GuidoMarcucciMD

PubMed

• Flotetuzumab as a salvage immunotherapy in advanced CD123-positive hematological malignancies, a phase 1 pilot study.
  Jianying Zhang, Marjorie Robbins, Monzr M Al Malki, Lucy Ghoda, Ibrahim Aldoss, Joo Song, Salman Otoukesh, Karamjeet Sandhu, Vaibhav Agrawal, Alex F Herrera, Leslie L ...> ;Leukemia & Lymphoma. 2024 Apr 17
• Therapy-related acute lymphoblastic leukaemia in women with antecedent breast cancer.
  Al Malki, M. M., Jianying Zhang, Jose Tinajero, Hoda Pourhassan, Vinod Pullarkat, Vaibhav Agrawal, Paul Koller, Ahmed Aribi, Amandeep Salhotra, Karamjeet Sandhu, Haris...> ;British Journal of Haematology. 2024 Mar 31
• Transcriptome free energy can serve as a dynamic patient-specific biomarker in acute myeloid leukemia.
  Lisa Uechi, Swetha Vasudevan, Daniela Vilenski, Sergio Branciamore, David Frankhouser, Denis O'Meally, Ya-Huei Kuo, Russell Rockne, Nataly Kravchenko-Balasha, Soheil M...> ;NPJ Systems Biology and Applications. 2024 Mar 25
• Gilteritinib as Post-Transplant Maintenance for Acute Myeloid Leukemia With Internal Tandem Duplication Mutation of.
  Mark J Levis, Mehdi Hamadani, Brent Logan, Richard J Jones, Anurag K Singh, Mark Litzow, John R Wingard, Esperanza B Papadopoulos, Alexander E Perl, Robert J Soiffer, ...> ;Journal of Clinical Oncology. 2024 Mar 12
• Targeting PRMT9-mediated arginine methylation suppresses cancer stem cell maintenance and elicits cGAS-mediated anticancer immunity.
  Haojie Dong, Xin He, Lei Zhang, Wei Chen, Yi-Chun Lin, Song-Bai Liu, Huafeng Wang, Le Xuan Truong Nguyen, Min Li, Yinghui Zhu, Dandan Zhao, Lucy Ghoda, Jonathan Serody...> ;Nature Cancer. 2024 Feb 27
• 1 citations
  Hypomethylating agents plus venetoclax compared with intensive induction chemotherapy regimens in molecularly defined secondary AML.
  Shai Shimony, Jan Philipp Bewersdorf, Rory M Shallis, Yiwen Liu, Eva J Schaefer, Amer M Zeidan, Aaron D Goldberg, Eytan M Stein, Guido Marcucci, R Coleman Lindsley, Ev...> ;Leukemia. 2024 Apr 1
• State-transition modeling of blood transcriptome predicts disease evolution and treatment response in chronic myeloid leukemia.
  David E Frankhouser, Russell C Rockne, Lisa Uechi, Dandan Zhao, Sergio Branciamore, Denis O'Meally, Jihyun Irizarry, Lucy Ghoda, Haris Ali, Jeffery M Trent, Stephen Fo...> ;Leukemia. 2024 Apr 1
• Clinical evaluation of complete remission (CR) with partial hematologic recovery (CRh) in acute myeloid leukemia: a report of 7235 patients from seven cohorts.
  Jacob S Appelbaum, Andrew H Wei, Sumithra J Mandrekar, Ing S Tiong, Chong Chyn Chua, Tse-Chieh Teh, Chun Yew Fong, Stephen B Ting, Daniela Weber, Axel Benner, Hannah H...> ;Leukemia. 2024 Feb 1
• OST-01, a natural product from Baccharis coridifolia, targets c-Myc-dependent ribogenesis in acute myeloid leukemia.
  Kang, H., Hoang, D., Valerio, M., Pathak, K., Zhang, L., Buettner, R., Chen, F., Estrella, K., Graff, W., Li, Z., Xie, J., Horne, D., Kuo, Y., Zhang, B., Pirrotte, P.,...> ;Leukemia. 2024 Mar 1
• 3 citations
  Therapeutic application of human type 2 innate lymphoid cells via induction of granzyme B-mediated tumor cell death.
  Li, Z., Ma, R., Tang, H., Guo, J., Shah, Z., Zhang, J., Liu, N., Cao, S., Artis, D., Yu, J., Marcucci, G., Caligiuri, M.> ;Cell. 2024 Feb 1
• Treatment of relapsed or refractory FLT-3 acute myelogenous leukemia with a triplet regimen of hypomethylating agent, venetoclax, and gilteritinib.
  Ngo, D., Tinajero, J., Li, S., Palmer, J., Pourhassan, H., Aribi, A., Nakamura, R., Stein, A., Marcucci, G., Salhotra, A., Sandhu, K., Pullarkat, V., Ball, B., Koller, P.> ;Leukemia & Lymphoma. 2024 Mar 1
• Acute lymphoblastic leukemia with myeloid mutations is a high-risk disease associated with clonal hematopoiesis.
  Patel, A. A., Caner Saygin, Pu Zhang, Jacob Stauber, Ibrahim Aldoss, Adam S Sperling, Lachelle D Weeks, Marlise R Luskin, Todd C Knepper, Pankhuri Wanjari, Peng Wang, ...> ;Blood Cancer Discovery. 2023 Dec 27
• Correction: TET2 deficiency promotes MDS-associated leukemogenesis.
  Feiteng Huang, Jie Sun, Wei Chen, Lei Zhang, Xin He, Haojie Dong, Yuhui Wu, Hanying Wang, Zheng Li, Brian Ball, Samer Khaled, Guido Marcucci, Ling Li> ;Blood Cancer Journal. 2023 Nov 28
