HarryOstrerMD

PubMed

• 4 citations
  Characterizing prostate cancer risk through multi-ancestry genome-wide discovery of 187 novel risk variants.
  Anqi Wang, Jiayi Shen, Alex A Rodriguez, Edward J Saunders, Fei Chen, Rohini Janivara, Burcu F Darst, Xin Sheng, Yili Xu, Alisha J Chou, Sara Benlloch, Tokhir Dadaev, ...> ;Nature Genetics. 2023 Dec 1
• 1 citations
  Identifying high-impact variants and genes in exomes of Ashkenazi Jewish inflammatory bowel disease patients.
  Yiming Wu, Kyle Gettler, Meltem Ece Kars, Mamta Giri, Dalin Li, Cigdem Sevim Bayrak, Peng Zhang, Aayushee Jain, Patrick Maffucci, Ksenija Sabic, Tielman Van Vleck, Gir...> ;Nature Communications. 2023 Apr 20
• 10 citations
  Genome-wide data from medieval German Jews show that the Ashkenazi founder event pre-dated the 14century.
  Shamam Waldman, Daniel Backenroth, Éadaoin Harney, Stefan Flohr, Nadia C Neff, Gina M Buckley, Hila Fridman, Ali Akbari, Nadin Rohland, Swapan Mallick, Iñigo Olalde, L...> ;Cell. 2022 Dec 8
• 45 citations
  Large-scale sequencing identifies multiple genes and rare variants associated with Crohn's disease susceptibility.
  Aleksejs Sazonovs, Christine R Stevens, Guhan R Venkataraman, Kai Yuan, Brandon Avila, Maria T Abreu, Tariq Ahmad, Matthieu Allez, Ashwin N Ananthakrishnan, Gil Atzmon...> ;Nature Genetics. 2022 Sep 1
• 2 citations
  Cancer Risk C (CR-C), a functional genomics test is a sensitive and rapid test for germline mismatch repair deficiency.
  Ishraq Alim, Johnny Loke, Sarah Yam, Allyson S Templeton, Polly Newcomb, Noralane M Lindor, Rish K Pai, Mark A Jenkins, Daniel D Buchanan, Steven Gallinger, Susan Klug...> ;Genetics in Medicine. 2022 Sep 1
• 1 citations
  Prediction of breast cancer risk based on flow variant analysis of circulating peripheral blood mononuclear cells.
  Johnny Loke, Ishraq Alim, Sarah Yam, Susan Klugman, Li C Xia, Dorota Gruber, David Tegay, Andrea LaBella, Kenan Onel, Harry Ostrer> ;HGG Advances. 2022 Apr 14
• 2 citations
  Pathogenic Variants in MAP3K1 Cause 46,XY Gonadal Dysgenesis: A Review.
  Harry Ostrer> ;Sexual Development. 2022 Jan 1
• 16 citations
  Novel ultra-rare exonic variants identified in a founder population implicate cadherins in schizophrenia.
  Todd Lencz, Jin Yu, Raiyan R. Khan, Erin Flaherty, Shai Carmi, Max Lam, Danny Ben-Avraham, Nir Barzilai, Susan B. Bressman, Ariel Darvasi, Judy H. Cho, Lorraine N. Cla...> ;Neuron. 2021 May 5
• 1 citations
  Health care professionals' attitudes toward cancer gene panel testing.
  Susan Klugman, Freya Schnabel, Ishraq Alim, Johnny Loke, Banu Arun, Jennifer Chun Kim, Harry Ostrer> ;The Breast Journal. 2021 Mar 6
• 3 citations
  Publisher Correction: Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction (N...
