HarshabadSinghMD

PubMed

• RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer.
  Harshabad Singh, Pranshu Sahgal, Kevin Kapner, Steven M Corsello, Hersh Gupta, Rahul Gujrathi, Yvonne Y Li, Andrew D Cherniack, Raquelle El Alam, Joseph Kerfoot, Eliza...> ;Clinical Cancer Research. 2024 Apr 15
• Mutational signature-based identification of DNA repair deficient gastroesophageal adenocarcinomas for therapeutic targeting.
  Aurel Prosz, Pranshu Sahgal, Brandon M Huffman, Zsofia Sztupinszki, Clare X Morris, David Chen, Judit Börcsök, Miklos Diossy, Viktoria Tisza, Sandor Spisak, Pornlada L...> ;NPJ Precision Oncology. 2024 Apr 8
• Biomarkers of pembrolizumab efficacy in advanced anal squamous cell carcinoma: analysis of a phase II clinical trial and a cohort of long-term responders.
  Huffman, B., Singh, H., Ali, L., Horick, N., Wang, S., Hoffman, M., Metayer, K., Murray, S., Bird, A., Abrams, T., Biller, L., Chan, J., Meyerhardt, J., McCleary, N., ...> ;Journal for Immunotherapy of Cancer. 2024 Jan 25
• 1 citations
  A Phase I Expansion Cohort Study Evaluating the Safety and Efficacy of the CHK1 Inhibitor LY2880070 with Low-dose Gemcitabine in Patients with Metastatic Pancreatic Ad...
  Huffman, B., Feng, H., Parmar, K., Wang, J., Kapner, K., Kochupurakkal, B., Martignetti, D., Sadatrezaei, G., Abrams, T., Biller, L., Giannakis, M., Ng, K., Patel, A.,...> ;Clinical Cancer Research. 2023 Dec 15
• 1 citations
  Replicative stress in gastroesophageal cancer is associated with chromosomal instability and sensitivity to DNA damage response inhibitors.
  Pranshu Sahgal, Deepa T Patil, Pratyusha Bala, Zsofia M Sztupinszki, Viktoria Tisza, Sandor Spisak, Anna G Luong, Brandon Huffman, Aurel Prosz, Harshabad Singh, Jean-B...> ;Iscience. 2023 Nov 17
• Systematic literature review and meta-analysis of HER2 amplification, overexpression, and positivity in colorectal cancer.
  Harshabad Singh, Ashley Kang, Lisa Bloudek, Ling-I Hsu, Maria Corinna Palanca-Wessels, Michael Stecher, Muriel Siadak, Kimmie Ng> ;JNCI Cancer Spectrum. 2024 Jan 4
• 3 citations
  Oncogenic Drivers and Therapeutic Vulnerabilities in KRAS Wild-Type Pancreatic Cancer.
  Harshabad Singh, Rachel B Keller, Kevin S Kapner, Julien Dilly, Srivatsan Raghavan, Chen Yuan, Elizabeth F Cohen, Michael Tolstorukov, Elizabeth Andrews, Lauren K Brai...> ;Clinical Cancer Research. 2023 Nov 14
• Highly Sensitive Circulating Tumor DNA Assay Aids Clinical Management of Radiographically Occult Isolated Peritoneal Metastases in Patients With GI Cancer.
  Harshabad Singh, Samuel J Klempner, Nelya Melnitchouk, Deepak P Chander, Ovidiu George Negrea, Anuj K Patel, Benjamin L Schlechter, Douglas A Rubinson, Brandon M Huffm...> ;JCO Precision Oncology. 2023 Jun 1
• G-CSF rescue of FOLFIRINOX-induced neutropenia leads to systemic immune suppression in mice and humans.
  Victoire Cardot-Ruffino, Naima Bollenrucher, Luisa Delius, S Jennifer Wang, Lauren K Brais, Joshua Remland, C Elizabeth Keheler, Keri M Sullivan, Thomas A Abrams, Leah...> ;Journal for Immunotherapy of Cancer. 2023 Jun 1
• 1 citations
  Replicative stress in gastroesophageal adenocarcinoma is associated with chromosomal instability and sensitivity to DNA damage response inhibitors.
  Pranshu Sahgal, Deepa T Patil, Zsofia M Sztupinszki, Viktoria Tisza, Sandor Spisak, Brandon Huffman, Aurel Prosz, Harshabad Singh, Jean-Bernard Lazaro, Zoltan Szallasi...> ;Biorxiv. 2023 Mar 28
• 2 citations
  Programmatic Precision Oncology Decision Support for Patients With Gastrointestinal Cancer.
  Rachel B Keller, Tali Mazor, Lynette Sholl, Andrew J Aguirre, Harshabad Singh, Nilay Sethi, Adam Bass, Ankur K Nagaraja, Lauren K Brais, Emma Hill, Connor Hennessey, M...> ;JCO Precision Oncology. 2023 Jan 1
• 4 citations
  Emerging Role of Targeted Therapy in Metastatic Pancreatic Adenocarcinoma.
  Brandon M Huffman, Haley Ellis, Alexander C Jordan, William A Freed-Pastor, Kimberly Perez, Douglas A Rubinson, Nilay Sethi, Harshabad Singh, Rishi Surana, Brian M Wol...> ;Cancers. 2022 Dec 16
• 13 citations
  Spatially Resolved Single-Cell Assessment of Pancreatic Cancer Expression Subtypes Reveals Co-expressor Phenotypes and Extensive Intratumoral Heterogeneity.
