Gregory D Lewis MD

Heart Failure & Transplantation

Section Head, Heart Failure Medical Director of Heart Transplantation Director, CPET Laboratory Massachusetts General Hospital Professor of Medicine, Harvard Medical School

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55 Fruit StGRB 800Boston, MA 02114
Phone+1 617-724-9254
Fax+1 617-726-4105

Summary

Dr. Gregory Lewis, based in Boston, MA, specializes in Cardiology with a sub-specialty in Heart Failure & Transplantation. His medical residency was completed at Massachusetts General Hospital after graduating from the University of Rochester School of Medicine and Dentistry. He has a broad foundation in cardiology, which includes critical care medicine, heart failure and transplantation. He has made significant contributions to the field through >200 publications in well-known journals such as Circulation, Nature Medicine, NEJM, and JAMA. He has been continuously funded by the NIH to explore metabolic and physiologic profiles of heart failure while maintaining an active clinical practice.

Education & Training

Mass General Brigham/Massachusetts General HospitalResidency, Internal Medicine, 1999 - 2002
University of Rochester School of Medicine and DentistryClass of 1999

Certifications & Licensure

MA State Medical License 2001 - 2026
NH State Medical License 2024 - 2024
American Board of Internal Medicine Advanced Heart Failure and Transplant Cardiology

Clinical Trials

Validation of Electrical Cardiometry Versus Fick Method in Cardiac Output Measurement Start of enrollment: 2012 Mar 01
Completed
Study to Evaluate Effect of Nebivolol on Angina in Women With Microvascular Disease Start of enrollment: 2013 Apr 01
Completed
Phase 4
Gas Exchange for Predicting Hospital Heart Failure Readmissions Start of enrollment: 2013 Oct 01
Unknown status
Pulmonary Hemodynamics During Exercise - Research Network Start of enrollment: 2018 Dec 01
Recruiting
Roles: Contact
TReatment of Pulmonary Hypertension Group II Study Start of enrollment: 2018 Nov 30
Active, not recruiting
Not Applicable
Roles: Contact, Principal Investigator
Impact of Intravenous Iron Repletion On Mechanisms of Exercise InTolerance in HFpEF (IRONMET-HFpEF) Start of enrollment: 2021 Nov 26
Recruiting
Phase 4
Roles: Principal Investigator, Contact
Tocilizumab in Cardiac Transplantation Start of enrollment: 2018 Dec 20
COMPLETED
PHASE2
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Publications & Presentations

PubMed

1 citations
Extended duration of ex-vivo perfusion is associated with worse survival in donation after circulatory death heart recipients: A national database analysis.
Ruby Singh, George Olverson, Kristian Punu, Adham Makarem, Chijioke C Chukwudi
The Journal of Heart and Lung Transplantation. 2025-05-01
Peak Oxygen Uptake Vs Ventilatory Efficiency-In Reply.
Matthew M Y Lee, Gregory D Lewis
JAMA Cardiology. 2025-03-19
Novel Controlled Metabolic Accelerator for Obesity-Related HFpEF: The HuMAIN-HFpEF Randomized Clinical Trial.
Ambarish Pandey, Gregory D Lewis, Barry A Borlaug, Sanjiv J Shah, Andrew J Sauer
JAMA Cardiology. 2025-03-12

Journal Articles

Effect of Inorganic Nitrite vs Placebo on Exercise Capacity Among Patients with Heart Failure with Preserved Ejection Fraction
Gregory D Lewis, David J Whellan, Martin M LeWinter, Margaret M Redfield, Andrew L Smith, Eugene Braunwald, Michael M Givertz, Adrian F Hernandez, Sanjiv J Shah, Horng..., JAMA
The Effect of Donor Age on Post‐Transplant Mortality in a Cohort of Adult Cardiac Transplant Recipients Aged 18 to 45
Gregory D Lewis, Amy G Fiedler, Heidi Yeh, American journal of transplantation
Heart Failure with Preserved Ejection Fraction Expert Panel Report
Kishan S Parikh, Howard K Surks, Sanjiv J Shah, Marvin A Konstam, Margaret M Redfield, Robert M Califf, Kavita Sharma, Narimon Honarpour, Gregory D Lewis, Scott D Solo..., ScienceDirect
Mini-Focus Issue: Exercise Performance and Cardiac Rehabilitation Relative Impairments in Hemodynamic Exercise Reserve Parameters in Heart Failure with Preserved Eject...
Barry A Borlaug, Dalane W Kitzman, Rohan Khera, Gregory D Lewis, Javed Butler, ScienceDirect
An Official European Respiratory Society Statement: Pulmonary Haemodynamics During Exercise
Gregory Lewis, MD, The European Respiratory Journal
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Press Mentions

Heart Drug Improved Exercise Tolerance in Clinical Trial of Patients with Hypertrophic Obstructive CardiomyopathySeptember 4th, 2024
Omecamtiv Mecarbil Fails to Improve Exercise Capacity in HFrEFAugust 5th, 2022
Short Bursts of Exercise Boost Markers of Good HealthJanuary 13th, 2021
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Grant Support

Iron Homeostasis in Heart FailureNIH2020–2024
Metabolic Profiling of ExerciseNIH2016–2020
Metabolic Profiling Of Acute Myocardial Injury In HumansNational Heart, Lung, And Blood Institute2008–2011