GrantEdwardO'KeefeMD

General Surgery • Seattle, WA

Trauma Surgery & Surgical Critical Care

Professor, Surgery, University of Washington School of Medicine

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Office
Harborview Medical Center
325 9th Ave
Seattle, WA 98104
Phone+1 206-731-3241
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Education & Training

University of WashingtonFellowship, Surgical Critical Care, 1995 - 1996
Memorial University, Faculty of MedicineTransitional Year, 1988 - 1989
University of AlbertaClass of 1988

Certifications & Licensure

WA State Medical License 1994 - 2024
TX State Medical License 2000 - 2003
American Board of Surgery Surgery
American Board of Surgery Surgical Critical Care

Awards, Honors, & Recognition

Fellow (FACS) American College of Surgeons

Clinical Trials

Genetic Polymorphisms & The Risk for Sepsis After Trauma Start of enrollment: 2013 Jun 01
Completed

Publications & Presentations

PubMed

112 citations
Lung epithelial and endothelial damage, loss of tissue repair, inhibition of fibrinolysis, and cellular senescence in fatal COVID-19.
Felice D’Agnillo, Kathie-Anne Walters, Yongli Xiao, Zong-Mei Sheng, Kelsey Scherler, Jae-Keun Park, Sebastian Gygli, Luz Angela Rosas, Kaitlyn Sadtler, Heather Kalish,...> ;Science Translational Medicine. 2021 Oct 14
2 citations
Acute ICU Resuscitation of Severely Injured Trauma Patients: Do We Need a New Strategy?
Catherine E Beni, Saman Arbabi, Bryce R.H. Robinson, Grant E. O'Keefe> ;The Journal of Trauma and Acute Care Surgery. 2021 Aug 3
Chronic critical illness after hypothermia in trauma patients.
David Miranda, Rebecca G. Maine, Mackenzie R. Cook, Scott C. Brakenridge, Lyle L. Moldawer, Saman Arbabi, Grant E. O'Keefe, Bryce R.H. Robinson, Eileen M. Bulger, Rona...> ;Trauma Surgery & Acute Care Open. 2021 Jan 1
3 citations
Application of the modified Nutrition Risk in Critically Ill score to nutritional risk stratification of trauma victims: A multicenter observational study.
Chinenye Iwuchukwu, Grant E. O'Keefe, Andrew G. Day, Xuran Jiang, Daren K. Heyland> ;The Journal of Trauma and Acute Care Surgery. 2020 Dec 1
15 citations
Persistent metabolomic alterations characterize chronic critical illness after severe trauma
Dara L. Horn, Lisa F. Bettcher, Sandi L. Navarro, Vadim Pascua, Fausto Carnevale Neto, Joseph Cuschieri, Daniel Raftery, Grant E. O'Keefe> ;The Journal of Trauma and Acute Care Surgery. 2021 Jan 1
4 citations
HLA-A Locus is Associated With Sepsis and Septic Shock After Traumatic Injury.
Dara L Horn, Michael N. Mindrinos, Kirsten M. Anderson, Sujatha Krishnakumar, Chunlin Wang, Ming Li, Jill A. Hollenbach, Grant E. O'Keefe> ;Annals of Surgery. 2020 May 19
15 citations
Predictors of mortality, limb loss, and discharge disposition at admission among patients with necrotizing skin and soft tissue infections.
Dara L. Horn, Jolie Shen, Emma A. Roberts, Theresa N Wang, Kevin S Li, Grant E. O'Keefe, Joseph Cuschieri, Eileen M. Bulger, Bryce R.H. Robinson> ;The Journal of Trauma and Acute Care Surgery. 2020 Jul 1
5 citations
Increasing Enteral Protein Intake in Critically Ill Trauma and Surgical Patients.
Grant E. O'Keefe, Marilyn Shelton, Qian Qiu, Jose Cruz Araujo-Lino> ;Nutrition in Clinical Practice. 2019 Oct 1
15 citations
Enhanced Perioperative Care for Major Spine Surgery.
Armagan Dagal, Carlo Bellabarba, Richard Bransford, Fangyi Zhang, Randall M Chesnut, Grant E O'Keefe, David R Wright, Timothy H Dellit, Ian Painter, Michael J Souter> ;Spine. 2019 Jul 1
Association between Age and Acute Respiratory Distress Syndrome Development and Mortality following Trauma.
Killien, E. Y.,Mills, B.,Vavilala, M. S.,Scott Watson, R.,O'Keefe, G. E.,Rivara, F. P.> ;J Trauma Acute Care Surg. 2019 Jan 12
Enhanced Perioperative Care for Major Spine Surgery.
Dagal, A.,Bellabarba, C.,Bransford, R.,Zhang, F.,Chesnut, R. M.,O'Keefe, G. E.,Wright, D. R.,Dellit, T. H.,Painter, I.,Souter, M. J.> ;Spine. 2019 Jan 03
5 citations
Injury in the transgender population: What the trauma surgeon needs to know
