HaroldCliffordSmithIIIMD

Emergency Medicine • Homer, AK

Physician

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Office
4300 Bartlett St
Homer, AK 99603
Phone+1 907-235-8101

Fax+1 907-235-0877
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Education & Training

University of Utah HealthResidency, Family Medicine, 1979 - 1982
University of Utah HealthInternship, Transitional Year, 1978 - 1979
Indiana University School of MedicineClass of 1978

Certifications & Licensure

UT State Medical License 1979 - 2024
AK State Medical License 1983 - 2024
WA State Medical License 1989 - 2019
HI State Medical License 1988 - 2018

Awards, Honors, & Recognition

Fellow (FACEP) American College of Emergency Physicians

Publications & Presentations

PubMed

46 citations
Modeling the Embrace of a Mutator: APOBEC Selection of Nucleic Acid Ligands.
Jason D. Salter, Harold C. Smith> ;Trends in Biochemical Sciences. 2018 May 23
10 citations
Structural and functional assessment of APOBEC3G macromolecular complexes.
Bogdan Polevoda, William M. McDougall, Ryan P. Bennett, Jason D. Salter, Harold C. Smith> ;Methods. 2016 Sep 1
30 citations
N-Methylation as a Strategy for Enhancing the Affinity and Selectivity of RNA-binding Peptides: Application to the HIV-1 Frameshift-Stimulating RNA.
Thomas A. Hilimire, Ryan P. Bennett, Ryan A. Stewart, Pablo García-Miranda, Alex Blume, Jordan T. Becker, Nathan M. Sherer, Eric D. Helms, Samuel E. Butcher, Harold C....> ;ACS Chemical Biology. 2016 Jan 15
26 citations
RNA binding to APOBEC3G induces the disassembly of functional deaminase complexes by displacing single-stranded DNA substrates
Bogdan Polevoda, William M. McDougall, Bradley N. Tun, Michael Cheung, Jason D. Salter, Alan E. Friedman, Harold C. Smith> ;Nucleic Acids Research. 2015 Oct 30
34 citations
Structural insights for HIV-1 therapeutic strategies targeting Vif
Jason D. Salter, Guillermo A. Morales, Harold C. Smith> ;Trends in Biochemical Sciences. 2014 Sep 1
41 citations
The multifaceted roles of RNA binding in APOBEC cytidine deaminase functions
Kimberly M. Prohaska, Ryan P. Bennett, Jason D. Salter, Harold C. Smith> ;Wiley Interdisciplinary Reviews. RNA. 2014 Jul 1
31 citations
High-Affinity Recognition of HIV-1 Frameshift-Stimulating RNA Alters Frameshifting in Vitro and Interferes with HIV-1 Infectivity
Leslie O. Ofori, Thomas A. Hilimire, Ryan P. Bennett, Nathaniel W. Brown, Harold C. Smith, Benjamin L. Miller> ;Journal of Medicinal Chemistry. 2014 Jan 15
147 citations
Functions and regulation of the APOBEC family of proteins.
Harold C. Smith, Ryan P. Bennett, Ayse Kizilyer, William M. McDougall, Kimberly M. Prohaska> ;Seminars in Cell & Developmental Biology. 2012 May 1
31 citations
Direct evidence that RNA inhibits APOBEC3G ssDNA cytidine deaminase activity.
William M. McDougall, Harold C. Smith> ;Biochemical and Biophysical Research Communications. 2011 Sep 9
37 citations
Deaminase Activity on Single-stranded DNA (ssDNA) Occurs in Vitro when APOBEC3G Cytidine Deaminase Forms Homotetramers and Higher-order Complexes
William M. McDougall, Chinelo Okany, Harold C. Smith> ;The Journal of Biological Chemistry. 2011 Sep 2
33 citations
APOBEC3G: a double agent in defense.
Harold C. Smith> ;Trends in Biochemical Sciences. 2011 May 1
3 citations
The expression of apoB mRNA editing factors is not the sole determinant for the induction of editing in differentiating Caco-2 cells.
Chad A. Galloway, Harold C. Smith> ;Biochemical and Biophysical Research Communications. 2010 Jan 1
38 citations
A hydrodynamic analysis of APOBEC3G reveals a monomer-dimer-tetramer self-association that has implications for anti-HIV function.
Jason D. Salter, Jolanta Krucinska, Jay Raina, Harold C. Smith, Joseph E. Wedekind> ;Biochemistry. 2009 Nov 17
41 citations
APOBEC3G Subunits Self-associate via the C-terminal Deaminase Domain
Ryan P. Bennett, Jason D. Salter, Xiang Liu, Joseph E. Wedekind, Harold C. Smith> ;The Journal of Biological Chemistry. 2008 Nov 28
41 citations
Nuclear Exclusion of the HIV-1 Host Defense Factor APOBEC3G Requires a Novel Cytoplasmic Retention Signal and Is Not Dependent on RNA Binding
Ryan P. Bennett, Vladimir Presnyak, Joseph E. Wedekind, Harold C. Smith> ;The Journal of Biological Chemistry. 2008 Mar 21
19 citations
Measuring editing activity and identifying cytidine-to-uridine mRNA editing factors in cells and biochemical isolates.
Harold C. Smith> ;Methods in Enzymology. 2007 Jan 1
76 citations
Nanostructures of APOBEC3G Support a Hierarchical Assembly Model of High Molecular Mass Ribonucleoprotein Particles from Dimeric Subunits
Joseph E. Wedekind, Richard E. Gillilan, Alena Janda, Jolanta Krucinska, Jason D. Salter, Ryan P. Bennett, Jay Raina, Harold C. Smith> ;The Journal of Biological Chemistry. 2006 Dec 15
27 citations
APOBEC-1 and AID are nucleo-cytoplasmic trafficking proteins but APOBEC3G cannot traffic.
Ryan P. Bennett, Elie J. Diner, Mark P. Sowden, Joshua A. Lees, Joseph E. Wedekind, Harold C. Smith> ;Biochemical and Biophysical Research Communications. 2006 Nov 10
29 citations
Structural Phylogenetic Analysis of Activation-Induced Deaminase Function
H. Travis Ichikawa, Mark P. Sowden, Andrew T. Torelli, Jürgen Bachl, Pinwei Huang, Geoffrey S. C. Dance, Shauna Marr, Jacques Robert, Joseph E. Wedekind, Harold C. Smi...> ;Journal of Immunology. 2006 Jul 1
71 citations
The structure of a yeast RNA-editing deaminase provides insight into the fold and function of activation-induced deaminase and APOBEC-1
Kefang Xie, Mark P. Sowden, Geoffrey S. C. Dance, Andrew T. Torelli, Harold C. Smith, Joseph E. Wedekind> ;Proceedings of the National Academy of Sciences of the United States of America. 2004 May 25
19 citations
Identification of Novel Alternative Splice Variants of APOBEC-1 Complementation Factor with Different Capacities to Support Apolipoprotein B mRNA Editing
Mark P. Sowden, David M. Lehmann, Xiaoyan Lin, Charles O. Smith, Harold C. Smith> ;The Journal of Biological Chemistry. 2004 Jan 2
50 citations
Increasing the yield of soluble recombinant protein expressed in E. coli by induction during late log phase.
Chad A. Galloway, Mark P. Sowden, Harold C. Smith> ;Biotechniques. 2003 Mar 1
16 citations
A course director's perspectives on problem-based learning curricula in biochemistry.
Harold C. Smith> ;Academic Medicine. 2002 Dec 1
36 citations
Two Proteins Essential for Apolipoprotein B mRNA Editing Are Expressed From a Single Gene Through Alternative Splicing
Geoffrey S. C. Dance, Mark P. Sowden, Luca Cartegni, Ellen Cooper, Adrian R. Krainer, Harold C. Smith> ;The Journal of Biological Chemistry. 2002 Apr 12
14 citations
Apolipoprotein B mRNA editing and the reduction in synthesis and secretion of the atherogenic risk factor, apolipoprotein B100 can be effectively targeted through TAT-...
Yan Yang, Nazzareno Ballatori, Harold C. Smith> ;Molecular Pharmacology. 2002 Feb 1
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Press Mentions

