GregoryAramDanielsMD

Oncology • San Diego, CA

Clinical Professor at UCSD School of Medicine

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Office
200 W Arbor Dr
Ucsd Medical Center
San Diego, CA 92103
Phone+1 858-822-6100

Fax+1 619-543-3183
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Education & Training

Mayo Clinic College of Medicine and Science (Rochester)Fellowship, Hematology and Medical Oncology, 2002 - 2005
Mayo Clinic College of Medicine and Science (Rochester)Residency, Internal Medicine, 1999 - 2002
Keck School of Medicine of the University of Southern CaliforniaClass of 1999

Certifications & Licensure

CA State Medical License 2005 - 2025
MN State Medical License 2000 - 2006
American Board of Internal Medicine Medical Oncology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2011-2012

Clinical Trials

Azacitidine and Interferon Alfa in Treating Patients With Metastatic Melanoma Start of enrollment: 2006 Feb 01
Completed
Phase 1
A Study of Transgenic Lymphocyte Immunization (TLI) Against Telomerase in Subjects With Stage III Melanoma Start of enrollment: 2007 Jun 01
Unknown status
Phase 2
PROCLAIM Registry to Evaluate the Treatment Patterns and Clinical Response in Malignancy Start of enrollment: 2011 Aug 01
Completed
Safety Study of Attenuated Vaccinia Virus (GL-ONC1)With Combination Therapy in Head & Neck Cancer Start of enrollment: 2012 Apr 01
Completed
Phase 1
HD IL-2 + Vemurafenib in Patients With BRAF Mutation Positive Metastatic Melanoma Start of enrollment: 2012 Aug 01
Terminated
Phase 4
Safety and Efficacy of LEE011 and LGX818 in Patients With BRAF Mutant Melanoma. Start of enrollment: 2013 Jul 01
Terminated
Phase 1, Phase 2
Chemotherapy Plus Cetuximab in Combination With VTX-2337 in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck Start of enrollment: 2013 Oct 14
Completed
Phase 2
Phase 1A/1B Study of PSA/IL-2/GM-CSF Vaccine for Recurrent Prostate Cancer in Hormone Naive and Hormone Independent Patients Start of enrollment: 2012 Apr 01
Unknown status
Phase 1
Adoptive Cell Transfer of Autologous Tumor Infiltrating Lymphocytes and High-Dose Interleukin 2 in Select Solid Tumors Start of enrollment: 2020 Oct 07
Recruiting
Phase 1
High Dose IL-2 in Combination With Anti-PD-1 to Overcome Anti-PD-1 Resistance in Metastatic Melanoma and Renal Cell Carcinoma Start of enrollment: 2019 May 23
Recruiting
Phase 2
Roles: Principal Investigator, Contact, Sponsor-Investigator
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Publications & Presentations