  Hannah L Williams, Andressa Dias Costa, Jinming Zhang, Srivatsan Raghavan, Peter S Winter, Kevin S Kapner, Scott P Ginebaugh, Sara A Väyrynen, Juha P Väyrynen, Chen Yu...> ;Cancer Research. 2023 Feb 3
• 16 citations
  Neoadjuvant Chemotherapy Is Associated with Altered Immune Cell Infiltration and an Anti-Tumorigenic Microenvironment in Resected Pancreatic Cancer.
  Andressa Dias Costa, Sara A Väyrynen, Akhil Chawla, Jinming Zhang, Juha P Väyrynen, Mai Chan Lau, Hannah L Williams, Chen Yuan, Vicente Morales-Oyarvide, Dalia Elganai...> ;Clinical Cancer Research. 2022 Dec 1
• 13 citations
  Secondary IDH1 resistance mutations and oncogenic IDH2 mutations cause acquired resistance to ivosidenib in cholangiocarcinoma.
  James M Cleary, Betty Rouaisnel, Antoine Daina, Srivatsan Raghavan, Lauren A Roller, Brandon M Huffman, Harshabad Singh, Patrick Y Wen, Nabeel Bardeesy, Vincent Zoete,...> ;NPJ Precision Oncology. 2022 Sep 2
• G-CSF-induced carotid inflammation.
  Harshabad Singh, Michael H Rosenthal, Brian M Wolpin> ;The Lancet. Oncology. 2022 May 1
• 8 citations
  ALK Inhibitors in Patients With ALK Fusion-Positive GI Cancers: An International Data Set and a Molecular Case Series.
  Margherita Ambrosini, Marzia Del Re, Paolo Manca, Andrew Hendifar, Alexander Drilon, Guilherme Harada, Anne Hansen Ree, Samuel Klempner, Gunhild Mari Mælandsmo, Kjerst...> ;JCO Precision Oncology. 2022 Apr 1
• 9 citations
  Transcription factor-mediated intestinal metaplasia and the role of a shadow enhancer.
  Harshabad Singh, Davide Seruggia, Shariq Madha, Madhurima Saxena, Ankur K Nagaraja, Zhong Wu, Jin Zhou, Aaron J Huebner, Adrianna Maglieri, Juliette Wezenbeek, Konrad ...> ;Genes & Development. 2022 Jan 1
• 2 citations
  Durable clinical benefit from PARP inhibition in a platinum-sensitive, BRCA2-mutated pancreatic cancer patient after earlier progression on placebo treatment on the PO...
  Douglas Rubinson, Brian M Wolpin, Ilana S Warsofsky, David P Ryan, Kimberly Perez, Osama Rahma, Harshabad Singh, Matthew B Yurgelun, Geoffrey I Shapiro, Andrew J Aguir...> ;Journal of Gastrointestinal Oncology. 2021 Dec 1
• 18 citations
  An Enhancer-Driven Stem Cell-Like Program Mediated by SOX9 Blocks Intestinal Differentiation in Colorectal Cancer.
  Xiaoyan Liang, Gina N. Duronio, Yaying Yang, Pratyusha Bala, Prajna Hebbar, Sándor Spisák, Pranshu Sahgal, Harshabad Singh, Yanxi Zhang, Yingtian Xie, Paloma Cejas, He...> ;Gastroenterology. 2021 Sep 25
• 3 citations
  Beyond the Front Line: Emerging Data for Maintenance Therapy in Pancreatic Cancer
  Harshabad Singh, Kimberly Perez, Brian M. Wolpin, Andrew J. Aguirre> ;Journal of Clinical Oncology. 2021 Aug 24
• 5 citations
  Opportunities for Utilization of DNA Repair Inhibitors in Homologous Recombination Repair-Deficient and Proficient Pancreatic Adenocarcinoma.
  James M. Cleary, Brian M. Wolpin, Stephanie K. Dougan, Srivatsan Raghavan, Harshabad Singh, Brandon M. Huffman, Nilay Sethi, Jonathan A. Nowak, Geoffrey I. Shapiro, An...> ;Clinical Cancer Research. 2021 Jul 20
• 15 citations
  Hybrid Stomach-Intestinal Chromatin States Underlie Human Barrett's Metaplasia.
  Harshabad Singh, Kyungsik Ha, Jason L. Hornick, Shariq Madha, Paloma Cejas, Kunal Jajoo, Pratik N.P. Singh, Paz Polak, Hwajin Lee, Ramesh A. Shivdasani> ;Gastroenterology. 2021 Sep 1
• 14 citations
  Molecular Characterization and Therapeutic Targeting of Colorectal Cancers Harboring Receptor Tyrosine Kinase Fusions
  Harshabad Singh, Yvonne Y. Li, Liam F. Spurr, Atul B. Shinagare, Ritika Abhyankar, Emma Reilly, Lauren K. Brais, Anwesha Nag, Matthew D. Ducar, Aaron R. Thorner, Geoff...> ;Clinical Cancer Research. 2021 Jan 7
• 25 citations
  Whole exome sequencing of urachal adenocarcinoma reveals recurrent NF1 mutations
  Harshabad Singh, Yang Liu, Xiuli Xiao, Ling Lin, Jaegil Kim, Paul Van Hummelen, Chin-Lee Wu, Adam J. Bass, Philip J. Saylor> ;Oncotarget. 2016 Apr 7
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