Gregory D Lewis MD

Heart Failure & Transplantation

Section Head, Heart Failure Medical Director of Heart Transplantation Director, CPET Laboratory Massachusetts General Hospital Professor of Medicine, Harvard Medical School

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55 Fruit StGRB 800Boston, MA 02114
Phone+1 617-724-9254
Fax+1 617-726-4105

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Summary

Dr. Gregory Lewis, based in Boston, MA, specializes in Cardiology with a sub-specialty in Heart Failure & Transplantation. His medical residency was completed at Massachusetts General Hospital after graduating from the University of Rochester School of Medicine and Dentistry. He has a broad foundation in cardiology, which includes critical care medicine, heart failure and transplantation. He has made significant contributions to the field through >200 publications in well-known journals such as Circulation, Nature Medicine, NEJM, and JAMA. He has been continuously funded by the NIH to explore metabolic and physiologic profiles of heart failure while maintaining an active clinical practice.

Education & Training

Mass General Brigham/Massachusetts General HospitalResidency, Internal Medicine, 1999 - 2002
University of Rochester School of Medicine and DentistryClass of 1999

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Certifications & Licensure

MA State Medical License 2001 - 2028
NH State Medical License 2024 - 2024
American Board of Internal Medicine Advanced Heart Failure and Transplant Cardiology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 2 Certification EpicCare Inpatient 2014 Certified EHR Suite, Epic Systems Corporation, 2013-2014, 2017
CMS Meaningful Use Stage 2 Certification EpicCare Ambulatory 2014 Certified EHR Suite, Epic Systems Corporation, 2013-2014, 2017
CMS Meaningful Use Stage 1 Certification Oncall, Massachusetts General Hospital, 2013-2014, 2017

Clinical Trials

Validation of Electrical Cardiometry Versus Fick Method in Cardiac Output Measurement
COMPLETED
Study to Evaluate Effect of Nebivolol on Angina in Women With Microvascular Disease
COMPLETED
PHASE4
Gas Exchange for Predicting Hospital Heart Failure Readmissions
UNKNOWN

Publications & Presentations

PubMed

The Threshold for a Clinically Meaningful Improvement in Cardiopulmonary Exercise Testing Measures for Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy.
Ahmad Masri, Gregory D Lewis, Roberto Barriales-Villa, Brian L Claggett, Caroline J Coats
Journal of Cardiac Failure. 2026-08-20
Body Composition, Obesity, and Cardiorespiratory Fitness in the Community.
Vaishnavi Krishnan, Sandhiya Ravichandran, Priya Gajjar, Andrew S Perry, Patricia E Miller
Medicine and Science in Sports and Exercise. 2026-08-18
Exercise Performance With Aficamten vs Metoprolol in Obstructive Hypertrophic Cardiomyopathy: The MAPLE-HCM Randomized Clinical Trial.
Gregory D Lewis, Pablo Garcia-Pavia, Ahmad Masri, Bela Merkely, Michael E Nassif
JAMA Cardiology. 2026-08-01

Journal Articles

Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients with Heart Failure with Preserved Ejection Fraction
Gregory D Lewis, David J Whellan, Martin M LeWinter, Margaret M Redfield, Andrew L Smith, Eugene Braunwald, Michael M Givertz, Adrian F Hernandez, Sanjiv J Shah, Horng..., JAMA
The Effect of Donor Age on Post‐Transplant Mortality in a Cohort of Adult Cardiac Transplant Recipients Aged 18 to 45
Gregory D Lewis, Amy G Fiedler, Heidi Yeh, American Journal of Transplantation
Heart Failure with Preserved Ejection Fraction Expert Panel Report
Kishan S Parikh, Howard K Surks, Sanjiv J Shah, Marvin A Konstam, Margaret M Redfield, Robert M Califf, Kavita Sharma, Narimon Honarpour, Gregory D Lewis, Scott D Solo..., ScienceDirect

Press Mentions

HEART-FID: How to Define Iron Deficiency in Patients with HF?November 5th, 2025
Cytokinetics Presents New Data Related to Aficamten at the HFSA Annual Scientific Meeting 2025September 30th, 2025
FOREST-HCM and MAPLE-HCM: Updates on Aficamten for Treating Hypertrophic CardiomyopathySeptember 30th, 2025

Grant Support

Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF SpectrumBOSTON UNIVERSITY MEDICAL CAMPUS2016–2027
Proteomic Profiling of Precise Exercise Pathophenotypes Across the HFpEF SpectrumBOSTON UNIVERSITY MEDICAL CAMPUS2016–2027
Mass General Brigham HeartShare Clinical CenterMASSACHUSETTS GENERAL HOSPITAL2021–2026
Characterization of Functional Iron Deficiency and Repletion in Heart Failure with Preserved Ejection FractionMASSACHUSETTS GENERAL HOSPITAL2021–2025
Characterization of Molecular and Physiologic Signatures of Impaired Multi-Organ System Reserve Capacity During Exercise in Heart Failure with Preserved Ejection FractionMASSACHUSETTS GENERAL HOSPITAL2020–2025