  David V. Conti, Burcu F. Darst, Lilit C. Moss, Edward J. Saunders, Xin Sheng, Alisha Chou, Fredrick R. Schumacher, Ali Amin Al Olama, Sara Benlloch, Tokhir Dadaev, Mar...> ;Nature Genetics. 2021 Mar 1
• 195 citations
  Trans-ancestry genome-wide association meta-analysis of prostate cancer identifies new susceptibility loci and informs genetic risk prediction
  David V. Conti, Burcu F. Darst, Lilit C. Moss, Edward J. Saunders, Xin Sheng, Alisha Chou, Fredrick R. Schumacher, Ali Amin Al Olama, Sara Benlloch, Tokhir Dadaev, Mar...> ;Nature Genetics. 2021 Jan 4
• Survey of Radiation Oncologists to Assess Interest and Potential Use of a Genetic Test Predicting Susceptibility for the Development of Toxicities After Prostate Cance...
  Kayla Collado, Sarah L. Kerns, Michael A. Diefenbach, Elizabeth Peterson-Roth, Raymond A. Koski, Harry Ostrer, Richard G. Stock, Martin Mattessich, Paul Kaplan, Barry ...> ;Advances in Radiation Oncology. 2020 Apr 18
• 63 citations
  Radiogenomics Consortium Genome-Wide Association Study Meta-analysis of Late Toxicity after Prostate Cancer Radiotherapy
  Sarah L. Kerns, Laura Fachal, Leila Dorling, Gillian C. Barnett, Andrea Baran, Derick R. Peterson, Michelle Hollenberg, Ke Hao, Antonio Fabio Di Narzo, Mehmet Eren Ahs...> ;Journal of the National Cancer Institute. 2020 Feb 1
• Diaspora, migration, and the sciences: a new integrated perspective
  Leonard V. Rutgers, Harry Ostrer, Tracy L. Prowse, Hannes Schroeder> ;European Journal of Human Genetics. 2019 Apr 1
• 6 citations
  Ectopic Otoconin 90 expression in triple negative breast cancer cell lines is associated with metastasis functions.
  Alexander Pearlman, Mohammed Tanjimur Rahman, Kinnari Upadhyay, Johnny Loke, Harry Ostrer> ;Plos One. 2019 Feb 14
• 8 citations
  Author Correction: Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
  Fredrick R. Schumacher, Olama Aaa., Sonja I. Berndt, Sara Benlloch, Munaza Ahmed, Ed Saunders, Tokhir Dadaev, D. Leongamornlert, Ezequiel Anokian, Clara Cieza-Borrella...> ;Nature Genetics. 2019 Feb 1
• 3 citations
  Author Correction: Germline variation at 8q24 and prostate cancer risk in men of European ancestry
  Marco Matejcic, Edward J. Saunders, Tokhir Dadaev, Mark N. Brook, Kan Wang, Xin Sheng, Ali Amin Al Olama, Fredrick R. Schumacher, Sue A. Ingles, Koveela Govindasami, S...> ;Nature Communications. 2019 Jan 17
• 17 citations
  Mutations in MAP3K1 that cause 46,XY disorders of sex development disrupt distinct structural domains in the protein.
  Adam C. Chamberlin, Robert Huether, Aline Zamboni Machado, Michael Groden, Hsiao Mei Liu, Kinnari Upadhyay, O. Vivian, Nathalia Lisboa Gomes, Antonio M. Lerario, Miria...> ;Human Molecular Genetics. 2019 May 15
• 1 citations
  Rapid Next-Generation Sequencing Method for Prediction of Prostate Cancer Risks
  Viacheslav Y. Fofanov, Kinnari Upadhyay, Alexander Pearlman, Johnny Loke, O. Vivian, Yongzhao Shao, Stephen J. Freedland, Harry Ostrer> ;The Journal of Molecular Diagnostics. 2019 Jan 1
• 15 citations
  Radiation biology and oncology in the genomic era
  Sarah L. Kerns, Kuang-Hsiang Chuang, William A. Hall, Zachary Werner, Yuhchyau Chen, Harry Ostrer, Catharine M L West, Barry S. Rosenstein> ;The British Journal of Radiology. 2018 Jun 14
• 74 citations
  Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
  , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , ,...> ;Nature Communications. 2018 Jun 11
• 483 citations
  Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci
  Fredrick R. Schumacher, Ali Amin Al Olama, Sonja I. Berndt, Sara Benlloch, Mahbubl Ahmed, Edward J. Saunders, Tokhir Dadaev, Daniel Leongamornlert, Ezequiel Anokian, C...> ;Nature Genetics. 2018 Jun 11
• 16 citations
  High-depth whole genome sequencing of an Ashkenazi Jewish reference panel: enhancing sensitivity, accuracy, and imputation
  Todd Lencz, Jin Yu, Cameron D. Palmer, Shai Carmi, Danny Ben-Avraham, Nir Barzilai, Susan Bressman, Ariel Darvasi, Judy H. Cho, Lorraine N. Clark, Zeynep H. Gümüş, Vij...> ;Human Genetics. 2018 Apr 28
• 48 citations
  Machine Learning on a Genome-wide Association Study to Predict Late Genitourinary Toxicity After Prostate Radiation Therapy.
