HartmutKoeppenMD

PubMed

• Automated tumor immunophenotyping predicts clinical benefit from anti-PD-L1 immunotherapy.
  Xiao Li, Jeffrey Eastham, Jennifer M Giltnane, Wei Zou, Andries Zijlstra, Evgeniy Tabatsky, Romain Banchereau, Ching-Wei Chang, Barzin Y Nabet, Namrata S Patil, Lucian...> ;The Journal of Pathology. 2024 Mar 25
• 1 citations
  Loss of CD20 expression as a mechanism of resistance to mosunetuzumab in relapsed/refractory B-cell lymphomas.
  Stephen J Schuster, Ling-Yuh Huw, Christopher R Bolen, Victor Maximov, Andrew G Polson, Katerina Hatzi, Elisabeth A Lasater, Sarit E Assouline, Nancy L Bartlett, L Eli...> ;Blood. 2024 Feb 29
• Immune heterogeneity in small-cell lung cancer and vulnerability to immune checkpoint blockade.
  Barzin Y Nabet, Habib Hamidi, Myung Chang Lee, Romain Banchereau, Stefanie Morris, Leah Adler, Velimir Gayevskiy, Ahmed M Elhossiny, Minu K Srivastava, Namrata S Patil...> ;Cancer Cell. 2024 Mar 11
• Development of a Cryo-Pre-Embedding Immunogold Labeling Protocol for the Ultrastructural Localization of PDL1 in Human Tonsils.
  Miriam Baca, Cecile Chalouni, Hartmut Koeppen, Linda Rangell, Meredith Sagolla, Mike Reichelt> ;Microscopy and Microanalysis. 2023 Jul 22
• 2 citations
  Disruption of stem cell niche-confined R-spondin 3 expression leads to impaired hematopoiesis.
  Antonina V Kurtova, Melanie Heinlein, Simon Haas, Lars Velten, Gerrit J P Dijkgraaf, Elaine E Storm, Noelyn M Kljavin, Soufiane Boumahdi, Patricia Himmels, Aurelie Her...> ;Blood Advances. 2023 Feb 28
• 25 citations
  CD8T cell-intrinsic IL-6 signaling promotes resistance to anti-PD-L1 immunotherapy.
  Mahrukh A Huseni, Lifen Wang, Joanna E Klementowicz, Kobe Yuen, Beatrice Breart, Christine Orr, Li-Fen Liu, Yijin Li, Vinita Gupta, Congfen Li, Deepali Rishipathak, Ji...> ;Cell Reports. Medicine. 2023 Jan 17
• 28 citations
  Whole-body CD8T cell visualization before and during cancer immunotherapy: a phase 1/2 trial.
  Laura Kist de Ruijter, Pim P van de Donk, Jahlisa S Hooiveld-Noeken, Danique Giesen, Sjoerd G Elias, Marjolijn N Lub-de Hooge, Sjoukje F Oosting, Mathilde Jalving, Wim...> ;Nature Medicine. 2022 Dec 1
• 22 citations
  Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers.
  Jennifer Cantley, Xiaofen Ye, Emma Rousseau, Tom Januario, Brian D Hamman, Christopher M Rose, Tommy K Cheung, Trent Hinkle, Leofal Soto, Connor Quinn, Alicia Harbin, ...> ;Nature Communications. 2022 Nov 10
• 164 citations
  Molecular correlates of clinical response and resistance to atezolizumab in combination with bevacizumab in advanced hepatocellular carcinoma.
  Andrew X Zhu, Alexander R Abbas, Marina Ruiz de Galarreta, Yinghui Guan, Shan Lu, Hartmut Koeppen, Wenjun Zhang, Chih-Hung Hsu, Aiwu Ruth He, Baek-Yeol Ryoo, Thomas Ya...> ;Nature Medicine. 2022 Aug 1
• 4 citations
  Immune contexture of paediatric cancers.
  Meghna Das Thakur, Carl J Franz, Laura Brennan, Jurriaan Brouwer-Visser, Rachel Tam, Konstanty Korski, Hartmut Koeppen, James Ziai, Galina Babitzki, Dominique Ranchere...> ;European Journal of Cancer. 2022 Jul 1
• 4 citations
  Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors.
  Christopher W Davies, Angela J Oh, Rana Mroue, Micah Steffek, John M Bruning, Yang Xiao, Siyu Feng, Sangeeta Jayakar, Emily Chan, Vidhyalakshmi Arumugam, Sean Carlo Ur...> ;Nature Biotechnology. 2022 May 1
• 11 citations
  Distinct resistance mechanisms arise to allosteric vs. ATP-competitive AKT inhibitors.
  Kristin M Zimmerman Savill, Brian B Lee, Jason Oeh, Jie Lin, Eva Lin, Wei-Jen Chung, Amy Young, Wennie Chen, Monika Miś, Kathryn Mesh, Jeffrey Eastham, Florian Gnad, Z...> ;Nature Communications. 2022 Apr 19
• 119 citations
  Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer.
  Namrata S Patil, Barzin Y Nabet, Sören Müller, Hartmut Koeppen, Wei Zou, Jennifer Giltnane, Amelia Au-Yeung, Shyam Srivats, Jason H Cheng, Chikara Takahashi, Patricia ...> ;Cancer Cell. 2022 Mar 14
• 23 citations
  Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α.
  Adrien Le Thomas, Elena Ferri, Scot Marsters, Jonathan M Harnoss, David A Lawrence, Iratxe Zuazo-Gaztelu, Zora Modrusan, Sara Chan, Margaret Solon, Cécile Chalouni, We...> ;Nature Communications. 2021 Dec 15
