1 suppresses prostate cancer growth and spread.  
  Narla G, DiFeo A, Yao S, Banno A, Hod E, Reeves H, Qiao RF, Camacho-Vanegas O, Levine A, Kirschenbaum A, Chan AM, Friedman SL, Martignetti JA, Cancer Res; 65:5761-8
• Role of KLF6 and KLF6-SV1 in ovarian cancer progression and intraperitoneal dissemination.  
  DiFeo A, Narla G, Hirschfeld J, Camacho-Vanegas O, Yao S, Rose S, Kalir T, Friedman SL, Buller RE, Martignetti JA, Clin Cancer Res; 12:3730-9
• In vivo Regulation of p21 by the KLF6 Tumor Suppressor Gene in Mouse Liver and Human Hepatocellular Carcinoma.  
  Narla G, Kremer-Tal S, Matsumoto N, Zhao X, Yao S, Kelley K, Tarocchi M, Friedman SL, Oncogene; 26:4428-34
• Insulin-like growth factor-1 regulates KLF6 gene expression in a p53-dependent manner.  
  Bentov I, Narla G, Schayek H, Akita K, Plymate SR, LeRoith D, Friedman SL, Werner H, Endrocrinology; 149:1890-7
• Increased alternative splicing of the KLF6 tumor suppressor gene correlates with prognosis and tumor grade in patients with pancreatic cancer.  
  Hartel M, Narla G, Wente MN, Giese NA, Martignoni ME, Martignetti JA, Friess H, Friedman SL, Eur J Cancer; 44:1895-903
• The Kruppel-like factor 6 (KLF6) genotype is associated with fibrosis in non-alcoholic fatty liver disease (NAFLD).  
  Miele S, Beale G, Patman G, Nobili V, Leathart J, Greco A, Abate M, Friedman SL, Narla G, Bugianesi E, Day CP, Reeves HL, Gastroenterology; 134:1521-31
• KLF6-SV1 is a key regulator of metastasis and survival in prostate cancer.  
  Narla G, DiFeo A, Fernandez Y, Dhanasekaran S, Huang F, Sangodkar J, Hod E, Leake D, Friedman SL, Hall S, Chinnaiyan AM, Gerald WL, Rubin MA, Martignetti JA, J Clin Invest; 118:2711-2721. PMCID: 2441856
• Ras promotes growth by alternative splicing-mediated inactivation of the KLF6 tumor suppressor gene in hepatocellular carcinoma.  
  Yea S, Narla G, Zhao X, Garg R, Kremer-Tal S, Hod E, Villaneuva A, Loke J, Tarocchi M, Akita K, Shirasawa S, Sasasuki T, Martignetti JA, Llovet JM, Friedman SL, Gastroenterology; 20:1521-31. PMCID: 2600656
• TGF-beta regulates the expression of transcription factor KLF6 and its splice variants and promotes co-operative transactivation of common target genes through a Smad3...  
  Botella LM, Sanz-Rodriguez F, Komi Y, Fernandez LA, Varela E, Garrido-Martin EM, Narla G, Friedman SL, Kojima S, Biochem J; 419:485-95
• KLF6-SV1 is a novel anti-apoptotic protein that targets the BH3-only protein NOXA for degradation and whose inhibition extends survival in an ovarian cancer model.  
  DiFeo A, Huang F, Sangodkar J, Terzo EA, Leake D, Choudhri A, Narla G, Martignetti JA, Cancer Res; 69:4733-41
• Functional role of the KLF6 tumor suppressor gene in gastric cancer.  
  Sangodkar J, Shi J, DiFeo A, Schwartz R, Bromberg R, Choudhri A, McClinch K, Scheer E, Martignetti J, Hui A, Leung WK, Friedman SL, Narla G, Eur J Cancer; 45:666-76
• Ribosome-inactivating proteins isolated from dietary bitter melon induce apoptosis and inhibit histone decetylase-1 selectively in premalignant and malignant prostate ...  
  Xiong SD, Yu K, Liu XH, Kirschenbaum A, Yao S, Narla G, DiFeo A, Wu JB, Yuan Y, Ho SM, Lam YW, Levine AC, Int J Cancer; 125:774-782
• Carcinogen-induced hepatic tumors in KLF6 +/- mice recapitulate aggressive human hepatocellular carcinoma associated with p53 pathway deregulation.  
