HaroldPhillipKoefflerMD

PubMed

• 1 citations
  Mitophagy is a novel protective mechanism for drug-tolerant persister (DTP) cancer cells.
  Yun Li, Hengxing Chen, Daning Lu, H Phillip Koeffler, Yin Zhang, Dong Yin> ;Autophagy. 2023 Sep 1
• 3 citations
  Targeting RNA Exonuclease XRN1 Potentiates Efficacy of Cancer Immunotherapy.
  Xue-Bin Ran, Ling-Wen Ding, Qiao-Yang Sun, Henry Yang, Jonathan W Said, Lao Zhentang, Vikas Madan, Pushkar Dakle, Jin-Fen Xiao, Xinyi Loh, Ying Li, Liang Xu, Xiao-Qian...> ;Cancer Research. 2023 Mar 15
• 14 citations
  PINK1-Mediated Mitophagy Promotes Oxidative Phosphorylation and Redox Homeostasis to Induce Drug-Tolerant Persister Cancer Cells.
  Yun Li, Hengxing Chen, Xuan Xie, Bing Yang, Xiaojuan Wang, Jingyuan Zhang, Tian Qiao, Jiao Guan, Yuntan Qiu, Yong-Xin Huang, Duanqing Tian, Xinyi Yao, Daning Lu, H Phi...> ;Cancer Research. 2023 Feb 3
• A Novel CEBPE Variant Causes Severe Infections and Profound Neutropenia.
  Aaqib Zaffar Banday, Anit Kaur, Tadayuki Akagi, Dharmagat Bhattarai, Masahiro Muraoka, Diksha Dev, Jhumki Das, Man Updesh Singh Sachdeva, Indrani Karmakar, Kanika Aror...> ;Journal of Clinical Immunology. 2022 Oct 1
• 14 citations
  Targeted siRNA nanocarrier: a platform technology for cancer treatment.
  Nicole Bäumer, Jessica Tiemann, Annika Scheller, Theresa Meyer, Lisa Wittmann, Matias Ezequiel Gutierrez Suburu, Lilo Greune, Matthias Peipp, Neele Kellmann, Annika Gu...> ;Oncogene. 2022 Apr 1
• 57 citations
  Integrated single-cell transcriptome analysis reveals heterogeneity of esophageal squamous cell carcinoma microenvironment.
  Huy Q Dinh, Feng Pan, Geng Wang, Qing-Feng Huang, Claire E Olingy, Zhi-Yong Wu, Shao-Hong Wang, Xin Xu, Xiu-E Xu, Jian-Zhong He, Qian Yang, Sandra Orsulic, Marcela Har...> ;Nature Communications. 2021 Dec 17
• 32 citations
  Sex-biased ZRSR2 mutations in myeloid malignancies impair plasmacytoid dendritic cell activation and apoptosis.
  Katsuhiro Togami, Sun Sook Chung, Vikas Madan, Christopher A G Booth, Christopher M. Kenyon, Lucia Cabal-Hierro, Justin Taylor, Sunhee S. Kim, Gabriel K. Griffin, Mahm...> ;Cancer Discovery. 2021 Oct 6
• 8 citations
  Selinexor, a selective inhibitor of nuclear export, enhances the anti-tumor activity of olaparib in triple negative breast cancer regardless of BRCA1 mutation status.
  Hélène Marijon, Sigal Gery, Hua Chang, Yosef Landesman, Sharon Shacham, Dhong Hyun Lee, Aimery de Gramont, Harold Phillip Koeffler> ;Oncotarget. 2021 Aug 31
• 41 citations
  Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer.
  Li Yan Li, Qian Yang, Yan-Yi Jiang, Wei Yang, Yuan Jiang, Xiang Li, Masaharu Hazawa, Bo Zhou, Guowei Huang, Xiu E. Xu, Sigal Gery, Ying Zhang, Ling-Wen Ding, Allen S. ...> ;Nature Communications. 2021 Jul 16
• 2 citations
  Publisher Correction: A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes
  Yueyuan Zheng, Guowei Huang, Tiago C. Silva, Qian Yang, Yan-Yi Jiang, H. Phillip Koeffler, De-Chen Lin, Benjamin P. Berman> ;Nature Communications. 2021 Jun 28
• 14 citations
  Topography of transcriptionally active chromatin in glioblastoma
  Liang Xu, Ye Chen, Yulun Huang, Edwin Sandanaraj, John S. Yu, Ruby Yu-Tong Lin, Pushkar Dakle, Xin-Yu Ke, Yuk Kien Chong, Lynnette Koh, Anand Mayakonda, Kassoum Nacro,...> ;Science Advances. 2021 Apr 30
• 18 citations
  A pan-cancer analysis of CpG Island gene regulation reveals extensive plasticity within Polycomb target genes
  Yueyuan Zheng, Guowei Huang, Tiago C. Silva, Qian Yang, Yan-Yi Jiang, H. Phillip Koeffler, De-Chen Lin, Benjamin P. Berman> ;Nature Communications. 2021 Apr 30
• 8 citations
  ZRSR1 cooperates with ZRSR2 in regulating splicing of U12-type introns in murine hematopoietic cells.