• Characterization of Tumor-immune Microenvironment by High-throughput Image Analysis of CD8 Immunohistochemistry Combined With Modified Masson’s Trichrome:
  Charles Havnar, Shari Lau, Jeffrey Hung, Jeffrey Eastham-Anderson, Carmina Espiritu, Linda Rangell, Hartmut Koeppen, James Ziai, Oded Foreman> ;The Journal of Histochemistry and Cytochemistry. 2021 Aug 5
• Recent Advances in Pathology: the 2021 Annual Review Issue of The Journal of Pathology.
  C Simon Herrington, Richard Poulsom, Hartmut Koeppen, Philip J Coates> ;The Journal of Pathology. 2021 Jul 1
• 11 citations
  Comparison of SP142 and 22C3 Immunohistochemistry PD-L1 Assays for Clinical Efficacy of Atezolizumab in Non-Small Cell Lung Cancer: Results From the Randomized OAK Trial.
  Shirish M. Gadgeel, Fred R. Hirsch, Keith M. Kerr, Fabrice Barlesi, Keunchil Park, Achim Rittmeyer, Wei Zou, Namrata Bhatia, Hartmut Koeppen, Sarah M. Paul, David S. S...> ;Clinical Lung Cancer. 2021 May 30
• 14 citations
  Microenvironmental regulation of tumour immunity and response to immunotherapy.
  Mark M. Kockx, Mark McCleland, Hartmut Koeppen> ;The Journal of Pathology. 2021 May 19
• 64 citations
  Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade.
  Romain Banchereau, Avantika S. Chitre, Alexis Scherl, Thomas D. Wu, Namrata Patil, Patrícia de Almeida, Edward E. Kadel, Shravan Madireddi, Amelia Au-Yeung, Chikara Ta...> ;Journal for Immunotherapy of Cancer. 2021 Apr 1
• 4 citations
  Author Correction: High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade.
  Kobe C. Yuen, Li-Fen Liu, Vinita Gupta, Shravan Madireddi, Shilpa Keerthivasan, Congfen Li, Deepali Rishipathak, Patrick Williams, Edward E. Kadel, Hartmut Koeppen, Yi...> ;Nature Medicine. 2021 Feb 5
• 221 citations
  Molecular Subsets in Renal Cancer Determine Outcome to Checkpoint and Angiogenesis Blockade
  Robert J. Motzer, Romain Banchereau, Habib Hamidi, Thomas Powles, David F. McDermott, Michael B. Atkins, Bernard Escudier, Li-Fen Liu, Ning Leng, Alexander R. Abbas, J...> ;Cancer Cell. 2020 Dec 14
• 50 citations
  Integrated digital pathology and transcriptome analysis identifies molecular mediators of T-cell exclusion in ovarian cancer.
  Mélanie Desbois, Akshata Udyavar, Lisa Ryner, Cleopatra Kozlowski, Yinghui Guan, Milena Dürrbaum, Shan Lu, Jean-Philippe Fortin, Hartmut Koeppen, James Ziai, Ching-Wei...> ;Nature Communications. 2020 Nov 4
• 34 citations
  IRE1α Disruption in Triple-Negative Breast Cancer Cooperates with Antiangiogenic Therapy by Reversing ER Stress Adaptation and Remodeling the Tumor Microenvironment.
  Jonathan M. Harnoss, Adrien Le Thomas, Mike Reichelt, Ofer Guttman, Thomas D. Wu, Scot A. Marsters, Anna Shemorry, David A. Lawrence, David Kan, Ehud Segal, Mark Merch...> ;Cancer Research. 2020 Jun 1
• 202 citations
  High systemic and tumor-associated IL-8 correlates with reduced clinical benefit of PD-L1 blockade.
  Kobe C. Yuen, Li-Fen Liu, Vinita Gupta, Shravan Madireddi, Shilpa Keerthivasan, Congfen Li, Deepali Rishipathak, Patrick Williams, Edward E. Kadel, Hartmut Koeppen, Yi...> ;Nature Medicine. 2020 May 1
• 361 citations
  Single-Cell RNA Sequencing Reveals Stromal Evolution into LRRC15+ Myofibroblasts as a Determinant of Patient Response to Cancer Immunotherapy
  Claudia X. Dominguez, Sören Müller, Shilpa Keerthivasan, Hartmut Koeppen, Jeffrey Hung, Sarah Gierke, Béatrice Breart, Oded Foreman, Travis W. Bainbridge, Alessandra C...> ;Cancer Discovery. 2020 Feb 1
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Journal Articles

• Differential Regulation of PD-L1 Expression by Immune and Tumor Cells in NSCLC and the Response to Treatment with Atezolizumab (Anti–PD-L1)  
  Alan Sandler, David S Shames, Hartmut Koeppen, Jamie Chaft, Scott N Gettinger, Alexander Spira, Daniel S Chen, Naiyer A Rizvi, David R Spigel, Proceedings of the National Academy of Sciences

Abstracts/Posters

• Pharmacodynamic Effects and Immune Correlates of Response to the CD20/CD3 Bispecific Antibody Mosunetuzumab in Relapsed or Refractory Non-Hodgkin Lymphoma
  Hartmut Koeppen, 61st Annual American Society of Hematology Meeting, Orlando, FL, 12/7/2019