GrantD.BarishMD

Endocrinology • Chicago, IL

Diabetes, Lipid Metabolism

Associate Professor, Medicine, Northwestern University, The Feinberg School of Medicine

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Office
251 E Huron St
Chicago, IL 60611
Phone+1 312-695-9797

Fax+1 312-695-6680
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Education & Training

University of California (San Francisco)Fellowship, Endocrinology, Diabetes, and Metabolism, 2002 - 2005
University of California (San Francisco)Residency, Internal Medicine, 2000 - 2003
University of Michigan Medical SchoolClass of 2000

Certifications & Licensure

IL State Medical License 2012 - 2026
CA State Medical License 2002 - 2025
American Board of Internal Medicine Endocrinology, Diabetes and Metabolism

Publications & Presentations

PubMed

Transcriptional programming of translation by BCL6 controls skeletal muscle proteostasis.
Krithika Ramachandran, Christopher R Futtner, Meredith A Sommars, Mattia Quattrocelli, Yasuhiro Omura, Ellen Fruzyna, Janice C Wang, Nathan J Waldeck, Madhavi D Senago...> ;Nature Metabolism. 2024 Feb 1
4 citations
Intermittent prednisone treatment in mice promotes exercise tolerance in obesity through adiponectin.
Mattia Quattrocelli, Michelle Wintzinger, Karen Miz, Manoj Panta, Ashok D Prabakaran, Grant D Barish, Navdeep S Chandel, Elizabeth M McNally> ;The Journal of Experimental Medicine. 2022 May 2
24 citations
NADH inhibition of SIRT1 links energy state to transcription during time-restricted feeding.
Daniel C Levine, Hsin-Yu Kuo, Hee-Kyung Hong, Jonathan Cedernaes, Chelsea Hepler, Alexandra G Wright, Meredith A Sommars, Yumiko Kobayashi, Biliana Marcheva, Peng Gao,...> ;Nature Metabolism. 2021 Dec 1
7 citations
Hepatic X-Box Binding Protein 1 and Unfolded Protein Response Is Impaired in Weanling Mice With Resultant Hepatic Injury.
Alyssa Kriegermeier, Angela Hyon, Meredith A. Sommars, Susan C. Hubchak, Brian LeCuyer, Xiaoying Liu, Grant D. Barish, Richard M. Green> ;Hepatology. 2021 Sep 9
10 citations
Epigenomic tensor predicts disease subtypes and reveals constrained tumor evolution.
Jacob R. Leistico, Priyanka Saini, Christopher R. Futtner, Miroslav Hejna, Yasuhiro Omura, Pritin N. Soni, Poorva Sandlesh, Magdy P. Milad, Jian-Jun Wei, Serdar E. Bul...> ;Cell Reports. 2021 Mar 30
29 citations
Role of PAI-1 in hepatic steatosis and dyslipidemia.
Joshua A. Levine, Carlota Oleaga, Mesut Eren, Ansel Philip Amaral, Meng Shang, Elizabeth Lux, Sadiya S. Khan, Sanjiv J. Shah, Yasuhiro Omura, Nathalie Pamir, Joshua Ha...> ;Scientific Reports. 2021 Jan 11
23 citations
Pulsed glucocorticoids enhance dystrophic muscle performance through epigenetic-metabolic reprogramming
Mattia Quattrocelli, Aaron S. Zelikovich, Zhen Jiang, Clara Bien Peek, Alexis R. Demonbreun, Nancy L. Kuntz, Grant D. Barish, Saptarsi M. Haldar, Joseph Bass, Elizabet...> ;JCI Insight. 2019 Dec 19
50 citations
Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet.
Fabiana Quagliarini, Ashfaq Ali Mir, Kinga Balazs, Michael Wierer, Kenneth A. Dyar, Céline Jouffe, Konstantinos Makris, Johann Hawe, Matthias Heinig, Fabian V. Filipp,...> ;Molecular Cell. 2019 Nov 21
24 citations
Dynamic enhancers control skeletal muscle identity and reprogramming.
Krithika Ramachandran, Madhavi D. Senagolage, Meredith A. Sommars, Christopher R. Futtner, Yasuhiro Omura, Amanda L. Allred, Grant D. Barish> ;Plos Biology. 2019 Oct 7
32 citations
Dynamic repression by BCL6 controls the genome-wide liver response to fasting and steatosis.
Meredith A. Sommars, Krithika Ramachandran, Madhavi D. Senagolage, Christopher R. Futtner, Derrik M Germain, Amanda L. Allred, Yasuhiro Omura, Ilya Bederman, Grant D. ...> ;Elife. 2019 Apr 15
19 citations
Loss of Transcriptional Repression by BCL6 Confers Insulin Sensitivity in the Setting of Obesity.
Madhavi D. Senagolage, Meredith A. Sommars, Krithika Ramachandran, Christopher R. Futtner, Yasuhiro Omura, Amanda L. Allred, Jianing Wang, Cynthia Yang, Daniele Procis...> ;Cell Reports. 2018 Dec 18
66 citations
Requirement for NF-κB in maintenance of molecular and behavioral circadian rhythms in mice
Hee Kyung Hong, Eleonore Maury, Kathryn Moynihan Ramsey, Mark Perelis, Biliana Marcheva, Chiaki Omura, Yumiko Kobayashi, Denis C. Guttridge, Grant D. Barish, Joseph Bass> ;Genes & Development. 2018 Oct 26
28 citations
Genomic integration of ERRγ-HNF1β regulates renal bioenergetics and prevents chronic kidney disease
