HaakonBergeNygaardMDPhD

Neurology • New Haven, CT

Neurodegenerative, Dementia & Geriatrics

Assistant Professor, Neurology, University of British Columbia

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Office
2215 Westbrook Mall
UBC Centre for Brain Health
New Haven, CT V6T1Z
Phone+1 203-688-2259
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Education & Training

Yale-New Haven Medical CenterResidency, Neurology, 2005 - 2008
Yale-New Haven Medical CenterInternship, Internal Medicine, 2004 - 2005
Creighton University School of MedicineClass of 2004

Certifications & Licensure

CT State Medical License 2008 - 2014
American Board of Psychiatry and Neurology Neurology

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013

Publications & Presentations

PubMed

3 citations
Consensus Statement Regarding the Application of Biogen to Health Canada for Approval of Aducanumab
Howard Chertkow, Kenneth Rockwood, David B. Hogan, Natalie A. Phillips, Manuel Montero-Odasso, Shabbir Amanullah, Sandra E. Black, Christian Bocti, Michael Borrie, How...> ;Canadian Geriatrics Journal. 2021 Dec 1
4 citations
Recommendations for Preclinical Testing of Treatments Against Alzheimer's Disease-Related Epileptiform Spikes in Transgenic Rodent Models
Nanxiang Jin, Claudio Babiloni, Wilhelmus Drinkenburg, Mihály Hajós, Haakon B. Nygaard, Heikki Tanila> ;Journal of Alzheimer's Disease. 2021 May 29
8 citations
A Deep Learning Strategy for Automatic Sleep Staging Based on Two-Channel EEG Headband Data
Amelia A. Casciola, Sebastiano K. Carlucci, Brianne A. Kent, Amanda M. Punch, Michael A. Muszynski, Daniel Zhou, Alireza Kazemi, Maryam S. Mirian, Jason Valerio, Marti...> ;Sensors. 2021 May 11
8 citations
Neuropathological and behavioral characterization of aged Grn R493X progranulin-deficient frontotemporal dementia knockin mice
Jonathan Frew, Haakon B. Nygaard> ;Acta Neuropathologica Communications. 2021 Apr 1
26 citations
Sleep and its regulation: An emerging pathogenic and treatment frontier in Alzheimer’s disease
Brianne A. Kent, Howard Feldman, Haakon B. Nygaard> ;Progress in Neurobiology. 2021 Feb 1
226 citations
World-Wide FINGERS Network: A global approach to risk reduction and prevention of dementia
Miia Kivipelto, Francesca Mangialasche, Heather M. Snyder, Ricardo F. Allegri, Sandrine Andrieu, Hidenori Arai, Laura D. Baker, Sylvie Belleville, Henry Brodaty, Sonia...> ;Alzheimer's & Dementia. 2020 Jul 1
8 citations
Community participation in activities and places among older adults with and without dementia
Habib Chaudhury, Tanveer Mahal, Kishore Seetharaman, Haakon B. Nygaard> ;Dementia. 2021 May 1
9 citations
The Use of Patient-Derived Induced Pluripotent Stem Cells for Alzheimer's Disease Modeling.
Christopher Lee, Stephanie M. Willerth, Haakon B. Nygaard> ;Progress in Neurobiology. 2020 May 25
18 citations
Premature termination codon readthrough upregulates progranulin expression and improves lysosomal function in preclinical models of GRN deficiency
Jonathan Frew, Alireza Baradaran-Heravi, Aruna D. Balgi, Xiujuan Wu, Tyler Yan, Steve Arns, Fahimeh S. Shidmoossavee, Jason Samuel Tan, James Brian Jaquith, Karen Jans...> ;Molecular Neurodegeneration. 2020 Mar 16
1 citations
Generation of an induced pluripotent stem cell line (UBCi001-A) from a presymptomatic individual carrying the R418X progranulin gene mutation.
Jonathan Frew, Xiujuan Wu, G.Y. Hsiung, Howard Feldman, Ian R. A. Mackenzie, Haakon B. Nygaard> ;Stem Cell Research. 2019 Dec 1
91 citations
Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial.
Christopher H. van Dyck, Haakon B. Nygaard, Kewei Chen, Michael C. Donohue, Rema Raman, Robert A. Rissman, James B. Brewer, Robert A. Koeppe, Tiffany W. Chow, Michael ...> ;JAMA Neurology. 2019 Oct 1
21 citations
Delayed daily activity and reduced NREM slow-wave power in the APPswe/PS1dE9 mouse model of Alzheimer's disease.
