GraceLGuoMD

PubMed

• 13 citations
  Regulation of Lung Macrophage Activation and Oxidative Stress Following Ozone Exposure by Farnesoid X Receptor
  Mary Francis, Grace L. Guo, Bo Kong, Elena Abramova, Jessica A. Cervelli, Andrew J. Gow, Jeffrey D. Laskin, Debra L. Laskin> ;Toxicological Sciences. 2020 Oct 1
• 86 citations
  Bile Acids and FXR: Novel Targets for Liver Diseases.
  Mary Stofan, Grace L. Guo> ;Frontiers in Medicine. 2020 Sep 11
• 20 citations
  Enhanced alcoholic liver disease in mice with intestine-specific farnesoid X receptor deficiency
  Mingxing Huang, Bo Kong, Min Zhang, Daniel Rizzolo, Laura E. Armstrong, Justin D. Schumacher, Monica D. Chow, Yi-Horng Lee, Laurie B. Joseph, Mary Stofan, Lanjing Zhan...> ;Laboratory Investigation; a Journal of Technical Methods and Pathology. 2020 May 13
• 25 citations
  Sex- and age-dependent effects of maternal organophosphate flame-retardant exposure on neonatal hypothalamic and hepatic gene expression.
  Samantha Adams, Kimberly Wiersielis, Ali Yasrebi, Kristie Conde, Laura E. Armstrong, Grace L. Guo, Troy A. Roepke> ;Reproductive Toxicology. 2020 Apr 29
• 48 citations
  Direct and Indirect Effects of Fibroblast Growth Factor (FGF) 15 and FGF19 on Liver Fibrosis Development.
  Justin D. Schumacher, Bo Kong, Jason Wu, Daniel Rizzolo, Laura E. Armstrong, Monica D. Chow, Michael Goedken, Yi-Horng Lee, Grace L. Guo> ;Hepatology. 2020 Feb 1
• 21 citations
  Is CYP2C70 the key to new mouse models to understand bile acids in humans
  Grace L. Guo, John Y.L. Chiang> ;Journal of Lipid Research. 2020 Jan 21
• 7 citations
  Effects of total parenteral nutrition on drug metabolism gene expression in mice.
  Christina Ferrucci Da Silva, Le Zhan, Jianliang Shen, Bo Kong, Michael J. Campbell, Naureen Memon, Thomas Hegyi, Lucy Lu, Grace L. Guo> ;Acta Pharmaceutica Sinica. B. 2020 Jan 1
• 3 citations
  Epigenetic Regulation of the Ontogenic Expression of the Dopamine Transporter.
  Ashley L. Green, Aseel Eid, Le Zhan, Helmut Zarbl, Grace L. Guo, Jason R. Richardson> ;Frontiers in Genetics. 2019 Nov 4
• 3 citations
  Age modulates liver responses to asparaginase-induced amino acid stress in mice
  Inna A. Nikonorova, Qiaoqiao Zhu, Christina C. Signore, Emily T. Mirek, William O Jonsson, Bo Kong, Grace L. Guo, William J. Belden, Tracy G. Anthony> ;The Journal of Biological Chemistry. 2019 Sep 20
• 45 citations
  Understanding Environmental Contaminants’ Direct Effects on Non-alcoholic Fatty Liver Disease Progression
  Laura E. Armstrong, Grace L. Guo> ;Current Environmental Health Reports. 2019 Sep 1
• 33 citations
  Bile Acid Homeostasis in a Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase Double Knockout Mouse Model
  Daniel Rizzolo, Kyle Buckley, Bo Kong, Le Zhan, Jianliang Shen, Mary Stofan, Anita M. Brinker, Michael Goedken, Brian Buckley, Grace L. Guo> ;Hepatology. 2019 Jul 1
• 22 citations
  Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling-activated Src maintains cholesterol levels and protects from atherosclerosis.
  Sangwon Byun, Hyun-Kyung Jung, Jinjing Chen, Young Chae Kim, Dong-Hyun Kim, Bo Kong, Grace L. Guo, Byron Kemper, Jongsook Kim Kemper> ;The Journal of Biological Chemistry. 2019 May 31
• 11 citations
  Activation of FXR by obeticholic acid induces hepatic gene expression of SR-BI through a novel mechanism of transcriptional synergy with the nuclear receptor LXR
  Bin Dong, Amar B. Singh, Grace L. Guo, Mark Young, Jingwen Liu> ;International Journal of Molecular Medicine. 2019 May 1
