GregoryGGerminoMD

Nephrology • Bethesda, MD

Physician

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Office
31 Center Drive
9A52
Bethesda, MD 20892
Phone+1 301-496-5877
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Education & Training

Yale-New Haven Medical CenterFellowship, Nephrology, 1986 - 1990
Yale-New Haven Medical CenterResidency, Internal Medicine, 1983 - 1986
University of Chicago Division of the Biological Sciences The Pritzker School of MedicineClass of 1983

Certifications & Licensure

MD State Medical License 1993 - 2024
American Board of Internal Medicine Internal Medicine

Awards, Honors, & Recognition

Elected Member The American Society for Clinical Investigation, 1998

Publications & Presentations

PubMed

1 citations
Mechanisms of Cyst Development in Polycystic Kidney Disease.
Jiahe Qiu, Gregory G Germino, Luis F Menezes> ;Advances in Kidney Disease and Health. 2023 May 1
2 citations
Mutation Has No Apparent Effects on Peroxisome Structure or Lipid Metabolism.
Takeshi Terabayashi, Luis F Menezes, Fang Zhou, Hongyi Cai, Peter J Walter, Hugo M Garraffo, Gregory G Germino> ;Kidney360. 2021 Oct 28
19 citations
Establishing a Core Outcome Set for Autosomal Dominant Polycystic Kidney Disease: Report of the Standardized Outcomes in Nephrology–Polycystic Kidney Disease (SONG-PKD...
, , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,...> ;American Journal of Kidney Diseases. 2021 Feb 1
5 citations
Pathway identification through transcriptome analysis.
Takeshi Terabayashi, Gregory G. Germino, Luis F. Menezes> ;Cellular Signalling. 2020 Jul 7
53 citations
The pathobiology of polycystic kidney disease from a metabolic viewpoint.
Luis F. Menezes, Gregory G. Germino> ;Nature Reviews. Nephrology. 2019 Sep 5
63 citations
A cleavage product of Polycystin-1 is a mitochondrial matrix protein that affects mitochondria morphology and function when heterologously expressed.
Cheng-Chao Lin, Mahiro Kurashige, Yi Liu, Takeshi Terabayashi, Yu Ishimoto, Tanchun Wang, Vineet Choudhary, Ryan Hobbs, Li-Ka Liu, Ping-Hsien Lee, Patricia Outeda, Fan...> ;Scientific Reports. 2018 Feb 9
A Report of the 24th Annual Congress on Women's Health—Workshop on Transforming Women's Health: From Research to Practice
Jennifer L. Plank-Bazinet, Annie Sampson, Susan G. Kornstein, Gregory G. Germino, Marjorie Robert-Guroff, Stephen E. Gilman, Cora Lee Wetherington, Nakela L. Cook, Ter...> ;Journal of Women's Health. 2018 Jan 1
35 citations
A novel model of autosomal recessive polycystic kidney questions the role of the fibrocystin C-terminus in disease mechanism.
Patricia Outeda, Luis F. Menezes, Erum A. Hartung, Stacey Bridges, Fang Zhou, Xianjun Zhu, Hangxue Xu, Qiong Huang, Qin Yao, Feng Qian, Gregory G. Germino, Terry Watnick> ;Kidney International. 2017 Nov 1
16 citations
NEDD4-family E3 ligase dysfunction due to PKHD1/Pkhd1 defects suggests a mechanistic model for ARPKD pathobiology.
Jun-ya Kaimori, Cheng-Chao Lin, Patricia Outeda, Miguel A. Garcia-Gonzalez, Luis F. Menezes, Erum A. Hartung, Ao Li, Guanqing Wu, Hideaki Fujita, Yasunori Sato, Yasuni...> ;Scientific Reports. 2017 Aug 10
108 citations
Fatty Acid Oxidation is Impaired in An Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney Disease
Luis F. Menezes, Cheng Chao Lin, Fang Zhou, Gregory G. Germino> ;Ebiomedicine. 2016 Mar 1
31 citations
The Future of Polycystic Kidney Disease Research—As Seen By the 12 Kaplan Awardees
Corinne Antignac, James P. Calvet, Gregory G. Germino, Jared J. Grantham, Lisa M. Guay-Woodford, Peter C. Harris, Friedhelm Hildebrandt, Dorien J.M. Peters, Stefan Som...> ;Journal of the American Society of Nephrology. 2015 May 7
14 citations
Systems biology of polycystic kidney disease: a critical review
Luis F. Menezes, Gregory G. Germino> ;Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 2015 Jan 1
84 citations
Ciliary membrane proteins traffic through the Golgi via a Rabep1/GGA1/Arl3-dependent mechanism
Hyunho Kim, Hangxue Xu, Qin Yao, Weizhe Li, Qiong Huang, Patricia Outeda, Valeriu Cebotaru, Marco Chiaravalli, Alessandra Boletta, Klaus Piontek, Gregory G. Germino, E...> ;Nature Communications. 2014 Nov 18
46 citations
Cby1 promotes Ahi1 recruitment to a ring-shaped domain at the centriole-cilium interface and facilitates proper cilium formation and function
Yin Loon Lee, Joshua Sante, Colin J. Comerci, Benjamin Cyge, Luis F. Menezes, Feng-Qian Li, Gregory G. Germino, W. E. Moerner, Ken-Ichi Takemaru, Tim Stearns> ;Molecular Biology of the Cell. 2014 Oct 1
24 citations
Intragenic motifs regulate the transcriptional complexity of Pkhd1/PKHD1
Ravindra Boddu, Chaozhe Yang, Amber K. O'Connor, Robert Curtis Hendrickson, Braden Boone, Xiangqin Cui, Miguel A. Garcia-Gonzalez, Peter Igarashi, Luiz F. Onuchic, Gre...> ;Journal of Molecular Medicine. 2014 Jul 3
4 citations
Determination of urinary lithogenic parameters in murine models orthologous to autosomal dominant polycystic kidney disease
Renato Ribeiro Nogueira Ferraz, Jonathan M. Fonseca, Gregory G. Germino, Luiz F. Onuchic, Ita Pfeferman Heilberg> ;Urolithiasis. 2014 May 10
62 citations
Polycystin Signaling Is Required for Directed Endothelial Cell Migration and Lymphatic Development
Patricia Outeda, David L. Huso, Steven A. Fisher, Marc K. Halushka, Hyunho Kim, Feng Qian, Gregory G. Germino, Terry Watnick> ;Cell Reports. 2014 May 8
7 citations
Impaired glomerulogenesis and endothelial cell migration in Pkd1-deficient renal organ cultures
Isaline Rowe, Marco Chiaravalli, Klaus Piontek, Gregory G. Germino, Alessandra Boletta> ;Biochemical and Biophysical Research Communications. 2014 Feb 21
10 citations
Murine Models of Polycystic Kidney Disease.
Luis F. Menezes, Gregory G. Germino> ;Drug Discovery Today. Disease Mechanisms. 2013 Dec 1
31 citations
A Pkd1-Fbn1 Genetic Interaction Implicates TGF-β Signaling in the Pathogenesis of Vascular Complications in Autosomal Dominant Polycystic Kidney Disease
Dongyan Liu, Connie Wang, Daniel P. Judge, Marc K. Halushka, Jie Ni, Jennifer P Habashi, Javid Moslehi, Djahida Bedja, Kathleen L. Gabrielson, Hangxue Xu, Feng Qian, D...> ;Journal of the American Society of Nephrology. 2014 Jan 1
7 citations
Polycystic kidney disease: Polycystin-1 and polycystin-2--it's complicated.
Terry Watnick, Gregory G. Germino> ;Nature Reviews. Nephrology. 2013 Apr 9
14 citations
Polycystin-1 regulates the stability and ubiquitination of transcription factor Jade-1
Rebecca L. Foy, Vipul C. Chitalia, Maria V. Panchenko, Liling Zeng, Delia Lopez, Jean W. Lee, Shaunak V. Rana, Alessandra Boletta, Feng Qian, Leonidas Tsiokas, Klaus P...> ;Human Molecular Genetics. 2012 Dec 15
63 citations
Network Analysis of a Pkd1-Mouse Model of Autosomal Dominant Polycystic Kidney Disease Identifies HNF4α as a Disease Modifier
Luis F. Menezes, Fang Zhou, Andrew D. Patterson, Klaus Piontek, Kristopher W. Krausz, Frank J. Gonzalez, Gregory G. Germino> ;Plos Genetics. 2012 Nov 29
3 citations
Progesterone induced mesenchymal differentiation and rescued cystic dilation of renal tubules of Pkd1−/− mice
Tomoka Wachi, Noriyuki Yoshida, Yoshihiko Funae, Munehisa Ueno, Gregory G. Germino, Shinji Hirotsune, Nobuhiro Deguchi> ;Biochemical and Biophysical Research Communications. 2012 Aug 24
27 citations
Polycystin-1 is required for stereocilia structure but not for mechanotransduction in inner ear hair cells
Katherine A. Steigelman, Andrea Lelli, Xudong Wu, Jiangang Gao, Susan Lin, Klaus Piontek, Claas Wodarczyk, Alessandra Boletta, Hyunho Kim, Feng Qian, Gregory G. Germin...> ;The Journal of Neuroscience. 2011 Aug 24
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Lectures

