GwenLucilleNicholsMD

PubMed

• Gene Therapy with p14/tBID Induces Selective and Synergistic Apoptosis in Mutant Ras and Mutant p53 Cancer Cells In Vitro and In Vivo.
  Robert L Fine, Yuehua Mao, Dario Garcia-Carracedo, Gloria H Su, Wanglong Qiu, Uri Hochfeld, Gwen Nichols, Yong-Liang Li, Richard D Dinnen, Anthony Raffo, Paul W Brandt...> ;Biomedicines. 2023 Jan 18
• 1 citations
  C-Terminal p53 Palindromic Tetrapeptide Restores Full Apoptotic Function to Mutant p53 Cancer Cells In Vitro and In Vivo.
  Robert L Fine, Yuehua Mao, Richard Dinnen, Ramon V Rosal, Anthony Raffo, Uri Hochfeld, Patrick Senatus, Jeffrey N Bruce, Gwen Nichols, Hsin Wang, Yongliang Li, Paul W ...> ;Biomedicines. 2023 Jan 5
• 9 citations
  Anti-spike T-cell and Antibody Responses to SARS-CoV-2 mRNA Vaccines in Patients with Hematologic Malignancies.
  Lee M Greenberger, Larry A Saltzman, Lore M Gruenbaum, Jun Xu, Sneha T Reddy, Jonathon W Senefeld, Patrick W Johnson, Paul A Fields, Catherine Sanders, Louis J DeGenna...> ;Blood Cancer Discovery. 2022 Nov 2
• 73 citations
  Anti-spike antibody response to SARS-CoV-2 booster vaccination in patients with B cell-derived hematologic malignancies.
  Lee M. Greenberger, Larry A. Saltzman, Jonathon W. Senefeld, Patrick W. Johnson, Louis J. DeGennaro, Gwen Nichols> ;Cancer Cell. 2021 Oct 11
• 185 citations
  Antibody response to SARS-CoV-2 vaccines in patients with hematologic malignancies.
  Lee M. Greenberger, Larry A. Saltzman, Jonathon W. Senefeld, Patrick W. Johnson, Louis J. DeGennaro, Gwen Nichols> ;Cancer Cell. 2021 Aug 9
• 11 citations
  Phase I study of daily and weekly regimens of the orally administered MDM2 antagonist idasanutlin in patients with advanced tumors
  Antoine Italiano, Wilson H. Miller, Jean-Yves Blay, Jourik A. Gietema, Yung-Jue Bang, Linda Mileshkin, Hal W. Hirte, Brian Higgins, Steven Blotner, Gwen Nichols, Lin-C...> ;Investigational New Drugs. 2021 Jun 28
• 25 citations
  Murine double minute 2 inhibition alone or with cytarabine in acute myeloid leukemia: Results from an idasanutlin phase 1/1b study⋆.
  Karen W.L. Yee, Cristina Papayannidis, Norbert Vey, Michael Dickinson, Kevin R. Kelly, Sarit Assouline, Margaret Kasner, Karen Seiter, Mark Drummond, Sung-Soo Yoon, Je...> ;Leukemia Research. 2021 Jan 1
• 12 citations
  Effects of posaconazole (a strong CYP3A4 inhibitor), two new tablet formulations, and food on the pharmacokinetics of idasanutlin, an MDM2 antagonist, in patients with...
  John Nemunaitis, Annie Young, Samuel Ejadi, Wilson H. Miller, Lin-Chi Chen, Gwen Nichols, Steven Blotner, Faye Vazvaei, Jianguo Zhi, Albiruni Ryan Abdul Razak> ;Cancer Chemotherapy and Pharmacology. 2018 Jan 24
• 171 citations
  Synthetic Lethality of Combined Bcl-2 Inhibition and p53 Activation in AML: Mechanisms and Superior Antileukemic Efficacy
  Rongqing Pan, Vivian Ruvolo, Hong Mu, Joel D. Leverson, Gwen Nichols, John C. Reed, Marina Konopleva, Michael Andreeff> ;Cancer Cell. 2017 Dec 11
• 70 citations
  Acute myeloid leukemia patients’ clinical response to idasanutlin (RG7388) is associated with pre-treatment MDM2 protein expression in leukemic blasts
  Bernhard Reis, Lori Jukofsky, Gong Chen, Giovanni Martinelli, Hua Zhong, W. Venus So, Michael Dickinson, Mark Drummond, Sarit Assouline, Maneja Hashemyan, Michel Thero...> ;Haematologica. 2016 May 1
• 226 citations
  Results of the phase i trial of RG7112, a small-molecule MDM2 antagonist in leukemia
  Michael Andreeff, Kevin R. Kelly, Karen W.L. Yee, Sarit Assouline, Roger Strair, Leslie Popplewell, David G. Bowen, Giovanni Martinelli, Mark Drummond, Paresh Vyas, Ma...> ;Clinical Cancer Research. 2016 Feb 15
• 15 citations
  MDM2 antagonist clinical response association with a gene expression signature in acute myeloid leukaemia.
