GraemeBBolgerMD

PubMed

• Therapeutic Targets and Precision Medicine in COPD: Inflammation, Ion Channels, Both, or Neither?
  Graeme B Bolger> ;International Journal of Molecular Sciences. 2023 Dec 11
• 5 citations
  The cAMP-signaling cancers: Clinically-divergent disorders with a common central pathway.
  Graeme B Bolger> ;Frontiers in Endocrinology. 2022 Jan 1
• 16 citations
  The PDE-Opathies: Diverse Phenotypes Produced by a Functionally Related Multigene Family.
  Graeme B. Bolger> ;Trends in Genetics. 2021 Apr 5
• 5 citations
  Dominant-Negative Attenuation of cAMP-Selective Phosphodiesterase PDE4D Action Affects Learning and Behavior.
  Graeme B. Bolger, Lisa High Mitchell Smoot, Thomas van Groen> ;International Journal of Molecular Sciences. 2020 Aug 9
• 46 citations
  Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases
  Faisa Omar, Jane E. Findlay, Gemma Carfray, Robert W. Allcock, Zhong Jiang, Caitlin Moore, Amy Muir, Morgane Lannoy, Bracy A. Fertig, Deborah Mai, Jonathan P. Day, Gra...> ;Proceedings of the National Academy of Sciences of the United States of America. 2019 Jul 2
• 6 citations
  Phosphodiesterases and cAMP Pathway in Pituitary Diseases.
  Mariana F Bizzi, Graeme B. Bolger, Márta Korbonits, Antônio Ribeiro-Oliveira> ;Frontiers in Endocrinology. 2019 Mar 19
• 10 citations
  Reduced protein expression of the phosphodiesterases PDE4A4 and PDE4A8 in AIP mutation positive somatotroph adenomas.
  Mariana F Bizzi, Sérgio Veloso Brant Pinheiro, Graeme B. Bolger, Júnia R O L Schweizer, Alexandre Varella Giannetti, Mary N Dang, Antônio Ribeiro-Oliveira, Márta Korbo...> ;Molecular and Cellular Endocrinology. 2018 Nov 15
• 21 citations
  Altered phosphorylation, electrophysiology, and behavior on attenuation of PDE4B action in hippocampus.
  Susan Campbell, Thomas van Groen, Inga Kadish, Lisa High Mitchell Smoot, Graeme B. Bolger> ;BMC Neuroscience. 2017 Dec 2
• 15 citations
  The RNA-binding protein SERBP1 interacts selectively with the signaling protein RACK1.
  Graeme B. Bolger> ;Cellular Signalling. 2017 Jul 1
• 27 citations
  The PDE4 cAMP-Specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-Enhancing Action.
  Graeme B. Bolger> ;Advances in Neurobiology. 2017 Jan 1
• 23 citations
  cAMP-specific PDE4 phosphodiesterases and AIP in the pathogenesis of pituitary tumors
  Graeme B. Bolger, Mariana F Bizzi, Sérgio Veloso Brant Pinheiro, Giampaolo Trivellin, Lisa High Mitchell Smoot, Mary-Ann Accavitti, Márta Korbonits, Antônio Ribeiro-Ol...> ;Endocrine-Related Cancer. 2016 May 1
• 4 citations
  Effect of African-American Race on Tumor Recurrence After Radical Cystectomy for Urothelial Carcinoma of the Bladder.
  Ravi Kumar Paluri, Charity J. Morgan, David James Mooney, Okechukwu Mgbemena, Eddy S. Yang, Shi Wei, Erik Kouba, Gurudatta Naik, Nemer R. El Mouallem, Tyler Poston, Be...> ;Clinical Genitourinary Cancer. 2015 Oct 1
• 12 citations
  RACK1 and β-arrestin2 attenuate dimerization of PDE4 cAMP phosphodiesterase PDE4D5
  Graeme B. Bolger> ;Cellular Signalling. 2016 Jul 1
• 79 citations
  Testicular cancer, version 2.2015: Clinical pactice guidelines in oncology
  Robert J. Motzer, Eric Jonasch, Neeraj Agarwal, Clair J. Beard, Sam B. Bhayani, Graeme B. Bolger, Sam S. Chang, Toni K. Choueiri, Brian A. Costello, Ithaar Derweesh, S...> ;Journal of the National Comprehensive Cancer Network. 2015 Jun 1
• 206 citations
  Kidney cancer, version 3.2015: Featured updates to the NCCN guidelines
