HToddSpencerMD

Internal Medicine • Wellfleet, MA

Physician

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Office
3130 State Hwy Rte 6
Wellfleet, MA 02667
Phone+1 508-349-3131

Fax+1 508-349-1311
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Summary

Dr. H Spencer, MD is an internist in Wellfleet, Massachusetts. He is currently licensed to practice medicine in Massachusetts, Vermont, and New Hampshire. He is affiliated with Cape Cod Hospital and Baystate Medical Center.

Education & Training

UMass Chan Medical SchoolResidency, Internal Medicine, 1984 - 1987
Boston University School of MedicineClass of 1984

Certifications & Licensure

VT State Medical License 2008 - 2020
MA State Medical License Active through 2020
NH State Medical License 1991 - 2019

Awards, Honors, & Recognition

Patient-Centered Medical Home Recognition Program National Committee for Quality Assurance, 2011-2014
Physician Practice Connections Recognition Program National Committee for Quality Assurance, 2011-2014

Publications & Presentations

PubMed

High-throughput screening identifies compounds that enhance lentiviral transduction.
Johnston, J. M.,Denning, G.,Moot, R.,Whitehead, D.,Shields, J.,Le Doux, J. M.,Doering, C. B.,Spencer, H. T.> ;Gene Ther.. 2014 Sep 19
Generation of an optimized lentiviral vector encoding a high-expression factor VIII transgene for gene therapy of hemophilia A.
Johnston JM, Denning G, Doering CB, Spencer HT> ;Gene Ther.. 2013-06-01
46 citations
Lentiviral vector platform for production of bioengineered recombinant coagulation factor VIII.
H. Trent Spencer, Gabriela Denning, Richard E. Gautney, Boro Dropulic, Andre Roy, Lajos Baranyi, Bagirath Gangadharan, Ernest T. Parker, Pete Lollar, Christopher B. Do...> ;Molecular Therapy. 2011 Feb 1
7 citations
Engineered drug-resistant immunocompetent cells enhance tumor cell killing during a chemotherapy challenge.
Anindya Dasgupta, David McCarty, H. Trent Spencer> ;Biochemical and Biophysical Research Communications. 2010 Jan 1
Advancements in gene transfer-based therapy for hemophilia A.
Doering, C.B., Spencer, H.T.> ;Expert Rev Hematol. 2009 Dec
56 citations
Directed engineering of a high-expression chimeric transgene as a strategy for gene therapy of hemophilia A.
Christopher B. Doering, Gabriela Denning, Kerry L. Dooriss, Bagirath Gangadharan, Jennifer M. Johnston, Keith W Kerstann, David McCarty, H. Trent Spencer> ;Molecular Therapy. 2009 Jul 1
31 citations
Comparison of Factor VIII Transgenes Bioengineered for Improved Expression in Gene Therapy of Hemophilia A
Kerry L. Dooriss, Gabriela Denning, Bagirath Gangadharan, Elisabeth H. Javazon, David McCarty, H. Trent Spencer, Christopher B. Doering> ;Human Gene Therapy. 2009 Apr 1
3 citations
Transduction of murine hematopoietic stem cells and in vivo selection of gene-modified cells.
Lucienne M. Ide, Elisabeth Javazon, H. Trent Spencer> ;Methods in Molecular Biology. 2008 Jan 1
75 citations
Hematopoietic stem cell gene therapy of hemophilia A incorporating a porcine factor VIII transgene and nonmyeloablative conditioning regimens
Lucienne M. Ide, Bagirath Gangadharan, Kuang-Yueh Chiang, Christopher B. Doering, H. Trent Spencer> ;Blood. 2007 Oct 15
51 citations
Hematopoietic stem cells encoding porcine factor VIII induce pro-coagulant activity in hemophilia A mice with pre-existing factor VIII immunity.
Christopher B. Doering, Bagirath Gangadharan, Hillary Z. Dukart, H. Trent Spencer> ;Molecular Therapy. 2007 Jun 1
14 citations
Complete regression of large solid tumors using engineered drug-resistant hematopoietic cells and anti-CD137 immunotherapy.