Brianne A. Kent, Mateusz Michalik, Elliott G. Marchant, Kiana W. Yau, Howard Feldman, Ralph E. Mistlberger, Haakon B. Nygaard> ;Neurobiology of Aging. 2019 Jun 1
46 citations
Sleep and EEG Power Spectral Analysis in Three Transgenic Mouse Models of Alzheimer’s Disease: APP/PS1, 3xTgAD, and Tg2576
Brianne A. Kent, Stephen M. Strittmatter, Haakon B. Nygaard> ;Journal of Alzheimer's Disease. 2018 Jan 1
12 citations
Whole-Exome Sequencing of an Exceptional Longevity Cohort.
Haakon B. Nygaard, E. Zeynep Erson-Omay, Xiujuan Wu, Brianne A. Kent, Cecily Q. Bernales, Daniel M. Evans, Matthew J. Farrer, Carles Vilariño-Güell, Stephen M. Strittm...> ;The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences. 2019 Aug 16
2 citations
Neurobehavioral characterization of adult-onset Alexander disease: A family study
Maya Lichtenstein, Emily Dwosh, Anupama Roy Chowdhury, Matthew J. Farrer, Marna B. McKenzie, Ilaria Guella, Daniel M. Evans, Haakon B. Nygaard, Jason R. Shewchuk, Sher...> ;Neurology. Clinical Practice. 2017 Oct 1
98 citations
Targeting Fyn Kinase in Alzheimer’s Disease
Haakon B. Nygaard> ;Biological Psychiatry. 2018 Feb 15
307 citations
Epileptic activity in Alzheimer's disease: causes and clinical relevance
Keith A. Vossel, Maria Carmela Tartaglia, Haakon B. Nygaard, Adam Zeman, Bruce L. Miller> ;The Lancet. Neurology. 2017 Apr 1
92 citations
Prion-Protein-interacting Amyloid-β Oligomers of High Molecular Weight Are Tightly Correlated with Memory Impairment in Multiple Alzheimer Mouse Models
Mikhail A. Kostylev, Adam C. Kaufman, Haakon B. Nygaard, Pujan R. Patel, Laura T. Haas, Erik C. Gunther, Alexander O. Vortmeyer, Stephen M. Strittmatter> ;The Journal of Biological Chemistry. 2015 Jul 10
219 citations
Fyn inhibition rescues established memory and synapse loss in Alzheimer mice.
Adam C. Kaufman, Santiago V. Salazar, Laura T. Haas, Jinhee Yang, Mikhail A. Kostylev, Amanda T. Jeng, Sophie A. Robinson, Erik C. Gunther, Christopher H. van Dyck, Ha...> ;Annals of Neurology. 2015 Jun 1
68 citations
Brivaracetam, but not ethosuximide, reverses memory impairments in an Alzheimer's disease mouse model
Haakon B. Nygaard, Adam C. Kaufman, Tomoko Sekine-Konno, Linda L Huh, Hilary Going, Samantha J Feldman, Mikhail A. Kostylev, Stephen M. Strittmatter> ;Alzheimer's Research & Therapy. 2015 May 5
106 citations
A phase Ib multiple ascending dose study of the safety, tolerability, and central nervous system availability of AZD0530 (saracatinib) in Alzheimer’s disease
Haakon B. Nygaard, Allison F. Wagner, Garrett S Bowen, Susan P Good, Martha G. MacAvoy, Kurt A Strittmatter, Adam C. Kaufman, Brian Rosenberg, Tomoko Sekine-Konno, Pra...> ;Alzheimer's Research & Therapy. 2015 Apr 14
121 citations
Fyn kinase inhibition as a novel therapy for Alzheimer's disease.
Haakon B. Nygaard, Christopher H. van Dyck, Stephen M. Strittmatter> ;Alzheimer's Research & Therapy. 2014 Feb 5
13 citations
A Novel Presenilin 1 Mutation in Early-Onset Alzheimer's Disease With Prominent Frontal Features.
Haakon B. Nygaard, Carol F. Lippa, Djekidel Mehdi, Joachim M. Baehring> ;American Journal of Alzheimer's Disease and Other Dementias. 2014 Jan 24
23 citations
Current and Emerging Therapies for Alzheimer’s Disease
Haakon B. Nygaard> ;Clinical Therapeutics. 2013 Oct 1
421 citations
Metabotropic Glutamate Receptor 5 Is a Coreceptor for Alzheimer Aβ Oligomer Bound to Cellular Prion Protein
Ji Won Um, Adam C. Kaufman, Mikhail A. Kostylev, Jacqueline K. Heiss, Massimiliano Stagi, Hideyuki Takahashi, Meghan E. Kerrisk, Alexander O. Vortmeyer, Thomas Wisniew...> ;Neuron. 2013 Sep 4
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Press Mentions

UBC Lab-Created Brain Cells Hold New Hope for Understanding Mechanics of Alzheimer's DiseaseApril 30th, 2021
Could A Seizure Medication Also Reduce the Risk of Alzheimer's?May 9th, 2015
Experimental Antiepileptic May Play a Role in Alzheimers TxMay 7th, 2015