GregoryLFreemanMD

Cardiology • San Antonio, TX

Adult Congenital Heart Disease

Professor of Medicine, University Tex San Antonio

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Office
4411 Medical Dr
Ste 300
San Antonio, TX 78229
Phone+1 210-614-5400

Fax+1 210-614-5732
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Education & Training

Loyola University Medical CenterFellowship, Cardiovascular Disease, 1979 - 1981
Cook County Health and Hospitals SystemResidency, Internal Medicine, 1977 - 1979
Loyola University Chicago Stritch School of MedicineClass of 1976

Certifications & Licensure

CA State Medical License 1981 - Present
TX State Medical License 1983 - 2025
IL State Medical License 1977 - 1987
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

America's Top Doctors Castle Connolly, 2002-2014
Top Doctors:SE Texas Castle Connolly, 2013
CMS Meaningful Use Stage 1 Certification NextGen Ambulatory EHR, NextGen Healthcare, 2012-2013
Men's Health Castle Connolly, 2007
Super Doctor SuperDoctors.com
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Clinical Trials

Asthma in a Decentralized Patient Population: Is Traditional Disease Management Enough? Start of enrollment: 2003 Oct 01
Completed
Not Applicable

Publications & Presentations

PubMed

12 citations
Macrophage LXRα gene therapy ameliorates atherosclerosis as well as hypertriglyceridemia in LDLR −/− mice
Guiming Li, K.C. Biju, Xiaoping Xu, Qing Zhou, Cang Chen, Anthony J. Valente, Weijing He, Robert L. Reddick, Gregory L. Freeman, Seema S. Ahuja, Robert A. Clark, Senli...> ;Gene Therapy. 2011 Mar 10
141 citations
Carotid atherosclerosis predicts incident acute coronary syndromes in rheumatoid arthritis.
Matthew R. Evans, Agustín Escalante, Daniel F. Battafarano, Gregory L. Freeman, Daniel H. O'Leary, Inmaculada del Rincón> ;Arthritis and Rheumatism. 2011 May 1
63 citations
Pulse Wave Analysis of the Aortic Pressure Waveform in Severe Left Ventricular Systolic Dysfunction
Scott J. Denardo, Ramavathi Nandyala, Gregory L. Freeman, Gary L. Pierce, Wilmer W. Nichols> ;Circulation. Heart Failure. 2010 Jan 1
90 citations
Wnt-induced secreted protein-1 is a prohypertrophic and profibrotic growth factor
James T. Colston, S. D. De La Rosa, M. Koehler, K. Gonzales, Ruben Mestril, G. L. Freeman, Steven R. Bailey, Bysani Chandrasekar> ;American Journal of Physiology. Heart and Circulatory Physiology. 2007 Sep 1
Early responses associated with chronic pathology in murine schistosomiasis.
Cêtre-Sossah CB, Montesano MA, Freeman GL, Willard MT, Colley DG, Secor WE> ;Parasite Immunol.. 2007-05-01
46 citations
Interleukin-18 knockout mice display maladaptive cardiac hypertrophy in response to pressure overload
James T. Colston, William H. Boylston, Marc D. Feldman, Christopher P. Jenkinson, Sam D. de la Rosa, Amanda Barton, Rodolfo J. Trevino, Gregory L. Freeman, Bysani Chan...> ;Biochemical and Biophysical Research Communications. 2007 Mar 9
91 citations
Acceleration of atherosclerosis during the course of rheumatoid arthritis
Inmaculada del Rincón, Daniel H. O'Leary, Gregory L. Freeman, Agustín Escalante> ;Atherosclerosis. 2007 Dec 1
12 citations
Impact of physiological variables and genetic background on myocardial frequency-resistivity relations in the intact beating murine heart.
Maricela Reyes, Mark E. Steinhelper, Jorge A Alvarez, Daniel Escobedo, John A. Pearce, Jonathan W. Valvano, Bradley H Pollock, Chia-Ling Wei, Anil Kottam, David G. Alt...> ;American Journal of Physiology. Heart and Circulatory Physiology. 2006 Oct 1
31 citations
Development of a synthetic promoter for macrophage gene therapy.
Weijing He, Mei Qiang, Wuqiong Ma, Anthony J. Valente, Marlon P. Quinones, Wen Wang, Robert L. Reddick, Qifu Xiao, Seema S. Ahuja, Robert A. Clark, Gregory L. Freeman,...> ;Human Gene Therapy. 2006 Sep 14
16 citations
Educational Attainment Has a Limited Impact on Disease Management Outcomes in Heart Failure
Brad Smith, Emma Forkner, Richard A. Krasuski, Autumn Dawn Galbreath, Gregory L. Freeman> ;Disease Management. 2006 Jun 9