  Sangkyu Lee, Sarah L. Kerns, Harry Ostrer, Barry S. Rosenstein, Joseph O. Deasy, Jung Hun Oh> ;International Journal of Radiation Oncology, Biology, Physics. 2018 May 1
• 224 citations
  Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease.
  Ken Y. Hui, Heriberto Fernandez-Hernandez, Jianzhong Hu, Adam Schaffner, Nathan Pankratz, Nai Yun Hsu, Ling-Shiang Chuang, Shai Carmi, Nicole Villaverde, Xianting Li, ...> ;Science Translational Medicine. 2018 Jan 10
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Journal Articles

• Biallelic mutations in FLNB cause a skeletal dysplasia with 46,XY gonadal dysgenesis by activating Beta-catenin  
  Upadhyay K, Loke J, O V, Taragin B, Ostrer H, Clin Genet, 1/1/2018
• Robust genomic copy number predictor of pan cancer metastasis  
  Pearlman A, Upadhyay K, Cole K, Loke J, Sun K, Fineberg S, Freedland SJ, Shao Y, Ostrer H, Genes and Cancer, 1/1/2018
• Germline variation at 8q24 and prostate cancer risk in men of European ancestry  
  Matejcic M, Saunders EJ, Dadaev T, Brook MN, Wang K, Sheng X, Olama AAA, et al, Nat Commun, 1/1/2018
• Prediction of breast cancer risk based on flow-variant analysis of circulating peripheral blood B cells  
  Syeda MM, Upadhyay K, Loke J, Pearlman A, Klugman S, Shao Y, Ostrer H, Genet Med, 1/1/2017
• How Will Big Data Improve Clinical and Basic Research in Radiation Therapy?  
  Rosenstein BS, Capala J, Efstathiou JA, Hammerbacher J, Kerns SL, Kong FM, Ostrer H, Prior FW, Vikram B, Wong J, Xiao Y, Int J Radiat Oncol Biol Phys, 1/1/2016
• Expanded genetic screening panel for the Ashkenazi Jewish population  
  Baskovich B, Hiraki S, Upadhyay K, Meyer P, Carmi S, Barzilai N, Darvasi A, Ozelius L, Peter I, Cho JH, Atzmon G, Clark L, Yu J, Lencz T, Pe'er I, Ostrer H, Oddoux C, Genet Med, 1/1/2016
• SU-D-204-06: Integration of Machine Learning and Bioinformatics Methods to Analyze Genome-Wide Association Study Data for Rectal Bleeding and Erectile Dysfunction Foll...  
  Oh J, Kerns S, Ostrer H, Rosenstein B, Deasy J, Med Phys, 1/1/2016
• Meta-analysis of Genome Wide Association Studies Identifies Genetic Markers of Late Toxicity Following Radiotherapy for Prostate Cancer  
  Kerns SL, Dorling L, Fachal L, Bentzen S, Pharoah PD, Barnes DR, G�mez-Caama�o A, Carballo AM, Dearnaley DP, Peleteiro P, Gulliford SL, Hall E, Michailidou K, Carraced..., EBioMedicine., 1/1/2016
• Individual patient data meta-analysis shows a significant association between the ATM rs1801516 SNP and toxicity after radiotherapy in 5456 breast and prostate cancer ...  
