HongSunNP

PubMed

• 167 citations
  Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.
  Wen Shen, Cheryl L De Hoyos, Michael T. Migawa, Timothy A. Vickers, Hong Sun, Audrey Low, Thomas A. Bell, Meghdad Rahdar, Swagatam Mukhopadhyay, Christopher E. Hart, M...> ;Nature Biotechnology. 2019 Apr 29
• 29 citations
  COPII vesicles can affect the activity of antisense oligonucleotides by facilitating the release of oligonucleotides from endocytic pathways.
  Xue-hai Liang, Hong Sun, Joshua G Nichols, Nickolas Allen, Shiyu Wang, Timothy A. Vickers, Wen Shen, Chih-Wei Hsu, Stanley T. Crooke> ;Nucleic Acids Research. 2018 Nov 2
• 49 citations
  Cellular uptake mediated by epidermal growth factor receptor facilitates the intracellular activity of phosphorothioate-modified antisense oligonucleotides.
  Shiyu Wang, Nickolas Allen, Timothy A. Vickers, Alexey S. Revenko, Hong Sun, Xue-hai Liang, Stanley T. Crooke> ;Nucleic Acids Research. 2018 Apr 20
• 51 citations
  Acute hepatotoxicity of 2' fluoro-modified 5-10-5 gapmer phosphorothioate oligonucleotides in mice correlates with intracellular protein binding and the loss of DBHS p...
  Wen Shen, Cheryl L De Hoyos, Hong Sun, Timothy A. Vickers, Xue-hai Liang, Stanley T. Crooke> ;Nucleic Acids Research. 2018 Mar 16
• 15 citations
  Translation can affect the antisense activity of RNase H1-dependent oligonucleotides targeting mRNAs
  Xue-hai Liang, Joshua G Nichols, Hong Sun, Stanley T. Crooke> ;Nucleic Acids Research. 2018 Jan 9
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