  Narla G, Hepatology. 54(2):522-31
• The FOXO1/KLF6 transcriptional network negatively regulates activated EGFR signaling and modulates response to anti-EGFR based therapy.  
  Sangodkar J, Dhawan N, Melville H, Singh V, Katz S, Albano T, Farrington C, Rana H, Yuan E, Arnovitz P, Galsky M, Olhmeyer M, Burstein D, Zhang D, Politi K, Difeo A, a..., JCI, Advanced Online Publication
• Drosophila Sin3a mediates cancer-like invasion through multiple pathways.  
  Das TK, Sangodkar J, Negre N, Narla G, and Cagan RL, Cancer Cell
• RAS/PI3-K/AKT promotes cellular growth by enhancing alternative splicing-mediated inactivation of the KLF6 tumor suppressor in human hepatocellular carcinoma.  
  Yea S, Narla G, Zhao X, Villanueva A, Martignetti JA, Llovet JM, Friedman SL, Hepatology ;46:303A-4A
• The apolipoprotein(a) gene is regulated by sex hormones and acute phase inducers in YAC transgenic mice.  
  Frazer KA, Narla G, Zhang JL, Rubin EM, Nat Genet ;9:424-31
• KLF6, a candidate tumor suppressor gene in prostate cancer.  
  Narla G, Heath KE, Reeves HL, Li D, Giono LE, Kimmelman AC, Glucksman MJ, Narla J, Eng FJ, Chan AM, Ferrari AC, Martignetti JA, Friedman SL, Science; 21:2563-6
• Mutations in capillary morphogenesis gene-2 result in the allelic disorders juvenile fibromatosis and infantile systemic hyalinosis.  
  Dowling O, DiFeo A, Ramirez MC, Tukel T, Narla G, Bonafe L, Kayserili H, Yuksel-Apak M, Paller AS, Norton K, Teebi AS, Grum-Tokars V, Martin GS, Davis GE, Glucksman MJ..., Am J Human Genet; 73:957-66. PMCID: 1180616
• Kruppel-like factor 6 (KLF6) is a tumor suppressor gene frequently inactivated in colorectal cancer.  
  Reeves HL, Narla G, Ogunbiyi O, Haq AI, Katz A, Benzeno S, Hod E, Harpaz N, Goldberg S, Kremer-Tal S, Eng FJ, Arthur MJ, Martignetti JA, Friedman SL, Gastroenterology; 126:1090-103
• Transcriptional activation of the insulin-like growth factor I receptor gene by the Kruppel-like factor (KLF6) tumor suppressor protein: potential interactions between...  
  Rubinstein M, Idelman G, Plymate SR, Narla G, Friedman SL, Werner H, Endocrinology; 145:3769-77
• KLF6 promotes preadipocyte differentiation through histone deacetylase 3 (HDAC3)-dependent repression of Dlk1.  
  Li D, Yea S, Cooreman MP, Li S, Narla G, Laborda J, Banck MS, Friedman SL, Walsh MJ, J Biol Chem; 280:26941-52
• Regulation of KLF6 tumor suppressor activity by acetylation.  
  Li D, Yea S, Dolios G, Martignetti JA, Narla G, Wang R, Walsh MJ, Friedman SL, Cancer Res; 65:9216-25
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Books/Book Chapters

• Alternative Splicing in Cancer. 
  Chapter: Alternative splicing of KLF6 and KLF6-SV1 in human cancer. Beyond guilt by association. 
  Page 1 - 20Narla G, DiFeo A, Martignetti JAEditors: JP Venables.ransworld Research Network, Trivandrum, India
• The Biology of Kruppel-like Factors. 
  Chapter: Kruppel-like factors and the liver. 
  Page 141 - 150Narla G, Friedman SLEditors: R Nagai, SL Friedman, M Kasuga.Springer, New York, NY
• The Biology of Kruppel-like Factors. 
  Chapter: Diagnostic and Therapeutic applications of Kruppel-like Factors. 
