GregoryLMooreMD

PubMed

• A robust heterodimeric Fc platform engineered for efficient development of bispecific antibodies of multiple formats.
  Moore, G. L.,Bernett, M. J.,Rashid, R.,Pong, E. W.,Nguyen, D. T.,Jacinto, J.,Eivazi, A.,Nisthal, A.,Diaz, J. E.,Chu, S. Y.,Muchhal, U. S.,Desjarlais, J. R.> ;Methods. 2018 Oct 27
• Regulation of IgE-mediated signalling in human basophils by CD32b and its role in Syk down-regulation: Basic Mechanisms in Allergic Disease.
  Macglashan, D.,Moore, G.,Muchhal, U.> ;Clin. Exp. Allergy. 2014 Apr 17
• Immune suppression in cynomolgus monkeys by XPro9523: An improved CTLA4-Ig fusion with enhanced binding to CD80, CD86 and neonatal Fc receptor FcRn.
  Bernett, M. J.,Chu, S. Y.,Leung, I.,Moore, G. L.,Lee, S. H.,Pong, E.,Chen, H.,Phung, S.,Muchhal, U. S.,Horton, H. M.,Lazar, G. A.,Desjarlais, J. R.,Szymkowski, D. E.> ;MAbs. 2013 Apr 2
• Suppression of mast cell degranulation through a dual-targeting tandem IgE-IgG Fc domain biologic engineered to bind with high affinity to Fc?RIIb.
  Cemerski, S., Chu, S.Y., Moore, G.L., Muchhal, U.S., Desjarlais, J.R., Szymkowski, D.E.> ;Immunol Lett. 2012 Mar 30
• Reduction of total IgE by targeted coengagement of IgE B-cell receptor and Fc?RIIb with Fc-engineered antibody.
  Chu, S.Y., Horton, H.M., Pong, E., Leung, I.L., Chen, H., Nguyen, D., Bautista, C., Muchhal, U.S., Bernett, M.J., Moore, G.L., Szymkowski, D.E., Desjarlais, J.R.> ;J Allergy Clin Immunol. 2012 Apr
• A novel bispecific antibody format enables simultaneous bivalent and monovalent co-engagement of distinct target antigens.
  Moore, G.L., Bautista, C., Pong, E., Nguyen, D.T., Jacinto, J., Eivazi, A., Muchhal, U.S., Karki, S., Chu, S.Y., Lazar, G.A.> ;MAbs. 2011-11-01
• Engineered Fc variant antibodies with enhanced ability to recruit complement and mediate effector functions.
  Moore, G.L., Chen, H., Karki, S., Lazar, G.A.> ;MAbs. 2010-03-10
• IPRO: an iterative computational protein library redesign and optimization procedure.
  Saraf, M.C., Moore, G.L., Goodey, N.M., Cao, V.Y., Benkovic, S.J., Maranas, C.D.> ;Biophys J. 2006 Jun 1
• Identifying residue-residue clashes in protein hybrids by using a second-order mean-field approach.
  Moore, G.L., Maranas, C.D.> ;Proc Natl Acad Sci U S A. 2003 Apr 29
• Independent and combined analyses of sequences from all three genomic compartments converge on the root of flowering plant phylogeny.
  Barkman TJ, Chenery G, McNeal JR, Lyons-Weiler J, Ellisens WJ, Moore G, Wolfe AD, dePamphilis CW> ;Proc. Natl. Acad. Sci. U.S.A.. 2000-11-21
• Construction of a genetic map of human chromosome 17 by use of chromosome-mediated gene transfer.
  Xu WM, Gorman PA, Rider SH, Hedge PJ, Moore G, Prichard C, Sheer D, Solomon E> ;Proc. Natl. Acad. Sci. U.S.A.. 1988-11-01
• Review of the TEIRESIAS-based tools of the IBM Bioinformatics and Pattern Discovery Group.
  Burgard, A. P., Moore, G. L., Maranas, C. D.> ;Metab Eng. 2001 Oct
• Creating multiple-crossover DNA libraries independent of sequence identity.
  Lutz, S., Ostermeier, M., Moore, G. L., Maranas, C. D., Benkovic, S. J.> ;Proc Natl Acad Sci U S A. 2001 Sep 25
• Predicting crossover generation in DNA shuffling.
  Moore, G. L., Maranas, C. D., Lutz, S., Benkovic, S. J.> ;Proc Natl Acad Sci U S A. 2001 Mar 13
• Modeling DNA mutation and recombination for directed evolution experiments.
  Moore, G. L., Maranas, C. D.> ;J Theor Biol. 2000 Aug 7
• Predicting out-of-sequence reassembly in DNA shuffling.
  Moore, G. L., Maranas, C. D.> ;J Theor Biol. 2002 Nov 7
• eCodonOpt: a systematic computational framework for optimizing codon usage in directed evolution experiments.
  Moore, G. L., Maranas, C. D.> ;Nucleic Acids Res. 2002 Jun 1
• Using multiple sequence correlation analysis to characterize functionally important protein regions.
  Saraf, M. C., Moore, G. L., Maranas, C. D.> ;Protein Eng. 2003 Jun
• Engineering fully human monoclonal antibodies from murine variable regions.
  Bernett, M. J., Karki, S., Moore, G. L., Leung, I. W., Chen, H., Pong, E., Nguyen, D. H., Jacinto, J., Zalevsky, J., Muchhal, U. S., Desjarlais, J. R., Lazar, G. A.> ;J Mol Biol. 2010 Mar 12
• Inhibition of B cell receptor-mediated activation of primary human B cells by coengagement of CD19 and FcgammaRIIb with Fc-engineered antibodies.
  Chu, S. Y., Vostiar, I., Karki, S., Moore, G. L., Lazar, G. A., Pong, E., Joyce, P. F., Szymkowski, D. E., Desjarlais, J. R.> ;Mol Immunol. 2008 Sep
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