• 41 citations
  FXR deficiency alters bile acid pool composition and exacerbates chronic alcohol induced liver injury.
  Bo Kong, Min Zhang, Mingxing Huang, Dan Rizzolo, Laura E. Armstrong, Justin D. Schumacher, Monica D. Chow, Yi-Horng Lee, Grace L. Guo> ;Digestive and Liver Disease. 2019 Apr 1
• 34 citations
  Pharmacologic Modulation of Bile Acid-FXR-FGF15/FGF19 Pathway for the Treatment of Nonalcoholic Steatohepatitis
  Justin D. Schumacher, Grace L. Guo> ;Handbook of Experimental Pharmacology. 2019 Jan 1
• 10 citations
  Metformin action through the microbiome and bile acids
  Grace L. Guo, Wen Xie> ;Nature Medicine. 2018 Dec 1
• 22 citations
  Farnesoid X receptor signaling activates the hepatic X-box binding protein 1 pathway in vitro and in mice.
  Xiaoying Liu, Grace L. Guo, Bo Kong, David B. Hilburn, Susan C. Hubchak, Seong Park, Brian LeCuyer, Antony Hsieh, Li Wang, Deyu Fang, Richard M. Green> ;Hepatology. 2018 Jul 1
• 17 citations
  Diminished gallbladder filling, increased fecal bile acids, and promotion of colon epithelial cell proliferation and neoplasia in fibroblast growth factor 15-deficient...
  Kunrong Cheng, Melissa Metry, Jessica Felton, Aaron C. Shang, Cinthia B. Drachenberg, Su Xu, Min Zhan, Justin D. Schumacher, Grace L. Guo, James E. Polli, Jean-Pierre ...> ;Oncotarget. 2018 May 22
• 18 citations
  FXR deletion in hepatocytes does not affect the severity of alcoholic liver disease in mice.
  Min Zhang, Bo Kong, Mingxing Huang, Ruixuan Wan, Laura E. Armstrong, Justin D. Schumacher, Daniel Rizzolo, Monica D. Chow, Yi-Horng Lee, Grace L. Guo> ;Digestive and Liver Disease. 2018 Oct 1
• A Novel Fibroblast Growth Factor 15 Dependent‐ and Bile Acid Independent‐Promotion of Liver Regeneration in Mice
  Monica D Chow, Grace L Guo> ;Hepatology.
• 43 citations
  Organophosphate Flame-Retardants Alter Adult Mouse Homeostasis and Gene Expression in a Sex-Dependent Manner Potentially Through Interactions With ERα
  Elizabeth A. Krumm, Vipa J Patel, Taylor S Tillery, Ali Yasrebi, Jianliang Shen, Grace L. Guo, Stephanie M Marco, Brian Buckley, Troy A. Roepke> ;Toxicological Sciences. 2018 Mar 1
• 19 citations
  Valproate increases dopamine transporter expression through histone acetylation and enhanced promoter binding of Nurr1
  Ashley L. Green, Le Zhan, Aseel Eid, Helmut Zarbl, Grace L. Guo, Jason R. Richardson> ;Neuropharmacology. 2017 Oct 1
• 37 citations
  The effect of fibroblast growth factor 15 deficiency on the development of high fat diet induced non-alcoholic steatohepatitis.
  Justin D. Schumacher, Bo Kong, Y. Pan, Le Zhan, Runbin Sun, Jiye Aa, Daniel Rizzolo, Jason R. Richardson, A. Chen, Michael Goedken, Lauren M. Aleksunes, Debra L. Laski...> ;Toxicology and Applied Pharmacology. 2017 Sep 1
• 13 citations
  Fibroblast growth factor 15 deficiency increases susceptibility but does not improve repair to acetaminophen-induced liver injury in mice.
  Mingxing Huang, Jessica A. Williams, Bo Kong, Yan Zhu, Guodong Li, Zhe Zhu, Grace L. Guo> ;Digestive and Liver Disease. 2017 Aug 12
• 50 citations
  A postprandial FGF19‐SHP‐LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy
  Sangwon Byun, Young Chae Kim, Yang Zhang, Bo Kong, Grace L. Guo, Junichi Sadoshima, Jian Ma, Byron Kemper, Jongsook Kim Kemper> ;The EMBO Journal. 2017 Jun 14
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Journal Articles

• Is This the Time to Reconsider the Names for Xenobiotic Nuclear Receptors?  
  Grace Guo, MD, Hepatology