Metabolic Reprogramming in Polycystic Kidney Disease
American Society of Nephrology Kidney Week 2019 - Washington, D.C. - 11/9/2019

Grant Support

Novel Approach To The Molecular Genetics Of PKD1National Institute Of Diabetes And Digestive And Kidney Diseases2004–2009
Molecular Genetics Of Human ArpkdNational Institute Of Diabetes And Digestive And Kidney Diseases1996–2008
Discovery &Characterization Of PKD Protein InteractionsNational Institute Of Diabetes And Digestive And Kidney Diseases2000–2004
Basic Science Training In NephrologyNational Institute Of Diabetes And Digestive And Kidney Diseases2003
Novel Approach To The Molecular Genetics Of PKD1National Institute Of Diabetes And Digestive And Kidney Diseases1994–2003
Hopkins Dk Center For The Analysis Of Gene ExpressionNational Institute Of Diabetes And Digestive And Kidney Diseases2000–2002
Identification Of PKD1 Protein Binding PartnersNational Institute Of Diabetes And Digestive And Kidney Diseases1999–2002
Discovery And Characterization Of PKD Protein InteractioNational Institute Of Diabetes And Digestive And Kidney Diseases1999
Identification Of PKD1 Protein Binding PartnersNational Institute Of Diabetes And Digestive And Kidney Diseases1995–1998

GregoryGGerminoMD

Dr. Germino is on Doximity

Education & Training

Certifications & Licensure

Awards, Honors, & Recognition

Publications & Presentations

Grant Support

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