Pericardial disease.
Little, W.C., Freeman, G.L.> ;Circulation. 2006 Mar 28
4 citations
β-Blockade in heart failure: adding SENIORS to the mix
Merry L. Lindsey, Gregory L. Freeman> ;European Heart Journal. 2006 Mar 1
49 citations
Interleukin-18 induces human cardiac endothelial cell death via a novel signaling pathway involving NF-κB-dependent PTEN activation ☆
Bysani Chandrasekar, Anthony J. Valente, Gregory L. Freeman, Lenin Mahimainathan, Srinivas Mummidi> ;Biochemical and Biophysical Research Communications. 2006 Jan 20
195 citations
Relative contribution of cardiovascular risk factors and rheumatoid arthritis clinical manifestations to atherosclerosis.
Inmaculada del Rincón, Gregory L. Freeman, Roy W. Haas, Daniel H. O'Leary, Agustín Escalante> ;Arthritis and Rheumatism. 2005 Nov 1
51 citations
Disease Management Produces Limited Quality-of-life Improvements in Patients With Congestive Heart Failure: Evidence From a Randomized Trial in Community-dwelling Pati...
Brad Smith, Emma Forkner, Barbara Zaslow, Richard A. Krasuski, Karl C. Stajduhar, Michael Kwan, Robert Ellis, Autumn Dawn Galbreath, Gregory L. Freeman> ;The American Journal of Managed Care. 2005 Nov 1
Comparison of Schistosoma mansoni irradiated cercariae and Sm23 DNA vaccines.
Ganley-Leal LM, Guarner J, Todd CW, Da'Dara AA, Freeman GL, Boyer AE, Harn DA, Secor WE> ;Parasite Immunol.. 2005-09-01
66 citations
The Pro-atherogenic Cytokine Interleukin-18 Induces CXCL16 Expression in Rat Aortic Smooth Muscle Cells via MyD88, Interleukin-1 Receptor-associated Kinase, Tumor Necr...
Bysani Chandrasekar, Srinivas Mummidi, Anthony J. Valente, Devang N. Patel, Steven R. Bailey, Gregory L. Freeman, Masahiko Hatano, Takeshi Tokuhisa, Liselotte E. Jensen> ;The Journal of Biological Chemistry. 2005 Jul 15
73 citations
H2O2 activates Nox4 through PLA2-dependent arachidonic acid production in adult cardiac fibroblasts
James T. Colston, Sam D. de la Rosa, James R. Strader, Matthew A. Anderson, Gregory L. Freeman> ;FEBS Letters. 2005 Apr 25
177 citations
Long-Term Healthcare and Cost Outcomes of Disease Management in a Large, Randomized, Community-Based Population With Heart Failure
Autumn Dawn Galbreath, Richard A. Krasuski, Brad Smith, Karl C. Stajduhar, Michael D. Kwan, Robert Ellis, Gregory L. Freeman> ;Circulation. 2004 Dec 7
6 citations
Enhanced left ventricular systolic function early in type 2 diabetic mice: clinical implications.
Jorge A Alvarez, Maricela Reyes, Daniel Escobedo, Gregory L. Freeman, Mark E. Steinhelper, Marc D. Feldman> ;Diabetes & Vascular Disease Research. 2004 Oct 1
94 citations
Multiple deficiencies in antioxidant enzymes in mice result in a compound increase in sensitivity to oxidative stress.
Holly Van Remmen, Wenbo Qi, Marian Sabia, Gregory Freeman, Larry Estlack, Hong Yang, Zhong Mao Guo, Ting-Ting Huang, Randy Strong, Shuko Lee, Charles J. Epstein, Arlan...> ;Free Radical Biology & Medicine. 2004 Jun 15
17 citations
Impact of brief oxidant stress on primary adult cardiac fibroblasts
James T. Colston, Sam D. de la Rosa, Gregory L. Freeman> ;Biochemical and Biophysical Research Communications. 2004 Mar 26
283 citations
Association between carotid atherosclerosis and markers of inflammation in rheumatoid arthritis patients and healthy subjects
Inmaculada del Rincón, Ken Williams, Michael P. Stern, Gregory L. Freeman, Daniel H. O'Leary, Agustín Escalante> ;Arthritis and Rheumatism. 2003 Jul 1
13 citations
Enhancement of Contractility With Sustained Afterload in the Intact Murine Heart Blunting of Length-Dependent Activation
Maricela Reyes, Gregory L. Freeman, Daniel Escobedo, Shuko Lee, Mark E. Steinhelper, Marc D. Feldman> ;Circulation. 2003 Jun 17
73 citations
TNF-α and H2O2 induce IL-18 and IL-18Rβ expression in cardiomyocytes via NF-κB activation
Bysani Chandrasekar, James T. Colston, Sam D. de la Rosa, Perla P. Rao, Gregory L. Freeman> ;Biochemical and Biophysical Research Communications. 2003 Apr 18
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