Juanjuan Zhao, Katherine Lupino, Benjamin J. Wilkins, Chengxiang Qiu, Jian Liu, Yasuhiro Omura, Amanda L. Allred, Caitlin McDonald, Katalin Susztak, Grant D. Barish, L...> ;Proceedings of the National Academy of Sciences of the United States of America. 2018 May 22
126 citations
A Stringent Systems Approach Uncovers Gene-Specific Mechanisms Regulating Inflammation
Ann Jay Tong, Xin Liu, Brandon J. Thomas, Michelle M. Lissner, Mairead R. Baker, Madhavi D. Senagolage, Amanda L. Allred, Grant D. Barish, Stephen T. Smale> ;Cell. 2016 Mar 24
258 citations
Pancreatic β cell enhancers regulate rhythmic transcription of genes controlling insulin secretion.
Mark Perelis, Biliana Marcheva, Kathryn Moynihan Ramsey, Matthew J. Schipma, Alan L. Hutchison, Akihiko Taguchi, Clara Bien Peek, Hee Kyung Hong, Wenyu Huang, Chiaki O...> ;Science. 2015 Nov 6
42 citations
Dependence of Hippocampal Function on ERRγ-Regulated Mitochondrial Metabolism
Liming Pei, Yangling Mu, Mathias Leblanc, William A. Alaynick, Grant D. Barish, Matthew T. Pankratz, Tiffany W. Tseng, Samantha Kaufman, Christopher Liddle, Ruth T. Yu...> ;Cell Metabolism. 2015 Apr 7
71 citations
Macrophage polarization phenotype regulates adiponectin receptor expression and adiponectin anti-inflammatory response
Caroline M. W. van Stijn, Jason Kim, Aldons J. Lusis, Grant D. Barish, Rajendra K. Tangirala> ;FASEB Journal. 2015 Feb 1
85 citations
A Role for WDR5 in Integrating Threonine 11 Phosphorylation to Lysine 4 Methylation on Histone H3 during Androgen Signaling and in Prostate Cancer
Ji-Young Kim, Taraswi Banerjee, Aurimas Vinckevicius, Qianyi Luo, J. Brandon Parker, Mairead R. Baker, Ishwar Radhakrishnan, Jian-Jun Wei, Grant D. Barish, Debabrata C...> ;Molecular Cell. 2014 May 22
42 citations
Adiponectin Expression Protects against Angiotensin II-Mediated Inflammation and Accelerated Atherosclerosis
Caroline M. W. van Stijn, Jason K. Kim, Grant D. Barish, Uwe J. F. Tietge, Rajendra K. Tangirala> ;Plos One. 2014 Jan 22
14 citations
Rescue of a primary myelofibrosis model by retinoid-antagonist therapy.
Suk Hyun Hong, Melita M Dvorak-Ewell, Hazel Y. Stevens, Grant D. Barish, Glenda L. Castro, Russell R. Nofsinger, John A. Frangos, Dolores M. Shoback, Ronald M. Evans> ;Proceedings of the National Academy of Sciences of the United States of America. 2013 Nov 19
452 citations
A Vitamin D Receptor/SMAD Genomic Circuit Gates Hepatic Fibrotic Response
Ning Ding, Ruth T. Yu, Nanthakumar Subramaniam, Mara H. Sherman, Caroline L. Wilson, Renuka Rao, Mathias Leblanc, Sally Coulter, Mingxiao He, Christopher Scott, Sue L....> ;Cell. 2013 Apr 25
197 citations
Insights into Negative Regulation by the Glucocorticoid Receptor from Genome-wide Profiling of Inflammatory Cistromes
N. Henriette Uhlenhaut, Grant D. Barish, Ruth T. Yu, Michael Downes, Malith S. Karunasiri, Christopher Liddle, Petra C. Schwalie, Norbert Hubner, Ronald M. Evans> ;Molecular Cell. 2013 Jan 10
31 citations
The LPS2 mutation in TRIF is atheroprotective in hyperlipidemic low density lipoprotein receptor knockout mice.
M. Rachel Richards, Audrey S. Black, David J. Bonnet, Grant D. Barish, Connie W.H. Woo, Ira Tabas, Linda K. Curtiss, Peter S. Tobias> ;Innate Immunity. 2013 Feb 1
725 citations
Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β
Han Cho, Xuan Zhao, Megumi Hatori, Ruth T. Yu, Grant D. Barish, Michael T. Lam, Ling Wa Chong, Luciano DiTacchio, Annette R. Atkins, Christopher K. Glass, Christopher ...> ;Nature. 2012 May 3
98 citations
The Bcl6-SMRT/NCoR cistrome represses inflammation to attenuate atherosclerosis
Grant D. Barish, Ruth T. Yu, Malith S. Karunasiri, Diana Becerra, Jason K. Kim, Tiffany W. Tseng, Li Jung Tai, Mathias Leblanc, Cody J. Diehl, Leandro Cerchietti, Yury...> ;Cell Metabolism. 2012 Apr 4
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Journal Articles

Requirement for NF-κB in Maintenance of Molecular and Behavioral Circadian Rhythms in Mice
Joseph Bass, Grant D Barish, Genes & Development
Genomic Integration of ERRγ-HNF1β Regulates Renal Bioenergetics and Prevents Chronic Kidney Disease
Grant D Barish, Katalin Susztak, Proceedings of the National Academy of Sciences
Genomic Integration of ERRγ-HNF1β Regulates Renal Bioenergetics and Prevents Chronic Kidney Disease
Katalin Susztak, Grant D. Barish, Proceedings of the National Academy of Sciences

Press Mentions

Uncovering Metabolism’s ClockworkFebruary 13th, 2017

Grant Support

Repressor-Ppar Interactions In Inflammation And AtherosclerosisNational Heart, Lung, And Blood Institute2009–2012
Ppars In Atherosclerosis And ImmunityNational Institute Of Diabetes And Digestive And Kidney Diseases2005–2006