Douglas W. McMillin, Becker Hewes, Bagirath Gangadharan, David R. Archer, Robert S. Mittler, H. Trent Spencer> ;Human Gene Therapy. 2006 Aug 30
50 citations
High-level expression of porcine factor VIII from genetically modified bone marrow-derived stem cells
Bagirath Gangadharan, Ernest T. Parker, Lucienne M. Ide, H. Trent Spencer, Christopher B. Doering> ;Blood. 2006 May 15
8 citations
Highly efficient transduction of repopulating bone marrow cells using rapidly concentrated polymer-complexed retrovirus
Douglas W. McMillin, Natalia Landázuri, Bagirath Gangadharan, Becker Hewes, David R. Archer, H. Trent Spencer, Joseph M. Le Doux> ;Biochemical and Biophysical Research Communications. 2005 May 13
80 citations
Correlating lamotrigine serum concentrations with tolerability in patients with epilepsy
Lawrence J. Hirsch, David Weintraub, Y. Du, Richard Buchsbaum, H. T. Spencer, M. Hager, T. Straka, Carl W. Bazil, David J. Adams, Stanley R. Resor, Martha J. Morrell> ;Neurology. 2004 Sep 28
8 citations
Retroviral expression of Escherichia coli thymidylate synthase cDNA confers high-level antifolate resistance to hematopoietic cells.
David E. Shaw, Franklin G. Berger, H. Trent Spencer> ;Human Gene Therapy. 2001 Jan 1
Catalytic cysteine of thymidylate synthase is activated upon substrate binding.
Phan, J., Mahdavian, E., Nivens, M.C., Minor, W., Berger, S., Spencer, H.T., Dunlap, R.B., Lebioda, L.> ;Biochemistry. 2000 Jun 13
Drug-resistant variants of Escherichia coli thymidylate synthase: effects of substitutions at Pro-254.
Fantz, C., Shaw, D., Jennings, W., Forsthoefel, A., Kitchens, M., Phan, J., Minor, W., Lebioda, L., Berger, F.G., Spencer, H.T.> ;Mol Pharmacol. 2000 Feb
Mechanisms of acquired resistance to thymidylate synthase inhibitors: the role of enzyme stability.
Kitchens, M.E., Forsthoefel, A.M., Barbour, K.W., Spencer, H.T., Berger, F.G.> ;Mol Pharmacol. 1999 Nov
Kinetic studies on drug-resistant variants of Escherichia coli thymidylate synthase: functional effects of amino acid substitutions at residue 4.
Mahdavian, E., Spencer, H.T., Dunlap, R.B.> ;Arch Biochem Biophys. 1999 Aug 15
Ligand-mediated induction of thymidylate synthase occurs by enzyme stabilization. Implications for autoregulation of translation.
Kitchens, M.E., Forsthoefel, A.M., Rafique, Z., Spencer, H.T., Berger, F.G.> ;J Biol Chem. 1999 Apr 30
Substitution at residue 214 of human thymidylate synthase alters nucleotide binding and isomerization of ligand-protein complexes.
Steadman, D.J., Spencer, H.T., Dunlap, R.B., Berger, S.H.> ;Biochemistry. 1999 Apr 27
A structural role for glutamine 214 in human thymidylate synthase.
Steadman, D.J., Zhao, P.S., Spencer, H.T., Dunlap, R.B., Berger, S.H.> ;Biochemistry. 1998 May 19
Retroviral coexpression of thymidylate synthase and dihydrofolate reductase confers fluoropyrimidine and antifolate resistance.
Fantz, C.R., Shaw, D., Moore, J.G., Spencer, H.T.> ;Biochem Biophys Res Commun. 1998 Feb 4
24 citations
Comparison of the Protection of Cells from Antifolates by Transduced Human Dihydrofolate Reductase Mutants
M. Patel, Susan Sleep, W. S. Lewis, H. T. Spencer, S. M. Mareya, Brian P. Sorrentino, Raymond L. Blakley> ;Human Gene Therapy. 1997 Nov 20
61 citations
Sensitization of Hematopoietic Stem and Progenitor Cells to Trimetrexate Using Nucleoside Transport Inhibitors
James A. Allay, H. T. Spencer, S. L. Wilkinson, Judith A. Belt, Raymond L. Blakley, Brian P. Sorrentino> ;Blood. 1997 Nov 1
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Hospital Affiliations

Mt. Ascutney Hospital and Health CenterWindsor, Vermont
Cape Cod HospitalHyannis, Massachusetts
Baystate Medical CenterSpringfield, Massachusetts
Baystate Medical CenterSpringfield, Massachusetts