  Vikas Madan, Zeya Cao, Weoi Woon Teoh, Pushkar Dakle, Lin Han, Pavithra Shyamsunder, Maya Jeitany, Siqin Zhou, Jia Li, Hazimah Binte Mohd Nordin, Jizhong Shi, Shuizhou...> ;Haematologica. 2021 Mar 11
• 10 citations
  MNK1 and MNK2 enforce expression of E2F1, FOXM1, and WEE1 to drive soft tissue sarcoma
  Xin-Yu Ke, Ye Chen, Valarie Yu-Yan Tham, Ruby Yu-Tong Lin, Pushkar Dakle, Kassoum Nacro, Mark E. Puhaindran, Peter J. Houghton, Angela Pang, Victor Kwan Min Lee, Ling-...> ;Oncogene. 2021 Feb 9
• 5 citations
  Novel carfilzomib-based combinations as potential therapeutic strategies for liposarcomas.
  Maya Jeitany, Aishvaryaa Prabhu, Pushkar Dakle, Elina Pathak, Vikas Madan, Deepika Kanojia, Vineeth T. Mukundan, Yan-Yi Jiang, Yosef Landesman, Wai Leong Tam, Dennis K...> ;Cellular and Molecular Life Sciences. 2021 Feb 1
• 30 citations
  A Transcriptional Regulatory Loop of Master Regulator Transcription Factors, PPARG, and Fatty Acid Synthesis Promotes Esophageal Adenocarcinoma
  Sai Ma, Bo Zhou, Qian Yang, Yunzhi Pan, Wei Yang, Stephen J. Freedland, Ling-Wen Ding, Michael R. Freeman, Joshua J. Breunig, Neil A. Bhowmick, Jian Pan, H. Phillip Ko...> ;Cancer Research. 2021 Mar 1
• 23 citations
  Reprogramming of m6A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.
  Yan-Jie Wang, Bing Yang, Qiao Lai, Jun-Fang Shi, Jiangyun Peng, Yin Zhang, Kaishun Hu, Ya-Qing Li, Jing-Wen Peng, Zhi-Zhi Yang, Yao-Ting Li, Yue Pan, H. Phillip Koeffl...> ;RNA Biology. 2021 Jan 2
• 4 citations
  Characteristics and predictors of post-transplant-associated hemophagocytic lymphohistiocytosis in adults
  Norimichi Hattori, Misuzu Sato, Yuka Uesugi, Ayaka Nakata, Yohei Sasaki, Shotaro Shimada, Megumi Watanuki, Shun Fujiwara, Yukiko Kawaguchi, Nana Arai, Yui Uto, Tomohar...> ;International Journal of Hematology. 2021 Jan 1
• 13 citations
  EWS-FLI1 regulates and cooperates with core regulatory circuitry in Ewing sarcoma.
  Xianping Shi, Yueyuan Zheng, Liling Jiang, Bo Zhou, Wei Yang, Liyan Li, Ling-Wen Ding, Moli Huang, Sigal Gery, De-Chen Lin, H. Phillip Koeffler> ;Nucleic Acids Research. 2020 Nov 18
• 32 citations
  Differentiation therapy of myeloid leukemia: four decades of development.
  Vikas Madan, H. Phillip Koeffler> ;Haematologica. 2020 Oct 9
• 80 citations
  TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines.
  Yan-Yi Jiang, Yuan Jiang, Chunquan Li, Ying Zhang, Pushkar Dakle, Harvinder Kaur, Jian-Wen Deng, Ruby Yu-Tong Lin, Lin Han, Jian-Jun Xie, Yiwu Yan, Ngan B. Doan, Yueyu...> ;Gastroenterology. 2020 Oct 1
• 29 citations
  Core transcriptional regulatory circuitries in cancer.
  Ye Chen, Liang Xu, Ruby Yu-Tong Lin, Markus Müschen, H. Phillip Koeffler> ;Oncogene. 2020 Sep 17
• 18 citations
  ATM-Dependent Recruitment of BRD7 is required for Transcriptional Repression and DNA Repair at DNA Breaks Flanking Transcriptional Active Regions
  Kaishun Hu, Yu Li, Wenjing Wu, Limin Xie, Haiyan Yan, Yuexin Cai, Dong Chen, Qiongchao Jiang, Lehang Lin, Zhen Chen, Jian-You Liao, Yin Zhang, H. Phillip Koeffler, Don...> ;Advanced Science. 2020 Sep 3
• 8 citations
  PARK2 promotes mitochondrial pathway of apoptosis and antimicrotubule drugs chemosensitivity via degradation of phospho-BCL-2.
  Hengxing Chen, Yun Li, Yu Li, Zhen Chen, Limin Xie, Wenjia Li, Yuanxin Zhu, Hong Xue, H. Phillip Koeffler, Wenjing Wu, Kaishun Hu, Dong Yin> ;Theranostics. 2020 Aug 8
• 20 citations
  Lineage-Specific Epigenomic and Genomic Activation of Oncogene HNF4A Promotes Gastrointestinal Adenocarcinomas
  Jian Pan, Tiago C. Silva, Nicole Gull, Qian Yang, Jasmine T. Plummer, Stephanie S. Chen, Kenji Daigo, Takao Hamakubo, Sigal Gery, Ling-Wen Ding, Yan-Yi Jiang, Shao-Yan...> ;Cancer Research. 2020 Jul 1
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Journal Articles

• ARID1A and CEBPα Cooperatively Inhibit UCA1 Transcription in Breast Cancer  
  Harold Koeffler, MD, Nature