PubMed

1 citations
Metastatic gastric cancer target lesion complete response with Claudin18.2-CAR T cells.
Botta, G., Chao, J., Ma, H., Hahn, M., Sierra, G., Jia, J., Hendrix, A., Nolte Fong, J., Ween, A., Vu, P., Miller, A., Choi, M., Heyman, B., Daniels, G., Kaufman, D., ...> ;Journal for Immunotherapy of Cancer. 2024 Feb 5
Pigmentary retinopathy associated with immune therapy for advanced cutaneous melanoma.
Andrew C Lin, Soo J Park, Gregory A Daniels, Shyamanga Borooah> ;American Journal of Ophthalmology Case Reports. 2023 Jun 1
5 citations
PSGL-1 attenuates early TCR signaling to suppress CD8T cell progenitor differentiation and elicit terminal CD8T cell exhaustion.
Jennifer L Hope, Dennis C Otero, Eun-Ah Bae, Christopher J Stairiker, Ashley B Palete, Hannah A Faso, Michelle Lin, Monique L Henriquez, Sreeja Roy, Hyungseok Seo, Xue...> ;Cell Reports. 2023 May 30
5 citations
Intratumoral oncolytic virus V937 plus ipilimumab in patients with advanced melanoma: the phase 1b MITCI study.
Brendan D Curti, Jon Richards, John R Hyngstrom, Gregory A Daniels, Mark Faries, Lynn Feun, Kim A Margolin, Sigrun Hallmeyer, Mark Grose, Yiwei Zhang, Anlong Li, Rober...> ;Journal for Immunotherapy of Cancer. 2022 Dec 1
18 citations
Dabrafenib Versus Dabrafenib + Trametinib in-Mutated Radioactive Iodine Refractory Differentiated Thyroid Cancer: Results of a Randomized, Phase 2, Open-Label Multicen...
Naifa L Busaidy, Bhavana Konda, Lai Wei, Lori J Wirth, Catherine Devine, Gregory A Daniels, Jonas A DeSouza, Ming Poi, Nathan D Seligson, Maria E Cabanillas, Jennifer ...> ;Thyroid. 2022 Oct 1
1 citations
Combination high-dose interleukin-2 and nivolumab for programmed cell death-1 refractory metastatic melanoma: a case series.
Mina Nikanjam, Jaren Mullen, Carol Yacoub, Gregory A Daniels> ;Journal of Medical Case Reports. 2022 Aug 31
6 citations
Circulating tumor DNA as a predictive biomarker in Merkel cell carcinoma.
Soo J Park, Aarthi Kannan, Jeremy P Harris, Curtis Lacy, Gregory A Daniels, Steve P Lee, Nils Lambrecht, Nicole Hook, Perry Olshan, Paul R Billings, Alexey Aleshin, Li...> ;Journal of the American Academy of Dermatology. 2022 Nov 1
10 citations
Intralesional SD-101 in Combination with Pembrolizumab in Anti-PD-1 Treatment-Naïve Head and Neck Squamous Cell Carcinoma: Results from a Multicenter, Phase II Trial.
Cohen, E., Nabell, L., Wong, D., Day, T., Daniels, G., Milhem, M., Deva, S., Jameson, M., Guntinas-Lichius, O., Almubarak, M., Strother, M., Whitman, E., Chisamore, M....> ;Clinical Cancer Research. 2022 Mar 15
338 citations
Long-Term Outcomes With Nivolumab Plus Ipilimumab or Nivolumab Alone Versus Ipilimumab in Patients With Advanced Melanoma
, , , , , , , , , , , , , , , , , , , , , , , , , , , > ;Journal of Clinical Oncology. 2021 Nov 24
2 citations
An Open–Label, Randomized, Multi–Center Study Comparing the Sequence of High Dose Aldesleukin (Interleukin–2) and Ipilimumab (Yervoy) in Patients with Metastatic Melanoma
Merve Hasanov, Denái R. Milton, William H. Sharfman, Bret Taback, Lee D. Cranmer, Gregory A. Daniels, Lawrence E. Flaherty, Sigrun Hallmeyer, Mohammed M. Milhem, Lynn ...> ;Oncoimmunology. 2021 Oct 9
3 citations
Genome-wide Sequencing of Cell-free DNA Enables Detection of Copy-number Alterations in Patients with Cancer Where Tissue Biopsy is Not Feasible.
Taylor J. Jensen, Aaron M. Goodman, Christopher K. Ellison, Kimberly A. Holden, Shumei Kato, Lisa Kim, Gregory A. Daniels, Kerry D. Fitzgerald, Erin McCarthy, Prachi N...> ;Molecular Cancer Therapeutics. 2021 Aug 31
31 citations
Clinical Responses of Oncolytic Coxsackievirus A21 (V937) in Patients With Unresectable Melanoma.
Robert H.I. Andtbacka, Brendan D. Curti, Gregory A. Daniels, Sigrun Hallmeyer, Eric D. Whitman, Jose Lutzky, Lynn E. Spitler, Karl Zhou, Praveen K. Bommareddy, Mark Gr...> ;Journal of Clinical Oncology. 2021 Aug 31
39 citations
Bempegaldesleukin Plus Nivolumab in First-Line Metastatic Melanoma.