• Sirolimus Is an Acceptable Alternative to Tacrolimus for Graft-versus-Host Disease Prophylaxis after Haploidentical Peripheral Blood Stem Cell Transplantation with Pos...
  Elmariah, H., Otoukesh, S., Kumar, A., Ali, H., Arslan, S., Shouse, G., Pourhassan, H., Nishihori, T., Faramand, R., Mishra, A., Khimani, F., Fernandez, H., Lazaryan, ...> ;Transplantation and Cellular Therapy. 2024 Feb 1
• 1 citations
  A randomized phase III study of standard versus high-dose cytarabine with or without vorinostat for AML.
  Guillermo Garcia-Manero, Nikolai A Podoltsev, Megan Othus, John M Pagel, Jerald P Radich, Min Fang, David A Rizzieri, Guido Marcucci, Stephen A Strickland, Mark R Litz...> ;Leukemia. 2024 Jan 1
• 1 citations
  A phase 1 trial of 8-chloro-adenosine in relapsed/refractory acute myeloid leukemia: An evaluation of safety and pharmacokinetics.
  Vinod Pullarkat, Lisa S Chen, Joycelynne Palmer, Jianying Zhang, Timothy W Synold, Ralf Buettner, Le Xuan Truong Nguyen, Guido Marcucci, Ni-Chun Tsai, Yan Wang, James ...> ;Cancer. 2024 Mar 1
• State-transition Modeling of Blood Transcriptome Predicts Disease Evolution and Treatment Response in Chronic Myeloid Leukemia.
  David E Frankhouser, Russell C Rockne, Lisa Uechi, Dandan Zhao, Sergio Branciamore, Denis O'Meally, Lucy Ghoda, Haris Ali, Stephen Forman, Yu-Hsuan Fu, Ya-Huei Kuo, Bi...> ;Biorxiv. 2023 Dec 9
• 3 citations
  Acquired miR-142 deficit in leukemic stem cells suffices to drive chronic myeloid leukemia into blast crisis.
  Bin Zhang, Dandan Zhao, Fang Chen, David Frankhouser, Huafeng Wang, Khyatiben V Pathak, Lei Dong, Anakaren Torres, Krystine Garcia-Mansfield, Yi Zhang, Dinh Hoa Hoang,...> ;Nature Communications. 2023 Sep 1
• 3 citations
  Proteomics and mathematical modeling of longitudinal CSF differentiates fast versus slow ALS progression.
  Lucas Vu, Krystine Garcia-Mansfield, Antonio Pompeiano, Jiyan An, Victoria David-Dirgo, Ritin Sharma, Vinisha Venugopal, Harkeerat Halait, Guido Marcucci, Ya-Huei Kuo,...> ;Annals of Clinical and Translational Neurology. 2023 Nov 1
• 4 citations
  TET2-mediated mRNA demethylation regulates leukemia stem cell homing and self-renewal.
  Yangchan Li, Meilin Xue, Xiaolan Deng, Lei Dong, Le Xuan Truong Nguyen, Lili Ren, Li Han, Chenying Li, Jianhuang Xue, Zhicong Zhao, Wei Li, Ying Qing, Chao Shen, Brand...> ;Cell Stem Cell. 2023 Aug 3
• -mutated acute myeloid leukemia is sensitive to fludarabine-based chemotherapy and conditioning regimens.
  Ahmed Aribi, Amandeep Salhotra, Michelle Afkhami, Anamaria Munteanu, Haris Ali, Ibrahim Aldoss, Salman Otoukesh, Monzr M Al Malki, Karamjeet S Sandhu, Paul Koller, Shu...> ;Leukemia & Lymphoma. 2023 Aug 3
• Targeting miR-126 in Ph+ acute lymphoblastic leukemia.
  Junjing Qiao, Dandan Zhao, Le Xuan Truong Nguyen, Fang Chen, Chen Liang, Katrina Estrella, Lucy Y Ghoda, Nora Heisterkamp, Emanuela C Marcucci, Ya-Huei Kuo, Guido Marc...> ;Leukemia. 2023 Jul 1
• 1 citations
  Tocilizumab for Cytokine Release Syndrome Management After Haploidentical Hematopoietic Cell Transplantation With Post-Transplantation Cyclophosphamide-Based Graft-Ver...
  Janny M Yao, Salman Otoukesh, Hanna Kim, Dongyun Yang, Sally Mokhtari, Yazeed Samara, Amanda Blackmon, Shukaib Arslan, Vaibhav Agrawal, Hoda Pourhassan, Idoroenyi Aman...> ;Transplantation and Cellular Therapy. 2023 Aug 1
• Use of monoclonal antibody therapy in hematologic patients with mild-to-moderate COVID-19: A retrospective single-center experience.
  Al Malki, M. M., Idoroenyi Amanam, Janny Yao, Alfredo Puing, Ni-Chun Tsai, Diana Samuels, Dat Ngo, Stephanie Ho, Haris Ali, Ahmed Aribi, Shukaib Arslan, Andrew Artz, M...> ;Cancer Medicine. 2023 May 1
• 15 citations
  Acute Myeloid Leukemia, Version 3.2023, NCCN Clinical Practice Guidelines in Oncology.
  Daniel A Pollyea, Jessica K Altman, Rita Assi, Dale Bixby, Amir T Fathi, James M Foran, Ivana Gojo, Aric C Hall, Brian A Jonas, Ashwin Kishtagari, Jeffrey Lancet, Lori...> ;Journal of the National Comprehensive Cancer Network. 2023 May 1
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Journal Articles