  Page 223 - 244DiFeo A, Narla G, Martignetti JAEditors: R Nagai, SL Friedman, M Kasuga.Springer, New York, NY

Abstracts/Posters

• PP2A Activators Enhance Efficacy of FLT3 Inhibitors in FLT3-ITD Acute Myeloid Leukemia Cells through AKT Inactivation-Dependent Pim-1 and c-Myc Proteasomal Degradation
  Goutham Narla, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• A 270 Kb Yeast Artificial Chromosome Containing Apolipoprotein(a) Appropriately Expresses in Transgenic Mice.
  Frazer KA, Narla G, Zhang JL, Rubin EM, Circulation ;90:624
• KLF6 induces growth arrest in vivo by transcriptional upregulation of P21 independent of P53.
  Li D, Narla G, Kelley K, Ratziu V, Albrecht JK, Eng FJ, Friedman SL, Hepatology ;32:209A-A
• Functional characterization of transcriptional regulatory elements in ribosomal protein S19 (RPS19) gene, frequently mutated in Diamond-Blackfan Anemia.
  Da Costa L, Narla G, Willig TN, Peters L, Parra M, Fixler J, Tchernia G, Mohandas N, Blood ;98:218A-A
• Acetylation status of KLF6 regulates its transactivation of p21 and may be a key determinant of hepatocellular growth.
  Li D, Walsh MJ, Narla G, Eng FJ, Friedman SL, Hepatology; 34:263A-A
• Myogenic determinants of KLF6 gene transcription in hepatic stellate cells and during myoblast differentiation.
  Liu HX, Narla G, Laub F, Engle F, Ramirez F, Friedman SL, Hepatology ;34:264A-A
• KLF6 polymorphism in prostate cancer reveals a novel mechanism of tumor suppressor gene inactivation.
  Hirshfeld I, Narla G, DiFeo A, Kalir T, Buller R, Friedmann S, Martignetti JA, J Invest Med ;51:336-7
• Novel growth suppressor targets of the KLF6 tumor suppressor gene identified by stringent microarray analysis.
  Reeves HL, Arthur MJP, Narla G, Katz A, Hod E, Walewski J, Goldberg S, Harpaz N, Martignetti JA, Friedman SL, Hepatology ;38:179A-A
• The role of Kruppel-like factor 6 (KLF6) in colorectal neoplasia.
  Reeves H, Arthur M, Narla G, Oginbiyi O, Haque A, Katz A, Hod E, Walewski J, Friedman SL, Gastroenterology 2003;124:A13-A
• KLF6 expression in clinically localized and metastatic prostate cancer.
  Zhu W, Kuefer R, Narla G, Mattfeldt T, Gschwend JE, Friedman SL, Martignetti JA, Chinnaiyan AM, Rubin MA, Modern Pathol ;16:178A-A
• Divergent roles of matrix metalloproteinase-2 in hepatic stellate cell activation and liver fibrosis.
  Radbill B, Gupta R, Alvarez C, Narla G, Martignetti J, Friedman SL, Bansal MB, Hepatology ;40:546A-A
• Alternative splicing of the KLF6 tumor suppressor gene in hepatic stellate cells during acute liver injury in vivo is an activating signal - Resolution of a paradox.
  Yea S, Katz A, Narla G, Friedman SL, Hepatology ;40:216A-A
• The Kruppel-like factor 6 tumour suppressor induces apoptosis in HepG2 cells.
  King B, MacDonald P, Kremer-Tal S, Narla G, Chattopadhyay D, Banck M, Friedman SL, Reeves HL, Hepatology ;42:310A-A.
• Absence of KLF6 gene mutation in 71 hepatocellular carcinomas - Reply.
  Kremer-Tal S, Reeves HL, Narla G, Martignetti JA, Friedman SL, Hepatology ;41:682-3
• PTTG1, a novel repressed target of KLF6 tumor suppressor in liver - A new pathway of carcinogenesis?.
  Lang U, Kremer-Tal S, Narla G, Paris A, Yea S, Friedman SL, Hepatology ;44:525A-6A
• Evidence of hedgehog signaling pathway activation in hepatocellular carcinoma.