  Robert J. Motzer, Eric Jonasch, Neeraj Agarwal, Clair J. Beard, Sam B. Bhayani, Graeme B. Bolger, Sam S. Chang, Toni K. Choueiri, Brian A. Costello, Ithaar Derweesh, S...> ;Journal of the National Comprehensive Cancer Network. 2015 Feb 1
• 23 citations
  Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains
  Graeme B. Bolger, Allan J. Dunlop, Dong Meng, Jon P. Day, Enno Klussmann, George S. Baillie, David R. Adams, Miles D. Houslay> ;Cellular Signalling. 2015 Apr 1
• 22 citations
  Prognostic risk stratification derived from individual patient level data for men with advanced penile squamous cell carcinoma receiving first-line systemic therapy
  Gregory R. Pond, Giuseppe Di Lorenzo, Andrea Necchi, Bernhard J. Eigl, Michael Kolinsky, Raju Titus Chacko, Tanya B. Dorff, Lauren C. Harshman, Matthew I. Milowsky, Ri...> ;Urologic Oncology. 2014 May 1
• 62 citations
  Cystic Fibrosis Transmembrane Conductance Regulator Activation by Roflumilast Contributes to Therapeutic Benefit in Chronic Bronchitis
  James A. Lambert, S. Vamsee Raju, Li Ping Tang, Carmel M. McNicholas, Yao Li, Clifford A. Courville, Roopan F. Farris, George Coricor, Lisa High Mitchell Smoot, Marina...> ;American Journal of Respiratory Cell and Molecular Biology. 2014 Mar 3
• 156 citations
  Kidney Cancer, Version 2.2014
  Robert J. Motzer, Eric Jonasch, Neeraj Agarwal, Clair J. Beard, Sam B. Bhayani, Graeme B. Bolger, Sam S. Chang, Toni K. Choueiri, Ithaar Derweesh, Shilpa Gupta, Steven...> ;Journal of the National Comprehensive Cancer Network. 2014 Feb 1
• 18 citations
  Interaction between LIS1 and PDE4, and its role in cytoplasmic dynein function
  Hannah Murdoch, Suryakiran Vadrevu, Anke Prinz, Allan J. Dunlop, Enno Klussmann, Graeme B. Bolger, Jim C. Norman, Miles D. Houslay> ;Journal of Cell Science. 2011 Jul 1
• 22 citations
  Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators
  Louise C. Pyle, Annette Ehrhardt, Lisa High Mitchell, Lijuan Fan, Aixia Ren, Anjaparavanda P. Naren, Yao Li, John P. Clancy, Graeme B. Bolger, Eric J. Sorscher, Steven...> ;American Journal of Physiology. Lung Cellular and Molecular Physiology. 2011 Jul 1
• 1 citations
  A phase II trial of weekly i.v. KW-2170 in advanced castrate-resistant prostate cancer.
  Paul de Souza, Scott North, Graeme B. Bolger, Harris Spiridonidis, Robert Lim, Kei Siong Khoo, James Phillips, Matt Fujimori> ;Asia-Pacific Journal of Clinical Oncology. 2010 Nov 3
• 120 citations
  Characterization of aryl hydrocarbon receptor interacting protein (AIP) mutations in familial isolated pituitary adenoma families
  Susana Igreja, Harvey S Chahal, Peter J. King, Graeme B. Bolger, Umasuthan Srirangalingam, Leonardo Guasti, Paul Chapple, Giampaolo Trivellin, Maria Gueorguiev, Katie ...> ;Human Mutation. 2010 Aug 1
• 367 citations
  NCCN clinical practice guidelines in oncology: kidney cancer.
  Robert J. Motzer, Neeraj Agarwal, Clair J. Beard, Graeme B. Bolger, Barry Boston, Michael A. Carducci, Toni K. Choueiri, Robert A. Figlin, Mayer Fishman, Steven L. Han...> ;Journal of the National Comprehensive Cancer Network. 2009 Jun 1
• 131 citations
  NCCN clinical practice guidelines in oncology: testicular cancer.
  Robert J. Motzer, Neeraj Agarwal, Clair J. Beard, Graeme B. Bolger, Barry Boston, Michael A. Carducci, Toni K. Choueiri, Robert A. Figlin, Mayer Fishman, Steven L. Han...> ;Journal of the National Comprehensive Cancer Network. 2009 Jun 1
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Journal Articles

• The RACK1 signaling scaffold protein selectively interacts with the cAMP-specific phosphodiesterase PDE4D5 isoform.  
  Yarwood, S.J., Steele, M.R., Scotland, G., Houslay, M.D., Bolger, G.B., J. Biol. Chem, 1999