  Hua Zhong, Gong Chen, Lori Jukofsky, David Geho, Sung Won Han, Fabian Birzele, Sabine Bader, Lucia Himmelein, James Cai, Zayed Albertyn, Mark Rothe, Laurent Essioux, H...> ;British Journal of Haematology. 2015 Nov 1
• 31 citations
  Clinical pharmacology characterization of RG7112, an MDM2 antagonist, in patients with advanced solid tumors
  Amita Patnaik, Anthony W. Tolcher, Murali Beeram, John Nemunaitis, Glen J. Weiss, Kapil N. Bhalla, Manish Agrawal, Gwen Nichols, Steven A. Middleton, Anna Beryozkina, ...> ;Cancer Chemotherapy and Pharmacology. 2015 Jul 26
• 57 citations
  Pre-clinical evaluation of the MDM2-p53 antagonist RG7388 alone and in combination with chemotherapy in neuroblastoma
  Lindi Chen, Raphael Rousseau, Steven A. Middleton, Gwen Nichols, David R. Newell, John Lunec, Deborah A. Tweddle> ;Oncotarget. 2015 Mar 10
• 33 citations
  Structurally diverse MDM2–p53 antagonists act as modulators of MDR-1 function in neuroblastoma
  Lindi Chen, Yan Zhao, G Halliday, Philip Berry, Raphael Rousseau, Steven A. Middleton, Gwen Nichols, F. del Bello, Alessandro Piergentili, David R. Newell, John Lunec,...> ;British Journal of Cancer. 2014 Aug 12
• 59 citations
  Activation of p53 by the MDM2 inhibitor RG7112 impairs thrombopoiesis
  Camelia Iancu-Rubin, Goar Mosoyan, Kelli Glenn, Ronald E. Gordon, Gwen Nichols, Ronald Hoffman> ;Experimental Hematology. 2014 Feb 1
• 20 citations
  Redirecting Apoptosis to Aponecrosis Induces Selective Cytotoxicity to Pancreatic Cancer Cells through Increased ROS, Decline in ATP Levels, and VDAC
  Richard D. Dinnen, Yuehua Mao, Wanglong Qiu, Nicholas D. Cassai, Vesna Slavkovich, Gwen Nichols, Gloria W. Su, Paul W. Brandt-Rauf, Robert L. Fine> ;Molecular Cancer Therapeutics. 2013 Dec 1
• 424 citations
  Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-m...
  Isabelle Ray-Coquard, Jean-Yves Blay, Antoine Italiano, Axel Le Cesne, Nicolas Penel, Jianguo Zhi, Florian Heil, Ruediger Rueger, Bradford Graves, Meichun Ding, David ...> ;The Lancet. Oncology. 2012 Nov 1
• 19 citations
  Treating anemia of cancer with every-4-week darbepoetin alfa: final efficacy and safety results from a phase II, randomized, double-blind, placebo-controlled study.
  David H. Gordon, Gwen Nichols, Ali Ben-Jacob, Dianne Tomita, Tom Lillie, Carole B. Miller> ;The Oncologist. 2008 Jun 1
• 47 citations
  The advisory dean program: a personalized approach to academic and career advising for medical students.
  William Macaulay, Lisa A. Mellman, Donald O. Quest, Gwen L. Nichols, Joseph Haddad, Peter J. Puchner> ;Academic Medicine. 2007 Jul 1
• 10 citations
  Randomized trial of low-dose interleukin-2 vs cyclosporine A and interferon- γ after high-dose chemotherapy with peripheral blood progenitor support in women with high...
  Linda T. Vahdat, D J Cohen, D Zipin, K M S Lo, Diana Donovan, David G. Savage, Amy Tiersten, Gwen Nichols, Andrea B. Troxel, C S Hesdorffer> ;Bone Marrow Transplantation. 2007 Jun 11
• 6 citations
  The spectrum of myelodysplastic syndromes post-solid organ transplantation: a single institutional experience
  M. Menes, Efsevia Vakiani, Christian E. Keller, E.K. Ho, Adriana I. Colovai, Gwen Nichols, D. Diuguid, JG Mears, Vundavalli V. Murty, Bachir Alobeid, Govind Bhagat> ;Leukemia Research. 2007 Jan 1
• 8 citations
  Do RARA/PML fusion gene deletions confer resistance to ATRA-based therapy in patients with acute promyelocytic leukemia?
  Shivakumar Subramaniyam, Subhadra V. Nandula, G Nichols, Michael A. Weiner, Prakash Satwani, Bachir Alobeid, Govind Bhagat, Vundavalli V. Murty> ;Leukemia. 2006 Dec 1
• Unusual uterine recurrence of primary central nervous system lymphoma.
  Gwen Nichols, Caron A. Jacobson, Debra Ferman, Stuart M. Lichtman> ;Clinical Advances in Hematology & Oncology. 2006 Sep 1
• 106 citations
  Update on treatment recommendations from the Third International Workshop on Waldenstrom's macroglobulinemia.
  Steven P. Treon, Morie A. Gertz, Meletios A. Dimopoulos, Athanasios Anagnostopoulos, Joan Bladé, Andrew R. Branagan, Ramón García-Sanz, Stephen L. Johnson, Eva Kimby, ...> ;Blood. 2006 May 1
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