Holly Ruth Middlekauff MD

Professor, Medicine (Cardiology) and Physiology, UCLA David Geffen School of Medicine; Assistant Dean for Student Affairs, UCLA David Geffen School of Medicine

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200 Medical 420 120 530 Plz# 365Los Angeles, CA 90095
Phone+1 310-206-6672
Fax+1 310-825-9014

Education & Training

UCLA David Geffen School of Medicine/UCLA Medical CenterFellowship, Cardiovascular Disease, 1989 - 1992
UCLA David Geffen School of Medicine/UCLA Medical CenterResidency, Internal Medicine, 1986 - 1989
Keck School of Medicine of the University of Southern CaliforniaClass of 1986

Certifications & Licensure

CA State Medical License 1988 - 2027
American Board of Internal Medicine Internal Medicine
American Board of Internal Medicine Cardiovascular Disease

Awards, Honors, & Recognition

CMS Meaningful Use Stage 1 Certification EpicCare Ambulatory EMR, Epic Systems Corporation, 2013
Fellow (FACC) American College of Cardiology

Clinical Trials

Acupuncture in Cardiovascular Disease Start of enrollment: 2001 Jul 01
Completed
Phase 2
Using Clonidine to Improve Leg Weakness in People With Heart Failure Start of enrollment: 2008 May 01
Completed
Phase 4
E-Cigarettes and SNA Start of enrollment: 2015 Apr 01
Completed
Not Applicable
Arterial Inflammation and E-Cigarettes Start of enrollment: 2015 Jul 01
Completed
Not Applicable
E-cigarettes and Blood Vessel Function Start of enrollment: 2015 Aug 01
Completed
Not Applicable
ECigs, Inflammation and Oxidative Stress Start of enrollment: 2019 Feb 08
Completed
Not Applicable
Smoking and Ventricular Repolarization Start of enrollment: 2019 Oct 01
Completed
Not Applicable
Acute Effects of TCIG vs ECIG in PLWH Start of enrollment: 2020 Oct 01
Completed
Not Applicable
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Publications & Presentations

PubMed

Atherogenic Effects of Acute Electronic Cigarette Compared With Tobacco Cigarette Smoking in People Living With HIV: A Randomized Crossover Trial.
Theodoros Kelesidis, Leila Fotooh Abadi, Isabelle Ruedisueli, Zoee U D'Costa, Holly R Middlekauff
Journal of the American Heart Association. 2025-04-01
Electronic cigarettes alter cardiac rhythm and heart rate variability hyperacutely in mice.
Jocelyn A Castellanos, Carson G Cornett, David H Gonzalez, Liqiao Li, Karla Luna
Toxicology and Applied Pharmacology. 2025-02-01
1 citations
Blunt Talk on "Blunts": The Increasingly Popular Tobacco Product That Is Potentially Exacerbating Tobacco-Related Health Disparities.
Joshua I Sanchez, Reece S Fong, Katherine Hampilos, Ziva D Cooper, Holly R Middlekauff
Journal of General Internal Medicine. 2025-02-01

Lectures

Vaping: What Every Cardiologist Needs to Know
2019 ACC Scientific Session & Expo, New Orleans - 3/18/2019

Press Mentions

E-cigarettes Linked to Lower Cardiac Risks Compared to Tobacco Cigarettes in People with HIVMarch 19th, 2025
UCLA Health Expert on the Rise and Hidden Health Risks of Blunt SmokingOctober 16th, 2024
Science Shows How a Surge of Anger Could Raise Heart Attack RiskMay 1st, 2024
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Grant Support

Sympathoexcitatory Effect Of Tobacco In Premenopausal WomenNational Center For Research Resources2010
Cardiac Resynchronization Therapy And The Skeletal Myopathy Of Heart FailureNational Center For Research Resources2010
The Effect Of Smoking On The Pattern Of Neural Sympathetic Outflow In PremenopauNational Center For Research Resources2009–2010
Clionidine And The Skeletal Myopathy Of Heart FailureNational Center For Research Resources2009–2010
Sympathetic Nerve Activity And The Skeletal Myopathy Of Heart FailureNational Heart, Lung, And Blood Institute2007–2010
Effect Of Smoking On The Pattern Of Neural Sympathetic Outflow InNational Center For Research Resources2008
Passive Exercise In The Arm In Heart Failure PatientsNational Center For Research Resources2005–2008
Does Endogenous Adenosine Sensitize Muscle Mechanoreceptor Control Of MuscleNational Center For Research Resources2005–2007
DO Endogenous Prostaglandins Sensitize Muscle Mechanoreceptor Control Of MUSCNational Center For Research Resources2005–2006
Effects Of Acupuncture On The Blood Pressure During Handgrip Exercise In Heal...National Center For Research Resources2004
Does Endogenous Lactic Acid Sensitize Muscle Mechaoreceptor Control Of Muscle...National Center For Research Resources2004
Does Endogenous Adenosine Sensitize Muscle Mechanoreceptor Control Of Muscle...National Center For Research Resources2004
DO Endogenous Prostaglandins Sensitize Muscle Mechanoreceptor Control Of Musc...National Center For Research Resources2004
Are Leg Muscle Mechanoreceptor Sensory Neurons Chronically Sensitized In Huma...National Center For Research Resources2004
Muscle Mechanosensitivity In Heart FailureNational Heart, Lung, And Blood Institute2001–2004
Acupuncture In Cardiovascular DiseaseNational Center For Complementary &Alternative Medicine2001–2002
Renal Blood Flow During Exercise In Heart FailureNational Center For Research Resources1998–2001
Renal Blood Flow During Exercise In Heart FailureNational Heart, Lung, And Blood Institute1997–2000
Abnormal Responses To Orthostatic Stress In Heart FailureNational Center For Research Resources1995–1999
Circardian Pattern Of Para/Sympathetic Regulation In Advanced Heart FailureNational Center For Research Resources1995–1997
Mechanisms Of Control Of Sympathetic Nerve Activity In Cirrhosis PatientsNational Center For Research Resources1995