Adi Diab, Scott S. Tykodi, Gregory A. Daniels, Michele Maio, Brendan D. Curti, Karl D. Lewis, Sekwon Jang, Ewa Kalinka, Igor Puzanov, Alexander I. Spira, Daniel C. Cho...> ;Journal of Clinical Oncology. 2021 Jul 13
100 citations
Pembrolizumab plus cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma: an open-label, multi-arm, non-randomised, multicentre, pha...
Assuntina G. Sacco, Ruifeng Chen, Francis P. Worden, Deborah J.L. Wong, Douglas Adkins, Paul L. Swiecicki, Wanxing Chai-Ho, Peter Oppelt, Debanjali Ghosh, Julie Bykows...> ;The Lancet. Oncology. 2021 Jun 1
11 citations
Safety and efficacy of combination nivolumab plus ipilimumab in patients with advanced melanoma: results from a North American expanded access program (CheckMate 218).
F. Stephen Hodi, Paul B. Chapman, Mario Sznol, Christopher D. Lao, Rene Gonzalez, Michael Smylie, Gregory A. Daniels, John A. Thompson, Ragini R. Kudchadkar, William H...> ;Melanoma Research. 2021 Feb 1
13 citations
Rapid onset type 1 diabetes with anti-PD-1 directed therapy.
Karen Yun, Gregory A. Daniels, Kathryn A. Gold, Karen C. McCowen, Sandip Pravin Patel> ;Oncotarget. 2020 Jul 14
13 citations
Prognostic implications of RAS alterations in diverse malignancies and impact of targeted therapies.
Shumei Kato, Ryosuke Okamura, Jason K. Sicklick, Gregory A. Daniels, David S. Hong, Aaron M. Goodman, Elizabeth Weihe, Suzanna Lee, Noor Khalid, Rachel Collier, Manvit...> ;International Journal of Cancer. 2020 Jun 15
5 citations
Author Correction: Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells.
Daniel Ramsköld, Shujun Luo, Yu-Chieh Wang, Robin Li, Qiaolin Deng, Omid R. Faridani, Gregory A. Daniels, Irina Khrebtukova, Jeanne F. Loring, Louise C. Laurent, Gary ...> ;Nature Biotechnology. 2020 Mar 1
248 citations
Cemiplimab in locally advanced cutaneous squamous cell carcinoma: results from an open-label, phase 2, single-arm trial.
Michael R. Migden, Nikhil I. Khushalani, Anne Lynn S. Chang, Karl D. Lewis, Chrysalyne D. Schmults, Leonel Hernandez-Aya, Friedegund Meier, Dirk Schadendorf, Alexander...> ;The Lancet. Oncology. 2020 Feb 1
28 citations
NCCN Guidelines Insights: Uveal Melanoma, Version 1.2019.
P. Kumar Rao, Christopher A. Barker, Daniel G. Coit, Richard W. Joseph, Miguel A. Materin, Ramesh Rengan, Jeffrey A. Sosman, John A. Thompson, Mark R. Albertini, Genev...> ;Journal of the National Comprehensive Cancer Network. 2020 Feb 1
13 citations
Next generation sequencing of cell free circulating tumor DNA in blood samples of recurrent and metastatic head and neck cancer patients
Ashleigh Porter, Mandy Natsuhara, Gregory A. Daniels, Sandip Pravin Patel, Assuntina G. Sacco, Julie Bykowski, Kimberly C. Banks, Ezra E.W. Cohen> ;Translational Cancer Research. 2020 Jan 1
9 citations
Challenge of immune-mediated adverse reactions in the emergency department
Gregory A. Daniels, Angela D Guerrera, Donna Katz, Jayne Viets-Upchurch> ;Emergency Medicine Journal. 2019 Jun 1
4 citations
Hybrid Capture-Based Genomic Profiling Identifies BRAF V600 and Non-V600 Alterations in Melanoma Samples Negative by Prior Testing.
Lise Boussemart, Annie W. Nelson, Michael Wong, Jeffrey S. Ross, Jeffrey A. Sosman, Janice M. Mehnert, Gregory A. Daniels, Kari Kendra, Siraj M. Ali, Vincent A. Miller...> ;The Oncologist. 2019 May 1
21 citations
Phenotypic and Genomic Determinants of Immunotherapy Response Associated with Squamousness.
Aaron M. Goodman, Shumei Kato, Ranajoy Chattopadhyay, Ryosuke Okamura, Ila M Saunders, Meagan Montesion, Garrett M. Frampton, Vincent A. Miller, Gregory A. Daniels, Ra...> ;Cancer Immunology Research. 2019 Apr 19
274 citations
Cutaneous melanoma, version 2.2019
Daniel G. Coit, John A. Thompson, Mark R. Albertini, Christopher A. Barker, William E. Carson, Carlo M. Contreras, Gregory A. Daniels, Dominick J. DiMaio, Ryan C. Fiel...> ;Journal of the National Comprehensive Cancer Network. 2019 Apr 1
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Press Mentions

Despite COVID-19 Pandemic First Patient Undergoes New Personalized ImmunotherapyDecember 10th, 2020
Deciding Between Surgery or Systemic TherapyJune 4th, 2019