  Andreassen CN, Rosenstein BS, Kerns SL, Ostrer H, De Ruysscher D, Cesaretti JA, Barnett GC, Dunning AM, Dorling L, West CM, Burnet NG, Elliott R, Coles C, Hall E, Fach..., Radiother Oncol, 1/1/2016
• The genetic history of Cochin Jews from India  
  Waldman YY, Biddanda A, Dubrovsky M, Campbell CL, Oddoux C, Friedman E, Atzmon G, Halperin E, Ostrer H, Keinan A, Hum Genet, 1/1/2016
• Functional Variant Analyses (FVAs) predict pathogenicity in the BRCA1 DNA double-strand break repair pathway  
  Loke J, Pearlman A, Upadhyay K, Tesfa L, Shao Y, Ostrer H, Hum Mol Genet, 1/1/2015
• The prediction of radiotherapy toxicity using single nucleotide polymorphism-based models: A step toward prevention  
  Kerns SL, Kundu S, Oh JH, Singhal SK, Janelsins M, Travis LB, Deasy JO, Janssens AC, Ostrer H, Parliament M, Usmani N, Rosenstein BS, Semin Radiat Oncol, 1/1/2015
• The origin of the pE180 growth hormone receptor gene mutation  
  Ostrer H, Growth Horm IGF Res, 1/1/2015
• Mutations in MAP3K1 tilt the balance from SOX9/FGF9 to WNT/Beta-catenin signaling  
  Loke J, Pearlman A, Radi O, Zuffardi O, Giussani U, Pallotta R, Camerino G and Ostrer H, Hum Mol Genet, 1/1/2014
• Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes  
  Vacic V, Ozelius LJ, Clark LN, Bar-Shira A, Gana-Weisz M, Gurevich T, Gusev A, Kedmi M, Kenny EE, Liu X, Mejia-Santana H, Mirelman A, Raymond D, Saunders-Pullman R, De..., Hum Mol Genet, 1/1/2014
• A novel variant in CDKN1C is associated with intrauterine growth restriction, short stature, and early-adulthood-onset diabetes  
  Kerns SL, Guevara-Aguirre J, Andrew S, Geng J, Guevara C, Guevara-Aguirre M, Guo M, Oddoux C, Shen Y, Zurita A, Rosenfeld RG, Ostrer H, Hwa V, Dauber A, J Clin Endocrinol Metab, 1/1/2014
• Disorders of sex development (DSDs): an update  
  Ostrer H, J Clin Endocrinol Metab, 1/1/2014
• Bioinformatics in otolaryngology research Part two: other high-throughput platforms in genomics and epigenetics  
  Ow TJ, Upadhyay K, Belbin TJ, Prystowsky MB, Ostrer H, Smith RV, J Laryngol Otol., 1/1/2014
• Radiogenomics: radiobiology enters the era of big data and team science  
  Rosenstein BS, West CM, Bentzen SM, Alsner J, Andreassen CN, Azria D, Barnett GC, Baumann M, Burnet N, Chang-Claude J, Chuang EY, Coles CE, Dekker A, De Ruyck K, De Ru..., Int J Radiat Oncol Biol Phys, 1/1/2014
• A two-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of erectile dysfunction following radiotherapy for pr...  