• Genomic Analyses Identify Recurrent MEF2D Fusions in Acute Lymphoblastic Leukaemia  
  Michael Borowitz, Hagop M Kantarjian, Cheryl L Willman, Stephen P Hunger, Selina M Luger, Clara D Bloomfield, Brent Wood, Jerald P Radich, Marina Konopleva, Stephen J ..., Nature

Abstracts/Posters

• Spred1 Insufficiency in the Hematopoietic and/or Vascular Compartments of the Bone Marrow (BM) Niche Promotes Aggressive Leukemogenesis in Chronic Myelogenous Leukemia...
  Guido Marcucci, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• HDAC8 Promotes MLL-Rearranged Acute Myeloid Leukemia By Inhibiting p53 Acetylation
  Guido Marcucci, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Effective Novel Fto Inhibitors Show Potent Anti-Cancer Efficacy and Suppress Drug ResistanceClinically Relevant Abstract
  Guido Marcucci, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• A 14q32.31 Genomic-Imprinted DLK1-DIO3 microrna promotes Leukemogenesis By Inducing Stem Cell Quiescence and Inhibiting NK Cell Anti-Cancer Immunity
  Guido Marcucci, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• FLT3-ITD Activates Cytoplasmic Drosha-Dependent Non-Canonical Mechanisms of Mir-155 Biogenesis in Acute Myeloid Leukemia
  Guido Marcucci, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/8/2019
• Proteasome Inhibitors Impair the Innate Antiviral Immune Response and Potentiate Pelareorep-Based Viral Therapy in Multiple Myeloma
  Guido Marcucci, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
• Optimization of Tacrolimus Serum Levels When Combined with Post-Transplant Cyclophosphamide As Graft-Versus-Host Disease Prophylaxis after Hematopoietic Cell Transplan...
  Guido Marcucci, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• The First-in-Class Anti-CD47 Antibody Magrolimab (5F9) in Combination with Azacitidine Is Effective in MDS and AML Patients: Ongoing Phase 1b Results
  Guido Marcucci, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/9/2019
• Targeting MiR-126 Blocks Progression of Myelodysplastic Syndrome and Transformation into Acute Myeloid Leukemia
  Guido Marcucci, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019
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Lectures

• Genomic Determinants of Response to Blinatumomab in Relapsed/Refractory (R/R) B-Cell Precursor Acute Lymphoblastic Leukemia in AdultsClinically Relevant Abstract 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Cytokine Gene Polymorphisms Are Associated with Disease Response to Blinatumomab in Patients with B-Cell Acute Lymphoblastic Leukemia 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• CAR22/19 Cocktail Therapy for Patients with Refractory/Relapsed B-Cell MalignanciesClinically Relevant Abstract 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• CD84: A Potential Novel Therapeutic Target in Multiple Myeloma 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Downregulation of Mir-142 Promotes Leukemia Growth in Philadelphia Chromosome-Positive (Ph+) Acute Lymphoblastic Leukemia (ALL): A Possible Novel Therapeutic Target? 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Event-Free Survival As a Surrogate Endpoint for Overall Survival in Previously Untreated Acute Myeloid Leukemia: An Individual Patient-Level Analysis of Multiple Rando... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Clinical Outcomes of MDS Patients Who Were Allogeneic Hematopoietic Stem Cell Transplant Candidates but Did Not Proceed with Transplantation 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• Allogeneic Hematopoietic Cell Transplantation (HCT) Vs. Non-HCT Consolidation Therapies in Acute Myeloid Leukemia (AML) Patients 60-75 Years of Age in First Complete R... 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
• MIPSS70+ V2.0 and Revised Cytogenetics Changes Predict Outcomes of Allogeneic Transplantation with Fludarabine and Melphalan Conditioning in Patients with Myelofibrosis 
  2018 ASH Annual Meeting - San Diego, CA - 12/1/2018
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