  Lemmer ER, Chen Y, Yea S, Wurmbach E, Schwartz M, Villanueva A, Narla G, Mazzaferro V, Bruix J, Waxman S, Friedman SL, Llovet JM, J Hepatology. ;44:S105-S
• Blockade of hedgehog pathway signaling inhibits growth of human hepatocellular carcinoma cell lines.
  Lemmer ER, Villanueva A, Yea S, Peix J, Schwartz M, Narla G, Waxman S, Friedman SL, Llovet JM, Hepatology ;44:236A-A
• The tumor suppressor gene KLF6 is a key molecular determinant of anti-EGFR based therapy in lung.
  Narla G, ASCI/AAP 2010 Joint Meeting, Chicago, IL
• The KLF6 tumor suppressor regulates hepatic expression of GADD45 gamma, a cell cycle regulatory protein, in vivo and in culture.
  Paris A, Kremer-Tal S, Narla G, Yea S, Lang U, Friedman SL, Hepatology ;44:598A-A
• Restoring sensitivity to anti-EGFR based therapy in lung adenocarcinoma by downstream modulation of the FOXO1/KLF6 transcriptional network.
  Narla G, AACR Translational Cancer Medicine, San Francisco, CA
• Reduced KLF6 Expression Correlates with Poor Prognosis in Human Hepatocellular Carcinoma (HCC) and Enhanced Chemical Carcinogenesis in KLF6+/- Mice.
  Tarocchi M, Narla G, Villanueva A, Llovet J, Friedman SL, Hepatology ;48:386A-A
• KLF6 Deficiency Promotes Hepatocellular Carcinoma in Mice and Humans by Increasing Mdm2 Expression and Accelerating P53 Degradation.
  21. Tarocchi M, Lee UE, Hannivoort R, Loke JC, Narla G, Villanueva A, Llovet JM, Friedman SL, Hepatology ;50:366A-7A
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Lectures

• Cancer Genetics: Past, Present, and Future. 
  Grand Rounds Seminar, Department of Medicine, Mount Sinai School of Medicine, New York, NY
• The Role of Alternative Splicing in the Regulation of the KLF6 Tumor Suppressor Gene. 
  Fred Hutchinson Cancer Research Center, Seattle, WA
• Personalized Medicine and Lung Cancer Treatment. 
  Charles R. Bronfman Institute for Personalized Medicine, Mount Sinai School of Medicine, New York
• Personalized-medicine-based approaches in lung cancer treatment. 
  Molecular Biology Seminar, Department of Chemistry, Pomona College, Claremont, CA
• Genetics of Lung Cancer. 
  Pulmonary and Critical Care Seminar, Department of Medicine, Mount Sinai School of Medicine, NY
• Diverse roles for the KLF6 gene family in prostate cancer. 
  Prostate Cancer Research Study Group, Department of Medicine, Mount Sinai School of Medicine, NY
• KLF6-SV1: An Oncogenic Splice Variant in Human Cancer. 
  2010 FASEB Summer Research Conferences, Steamboat Springs, CO
• The KLF6 gene family in human cancer. 
  Cancer Center Grand Rounds, University of Michigan, Ann Arbor, MI
• The KLF6 gene in human cancer: One gene, many functions. 
  Cancer Center Seminar Series, Case Comprehensive Cancer Center, Cleveland, OH
• Small-molecule-based transcriptional modulation of a key tumor suppressor gene network in lung adenocarcinoma. 
  Research Conference, Department of Medicine, Mount Sinai School of Medicine, New York, NY
• The Physician Scientist: A story of translation and compromise. 
  New York University Langone Center, New York, NY
• The story of KLF6: a tale of one gene with many functions. 
  Grand Rounds Cancer Center, University of Vermont
• Small molecule based approaches to reactive transcriptional networks in human cancer. 
  Experimental Therapeutics Institute, Mount Sinai, New York NY
• Regulation of cancer gene function by alternative splicing. 
  RNA Center Invited Seminar
• Small molecule based approaches to reactivate transcriptional networks in cancer. 
  Department of Medicine Research Day CWRU
• Targeting transcriptional networks in cancer. 
  2012 FASEB Summer Research Conferences, Steamboat Springs, CO
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