  Kerns SL, Stock R, Stone N, Buckstein M, Campbell C, Rath L, Lammering G, Hixson R, Cesaretti J, Terk M, Li W, Moore J, Pearlman A, Shao Y, Ostrer H, Rosenstein BS, Int J Radiat Oncol Biol Phys, 1/1/2013
• A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer  
  Kerns SL, Stone NN, Stock RG, Rath L, Ostrer H, Rosenstein BS, J Urol, 1/1/2013
• Genome-wide association of single-nucleotide polymorphisms with weight loss outcomes after Roux-en-Y gastric bypass surgery  
  Rinella ES, Still C, Shao Y, Wood GC, Chu X, Salerno B, Gerhard GS, Ostrer H, J Clin Endocrinol Metab, 1/1/2013
• Prostate cancer susceptibility genes on 8p21-23 in a Dutch population  
  Zeegers MP, Nekeman D, Khan HS, van Dijk BA, Goldbohm RA, Schalken J, Shajahan S, Pearlman A, Oddoux C, van den Brandt PA, Schouten LJ, Ostrer H, Prostate Cancer Prostatic Dis, 1/1/2013
• Genome-wide association study identifies a region on chromosome 11q143 associated with late rectal bleeding following radiation therapy for prostate cancer  
  Kerns SL, Stock RG, Stone NN, Blacksburg SR, Rath L, Vega A, Fachal L, G�mez-Caama�o A, De Ruysscher D, Lammering G, Parliament M, Blackshaw M, Sia M, Cesaretti J, Ter..., Radiother Oncol, 1/1/2013
• Missense mutation in the MEN1 gene discovered through whole exome sequencing co-segregates with familial hyperparathyroidism  
  Isakov O, Rinella ES, Olchovsky D, Shimon I, Ostrer H, Shomron N, Friedman E, Genet Res, 1/1/2013
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Books/Book Chapters

• Encyclopedia of Life Sciences 
  Chapter: Sex determination, male: genetics of 
  Ostrer HJohn Wiley and Sons, Chichester, United Kingom2017
• Legacy: A Genetic History of the Jewish People 
  Ostrer HOxford University Press, New York, NY2012
• Essentials of Medical Genomics 
  Chapter: Genetic testing 
  Ostrer HJohn Wiley and Sons, New York, NY2003
• Gynecology and Obstetrics 
  Chapter: Genetics of Sexual Differentiation 
  Ostrer HEditors: Scott JR.JB Lippincott, Philadelphia, PA2002
• UpToDate 
  Chapter: Basic Principles of Genetic Counseling for the Practicing Obstetrician 
  Ostrer HEditors: Rose BD.Wellesley, MA2001
• UpToDate 
  Chapter: Etiology of Birth Defects 
  Ostrer HEditors: Rose BD.Wellesley, MA2001
• Breast Cancer 
  Chapter: Genetic counseling for patients with breast cancer and their families 
  Reich EW, Ostrer, HEditors: Roses D.JB Lippincott, Philadelphia, PA1999
• Non-Mendelian Genetics in Humans 
  Ostrer HOxford University Press, New York, NY1998
• Child and Adolescent Psychiatry 
  Chapter: The developing brain and mind: Advances in research techniques 
  Young JG, Brasic JR, Ostrer H, Kaplan D, Will M, John ER, Prichep L, Buchsbaum MEditors: Lewis M.Williams and Wilkins, Baltimore, MDEdition 2nd,1996
• Principles and Practice of Endocrinology and Metabolism 
  Chapter: Genetic testing in endocrinology 
  Hejtmancik JF, Ostrer HEditors: Becker KL.JB Lippincott, Philadelphia, PA1994
• Reproductive Endocrinology, Surgery, and Technology 
  Chapter: Sex determination 
  Ostrer HEditors: Adashi EY, Rock JA, Rosenwaks Z.Raven Press, New York, NY1994
• Cancer of the Ovary 
  Chapter: Hereditary/familial ovarian cancer 
  Hoskins IA, Ostrer HEditors: Markman M, Hoskins WJ.Raven Press, New York, NY1993
• Child and Adolescent Psychiatry 
  Chapter: Advances in research techniques 
  Young JG, Brasic JR, Kaplan D, Golomb J, Ostrer H, Furman J, Bigeon AEditors: Lewis M.Williams and Wilkins, Baltimore, MD1991
• Encyclopedia of the Human Genome 
  Chapter: Sex determination, male: genetics of 
  Ostrer HNature Publishing Group, London, United Kingdom
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Lectures

• We're All Mishpocha: The Shared Population Genetics of Ashkenazi, Sephardic and Middle Eastern Jews 
  San Francisco, CA - 1/1/2018
• How mutations in signal transduction pathways can cause 46,XY gonadal dysgenesis 
  Kona, HI - 1/1/2018
• Functional genomic approaches for understanding the consequences of genetic variation 
  Haifa, Israel - 1/1/2018
• Functional genomic approaches to address the challenge of variants of uncertain significance 
  San Diego, CA - 1/1/2018
• Robust Predictor of Colon Cancer Risk 
  Honolulu, HI - 1/1/2018
• Adam and Eve Seek NextGen Sequencing and Functional Variant Analysis to Understand Sex Determination and Its Disorders 
  Children�s Hospital of Eastern Ontario, Ottawa, Canada, 2016; University of Florida, Gainesville, FL - 1/1/2017
• The Inaugural Talk: Ask Not What Genomics Can Do For You 
  New Hyde Park, NY - 1/1/2017
• Functional Genomic Approaches to Understanding Cancer Risks 
  Multiple locations, 2017 - 1/1/2017
• Why Do Cancers Become Metastatic and What Can We Do About It? 