AREV Engages Dr. Harold C. Smith to Join Scientific Advisory BoardJune 2nd, 2021

Grant Support

Development Of A Novel HIV/AIDS Therapeutic Activating The APOBEC3G Host DefenseNational Institute Of Allergy And Infectious Diseases2011
Development Of A High Throughput Screen For Antagonists Of Vif DimerizationNational Institute Of Neurological Disorders And Stroke2009–2011
Based Deamination By CEM15 Suppresses HIV-1 InfectivityNational Institute Of Allergy And Infectious Diseases2004–2005
The Role Of MRNA Editing In B Cell DevelopmentNational Institute Of Allergy And Infectious Diseases2004
Role Of MRNA Editing In B Cell DevelopmentNational Institute Of Allergy And Infectious Diseases2003
Metabolic Regulation Of Apolipoprotein B MRNA EditingNational Institute Of Diabetes And Digestive And Kidney Diseases1995–2003
Metabolic Regulation Of APO B MRNA EditingNational Institute Of Diabetes And Digestive And Kidney Diseases1992–1994

Professional Memberships

American College of Emergency Physicians - ACEP
Fellow

Hospital Affiliations

South Peninsula HospitalHomer, Alaska

HaroldCliffordSmithIIIMD

Dr. Smith is on Doximity

Education & Training

Certifications & Licensure

Awards, Honors, & Recognition

Publications & Presentations

Press Mentions

Grant Support

Professional Memberships

Hospital Affiliations

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