Shane D. Morrison, Sarah M. Kolnik, Jonathan P. Massie, Christopher S. Crowe, Daniel Dugi, Jeffrey B. Friedrich, Tam N. Pham, Jens U. Berli, Grant E. O'Keefe, Eileen M...> ;The Journal of Trauma and Acute Care Surgery. 2018 Oct 1
2 citations
Duration of Respiratory Failure After Trauma Is Not Associated With Increased Long-Term Mortality.
Mackenzie R. Cook, Kathleen M O'Connell, Qian Qiu, Andrew J. Riggle, Thomas Hugh Shoultz, Rebecca G. Maine, Saman Arbabi, Grant E. O'Keefe, Joseph Cuschieri, Ronald V....> ;Critical Care Medicine. 2018 Aug 1
7 citations
A Potential Mechanism for Immune Suppression by Beta-Adrenergic Receptor Stimulation following Traumatic Injury.
Nicholas J. Shubin, Tam N. Pham, Kristan Staudenmayer, Brodie Parent, Qian Qiu, Grant E. O'Keefe> ;Journal of Innate Immunity. 2018 Feb 16
15 citations
Parenteral and enteral nutrition in surgical critical care: Plasma metabolomics demonstrates divergent effects on nitrogen, fatty-acid, ribonucleotide, and oxidative m...
Brodie Parent, Max Seaton, Danijel Djukovic, Haiwei Gu, Brittany Wheelock, Sandi L. Navarro, Daniel Raftery, Grant E. O'Keefe> ;The Journal of Trauma and Acute Care Surgery. 2017 Apr 1
6 citations
Outcomes in necrotizing soft tissue infections treated with therapeutic plasma exchange.
Nabiha Huq Saifee, Heather L. Evans, Amalia Magaret, John R. Hess, Meghan Delaney, Grant E. O'Keefe, Tam N. Pham, Hugh M. Foy, Eileen M. Bulger, Monica B. Pagano> ;Transfusion. 2017 Mar 7
35 citations
Protein Delivery in the Intensive Care Unit: Optimal or Suboptimal?
Daren K. Heyland, Peter J.M. Weijs, Jorge A. Coss-Bu, Beth Taylor, Arnold S. Kristof, Grant E. O'Keefe, Robert G. Martindale> ;Nutrition in Clinical Practice. 2017 Mar 1
9 citations
Melanocortin-1 Receptor Polymorphisms and the Risk of Complicated Sepsis After Trauma: A Candidate Gene Association Study.
Max Seaton, Brodie Parent, Ravi F. Sood, Mark M. Wurfel, Lara A. Muffley, Grant E. O'Keefe, Nicole S. Gibran> ;Shock. 2017 Jan 1
134 citations
Time is the enemy: Mortality in trauma patients with hemorrhage from torso injury occurs long before the “golden hour”
Abdul Q. Alarhayem, John G. Myers, Daniel L. Dent, Lillian F. Liao, Mark T. Muir, Deborah L Mueller, Susannah E. Nicholson, Ramon F. Cestero, Mark C. Johnson, Ronald M...> ;American Journal of Surgery. 2016 Dec 1
47 citations
Acute kidney injury subphenotypes based on creatinine trajectory identifies patients at increased risk of death
Pavan K. Bhatraju, Paramita Mukherjee, Cassianne Robinson-Cohen, Grant E. O'Keefe, Angela J. Frank, Jason D. Christie, Nuala J. Meyer, Kathleen D. Liu, Michael A. Matt...> ;Critical Care. 2016 Nov 17
9 citations
Parenteral Nutrition Utilization After Implementation of Multidisciplinary Nutrition Support Team Oversight: A Prospective Cohort Study.
Brodie Parent, Marilyn Shelton, Megan Nordlund, Shahram Aarabi, Grant E. O'Keefe> ;JPEN. Journal of Parenteral and Enteral Nutrition. 2016 Nov 1
15 citations
Biochemical Markers of Nutrition Support in Critically Ill Trauma Victims
Brodie Parent, Max Seaton, Grant E. O'Keefe> ;JPEN. Journal of Parenteral and Enteral Nutrition. 2016 Oct 4
30 citations
Use of Metabolomics to Trend Recovery and Therapy After Injury in Critically Ill Trauma Patients
Brodie Parent, Max Seaton, Ravi F. Sood, Haiwei Gu, Danijel Djukovic, Daniel Raftery, Grant E. O’Keefe> ;JAMA Surgery. 2016 Jul 1
14 citations
Safety of minimizing preoperative starvation in critically ill and intubated trauma patients
Brodie Parent, Samuel P. Mandell, Ronald V. Maier, Joseph P. Minei, Jason L. Sperry, Ernest E. Moore, Grant E. O'Keefe> ;The Journal of Trauma and Acute Care Surgery. 2016 Jun 1
10 citations
Traumatic injury, early gene expression, and gram-negative bacteremia.
Callie M. Thompson, Chin H. Park, Ronald V. Maier, Grant E. O'Keefe> ;Critical Care Medicine. 2014 Jun 1
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Grant Support

Postdoctoral TrainingNational Institute Of General Medical Sciences2005–2011
Gene Polymorphisms, Inflammation And Outcome From TraumaNational Institute Of General Medical Sciences2003–2007
Genetic Determinants Of Inflammation And Organ Function After Burn TraumaNational Institute Of General Medical Sciences2000–2002