  Kibbutz Hagoshrim, Israel - 1/1/2017
• Setting the Record Straight: The DNA and Yiddish Origins of Ashkenazi Jewry 
  Orlando, FL - 1/1/2017
• How do you reconstruct the genetic history of a people in the present and in the past? 
  Amsterdam, The Netherlands - 1/1/2017
• Functional Genomic Approaches to Understanding Developmental Disorders and Cancer Risks 
  Groningen University, The Netherlands - 1/1/2017
• How Will I Interpret My Genomic Information 
  Salt Lake City, UT, 2016; Haifa Israel, 2016 - 1/1/2016
• Whole exome sequencing analysis of severe toxicity cases and controls 
  Maastricht, Netherlands - 1/1/2016
• Predictive biomarkers of adverse reactions of radiotherapy in prostate cancer 
  Kona, HI - 1/1/2016
• Splicing and Dicing DNA: Genome Engineering and the CRISPR Revolution 
  John Jay College, New York, NY - 1/1/2016
• Regulatory Oversight of Laboratory Developed Tests by the FDA from the Laboratory Director's Perspective 
  New York, NY - 1/1/2015
• Origin of the Growth Hormone Receptor Gene p.E180 Mutation 
  Universdad San Francisco de Quito, Ecuador - 1/1/2015
• Adam and Eve Seek NextGen Sequencing to Understand Disorders of Sex Development 
  Universdad San Francisco de Quito, Ecuador - 1/1/2015
• Predicting the Pathogenicity of Genetic Variants in the DNA Double Strand Break Repair Pathway 
  Baltimore, MD - 1/1/2015
• The Population and Disease Genetics of Ashkenazi Jews: America's Largest Genetic Isolate 
  University of Maryland, Baltimore, MD - 1/1/2015
• Functional and predictive assays in radiation oncology 
  Memorial Sloan-Kettering Cancer Center, New York, NY - 1/1/2015
• Adam and Eve Seek NextGen Sequencing to Understand Sex Determination and Its Disorders 
  Florida International University College of Medicine, Miami, FL - 1/1/2014
• Genomics from a Medical Geneticist's Perspective 
  New York, NY - 1/1/2014
• Genomic Analysis for Breast Cancer Risk Prediction 
  Kibbutz Hagoshrim, Israel - 1/1/2014
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Other

• 46,XY disorders of sexual development (DSD) and 46,XY complete gonadal dysgenesis 
  Ostrer, H, GeneReviews
  http://www.genetests.org
  1/1/2008
• Genetic and environmental causes of birth defects 
  Ostrer H
  http://www.uptodate.com/contents/genetic-and-environmental-causes-of-birth-defects
  UpToDate, Wolters Kluwer Health - 2013-04-01
• Basic principles of genetic counseling for the obstetrical provider 
  Ostrer H
  http://www.uptodate.com/contents/basic-principles-of-genetic-counseling-for-the-obstetrical-provider
  UpToDate, Wolters Kluwer Health - 2012-04-30